Linda P. Dwoskin

Pharmacological similarities between native brain and heterologously expressed α4β2 nicotinic receptors

Shafaee, Navid, Houng, McCann, Truong, Anthony, Viseshakul, Nareerat, Figl, Antonio, Sandhu, Sumandeep, ...

We studied the pharmacological properties of native rat brain and heterologously expressed rat α4β2 nicotinic receptors immunoprecipitated onto a fixed substrate with the anti-α4 antibody mAb...

N-n-alkylnicotinium analogs, a novel class of antagonists at α4β2* Nicotinic acetylcholine receptors: Inhibition of S(-)-nicotine-evoked 86Rb+Efflux from rat thalamic synaptosomes

Wilkins, Lincoln H., Miller, Dennis K., Ayers, Joshua T., Crooks, Peter A., Dwoskin, Linda P.

PyridineN-n-alkylation of S(-)-nicotine (NIC) affordsN-n-alkylnicotinium analogs, previously shown to competitively inhibit [3H]NIC binding and interact with α4β2* nicotinic receptors (nAChRs). The...

Molecular modeling of mono- and bis-quaternary ammonium salts as ligands at the α4β2 nicotinic acetylcholine receptor subtype using nonlinear techniques

Ayers, Joshua T., Clauset, Aaron, Schmitt, Jeffrey D., Dwoskin, Linda P., Crooks, Peter A.

The neuronal nicotinic acetylcholine receptor (nAChR) has been a target for drug development studies for over a decade. A series ofmono- andbis-quaternary ammonium salts, known to be antagonists at...

A general procedure for the enantioselective synthesis of the minor tobacco alkaloids nornicotine, anabasine, and anatabine

Ayers, Joshua T., Xu, Rui, Dwoskin, Linda P., Crooks, Peter A.

The minor tobacco alkaloids nornicotine, anabasine, and anatabine fromNicotiana tobacum are known to possess nicotinic receptor agonist activity, although they are relatively less potent than...

Vesicular monoamine transporter 2: Role as a novel target for drug development

Zheng, Guangrong, Dwoskin, Linda P., Crooks, Peter A.

In the central nervous, system, vesicular monoamine transporter 2 (VMAT2) is the only transporter that moves cytoplasmic dopamine (DA) into synaptic vesicles for storage and subsequent exocytotic...

Introduction of unsaturation into theN-n-alkyl chain of the nicotinic receptor antagonists, NONI and NDNI: Effect on affinity and selectivity

Sumithran, Sangeetha P., Crooks, Peter A., Xu, Rui, Zhu, Jun, Deaciuc, Agripina G., Wilkins, Lincoln H., ...

N-n-Octylnicotinium iodide (NONI) andN-n-decylnicotinium iodide (NDNI) are selective nicotinic receptor (nAChR) antagonists mediating nicotine-evoked striatal dopamine (DA) release, and inhibiting...