Zhang, Qian, Guo, Ruolin, Schwarz, Edward M, Boyce, Brendan F, Xing, Lianping
Abstract Introduction The objective of the present study was to investigate the role of the stromal cell-derived factor 1 (SDF-1)/CXCR4 axis in TNF-induced mobilization of osteoclast precursors...
Increased lymphangiogenesis in joints of mice with inflammatory arthritis (2007)
Zhang, Qian, Lu, Yan, Proulx, Steven T, Guo, Ruolin, Yao, Zhenqiang, Schwarz, Edward M, ...
Abstract Angiogenesis is involved in the pathogenesis of inflammatory arthritis, but little is known about the role of lymphangiogenesis in this setting. Here, we examined whether tumor necrosis...
Biology of RANK, RANKL, and osteoprotegerin (2007)
Boyce, Brendan F, Xing, Lianping
Abstract The discovery of the receptor activator of nuclear factor-κB ligand (RANKL)/RANK/osteoprotegerin (OPG) system and its role in the regulation of bone resorption exemplifies how both...
Choi, Je-Yong, Pratap, Jitesh, Javed, Amjad, Zaidi, Sayyed K., Xing, Lianping, Balint, Eva, ...
Runx (Cbfa/AML) transcription factors are critical for tissue-specific gene expression. A unique targeting signal in the C terminus directs Runx factors to discrete foci within the nucleus. Using...
Xing, Lianping, Venegas, Ana M., Chen, Amy, Garrett-Beal, Lisa, Boyce, Brendan F., Varmus, Harold E., ...
Schwartzberg, Pamela L., Xing, Lianping, Hoffmann, Oskar, Lowell, Clifford A., Garrett, Lisa, Boyce, Brendan F., ...
The role of CREB, cAMP response element binding protein in basal transcription / (1994)
Thesis (Ph. D.)--Pennsylvania State University. The Milton S. Hershey Medical Center.
Choi, Je-Yong, Pratap, Jitesh, Javed, Amjad, Zaidi, S. Kaleem, Xing, Lianping, Balint, Eva, ...
Runx (Cbfa/AML) transcription factors are critical for tissue-specific gene expression. A unique targeting signal in the C terminus directs Runx factors to discrete foci within the nucleus. Using...
Yeh, Shuyuan, Tsai, Meng-Yin, Xu, Qingquan, Mu, Xiao-Min, Lardy, Henry, Huang, Ko-En, ...
By using a cre-lox conditional knockout strategy, we report here the generation of androgen receptor knockout (ARKO) mice. Phenotype analysis shows that ARKO male mice have a female-like appearance...
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src−/− mutant mice
Schwartzberg, Pamela L., Xing, Lianping, Hoffmann, Oskar, Lowell, Clifford A., Garrett, Lisa, Boyce, Brendan F., ...
The Src tyrosine kinase has been implicated in a wide variety of signal transduction pathways, yet despite the nearly ubiquitous expression of c-src, src−/− mice show only one major...
Requirement for NF-κB in osteoclast and B-cell development
Franzoso, Guido, Carlson, Louise, Xing, Lianping, Poljak, Ljiljana, Shores, Elizabeth W., Brown, Keith D., ...
NF-κB is a family of related, dimeric transcription factors that are readily activated in cells by signals associated with stress or pathogens. These factors are critical to host defense, as...
Xing, Lianping, Venegas, Ana M., Chen, Amy, Garrett-Beal, Lisa, Boyce, Brendan F., Varmus, Harold E., ...
Mutant src−/− mice have osteopetrosis resulting from defective osteoclasts, the cells that resorb bone. However, signaling pathways involving Src family members in osteoclasts remain unclear. We...
Choi, Je-Yong, Pratap, Jitesh, Javed, Amjad, Zaidi, S. Kaleem, Xing, Lianping, Balint, Eva, ...
Runx (Cbfa/AML) transcription factors are critical for tissue-specific gene expression. A unique targeting signal in the C terminus directs Runx factors to discrete foci within the nucleus. Using...
