Combined analysis reveals a core set of cycling genes (2007)
Lu, Yong, Mahony, Shaun, Benos, Panayiotis V, Rosenfeld, Roni, Simon, Itamar, Breeden, Linda L, ...
Abstract Background Global transcript levels throughout the cell cycle have been characterized using microarrays in several species. Early analysis of these experiments focused on individual species....
MacKay, Vivian L., Mai, Bernard, Waters, Laurie, Breeden, Linda L.
The Cln3-Cdc28 kinase is required to activate the Swi4-Swi6 transcription complex which induces CLN1 and CLN2 transcription in late G1 and drives the transition to S. Cln3 and Swi4 are both rate...
Mai, Bernard, Miles, Shawna, Breeden, Linda L.
The transcription factor Mcm1 is regulated by adjacent binding of a variety of different factors regulating the expression of cell-type-specific, cell cycle-specific, and metabolic genes. In this...
Sidorova, Julia M., Breeden, Linda L.
Rad53 of Saccharomyces cerevisiae is a checkpoint kinase whose structure and function are conserved among eukaryotes. When a cell detects damaged DNA, Rad53 activity is dramatically increased, which...
Pramila, Tata, Miles, Shawna, GuhaThakurta, Debraj, Jemiolo, Dave, Breeden, Linda L.
Two homeodomain proteins, Yox1 and Yhp1, act as repressors at early cell cycle boxes (ECBs) to restrict their activity to the M/G1 phase of the cell cycle in budding yeast. These proteins bind to...
Sidorova, Julia M., Breeden, Linda L.
Budding yeast possesses a checkpoint-dependent mechanism of delaying G1 progression in response to UV and ionizing radiation DNA damage. We have shown that after a pulse of DNA damage in G1 with the...
Guo, Yingying, Breeden, Linda L., Zarbl, Helmut, Preston, Bradley D., Eaton, David L.
Aflatoxin B1 (AFB1) is a human hepatotoxin and hepatocarcinogen produced by the mold Aspergillus flavus. In humans, AFB1 is primarily bioactivated by cytochrome P450 1A2 (CYP1A2) and 3A4 to a...
Li, Lihong, Quinton, Tina, Miles, Shawna, Breeden, Linda L.
Swi6 associates with Swi4 to activate HO and many other late G1-specific transcripts in budding yeast. Genetic screens for suppressors of SWI6 mutants have been carried out. A total of 112 of these...
Sidorova, Julia M, Breeden, Linda L
Precocious entry into S phase due to overproduction of G1 regulators can cause genomic instability. The mechanisms of this phenomenon are largely unknown. We explored the consequences of precocious S...
MacKay, Vivian L., Mai, Bernard, Waters, Laurie, Breeden, Linda L.
The Cln3-Cdc28 kinase is required to activate the Swi4-Swi6 transcription complex which induces CLN1 and CLN2 transcription in late G1 and drives the transition to S. Cln3 and Swi4 are both rate...
Mai, Bernard, Miles, Shawna, Breeden, Linda L.
The transcription factor Mcm1 is regulated by adjacent binding of a variety of different factors regulating the expression of cell-type-specific, cell cycle-specific, and metabolic genes. In this...
Sidorova, Julia M., Breeden, Linda L.
Rad53 of Saccharomyces cerevisiae is a checkpoint kinase whose structure and function are conserved among eukaryotes. When a cell detects damaged DNA, Rad53 activity is dramatically increased, which...
Pramila, Tata, Miles, Shawna, GuhaThakurta, Debraj, Jemiolo, Dave, Breeden, Linda L.
Two homeodomain proteins, Yox1 and Yhp1, act as repressors at early cell cycle boxes (ECBs) to restrict their activity to the M/G1 phase of the cell cycle in budding yeast. These proteins bind to...
Sidorova, Julia M., Breeden, Linda L.
Budding yeast possesses a checkpoint-dependent mechanism of delaying G1 progression in response to UV and ionizing radiation DNA damage. We have shown that after a pulse of DNA damage in G1 with the...
Guo, Yingying, Breeden, Linda L., Zarbl, Helmut, Preston, Bradley D., Eaton, David L.
Aflatoxin B1 (AFB1) is a human hepatotoxin and hepatocarcinogen produced by the mold Aspergillus flavus. In humans, AFB1 is primarily bioactivated by cytochrome P450 1A2 (CYP1A2) and 3A4 to a...
Li, Lihong, Quinton, Tina, Miles, Shawna, Breeden, Linda L.
Swi6 associates with Swi4 to activate HO and many other late G1-specific transcripts in budding yeast. Genetic screens for suppressors of SWI6 mutants have been carried out. A total of 112 of these...
Sidorova, Julia M, Breeden, Linda L
Precocious entry into S phase due to overproduction of G1 regulators can cause genomic instability. The mechanisms of this phenomenon are largely unknown. We explored the consequences of precocious S...
Pramila, Tata, Wu, Wei, Miles, Shawna, Noble, William Stafford, Breeden, Linda L.
Transcription patterns shift dramatically as cells transit from one phase of the cell cycle to another. To better define this transcriptional circuitry, we collected new microarray data across the...
Braun, Katherine A., Breeden, Linda L.
The minichromosome maintenance genes (MCM2-7) are transcribed at M/G1 just as the Mcm complex is imported into the nucleus to be assembled into prereplication complexes, during a period of low...
Combined analysis reveals a core set of cycling genes
Lu, Yong, Mahony, Shaun, Benos, Panayiotis V, Rosenfeld, Roni, Simon, Itamar, Breeden, Linda L, ...
The simultaneous analysis of expression data from multiple species reveals a core set of conserved cycling genes that is much larger than previously thought.