Lia Molenaar

Tumorigenesis and Neoplastic Progression Aneuploidy Arises at Early Stages of Apc-Driven Intestinal Tumorigenesis and Pinpoints Conserved Chromosomal Loci of Allelic Imbalance between (2008)

Paola Alberici, Emma De Pater, Joana Cardoso, Mieke Bevel, Lia Molenaar, Jos Jonkers, ...

Although chromosomal instability characterizes the majority of human colorectal cancers, the contribution of genes such as adenomatous polyposis coli (APC), KRAS, and p53 to this form of genetic...

Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH (2004)

Cardoso, Joana, Molenaar, Lia, De Menezes, Renée X., Rosenberg, Carla, Morreau, Hans, Möslein, Gabriela, ...

Comparative genomic hybridization by means of BAC microarrays (array CGH) allows high-resolution profiling of copy-number aberrations in tumor DNA. However, specific genetic lesions associated with...

Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH

Cardoso, Joana, Molenaar, Lia, De Menezes, Renée X., Rosenberg, Carla, Morreau, Hans, Möslein, Gabriela, ...

Comparative genomic hybridization by means of BAC microarrays (array CGH) allows high-resolution profiling of copy-number aberrations in tumor DNA. However, specific genetic lesions associated with...

Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH

Cardoso, Joana, Molenaar, Lia, De Menezes, Renée X., Rosenberg, Carla, Morreau, Hans, Möslein, Gabriela, ...

Comparative genomic hybridization by means of BAC microarrays (array CGH) allows high-resolution profiling of copy-number aberrations in tumor DNA. However, specific genetic lesions associated with...

Aneuploidy Arises at Early Stages of Apc-Driven Intestinal Tumorigenesis and Pinpoints Conserved Chromosomal Loci of Allelic Imbalance between Mouse and Human

Alberici, Paola, De Pater, Emma, Cardoso, Joana, Bevelander, Mieke, Molenaar, Lia, Jonkers, Jos, ...

Although chromosomal instability characterizes the majority of human colorectal cancers, the contribution of genes such as adenomatous polyposis coli (APC), KRAS, and p53 to this form of genetic...

Cross-Species Comparison of Human and Mouse Intestinal Polyps Reveals Conserved Mechanisms in Adenomatous Polyposis Coli (APC)-Driven Tumorigenesis

Gaspar, Claudia, Cardoso, Joana, Franken, Patrick, Molenaar, Lia, Morreau, Hans, Möslein, Gabriela, ...

Expression profiling is a well established tool for the genome-wide analysis of human cancers. However, the high sensitivity of this approach combined with the well known cellular and molecular...

A Targeted Constitutive Mutation in the Apc Tumor Suppressor Gene Underlies Mammary But Not Intestinal Tumorigenesis

Gaspar, Claudia, Franken, Patrick, Molenaar, Lia, Breukel, Cor, Van Der Valk, Martin, Smits, Ron, ...

Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary predisposition to the development of...