Guangying K. Wu, Pingyang Li, Huizhong W. Tao, Li I. Zhang, Zilkha Neurogenetic
Intensity-tuned neurons, characterized by their nonmonotonic response-level function, may play important roles in the encoding of sound intensity-related information. The synaptic mechanisms...
Disruption of primary auditory cortex by synchronous auditory inputs during a critical period
Zhang, Li I., Bao, Shaowen, Merzenich, Michael M.
In the primary auditory cortex (AI), the development of tone frequency selectivity and tonotopic organization is influenced by patterns of neural activity. Introduction of synchronous inputs into the...
Suppression of cortical representation through backward conditioning
Bao, Shaowen, Chan, Vincent T., Zhang, Li I., Merzenich, Michael M.
Temporal stimulus reinforcement sequences have been shown to determine the directions of synaptic plasticity and behavioral learning. Here, we examined whether they also control the direction of...
Specialization of primary auditory cortex processing by sound exposure in the “critical period”
Nakahara, Haruka, Zhang, Li I., Merzenich, Michael M.
Environmental acoustic exposure to a complex tone sequence within the critical period in infant rats resulted in the emergence of large-scale, selective changes that radically altered primary...
Disruption of primary auditory cortex by synchronous auditory inputs during a critical period
Zhang, Li I., Bao, Shaowen, Merzenich, Michael M.
In the primary auditory cortex (AI), the development of tone frequency selectivity and tonotopic organization is influenced by patterns of neural activity. Introduction of synchronous inputs into the...
Suppression of cortical representation through backward conditioning
Bao, Shaowen, Chan, Vincent T., Zhang, Li I., Merzenich, Michael M.
Temporal stimulus reinforcement sequences have been shown to determine the directions of synaptic plasticity and behavioral learning. Here, we examined whether they also control the direction of...
Specialization of primary auditory cortex processing by sound exposure in the “critical period”
Nakahara, Haruka, Zhang, Li I., Merzenich, Michael M.
Environmental acoustic exposure to a complex tone sequence within the critical period in infant rats resulted in the emergence of large-scale, selective changes that radically altered primary...
A Genetic Strategy for Stochastic Gene Activation with Regulated Sparseness (STARS)
Wang, Sheng-zhi, Liu, Bao-hua, Tao, Huizhong W., Xia, Kun, Zhang, Li I.
It remains a challenge to establish a straightforward genetic approach for controlling the probability of gene activation or knockout at a desired level. Here, we developed a method termed STARS:...