Yeh, Shuyuan, Tsai, Meng-Yin, Xu, Qingquan, Mu, Xiao-Min, Lardy, Henry, Huang, Ko-En, ...
By using a cre-lox conditional knockout strategy, we report here the generation of androgen receptor knockout (ARKO) mice. Phenotype analysis shows that ARKO male mice have a female-like appearance...
Xing, Lianping, Venegas, Ana M., Chen, Amy, Garrett-Beal, Lisa, Boyce, Brendan F., Varmus, Harold E., ...
Mutant src−/− mice have osteopetrosis resulting from defective osteoclasts, the cells that resorb bone. However, signaling pathways involving Src family members in osteoclasts remain unclear. We...
Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src−/− mutant mice
Schwartzberg, Pamela L., Xing, Lianping, Hoffmann, Oskar, Lowell, Clifford A., Garrett, Lisa, Boyce, Brendan F., ...
The Src tyrosine kinase has been implicated in a wide variety of signal transduction pathways, yet despite the nearly ubiquitous expression of c-src, src−/− mice show only one major...
Requirement for NF-κB in osteoclast and B-cell development
Franzoso, Guido, Carlson, Louise, Xing, Lianping, Poljak, Ljiljana, Shores, Elizabeth W., Brown, Keith D., ...
NF-κB is a family of related, dimeric transcription factors that are readily activated in cells by signals associated with stress or pathogens. These factors are critical to host defense, as...
Biology of RANK, RANKL, and osteoprotegerin
Boyce, Brendan F, Xing, Lianping
The discovery of the receptor activator of nuclear factor-κB ligand (RANKL)/RANK/osteoprotegerin (OPG) system and its role in the regulation of bone resorption exemplifies how both serendipity and a...
Increased lymphangiogenesis in joints of mice with inflammatory arthritis
Zhang, Qian, Lu, Yan, Proulx, Steven T, Guo, Ruolin, Yao, Zhenqiang, Schwarz, Edward M, ...
Angiogenesis is involved in the pathogenesis of inflammatory arthritis, but little is known about the role of lymphangiogenesis in this setting. Here, we examined whether tumor necrosis factor (TNF)...
Yao, Zhenqiang, Xing, Lianping, Qin, Chunlin, Schwarz, Edward M., Boyce, Brendan F.
Interleukin-1 (IL-1) and tumor necrosis factor (TNF) mediate bone resorption in a variety of diseases affecting bone. Like TNF, IL-1 is secreted by osteoclast precursors (OCPs), but unlike TNF, it...
Zhang, Qian, Guo, Ruolin, Lu, Yan, Zhao, Lan, Zhou, Quan, Schwarz, Edward M., ...
Osteoclasts are bone-resorbing cells, but they also secrete and respond to cytokines. Here, we test the hypothesis that osteoclasts secrete the lymphatic growth factor, VEGF-C, to increase their...
Murine and Chicken Chondrocytes Regulate Osteoclastogenesis by Producing RANKL in Response to BMP2
Usui, Michihiko, Xing, Lianping, Drissi, Hicham, Zuscik, Michael, O'Keefe, Regis, Chen, Di, ...
Chondrocytes express RANKL, but their role in osteoclastogenesis is not clear. We report that hypertrophic chondrocytes induce osteoclast formation through RANKL production stimulated by BMP2 and...
Guo, Ruolin, Yamashita, Motozo, Zhang, Qian, Zhou, Quan, Chen, Di, Reynolds, David G., ...
Chronic inflammatory disorders, such as rheumatoid arthritis, are often accompanied by systemic bone loss, which is thought to occur through inflammatory cytokine-mediated stimulation of osteoclast...
NF-κB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanism
Yao, Zhenqiang, Xing, Lianping, Boyce, Brendan F.
TNF and RANKL mediate bone destruction in common bone diseases, including osteoarthritis and RA. They activate NF-κB canonical signaling directly in osteoclast precursors (OCPs) to induce osteoclast...