Antibody mediated protection of immunized macaques against pathogenic SHIV challenge (2006)
Srivastava, Indresh K, Kan, Elaine, Sun, Yide, Legg, Harold, Lee, Queency, Burke, Brian, ...
No abstract available.
Fikkert, Valery, O'Keefe, Barry R, McMahon, James, ...
Due to the biological significance of the carbohydrate component of the human immunodeficiency virus type 1 (HIV-1) glycoproteins in viral pathogenesis, the glycosylation step constitutes an...
Development of cationic liposomes to transfer proteins between membranes / (1988)
Written for the Dept. of Biochemistry.
Development of cationic liposomes to transfer proteins between membranes (1988)
The overall goal of this thesis work has been the construction of liposomes that can be used to deliver biologically active molecules efficiently into the plasma membranes of animal cells in tissue...
Stamatatos, Leonidas, Cheng-Mayer, Cecilia
SF162 is a primary (PR), non-syncytium-inducing, macrophagetropic human immunodeficiency virus type 1 (HIV-1) clade B isolate which is resistant to antibody-mediated neutralization. Deletion of the...
We examined the role of asparagine-linked glycosylation of the V2 loop of the human immunodeficiency virus (HIV) SF162 envelope on viral replication potential and neutralization susceptibility. We...
Srivastava, Indresh K., Stamatatos, Leonidas, Legg, Harold, Kan, Elaine, Fong, Anne, Coates, Stephen R., ...
Human immunodeficiency virus (HIV) continues to be a major public health problem throughout the world, with high levels of mortality and morbidity associated with AIDS. Considerable efforts to...
Srivastava, Indresh K., VanDorsten, Keating, Vojtech, Lucia, Barnett, Susan W., Stamatatos, Leonidas
Immunization of macaques with the soluble oligomeric gp140 form of the SF162 envelope (SF162gp140) or with an SF162gp140-derived construct lacking the central region of the V2 loop (ΔV2gp140)...
Srivastava, Indresh K., Stamatatos, Leonidas, Kan, Elaine, Vajdy, Michael, Lian, Ying, Hilt, Susan, ...
The envelope (Env) glycoprotein of human immunodeficiency virus type 1 (HIV-1) is the major target of neutralizing antibody responses and is likely to be a critical component of an effective vaccine...
Gummuluru, Suryaram, Rogel, Mark, Stamatatos, Leonidas, Emerman, Michael
Interactions of human immunodeficiency virus type 1 (HIV-1) with immature dendritic cells (DC) are believed to be multifactorial and involve binding to the CD4 antigen, DC-specific ICAM-3-grabbing...
McCaffrey, Ruth A., Saunders, Cheryl, Hensel, Mike, Stamatatos, Leonidas
We examined how asparagine-linked glycans within and adjacent to the V3 loop (C2 and C3 regions) and within the immunologically silent face (V4, C4, and V5 regions) of the human immunodeficiency...
Gorny, Miroslaw K., Stamatatos, Leonidas, Volsky, Barbara, Revesz, Kathy, Williams, Constance, Wang, Xiao-Hong, ...
The selection of human monoclonal antibodies (MAbs) specific for human immunodeficiency virus (HIV) type 1 by binding assays may fail to identify Abs to quaternary epitopes on the intact virions. The...
Witvrouw, Myriam, Fikkert, Valery, Hantson, Anke, Pannecouque, Christophe, O'Keefe, Barry R., McMahon, James, ...
Due to the biological significance of the carbohydrate component of the human immunodeficiency virus type 1 (HIV-1) glycoproteins in viral pathogenesis, the glycosylation step constitutes an...
Li, Ming, Gao, Feng, Mascola, John R., Stamatatos, Leonidas, Polonis, Victoria R., Koutsoukos, Marguerite, ...
Induction of broadly cross-reactive neutralizing antibodies is a high priority for AIDS vaccine development but one that has proven difficult to be achieved. While most immunogens generate antibodies...
Saunders, Cheryl J., McCaffrey, Ruth A., Zharkikh, Irina, Kraft, Zane, Malenbaum, Susan E., Burke, Brian, ...
It is well documented that removal of the V1V2 region or of the V2 loop alone from the envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) or simian immunodeficiency virus (SIV)...
Stamatatos, Leonidas, Cheng-Mayer, Cecilia
SF162 is a primary (PR), non-syncytium-inducing, macrophagetropic human immunodeficiency virus type 1 (HIV-1) clade B isolate which is resistant to antibody-mediated neutralization. Deletion of the...
We examined the role of asparagine-linked glycosylation of the V2 loop of the human immunodeficiency virus (HIV) SF162 envelope on viral replication potential and neutralization susceptibility. We...
Srivastava, Indresh K., Stamatatos, Leonidas, Legg, Harold, Kan, Elaine, Fong, Anne, Coates, Stephen R., ...
