of Fully Automated Structure Prediction (2009)
Daniel Fischer, Christian Barret, Kevin Bryson, Arne Elofsson, Adam Godzik, David Jones, ...
ABSTRACT The results of the first Critical Assessment
Molecular determinants archetypical to the phylum Nematoda (2009)
Yin, Yong, Martin, John, Abubucker, Sahar, Wang, Zhengyuan, Wyrwicz, Lucjan, Rychlewski, Leszek, ...
Abstract Background Nematoda diverged from other animals between 600–1,200 million years ago and has become one of the most diverse animal phyla on earth. Most nematodes are free-living animals,...
COMMUNICATION The 2002 Olympic Games of Protein Structure Prediction (2008)
Daniel Fischer, Leszek Rychlewski
2To whom correspondence should be addressed.
A Support Vector Machine Approach to the Identification of Phosphorylation (2008)
Dariusz Plewczyński, Adrian Tkacz, Adam Godzik, Leszek Rychlewski
Abstract: We describe a bioinformatics tool that can be used to predict the position of phosphorylation sites in proteins based only on sequence information. The method uses the support vector...
Structural bioinformatics XtalPred: a web server for prediction of protein crystallizability (2008)
Lukasz Slabinski, Lukasz Jaroszewski, Leszek Rychlewski, Ian A. Wilson, Scott A, Adam Godzik, ...
Summary: XtalPred is a web server for prediction of protein crystallizability. The prediction is made by comparing several features of the protein with distributions of these features in TargetDB and...
BIOINFORMATICS APPLICATIONS NOTE Sequence analysis (2008)
Dariusz Plewczynski, Adrian Tkacz, Lucjan Stanisław Wyrwicz, Leszek Rychlewski
Vol. 21 no. 10 2005, pages 2525–2527 doi:10.1093/bioinformatics/bti333 AutoMotif server: prediction of single residue post-translational modifications in proteins
Supplementary information: (2008)
Dariusz Plewczyński, Jakub Paś, Marcin Von Grotthuss, Leszek Rychlewski
3D-Hit is a fast scanning method for detecting structural similarities between proteins. The algorithm is based on a hashing function, which decomposes proteins into segments of 13 residues. The...
3D-Fun: predicting enzyme function from structure (2008)
Von Grotthuss, Marcin, Plewczynski, Dariusz, Vriend, Gert, Rychlewski, Leszek
The ‘omics’ revolution is causing a flurry of data that all needs to be annotated for it to become useful. Sequences of proteins of unknown function can be annotated with a putative function by...
The challenge of protein structure determination lessons from structural genomics (2007)
Slabinski, Lukasz, Jaroszewski, Lukasz, Rodrigues, Ana P.C., Rychlewski, Leszek, Wilson, Ian A., Lesley, Scott A., ...
The process of experimental determination of protein structure is marred with a high ratio of failures at many stages. With availability of large quantities of data from high-throughput structure...
Evaluation of 3D-Jury on CASP7 models (2007)
Kaján, László, Rychlewski, Leszek
Abstract Background 3D-Jury, the structure prediction consensus method publicly available in the Meta Server http://meta.bioinfo.pl/ , was evaluated using models gathered in the 7 th round of the...
Knizewski, Lukasz, Kinch, Lisa N, Grishin, Nick V, Rychlewski, Leszek, Ginalski, Krzysztof
Abstract Background PD-(D/E)XK nucleases constitute a large and highly diverse superfamily of enzymes that display little sequence similarity despite retaining a common core fold and a few critical...
Regular paper Fold recognition insights into function of herpes ICP4 protein (2007)
Lucjan S. Wyrwicz, Leszek Rychlewski
ICP4 is an important factor regulating the life cycle of HSV1. This conserved protein has several molecular functions, including activation of expression of viral late gene transcripts and inhibition...
XtalPred: a web server for prediction of protein crystallizability (2007)
Slabinski, Lukasz, Jaroszewski, Lukasz, Rychlewski, Leszek, Wilson, Ian A., Lesley, Scott A., Godzik, Adam
Summary: XtalPred is a web server for prediction of protein crystallizability. The prediction is made by comparing several features of the protein with distributions of these features in TargetDB and...
Von Grotthuss, Marcin, Plewczynski, Dariusz, Ginalski, Krzysztof, Rychlewski, Leszek, Shakhnovich, Eugene I
Abstract Background The number of protein structures from structural genomics centers dramatically increases in the Protein Data Bank (PDB). Many of these structures are functionally unannotated...
