Li Wei Chang

Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia (2008)

Chang, Li Wei, Payton, Jacqueline E, Yuan, Wenlin, Ley, Timothy J, Nagarajan, Rakesh, Stormo, Gary D

Abstract Background Acute myeloid leukemia (AML) comprises a group of diseases characterized by the abnormal development of malignant myeloid cells. Recent studies have demonstrated an important role...

Computational identification of the normal and perturbed genetic networks involved in myeloid differentiation and acute promyelocytic leukemia

Chang, Li Wei, Payton, Jacqueline E, Yuan, Wenlin, Ley, Timothy J, Nagarajan, Rakesh, Stormo, Gary D

A dissection of the genetic networks and circuitries is described for two form of leukaemia. Integrating transcription factor binding and gene expression profiling, networks are revealed that underly...