Linda N. Lee

Genome of the Bacterium Streptococcus pneumoniae Strain R6

Hoskins, JoAnn, Alborn, William E., Arnold, Jeffrey, Blaszczak, Larry C., Burgett, Stanley, DeHoff, Bradley S., ...

Streptococcus pneumoniae is among the most significant causes of bacterial disease in humans. Here we report the 2,038,615-bp genomic sequence of the gram-positive bacterium S. pneumoniae R6. Because...

An Effective Strategy, Applicable to Streptococcus salivarius and Related Bacteria, To Enhance or Confer Electroporation Competence

Buckley, Nicole D., Vadeboncoeur, Christian, LeBlanc, Donald J., Lee, Linda N., Frenette, Michel

Despite the large number of techniques available for transformation of bacteria, certain species and strains are still resistant to introduction of foreign DNA. Some oral streptococci are among the...

Detection of Tn917-Like Sequences within a Tn916-like Conjugative Transposon (Tn3872) in Erythromycin-Resistant Isolates of Streptococcus pneumoniae

McDougal, Linda K., Tenover, Fred C., Lee, Linda N., Rasheed, J. Kamile, Patterson, Jan E., Jorgensen, James H., ...

A series of macrolide-lincosamide-streptogramin B (MLS)-resistant pneumococcal isolates of a variety of serotypes was examined and was found to contain Tn917-like elements by DNA-DNA hybridization....

Distinct Patterns of Gene Expression Associated with Development of Fluconazole Resistance in Serial Candida albicans Isolates from Human Immunodeficiency Virus-Infected Patients with Oropharyngeal Candidiasis

Lopez-Ribot, Jose L., McAtee, Robert K., Lee, Linda N., Kirkpatrick, William R., White, Theodore C., Sanglard, Dominique, ...

Resistance to fluconazole is becoming an increasing problem in the management of oropharyngeal candidiasis in human immunodeficiency virus-infected patients. Strains obtained from five patients...

Influence of the Lactose Plasmid on the Metabolism of Galactose by Streptococcus lactis

LeBlanc, Donald J., Crow, Vaughan L., Lee, Linda N., Garon, Claude F.

Streptococcus lactis strain DR1251 was capable of growth on lactose and galactose with generation times, at 30°C, of 42 and 52 min, respectively. Phosphoenolpyruvate-dependent phosphotransferase...

Secretion of Proinflammatory Cytokines and Chemokines during Amphotericin B Exposure Is Mediated by Coactivation of Toll-Like Receptors 1 and 2

Razonable, Raymund R., Henault, Martin, Lee, Linda N., Laethem, Carmen, Johnston, Paul A., Watson, Harold L., ...

Amphotericin B (AmB) is a ligand of toll-like receptor 2 (TLR2). Here, we demonstrate the participation of TLR1 in AmB-induced cell activation that led to the secretion of tumor necrosis factor...

Genome of the Bacterium Streptococcus pneumoniae Strain R6

Hoskins, JoAnn, Alborn, William E., Arnold, Jeffrey, Blaszczak, Larry C., Burgett, Stanley, DeHoff, Bradley S., ...

Streptococcus pneumoniae is among the most significant causes of bacterial disease in humans. Here we report the 2,038,615-bp genomic sequence of the gram-positive bacterium S. pneumoniae R6. Because...

An Effective Strategy, Applicable to Streptococcus salivarius and Related Bacteria, To Enhance or Confer Electroporation Competence

Buckley, Nicole D., Vadeboncoeur, Christian, LeBlanc, Donald J., Lee, Linda N., Frenette, Michel

Despite the large number of techniques available for transformation of bacteria, certain species and strains are still resistant to introduction of foreign DNA. Some oral streptococci are among the...

Detection of Tn917-Like Sequences within a Tn916-like Conjugative Transposon (Tn3872) in Erythromycin-Resistant Isolates of Streptococcus pneumoniae

McDougal, Linda K., Tenover, Fred C., Lee, Linda N., Rasheed, J. Kamile, Patterson, Jan E., Jorgensen, James H., ...

A series of macrolide-lincosamide-streptogramin B (MLS)-resistant pneumococcal isolates of a variety of serotypes was examined and was found to contain Tn917-like elements by DNA-DNA hybridization....

Distinct Patterns of Gene Expression Associated with Development of Fluconazole Resistance in Serial Candida albicans Isolates from Human Immunodeficiency Virus-Infected Patients with Oropharyngeal Candidiasis

Lopez-Ribot, Jose L., McAtee, Robert K., Lee, Linda N., Kirkpatrick, William R., White, Theodore C., Sanglard, Dominique, ...

Resistance to fluconazole is becoming an increasing problem in the management of oropharyngeal candidiasis in human immunodeficiency virus-infected patients. Strains obtained from five patients...

Influence of the Lactose Plasmid on the Metabolism of Galactose by Streptococcus lactis

LeBlanc, Donald J., Crow, Vaughan L., Lee, Linda N., Garon, Claude F.

Streptococcus lactis strain DR1251 was capable of growth on lactose and galactose with generation times, at 30°C, of 42 and 52 min, respectively. Phosphoenolpyruvate-dependent phosphotransferase...

Secretion of Proinflammatory Cytokines and Chemokines during Amphotericin B Exposure Is Mediated by Coactivation of Toll-Like Receptors 1 and 2

Razonable, Raymund R., Henault, Martin, Lee, Linda N., Laethem, Carmen, Johnston, Paul A., Watson, Harold L., ...

Amphotericin B (AmB) is a ligand of toll-like receptor 2 (TLR2). Here, we demonstrate the participation of TLR1 in AmB-induced cell activation that led to the secretion of tumor necrosis factor...