Lewis L. Hsu

Erythrocytes are the major intravascular storage sites of nitrite in human blood

Dejam, André, Hunter, Christian J., Pelletier, Mildred M., Hsu, Lewis L., Machado, Roberto F., Shiva, Sruti, ...

Plasma levels of nitrite ions have been used as an index of nitric oxide synthase (NOS) activity in vivo. Recent data suggest that nitrite is a potential intravascular repository for nitric oxide...

Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability

Hsu, Lewis L., Champion, Hunter C., Campbell-Lee, Sally A., Bivalacqua, Trinity J., Manci, Elizabeth A., Diwan, Bhalchandra A., ...

Pulmonary hypertension is a highly prevalent complication of sickle cell disease and is a strong risk factor for early mortality. However, the pathophysiologic mechanisms leading to pulmonary...

The proverbial chicken or the egg? Dissection of the role of cell-free hemoglobin versus reactive oxygen species in sickle cell pathophysiology

Krajewski, Megan L., Hsu, Lewis L., Gladwin, Mark T.