BMC Bioinformatics Database (2006)
Marcin Von Grotthuss, Dariusz Plewczynski, Krzysztof Ginalski, Leszek Rychlewski, Eugene I Shakhnovich, Leszek Rychlewski, ...
PDB-UF: database of predicted enzymatic functions for unannotated protein structures from structural genomics
NOTES Human Herpesvirus 1 UL24 Gene (2005)
Encodes A Potential, Lisa Kinch, Nick V. Grishin, Leszek Rychlewski, Krzysztof Ginalski
Using Meta-BASIC, a highly sensitive method for detection of distant similarity between proteins, we have identified another potential PD-(D/E)XK endonuclease in human herpesvirus 1 (HHV-1) encoded...
FFAS03: a server for profile-profile sequence alignments (2005)
Jaroszewski, Lukasz, Rychlewski, Leszek, Li, Zhanwen, Li, Weizhong, Godzik, Adam
The FFAS03 server provides a web interface to the third generation of the profile–profile alignment and fold-recognition algorithm of fold and function assignment system (FFAS) [L. Rychlewski, L....
Practical lessons from protein structure prediction (2005)
Ginalski, Krzysztof, Grishin, Nick V., Godzik, Adam, Rychlewski, Leszek
Despite recent efforts to develop automated protein structure determination protocols, structural genomics projects are slow in generating fold assignments for complete proteomes, and spatial...
LiveBench-8: The large-scale, continuous assessment of automated protein structure prediction (2005)
Rychlewski, Leszek, Fischer, Daniel
We present the results of the evaluation of the latest LiveBench-8 experiment. These results provide a snapshot view of the state of the art in automated protein structure prediction, just before the...
AutoMotif server: prediction of single residue post-translational modifications in proteins (2005)
Plewczynski, Dariusz, Tkacz, Adrian, Wyrwicz, Lucjan Stanislaw, Rychlewski, Leszek
Summary: The AutoMotif Server allows for identification of post-translational modification (PTM) sites in proteins based only on local sequence information. The local sequence preferences of short...
AutoMotif Server: prediction of single residue post-translational modifications in proteins (2005)
Plewczynski, Dariusz, Tkacz, Adrian, Wyrwicz, Lucjan Stanisaw, Rychlewski, Leszek
The AutoMotif Server allows for identification of post-translational modification (PTM) sites in proteins based only on local sequence information. The local sequence preferences of short segments...
Kinch, Lisa N., Ginalski, Krzysztof, Rychlewski, Leszek, Grishin, Nick V.
Restriction endonucleases and other nucleic acid cleaving enzymes form a large and extremely diverse superfamily that display little sequence similarity despite retaining a common core fold...
Integrated web service for improving alignment quality based on segments comparison (2004)
Plewczynski, Dariusz, Rychlewski, Leszek, Ye, Yuzhen, Jaroszewski, Lukasz, Godzik, Adam
Abstract Background Defining blocks forming the global protein structure on the basis of local structural regularity is a very fruitful idea, extensively used in description, and prediction of...
Detecting distant homology with meta-BASIC (2004)
Krzysztof Ginalski, Marcin Von Grotthuss, Nick V. Grishin, Leszek Rychlewski
Meta-BASIC
The PDB-preview database: a repository of in-silico models of "on-hold" PDB entries (2004)
Fischer, Daniel, Pa, Jakub, Rychlewski, Leszek
Summary: The PDB-Preview database is a dynamic web repository of in-silico predicted 3D models of experimentally determined structures that are deposited into the PDB but are not yet publicly...
Detecting distant homology with Meta-BASIC (2004)
Ginalski, Krzysztof, Von Grotthuss, Marcin, Grishin, Nick V., Rychlewski, Leszek
Meta-BASIC (http://basic.bioinfo.pl) is a novel sensitive approach for recognition of distant similarity between proteins based on consensus alignments of meta profiles. Specifically, Meta-BASIC...
The PDB-Preview database: a repository of in-silico models of 'on-hold' PDB entries (2004)
Fischer, Daniel, Pas, Jakub, Rychlewski, Leszek
Summary: The PDB-Preview database is a dynamic web repository of in-silico predicted three-dimensional (3D) models of experimentally determined structures that are deposited into the PDB but are not...
