Mangada, Julie A., Pearson, Todd, Brehm, Michael A., Wicker, Linda S., Peterson, Laurence B., Shultz, Leonard D., ...
OBJECTIVE: NOD mice model human type 1 diabetes and are used to investigate tolerance induction protocols for islet transplantation in a setting of autoimmunity. However, costimulation blockade-based...
T1DBase: integration and presentation of complex data for type 1 diabetes research (2007)
Hulbert, Erin M., Smink, Luc J., Adlem, Ellen C., Allen, James E., Burdick, David B., Burren, Oliver S., ...
T1DBase (http://T1DBase.org) [Smink et al. (2005) Nucleic Acids Res., 33, D544–D549; Burren et al. (2004) Hum. Genomics, 1, 98–109] is a public website and database that supports the type 1...
Taniguchi, Hidenori, Lowe, Christopher E, Cooper, Jason D, Smyth, Deborah J, Bailey, Rebecca, Nutland, Sarah, ...
Abstract Background Type 1 diabetes (T1D) is a common autoimmune disease resulting from T-cell mediated destruction of pancreatic beta cells. Decay accelerating factor (DAF, CD55), a...
T1DBase: integration and presentation of complex data for type 1 diabetes research (2006)
Hulbert, Erin M., Smink, Luc J., Adlem, Ellen C., E. Allen, James, Burdick, David B., Burren, Oliver S., ...
T1DBase (http://T1DBase.org) [Smink et al. (2005) Nucleic Acids Res., 33, D544–D549; Burren et al. (2004) Hum. Genomics, 1, 98–109] is a public website and database that supports the type 1...
T1DBase: integration and presentation of complex data for type 1 diabetes research (2006)
Hulbert, Erin M., Smink, Luc J., Adlem, Ellen C., E. Allen, James, Burdick, David B., Burren, Oliver S., ...
T1DBase (http://T1DBase.org) [Smink et al. (2005) Nucleic Acids Res., 33, D544–D549; Burren et al. (2004) Hum. Genomics, 1, 98–109] is a public website and database that supports the type 1...
Maier, Lisa M, Smyth, Deborah J, Vella, Adrian, Payne, Felicity, Cooper, Jason D, Pask, Rebecca, ...
Abstract Background One strategy to help identify susceptibility genes for complex, multifactorial diseases is to map disease loci in a representative animal model of the disorder. The nonobese...
T1DBase, a community web-based resource for type 1 diabetes research (2005)
Luc J. Smink, Erin M. Helton, Barry C. Healy, Christopher C. Cavnor, Alex C. Lam, Daisy Flamez, ...
doi:10.1093/nar/gki095
T1DBase, a community web-based resource for type 1 diabetes research (2005)
Smink, Luc J., Helton, Erin M., Healy, Barry C., Cavnor, Christopher C., Lam, Alex C., Flamez, Daisy, ...
T1DBase (http://T1DBase.org) is a public website and database that supports the type 1 diabetes (T1D) research community. The site is currently focused on the molecular genetics and biology of T1D...
Autoimmune diabetes and resistance to xenograft transplantation tolerance in NOD mice (2004)
Gordon, Ethel J., Wicker, Linda S., Peterson, Laurence B., Serreze, David V., Markees, Thomas G., Shultz, Leonard D., ...
Costimulation blockade induces prolonged rat islet and skin xenograft survival in C57BL/6 mice. Nonobese diabetic (NOD) mice, which are used to model human autoimmune diabetes, are resistant to...
Pearson, Todd, Weiser, Peter, Markees, Thomas G., Serreze, David V., Wicker, Linda S., Peterson, Laurence B., ...
NOD mice develop type 1 autoimmune diabetes and exhibit genetically dominant resistance to transplantation tolerance induction. These two phenotypes are genetically separable. Costimulation blockade...
Islet cell autoimmunity and transplantation tolerance: two distinct mechanisms (2003)
Pearson, Todd, Markees, Thomas G., Serreze, David V., Pierce, Melissa A., Wicker, Linda S., Peterson, Laurence B., ...
Recent advances in islet transplantation have enabled physicians to cure type 1 autoimmune diabetes, but at the cost of lifelong immunosuppression with its attendant side effects and long-term health...
Genetic separation of the transplantation tolerance and autoimmune phenotypes in NOD mice (2003)
Pearson, Todd, Markees, Thomas G., Serreze, David V., Pierce, Melissa A., Wicker, Linda S., Peterson, Laurence B., ...
Pearson, Todd, Markees, Thomas G., Serreze, David V., Pierce, Melissa A., Marron, Michele P., Wicker, Linda S., ...
Curing type 1 diabetes by islet transplantation requires overcoming both allorejection and recurrent autoimmunity. This has been achieved with systemic immunosuppression, but tolerance induction...
Pearson, Todd, Markees, Thomas G., Wicker, Linda S., Serreze, David V., Peterson, Laurence B., Mordes, John P., ...
The loss of self-tolerance leading to autoimmune type 1 diabetes in the NOD mouse model involves at least 19 genetic loci. In addition to their genetic defects in self-tolerance, NOD mice resist...
Eaves, Iain A., Wicker, Linda S., Ghandour, Ghassan, Lyons, Paul A., Peterson, Laurence B., Todd, John A., ...
Eaves, Iain A., Wicker, Linda S., Ghandour, Ghassan, Lyons, Paul A., Peterson, Laurence B., Todd, John A., ...
Lyons, Paul A., Armitage, Nicola, Argentina, Fabio, Denny, Paul, Hill, Natasha J., Lord, Christopher J., ...
Lyons, Paul A., Armitage, Nicola, Argentina, Fabio, Denny, Paul, Hill, Natasha J., Lord, Christopher J., ...
Type 1 diabetes in the nonobese diabetic (NOD) mouse arises as a consequence of T cell-mediated destruction of the insulin-producing β cells of the pancreas. Although little is known of the events...
T1DBase, a community web-based resource for type 1 diabetes research
Smink, Luc J., Helton, Erin M., Healy, Barry C., Cavnor, Christopher C., Lam, Alex C., Flamez, Daisy, ...
T1DBase (http://T1DBase.org) is a public website and database that supports the type 1 diabetes (T1D) research community. The site is currently focused on the molecular genetics and biology of T1D...
Genetic Control of Susceptibility to Cryptococcus neoformans in Mice
Rhodes, Judith C., Wicker, Linda S., Urba, Walter J.
Inbred mice injected intravenously with 5 × 106 cells of Cryptococcus neoformans showed two patterns of survival: sensitive (A/WySn, A.BY, A/J, DBA/2J, NZB/B1NJ, and SWR/J) and resistant...
Maier, Lisa M, Smyth, Deborah J, Vella, Adrian, Payne, Felicity, Cooper, Jason D, Pask, Rebecca, ...
Taniguchi, Hidenori, Lowe, Christopher E, Cooper, Jason D, Smyth, Deborah J, Bailey, Rebecca, Nutland, Sarah, ...
Lyons, Paul A., Armitage, Nicola, Argentina, Fabio, Denny, Paul, Hill, