J. Arjan, G. M. Visser, Joachim Hermisson, Günter P. Wagner, Ancel Meyers, Homayoun Bagheri-chaichian, ...
1 23-12-02 Abstract. – Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene...
Preface: Wireless Technologies (2008)
Seamless Connectivity To, Lin Chao
Wireless technologies offer significant opportunity for the computing and communication industries.
ASP.NET Platform Runtime Environment Security Models Runtime Abstractions in the Wireless and (2008)
This issue of Intel Technology Journal (Vol. 7, Issue 1, 2003) explores Intel's investigations into the behavior of dynamic managed runtime technologies as they relate to compilers, virtual...
Understanding the Evolutionary Fate of Finite Populations: The Dynamics of Mutational Effects (2007)
Olin K. Silander, Olivier Tenaillon, Lin Chao
The most consistent result in more than two decades of experimental evolution is that the fitness of populations adapting to a constant environment does not increase indefinitely, but reaches a...
DNA Sequences Shaped by Selection for Stability (2006)
The sequence of a stretch of nucleotides affects its propensity for errors during replication and expression. Are proteins encoded by stable or unstable nucleotide sequences? If selection for...
PERSPECTIVE:SIGN EPISTASIS AND GENETIC CONSTRAINT ON EVOLUTIONARY TRAJECTORIES (2005)
Daniel M. Weinreich, Richard A. Watson, Lin Chao
Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic background in which it appears. Although epistasis is widely observed in nature, our understanding of...
RAPID EVOLUTIONARY ESCAPE BY LARGE POPULATIONS FROM LOCAL FITNESS PEAKS IS LIKELY IN NATURE (2005)
Fitness interactions between loci in the genome, or epistasis, can result in mutations that are individually deleterious but jointly beneficial. Such epistasis gives rise to multiple peaks on the...
Perspective:Sign Epistasis and Genetic Constraint on Evolutionary Trajectories (2005)
Weinreich, Daniel M., Watson, Richard A., Chao, Lin
Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic background in which it appears. Although epistasis is widely observed in nature, our understanding of...
Perspective:Sign Epistasis and Genetic Constraint on Evolutionary Trajectories (2005)
Weinreich, Daniel M., Watson, Richard A., Chao, Lin
Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic background in which it appears. Although epistasis is widely observed in nature, our understanding of...
Perspective:Sign Epistasis and Genetic Constraint on Evolutionary Trajectories (2005)
Weinreich, Daniel M., Watson, Richard A., Chao, Lin
Epistasis for fitness means that the selective effect of a mutation is conditional on the genetic background in which it appears. Although epistasis is widely observed in nature, our understanding of...
PERSPECTIVE:EVOLUTION AND DETECTION OF GENETIC ROBUSTNESS (2003)
Joachim Hermisson, Günter P. Wagner, Lauren Ancel Meyers, Homayoun Bagheri-Chaichian, Jeffrey L. Blanchard, ...
Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding,...
Selection for multiple mating in females due to mates that reduce female fitness (2003)
If females are unable to discriminate among males before mating, remating by females that store sperm may have evolved as a hedge against having only “costly” mates (less preferred males that...
Typescript.
Evolution of polyandry in a communal breeding system (1997)
The evolution of polyandry requires an asymmetrical factor that favors more matings per breeding female than per breeding male, thus reversing Bateman's principle. Here a model is presented for the...
Typescript.
Thesis (M.A.) - Mount Holyoke College, 1975. Dept. of Biological Sciences.
Shang government--[microform] /--by Lin Chao. (1972)
Thesis (Ph. D.)--University of Chicago, 1972.
Perspective: Evolution And Detection Of Genetic Robustness (1972)
J. Arjan, G. M. Visser, Joachim Hermisson, Günter P. Wagner, Lauren Ancel Meyers, ...
Robustness is the invariance of phenotypes in the face of perturbation. The robustness of phenotypes appears at various levels of biological organization, including gene expression, protein folding,...
Rang, Camilla U., Licht, Tine Rask, Midtvedt, Tore, Conway, Patricia L., Chao, Lin, Krogfelt, Karen A., ...
The growth physiology of Escherichia coli during colonization of the intestinal tract was studied with four animal models: the streptomycin-treated mouse carrying a reduced microflora, the...
Hybrid Frequencies Confirm Limit to Coinfection in the RNA Bacteriophage φ6
Turner, Paul E., Burch, Christina L., Hanley, Kathryn A., Chao, Lin
Coinfection of the same host cell by multiple viruses may lead to increased competition for limited cellular resources, thus reducing the fitness of an individual virus. Selection should favor...
Chao, Lin, Rang, Camilla U., Wong, Linda E.
When a parent virus replicates inside its host, it must first use its own genome as the template for replication. However, once progeny genomes are produced, the progeny can in turn act as templates....
DNA Sequences Shaped by Selection for Stability
The sequence of a stretch of nucleotides affects its propensity for errors during replication and expression. Are proteins encoded by stable or unstable nucleotide sequences? If selection for...
Widespread genetic exchange among terrestrial bacteriophages
Silander, Olin K., Weinreich, Daniel M., Wright, Kevin M., O'Keefe, Kara J., Rang, Camilla U., Turner, Paul E., ...
Bacteriophages are the most numerous entities in the biosphere. Despite this numerical dominance, the genetic structure of bacteriophage populations is poorly understood. Here, we present a...
Co-infection Weakens Selection Against Epistatic Mutations in RNA Viruses
Froissart, Rémy, Wilke, Claus O., Montville, Rebecca, Remold, Susanna K., Chao, Lin, Turner, Paul E.
Co-infection may be beneficial in large populations of viruses because it permits sexual exchange between viruses that is useful in combating the mutational load. This advantage of sex should be...
Poon, Art, Davis, Bradley H., Chao, Lin
Compensatory mutation occurs when a loss of fitness caused by a deleterious mutation is restored by its epistatic interaction with a second mutation at a different site in the genome. How many...
The Rate of Compensatory Mutation in the DNA Bacteriophage φX174
A compensatory mutation occurs when the fitness loss caused by one mutation is remedied by its epistatic interaction with a second mutation at a different site in the genome. This poorly understood...
Amelioration of the cost of conjugative plasmid carriage in Eschericha coli K12.
Although plasmids can provide beneficial functions to their host bacteria, they might confer a physiological or energetic cost. This study examines how natural selection may reduce the cost of...
Drift increases the advantage of sex in RNA bacteriophage Phi6.
The pervasiveness of sex and recombination remains one of the most enigmatic problems in evolutionary biology. According to many theoretical models, recombination can increase the rate of adaptation...
Epistasis and its relationship to canalization in the RNA virus phi 6.
Although deleterious mutations are believed to play a critical role in evolution, assessing their realized effect has been difficult. A key parameter governing the effect of deleterious mutations is...
Rang, Camilla U., Licht, Tine Rask, Midtvedt, Tore, Conway, Patricia L., Chao, Lin, Krogfelt, Karen A., ...
The growth physiology of Escherichia coli during colonization of the intestinal tract was studied with four animal models: the streptomycin-treated mouse carrying a reduced microflora, the...
Hybrid Frequencies Confirm Limit to Coinfection in the RNA Bacteriophage φ6
Turner, Paul E., Burch, Christina L., Hanley, Kathryn A., Chao, Lin
Coinfection of the same host cell by multiple viruses may lead to increased competition for limited cellular resources, thus reducing the fitness of an individual virus. Selection should favor...
Chao, Lin, Rang, Camilla U., Wong, Linda E.
When a parent virus replicates inside its host, it must first use its own genome as the template for replication. However, once progeny genomes are produced, the progeny can in turn act as templates....
Widespread genetic exchange among terrestrial bacteriophages
Silander, Olin K., Weinreich, Daniel M., Wright, Kevin M., O'Keefe, Kara J., Rang, Camilla U., Turner, Paul E., ...
Bacteriophages are the most numerous entities in the biosphere. Despite this numerical dominance, the genetic structure of bacteriophage populations is poorly understood. Here, we present a...
DNA Sequences Shaped by Selection for Stability
The sequence of a stretch of nucleotides affects its propensity for errors during replication and expression. Are proteins encoded by stable or unstable nucleotide sequences? If selection for...
Co-infection Weakens Selection Against Epistatic Mutations in RNA Viruses
Froissart, Rémy, Wilke, Claus O., Montville, Rebecca, Remold, Susanna K., Chao, Lin, Turner, Paul E.
Co-infection may be beneficial in large populations of viruses because it permits sexual exchange between viruses that is useful in combating the mutational load. This advantage of sex should be...
Poon, Art, Davis, Bradley H., Chao, Lin
Compensatory mutation occurs when a loss of fitness caused by a deleterious mutation is restored by its epistatic interaction with a second mutation at a different site in the genome. How many...
The Rate of Compensatory Mutation in the DNA Bacteriophage φX174
A compensatory mutation occurs when the fitness loss caused by one mutation is remedied by its epistatic interaction with a second mutation at a different site in the genome. This poorly understood...
Amelioration of the cost of conjugative plasmid carriage in Eschericha coli K12.
Although plasmids can provide beneficial functions to their host bacteria, they might confer a physiological or energetic cost. This study examines how natural selection may reduce the cost of...
Drift increases the advantage of sex in RNA bacteriophage Phi6.
The pervasiveness of sex and recombination remains one of the most enigmatic problems in evolutionary biology. According to many theoretical models, recombination can increase the rate of adaptation...
Epistasis and its relationship to canalization in the RNA virus phi 6.
Although deleterious mutations are believed to play a critical role in evolution, assessing their realized effect has been difficult. A key parameter governing the effect of deleterious mutations is...
Quantifying Organismal Complexity using a Population Genetic Approach
Tenaillon, Olivier, Silander, Olin K., Uzan, Jean-Philippe, Chao, Lin
Understanding the Evolutionary Fate of Finite Populations: The Dynamics of Mutational Effects
Silander, Olin K, Tenaillon, Olivier, Chao, Lin
The most consistent result in more than two decades of experimental evolution is that the fitness of populations adapting to a constant environment does not increase indefinitely, but reaches a...
On the evolutionary origin of aging
Ackermann, Martin, Chao, Lin, Bergstrom, Carl T, Doebeli, Michael
It is generally believed that the first organisms did not age, and that aging thus evolved at some point in the history of life. When and why this transition occurred is a fundamental question in...