The PDB-preview database: a repository of in-silico models of "on-hold" PDB entries (2004)
Fischer, Daniel, Pa, Jakub, Rychlewski, Leszek
Summary: The PDB-Preview database is a dynamic web repository of in-silico predicted 3D models of experimentally determined structures that are deposited into the PDB but are not yet publicly...
Bmc Bioinformatics, Dariusz Plewczynski, Leszek Rychlewski, Yuzhen Ye
Software Integrated web service for improving alignment quality based on segments comparison
Rune Linding, Christine Gemünd, Sophie Chabanis-davidson, Morten Mattingsdal, Scott Cameron, ...
Multidomain proteins predominate in eukaryotic proteomes. Individual functions assigned to different sequence segments combine to create a complex function for the whole protein. While on-line...
3D-Jury: a simple approach to improve protein structure predictions (2003)
Ginalski, Krzysztof, Elofsson, Arne, Fischer, Daniel, Rychlewski, Leszek
Motivation: Consensus structure prediction methods (meta-predictors) have higher accuracy than individual structure prediction algorithms (their components). The goal for the development of the...
Ligand-Info, searching for similar small compounds using index profiles (2003)
Von Grotthuss, Marcin, Pas, Jakub, Rychlewski, Leszek
Motivation: The Ligand-Info system is based on the assumption that small molecules with similar structure have similar functional (binding) properties. The developed system enables a fast and...
Detection of reliable and unexpected protein fold predictions using 3D-Jury (2003)
Ginalski, Krzysztof, Rychlewski, Leszek
3D-Jury is a fully automated protein structure meta prediction system accessible via the Meta Server interface (http://BioInfo.PL/Meta). This is one of the meta predictors, which have made a...
Puntervoll, Pål, Linding, Rune, Gemünd, Christine, Chabanis-Davidson, Sophie, Mattingsdal, Morten, Cameron, Scott, ...
Multidomain proteins predominate in eukaryotic proteomes. Individual functions assigned to different sequence segments combine to create a complex function for the whole protein. While on-line...
Ginalski, Krzysztof, Pas, Jakub, Wyrwicz, Lucjan S., Grotthuss, Marcin Von, Bujnicki, Janusz M., Rychlewski, Leszek
ORFeus is a fully automated, sensitive protein sequence similarity search server available to the academic community via the Structure Prediction Meta Server (http://BioInfo.PL/Meta/). The goal of...
The 2002 Olympic Games of Protein Structure Prediction (2003)
Fischer, Daniel, Rychlewski, Leszek
The summer of every even year is considered by the protein structure prediction community as the Olympic Games season, because in addition to a number of continuous benchmarking experiments such as...
Bujnicki, Janusz M, Rychlewski, Leszek
Abstract Background Escherichia coli guanine-N2 (m 2 G) methyltransferases (MTases) RsmC and RsmD modify nucleosides G1207 and G966 of 16S rRNA. They possess a common MTase domain in the C-terminus...
Bujnicki, Janusz M., Rychlewski, Leszek
The Escherichia coli RrmJ gene product has recently been shown to be the 23S rRNA:U2552 specific 2′-O-ribose methyltransferase (MTase) (RrmJ). Its structure has been solved and refined to 1.5 Å...
Fold-recognition detects an error in the Protein Data Bank (2002)
Bujnicki, Janusz, Rychlewski, Leszek, Fischer, Daniel
* To whom correspondence should be addressed dfischer@cs.bu.ac.il
Bujnicki, Janusz M, Rychlewski, Leszek
Abstract Background The reovirus λ2 protein catalyzes mRNA capping, that is, addition of a guanosine to the 5' end of each transcript in a 5'-to-5' orientation, as well as transfer of a methyl group...
A study of quality measures for protein threading models (2001)
Cristobal, Susana, Zemla, Adam, Fischer, Daniel, Rychlewski, Leszek, Elofsson, Arne
Abstract Background Prediction of protein structures is one of the fundamental challenges in biology today. To fully understand how well different prediction methods perform, it is necessary to use...
Bujnicki, Janusz M, Feder, Marcin, Radlinska, Monika, Rychlewski, Leszek
Abstract Background The 5'-terminal cap structure plays an important role in many aspects of mRNA metabolism. Capping enzymes encoded by viruses and pathogenic fungi are attractive targets for...
