Li-Wei Chang

Predicting Transcription Regulatory Mechanisms by Systematic Promoter Analysis (2008)

Li-wei Chang, Rakesh Nagarajan, Jeffrey A. Magee, Jeffrey Milbr, Gary D. Stormo

An important part of understanding a biological pathway or a cellular function is to delineate the transcriptional regulatory mechanisms of the genes involved. Key participants in these mechanisms...

Computational identification and functional validation of regulatory motifs in cartilage-expressed genes (2007)

Davies, Sherri R., Chang, Li-Wei, Patra, Debabrata, Xing, Xiaoyun, Posey, Karen, Hecht, Jacqueline, ...

Chondrocyte gene regulation is important for the generation and maintenance of cartilage tissues. Several regulatory factors have been identified that play a role in chondrogenesis, including the...

PAP: a comprehensive workbench for mammalian transcriptional regulatory sequence analysis (2007)

Chang, Li-Wei, Fontaine, Burr R., Stormo, Gary D., Nagarajan, Rakesh

Given the recent explosion of publications that employ microarray technology to monitor genome-wide expression and that correlate these expression changes to biological processes or to disease...

A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles (2006)

Chang, Li-Wei, Nagarajan, Rakesh, Magee, Jeffrey A., Milbrandt, Jeffrey, Stormo, Gary D.

An important aspect of understanding a biological pathway is to delineate the transcriptional regulatory mechanisms of the genes involved. Two important tasks are often encountered when studying...

A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles (2006)

Chang, Li-Wei, Nagarajan, Rakesh, Magee, Jeffrey A., Milbrandt, Jeffrey, Stormo, Gary D.

An important aspect of understanding a biological pathway is to delineate the transcriptional regulatory mechanisms of the genes involved. Two important tasks are often encountered when studying...

A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles

Chang, Li-Wei, Nagarajan, Rakesh, Magee, Jeffrey A., Milbrandt, Jeffrey, Stormo, Gary D.

An important aspect of understanding a biological pathway is to delineate the transcriptional regulatory mechanisms of the genes involved. Two important tasks are often encountered when studying...

A systematic model to predict transcriptional regulatory mechanisms based on overrepresentation of transcription factor binding profiles

Chang, Li-Wei, Nagarajan, Rakesh, Magee, Jeffrey A., Milbrandt, Jeffrey, Stormo, Gary D.

An important aspect of understanding a biological pathway is to delineate the transcriptional regulatory mechanisms of the genes involved. Two important tasks are often encountered when studying...

PAP: a comprehensive workbench for mammalian transcriptional regulatory sequence analysis

Chang, Li-Wei, Fontaine, Burr R., Stormo, Gary D., Nagarajan, Rakesh

Given the recent explosion of publications that employ microarray technology to monitor genome-wide expression and that correlate these expression changes to biological processes or to disease...

Computational identification and functional validation of regulatory motifs in cartilage-expressed genes

Davies, Sherri R., Chang, Li-Wei, Patra, Debabrata, Xing, Xiaoyun, Posey, Karen, Hecht, Jacqueline, ...

Chondrocyte gene regulation is important for the generation and maintenance of cartilage tissues. Several regulatory factors have been identified that play a role in chondrogenesis, including the...

Neurogenin and NeuroD direct transcriptional targets and their regulatory enhancers

Seo, Seongjin, Lim, Jong-Won, Yellajoshyula, Dhananjay, Chang, Li-Wei, Kroll, Kristen L

Proneural basic helix–loop–helix proteins are key regulators of neurogenesis but their ‘proneural' function is not well understood, partly because primary targets have not been systematically...

High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples

Payton, Jacqueline E., Grieselhuber, Nicole R., Chang, Li-Wei, Murakami, Mark, Geiss, Gary K., Link, Daniel C., ...

Acute promyelocytic leukemia (APL) is characterized by the t(15;17) chromosomal translocation, which results in fusion of the retinoic acid receptor α (RARA) gene to another gene, most commonly...