Lewis Cantley

High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif

Li, Shun-Cheng, Songyang, Zhou, Vincent, Sébastien J. F., Zwahlen, Catherine, Wiley, Sandra, Cantley, Lewis, ...

The phosphotyrosine-binding (PTB) domain is a recently identified protein module that has been characterized as binding to phosphopeptides containing an NPXpY motif (X = any amino acid). We describe...

High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif

Li, Shun-Cheng, Songyang, Zhou, Vincent, Sébastien J. F., Zwahlen, Catherine, Wiley, Sandra, Cantley, Lewis, ...

The phosphotyrosine-binding (PTB) domain is a recently identified protein module that has been characterized as binding to phosphopeptides containing an NPXpY motif (X = any amino acid). We describe...

PtdIns(5)P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection

Pendaries, Caroline, Tronchère, Hélène, Arbibe, Laurence, Mounier, Joelle, Gozani, Or, Cantley, Lewis, ...

The virulence factor IpgD, delivered into nonphagocytic cells by the type III secretion system of the pathogen Shigella flexneri, is a phosphoinositide 4-phosphatase generating phosphatidylinositol 5...