Pcons: A neural-network-based consensus predictor that improves fold recognition (2001)
Jesper Lundström, Leszek Rychlewski, Janusz Bujnicki, Arne Elofsson
improves fold recognition
Susana Cristobal, Adam Zemla, Daniel Fischer, Leszek Rychlewski, Arne Elofsson, Leszek Rychlewski, ...
© 2001 Cristobal et al; licensee BioMed Central Ltd. Verbatim copying and redistribution of this article are permitted in any medium for any noncommercial purpose, provided this notice is preserved...
Janusz M Bujnicki, Marcin Feder, Monika Radlinska, Leszek Rychlewski, Leszek Rychlewski
mRNA:guanine-N7 cap methyltransferases: identification of novel
Pcons: A neural-network-based consensus predictor that improves fold recognition (2001)
Lundström, Jesper, Rychlewski, Leszek, Bujnicki, Janusz, Elofsson, Arne
During recent years many protein fold recognition methods have been developed, based on different algorithms and using various kinds of information. To examine the performance of these methods...
Structure prediction meta server (2001)
Bujnicki, Janusz M., Elofsson, Arne, Fischer, Daniel, Rychlewski, Leszek
Summary: The Structure Prediction Meta Server offers a convenient way for biologists to utilize various high quality structure prediction servers available worldwide. The meta server translates the...
Bujnicki, Janusz M., Rotkiewicz, Piotr, Kolinski, Andrzej, Rychlewski, Leszek
Using a recent version of the SICHO algorithm for in silico protein folding, we made a blind prediction of the tertiary structure of the N-terminal, independently folded, catalytic domain (CD) of the...
ToolShop: prerelease inspections for protein structure prediction servers (2001)
Summary: The ToolShop server offers a possibility to compare a protein tertiary structure prediction server with other popular servers before releasing it to the public. The comparison is conducted...
LiveBench-1: Continuous benchmarking of protein structure prediction servers (2001)
Bujnicki, Janusz M., Elofsson, Arne, Fischer, Daniel, Rychlewski, Leszek
We present a novel, continuous approach aimed at the large-scale assessment of the performance of available fold-recognition servers. Six popular servers were investigated: PDB-Blast, FFAS, T98-lib,...
Bujnicki, Janusz M., Rychlewski, Leszek
The tRNA splicing endoribonuclease EndA from Methanococcus jannaschii is a homotetramer formed via heterologous interaction between the two pairs of homodimers. Each monomer consists of two...
Janusz M Bujnicki, Leszek Rychlewski
Background: The reovirus λ2 protein catalyzes mRNA capping, that is, addition of a guanosine to the 5 ′ end of each transcript in a 5′-to-5 ′ orientation, as well as transfer of a methyl group...
Fischer, Daniel, Elofsson, Arne, Rychlewski, Leszek
In this commentary, we describe two new protein structure prediction experiments being run in parallel with the CASP experiment, which together may be regarded as the 2000 Olympic Games of structure...
MaxSub: an automated measure for the assessment of protein structure prediction quality (2000)
Siew, Naomi, Elofsson, Arne, Rychlewski, Leszek, Fischer, Daniel
Motivation: Evaluating the accuracy of predicted models is critical for assessing structure prediction methods. Because this problem is not trivial, a large number of different assessment measures...
CAFASP-1: critical assessment of fully automated structure prediction methods (1999)
Daniel Fischer, Arne Elofsson, Leszek Rychlewski, Florencio Pazos, Alfonso Valencia, Burkhard Rost, ...
ABSTRACT The results of the second Critical
A study of quality measures for protein threading models
Cristobal, Susana, Zemla, Adam, Fischer, Daniel, Rychlewski, Leszek, Elofsson, Arne
Detection of reliable and unexpected protein fold predictions using 3D-Jury
Ginalski, Krzysztof, Rychlewski, Leszek
3D-Jury is a fully automated protein structure meta prediction system accessible via the Meta Server interface (http://BioInfo.PL/Meta). This is one of the meta predictors, which have made a...
ORFeus: detection of distant homology using sequence profiles and predicted secondary structure
Ginalski, Krzysztof, Pas, Jakub, Wyrwicz, Lucjan S., Grotthuss, Marcin Von, Bujnicki, Janusz M., Rychlewski, Leszek
ORFeus is a fully automated, sensitive protein sequence similarity search server available to the academic community via the Structure Prediction Meta Server (http://BioInfo.PL/Meta/). The goal of...