Human immunodeficiency virus (HIV) continues to be a major public health problem throughout the world, with high levels of mortality and morbidity associated with AIDS. Considerable efforts to...
Srivastava, Indresh K., VanDorsten, Keating, Vojtech, Lucia, Barnett, Susan W., Stamatatos, Leonidas
Immunization of macaques with the soluble oligomeric gp140 form of the SF162 envelope (SF162gp140) or with an SF162gp140-derived construct lacking the central region of the V2 loop (ΔV2gp140)...
Srivastava, Indresh K., Stamatatos, Leonidas, Kan, Elaine, Vajdy, Michael, Lian, Ying, Hilt, Susan, ...
The envelope (Env) glycoprotein of human immunodeficiency virus type 1 (HIV-1) is the major target of neutralizing antibody responses and is likely to be a critical component of an effective vaccine...
Gummuluru, Suryaram, Rogel, Mark, Stamatatos, Leonidas, Emerman, Michael
Interactions of human immunodeficiency virus type 1 (HIV-1) with immature dendritic cells (DC) are believed to be multifactorial and involve binding to the CD4 antigen, DC-specific ICAM-3-grabbing...
McCaffrey, Ruth A., Saunders, Cheryl, Hensel, Mike, Stamatatos, Leonidas
We examined how asparagine-linked glycans within and adjacent to the V3 loop (C2 and C3 regions) and within the immunologically silent face (V4, C4, and V5 regions) of the human immunodeficiency...
Gorny, Miroslaw K., Stamatatos, Leonidas, Volsky, Barbara, Revesz, Kathy, Williams, Constance, Wang, Xiao-Hong, ...
The selection of human monoclonal antibodies (MAbs) specific for human immunodeficiency virus (HIV) type 1 by binding assays may fail to identify Abs to quaternary epitopes on the intact virions. The...
Witvrouw, Myriam, Fikkert, Valery, Hantson, Anke, Pannecouque, Christophe, O'Keefe, Barry R., McMahon, James, ...
Due to the biological significance of the carbohydrate component of the human immunodeficiency virus type 1 (HIV-1) glycoproteins in viral pathogenesis, the glycosylation step constitutes an...
Saunders, Cheryl J., McCaffrey, Ruth A., Zharkikh, Irina, Kraft, Zane, Malenbaum, Susan E., Burke, Brian, ...
It is well documented that removal of the V1V2 region or of the V2 loop alone from the envelope glycoprotein of human immunodeficiency virus type 1 (HIV-1) or simian immunodeficiency virus (SIV)...
Li, Ming, Gao, Feng, Mascola, John R., Stamatatos, Leonidas, Polonis, Victoria R., Koutsoukos, Marguerite, ...
Induction of broadly cross-reactive neutralizing antibodies is a high priority for AIDS vaccine development but one that has proven difficult to be achieved. While most immunogens generate antibodies...
Antibody mediated protection of immunized macaques against pathogenic SHIV challenge
Srivastava, Indresh K, Kan, Elaine, Sun, Yide, Legg, Harold, Lee, Queency, Burke, Brian, ...
Derby, Nina R., Kraft, Zane, Kan, Elaine, Crooks, Emma T., Barnett, Susan W., Srivastava, Indresh K., ...
The antibody responses elicited in rhesus macaques immunized with soluble human immunodeficiency virus (HIV) Env gp140 proteins derived from the R5-tropic HIV-1 SF162 virus were analyzed and compared...
Derby, Nina R., Kraft, Zane, Kan, Elaine, Crooks, Emma T., Barnett, Susan W., Srivastava, Indresh K., ...
Kraft, Zane, Derby, Nina R., McCaffrey, Ruth A., Niec, Rachel, Blay, Wendy M., Haigwood, Nancy L., ...
The development of anti-human immunodeficiency virus (anti-HIV) neutralizing antibodies and the evolution of the viral envelope glycoprotein were monitored in rhesus macaques infected with a...
Ching, Lance K., Vlachogiannis, Giorgos, Bosch, Katherine A., Stamatatos, Leonidas
Current vaccine efforts to elicit cross-reactive neutralizing antibodies (NAbs) against human immunodeficiency virus (HIV) focus on the engineering of soluble mimetics of the trimeric HIV Env...
Kraft, Zane, Strouss, Katharine, Sutton, William F., Cleveland, Brad, Tso, For Yue, Polacino, Patricia, ...
The vast majority of studies with candidate immunogens based on the human immunodeficiency virus envelope (Env) have been conducted with Env proteins derived from clade B viruses isolated during...
Sather, D. Noah, Armann, Jakob, Ching, Lance K., Mavrantoni, Angeliki, Sellhorn, George, Caldwell, Zachary, ...
The characterization of the cross-reactive, or heterologous, neutralizing antibody responses developed during human immunodeficiency virus type 1 (HIV-1) infection and the identification of factors...