Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome (2008)
Dadabhoy, Dina, Crofford, Leslie J, Spaeth, Michael, Russell, I Jon, Clauw, Daniel J
Abstract Researchers studying fibromyalgia strive to identify objective, measurable biomarkers that may identify susceptible individuals, may facilitate diagnosis, or that parallel activity of the...
McLean, Samuel A., Williams, David A., Harris, Richard E., Gracely, Richard H., Geisser, Michael E., Sen, Ananda, ...
No abstract.
McLean, Samuel A., Williams, David A., Harris, Richard E., Kop, Willem J., Groner, Kimberly H., Ambrose, Kirsten, ...
Objective To compare the momentary association between salivary cortisol levels and pain, fatigue, and stress symptoms in patients with fibromyalgia (FM), and to compare diurnal cycles of cortisol...
Kocheril, Sosa V., Appleton, Brent E., Somers, Emily C., Kazerooni, Ella A., Flaherty, K. R., Martinez, Fernando J., ...
Objective To compare disease progression and mortality between idiopathic interstitial pneumonia (IIP) and interstitial lung disease (ILD) due to connective tissue diseases (CTD) including...
Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2 (2005)
Sampey, Annaleise V, Monrad, Seetha, Crofford, Leslie J
Abstract Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H 2 to PGE 2 . Proinflammatory stimuli markedly increase levels of...
Crofford, Leslie J., Rowbotham, Michael C., Mease, Philip J., Russell, I. Jon, Dworkin, Robert H., Corbin, Ann E., ...
Objective Fibromyalgia syndrome (FMS) is characterized by widespread musculoskeletal pain and lowered pain threshold. Other prominent symptoms include disordered sleep and fatigue. FMS affects an...
Crofford, Leslie J., McDonagh, Kevin T., Guo, Sutang, Mehta, Hemal, Bian, Huimin, Petruzelli, Lilli M., ...
Background Recombinant adenovirus can be administered in vivo to achieve transduction of a number of cell types including human synoviocytes. Immunogenicity of adenoviruses has limited their utility...
Crofford, Leslie J., Clauw, Daniel J., Crofford, Leslie J., Clauw, Daniel J.
No abstract.
Abstract The use of analgesic anti-inflammatory agents in patients with asthma is clinically challenging because of the prevalence (10–20%) of aspirin hypersensitivity. Aspirin-exacerbated...
Crofford, Leslie J., Clauw, Daniel J.
No abstract.
Yang, Jianmin, Friedman, Michael S, Bian, Huimin, Crofford, Leslie J, Roessler, Blake, McDonagh, Kevin T
Abstract We are developing retroviral-mediated gene transfer to human fibroblast-like synovial cells (FLS) as one approach to characterizing genetic pathways involved in synoviocyte pathophysiology....
Cognitive function in fibromyalgia patients (2001)
Park, Denise C., Glass, Jennifer M., Minear, Meredith, Crofford, Leslie J.
Objective To evaluate fibromyalgia (FM) patients for the presence of cognitive deficits and to test the hypothesis that abnormalities would fit a model of cognitive aging. Methods We studied 3 groups...
Crofford, Leslie J., McDonagh, Kevin T., Schmaier, Alvin H., Oates, James C.
No abstract.
Crofford, Leslie J., Oates, James C., McCune, William Joseph, Gupta, Samardeep, Kaplan, Mariana J., Catella-Lawson, Francesca, ...
Specific inhibitors of cyclooxygenase 2 (COX-2) have been approved for the treatment of osteoarthritis and rheumatoid arthritis. Unlike nonsteroidal anti-inflammatory drugs, specific COX-2 inhibitors...
Basic biology and clinical application of specific cyclooxygenase-2 inhibitors (2000)
Crofford, Leslie J., Lipsky, Peter E., Brooks, Peter, Abramson, Steven B., Simon, Lee S.
No abstract.
Basic biology and clinical application of specific cyclooxygenase-2 inhibitors (2000)
Crofford, Leslie J., Lipsky, Peter E., Brooks, Peter, Abramson, Steven B., Simon, Lee S.
Basic biology and clinical application of specific cyclooxygenase-2 inhibitors (2000)
Crofford, Leslie J., Lipsky, Peter E., Brooks, Peter, Abramson, Steven B., Simon, Lee S.
The Role of COX-2 in Rheumatoid Arthritis Synovial Tissues (1999)
No abstract available.
The hypothalamic-pituitary-adrenal stress axis in fibromyalgia and chronic fatigue syndrome (1998)
HPA axis abnormalities in FM, CFS, and other stress-related disorders must be placed in a broad clinical context. We know that interventions providing symptomatic improvement in patients with FM and...
Crofford, Leslie J., Tan, Bing, McCarthy, Conor J., Hla, Timothy
Objective . To evaluate involvement of the transcription factor nuclear factor k B (NF- k B) in the increased expression of cyclooxygenase-2 (COX-2) stimulated by interleukin-1Β (IL-1Β) in primary...
Tsai, Carlene, Diaz, Luis A., Singer, Nora G., Li, Lan Lan, Kirsch, Anita H., Mitra, Raj, ...
Objective . Type B fibroblastic synoviocytes are abundant in inflamed joints of patients with rheumatoid arthritis (RA), and can secrete cytokines and other mediators of inflammation. The aim of this...
Yang, Jianmin, Friedman, Michael S, Bian, Huimin, Crofford, Leslie J, Roessler, Blake, McDonagh, Kevin T
We are developing retroviral-mediated gene transfer to human fibroblast-like synovial cells (FLS) as one approach to characterizing genetic pathways involved in synoviocyte pathophysiology. Prior...
The use of analgesic anti-inflammatory agents in patients with asthma is clinically challenging because of the prevalence (10–20%) of aspirin hypersensitivity. Aspirin-exacerbated respiratory...
Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2
Sampey, Annaleise V, Monrad, Seetha, Crofford, Leslie J
Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1...
Yang, Jianmin, Friedman, Michael S, Bian, Huimin, Crofford, Leslie J, Roessler, Blake, McDonagh, Kevin T
We are developing retroviral-mediated gene transfer to human fibroblast-like synovial cells (FLS) as one approach to characterizing genetic pathways involved in synoviocyte pathophysiology. Prior...
The use of analgesic anti-inflammatory agents in patients with asthma is clinically challenging because of the prevalence (10–20%) of aspirin hypersensitivity. Aspirin-exacerbated respiratory...
Microsomal prostaglandin E synthase-1: the inducible synthase for prostaglandin E2
Sampey, Annaleise V, Monrad, Seetha, Crofford, Leslie J
Microsomal prostaglandin E synthase-1 (mPGES-1) is an inducible enzyme that catalyzes the conversion of prostaglandin (PG)H2 to PGE2. Proinflammatory stimuli markedly increase levels of mPGES-1...
Nash, Richard A., McSweeney, Peter A., Crofford, Leslie J., Abidi, Muneer, Chen, Chien-Shing, Godwin, J. David, ...
More effective therapeutic strategies are required for patients with poor-prognosis systemic sclerosis (SSc). A phase 2 single-arm study of high-dose immunosuppressive therapy (HDIT) and autologous...
Biology and therapy of fibromyalgia. Evidence-based biomarkers for fibromyalgia syndrome
Dadabhoy, Dina, Crofford, Leslie J, Spaeth, Michael, Russell, I Jon, Clauw, Daniel J
Researchers studying fibromyalgia strive to identify objective, measurable biomarkers that may identify susceptible individuals, may facilitate diagnosis, or that parallel activity of the disease....