ELM server: a new resource for investigating short functional sites in modular eukaryotic proteins
Puntervoll, Pål, Linding, Rune, Gemünd, Christine, Chabanis-Davidson, Sophie, Mattingsdal, Morten, Cameron, Scott, ...
Multidomain proteins predominate in eukaryotic proteomes. Individual functions assigned to different sequence segments combine to create a complex function for the whole protein. While on-line...
Protein structure prediction for the male-specific region of the human Y chromosome
Ginalski, Krzysztof, Rychlewski, Leszek, Baker, David, Grishin, Nick V.
The complete sequence of the male-specific region of the human Y chromosome (MSY) has been determined recently; however, detailed characterization for many of its encoded proteins still remains to be...
Detecting distant homology with Meta-BASIC
Ginalski, Krzysztof, Von Grotthuss, Marcin, Grishin, Nick V., Rychlewski, Leszek
Meta-BASIC (http://basic.bioinfo.pl) is a novel sensitive approach for recognition of distant similarity between proteins based on consensus alignments of meta profiles. Specifically, Meta-BASIC...
Integrated web service for improving alignment quality based on segments comparison
Plewczynski, Dariusz, Rychlewski, Leszek, Ye, Yuzhen, Jaroszewski, Lukasz, Godzik, Adam
Practical lessons from protein structure prediction
Ginalski, Krzysztof, Grishin, Nick V., Godzik, Adam, Rychlewski, Leszek
Despite recent efforts to develop automated protein structure determination protocols, structural genomics projects are slow in generating fold assignments for complete proteomes, and spatial...
Identification of novel restriction endonuclease-like fold families among hypothetical proteins
Kinch, Lisa N., Ginalski, Krzysztof, Rychlewski, Leszek, Grishin, Nick V.
Restriction endonucleases and other nucleic acid cleaving enzymes form a large and extremely diverse superfamily that display little sequence similarity despite retaining a common core fold...
FFAS03: a server for profile–profile sequence alignments
Jaroszewski, Lukasz, Rychlewski, Leszek, Li, Zhanwen, Li, Weizhong, Godzik, Adam
The FFAS03 server provides a web interface to the third generation of the profile–profile alignment and fold-recognition algorithm of fold and function assignment system (FFAS) [L. Rychlewski, L....
Von Grotthuss, Marcin, Plewczynski, Dariusz, Ginalski, Krzysztof, Rychlewski, Leszek, Shakhnovich, Eugene I
Human Herpesvirus 1 UL24 Gene Encodes a Potential PD-(D/E)XK Endonuclease
Kniżewski, Łukasz, Kinch, Lisa, Grishin, Nick V., Rychlewski, Leszek, Ginalski, Krzysztof
Using Meta-BASIC, a highly sensitive method for detection of distant similarity between proteins, we have identified another potential PD-(D/E)XK endonuclease in human herpesvirus 1 (HHV-1) encoded...
A study of quality measures for protein threading models
Cristobal, Susana, Zemla, Adam, Fischer, Daniel, Rychlewski, Leszek, Elofsson, Arne
Detection of reliable and unexpected protein fold predictions using 3D-Jury
Ginalski, Krzysztof, Rychlewski, Leszek
3D-Jury is a fully automated protein structure meta prediction system accessible via the Meta Server interface (http://BioInfo.PL/Meta). This is one of the meta predictors, which have made a...
ORFeus: detection of distant homology using sequence profiles and predicted secondary structure
Ginalski, Krzysztof, Pas, Jakub, Wyrwicz, Lucjan S., Grotthuss, Marcin Von, Bujnicki, Janusz M., Rychlewski, Leszek
ORFeus is a fully automated, sensitive protein sequence similarity search server available to the academic community via the Structure Prediction Meta Server (http://BioInfo.PL/Meta/). The goal of...
ELM server: a new resource for investigating short functional sites in modular eukaryotic proteins
Puntervoll, Pål, Linding, Rune, Gemünd, Christine, Chabanis-Davidson, Sophie, Mattingsdal, Morten, Cameron, Scott, ...
Multidomain proteins predominate in eukaryotic proteomes. Individual functions assigned to different sequence segments combine to create a complex function for the whole protein. While on-line...
Protein structure prediction for the male-specific region of the human Y chromosome
Ginalski, Krzysztof, Rychlewski, Leszek, Baker, David, Grishin, Nick V.
The complete sequence of the male-specific region of the human Y chromosome (MSY) has been determined recently; however, detailed characterization for many of its encoded proteins still remains to be...
Detecting distant homology with Meta-BASIC
Ginalski, Krzysztof, Von Grotthuss, Marcin, Grishin, Nick V., Rychlewski, Leszek
Meta-BASIC (http://basic.bioinfo.pl) is a novel sensitive approach for recognition of distant similarity between proteins based on consensus alignments of meta profiles. Specifically, Meta-BASIC...
Integrated web service for improving alignment quality based on segments comparison
Plewczynski, Dariusz, Rychlewski, Leszek, Ye, Yuzhen, Jaroszewski, Lukasz, Godzik, Adam
Practical lessons from protein structure prediction
Ginalski, Krzysztof, Grishin, Nick V., Godzik, Adam, Rychlewski, Leszek
Despite recent efforts to develop automated protein structure determination protocols, structural genomics projects are slow in generating fold assignments for complete proteomes, and spatial...
Identification of novel restriction endonuclease-like fold families among hypothetical proteins
Kinch, Lisa N., Ginalski, Krzysztof, Rychlewski, Leszek, Grishin, Nick V.
Restriction endonucleases and other nucleic acid cleaving enzymes form a large and extremely diverse superfamily that display little sequence similarity despite retaining a common core fold...
FFAS03: a server for profile–profile sequence alignments
Jaroszewski, Lukasz, Rychlewski, Leszek, Li, Zhanwen, Li, Weizhong, Godzik, Adam
The FFAS03 server provides a web interface to the third generation of the profile–profile alignment and fold-recognition algorithm of fold and function assignment system (FFAS) [L. Rychlewski, L....
Human Herpesvirus 1 UL24 Gene Encodes a Potential PD-(D/E)XK Endonuclease
Kniżewski, Łukasz, Kinch, Lisa, Grishin, Nick V., Rychlewski, Leszek, Ginalski, Krzysztof
Using Meta-BASIC, a highly sensitive method for detection of distant similarity between proteins, we have identified another potential PD-(D/E)XK endonuclease in human herpesvirus 1 (HHV-1) encoded...
Von Grotthuss, Marcin, Plewczynski, Dariusz, Ginalski, Krzysztof, Rychlewski, Leszek, Shakhnovich, Eugene I
LiveBench-8: The large-scale, continuous assessment of automated protein structure prediction
Rychlewski, Leszek, Fischer, Daniel
We present the results of the evaluation of the latest LiveBench-8 experiment. These results provide a snapshot view of the state of the art in automated protein structure prediction, just before the...
LiveBench-1: Continuous benchmarking of protein structure prediction servers
Bujnicki, Janusz M., Elofsson, Arne, Fischer, Daniel, Rychlewski, Leszek
We present a novel, continuous approach aimed at the large-scale assessment of the performance of available fold-recognition servers. Six popular servers were investigated: PDB-Blast, FFAS, T98-lib,...
Pcons: A neural-network–based consensus predictor that improves fold recognition
Lundström, Jesper, Rychlewski, Leszek, Bujnicki, Janusz, Elofsson, Arne
During recent years many protein fold recognition methods have been developed, based on different algorithms and using various kinds of information. To examine the performance of these methods...
Bujnicki, Janusz M., Rychlewski, Leszek
The tRNA splicing endoribonuclease EndA from Methanococcus jannaschii is a homotetramer formed via heterologous interaction between the two pairs of homodimers. Each monomer consists of two α/β...
3D-Fun: predicting enzyme function from structure
Von Grotthuss, Marcin, Plewczynski, Dariusz, Vriend, Gert, Rychlewski, Leszek
The ‘omics’ revolution is causing a flurry of data that all needs to be annotated for it to become useful. Sequences of proteins of unknown function can be annotated with a putative function by...
The challenge of protein structure determination—lessons from structural genomics
Slabinski, Lukasz, Jaroszewski, Lukasz, Rodrigues, Ana P.C., Rychlewski, Leszek, Wilson, Ian A., Lesley, Scott A., ...
The process of experimental determination of protein structure is marred with a high ratio of failures at many stages. With availability of large quantities of data from high-throughput structure...
Jiménez, José I., Canales, Ángeles, Jiménez-Barbero, Jesús, Ginalski, Krzysztof, Rychlewski, Leszek, García, José L., ...
The aerobic catabolism of nicotinic acid (NA) is considered a model system for degradation of N-heterocyclic aromatic compounds, some of which are major environmental pollutants; however, the...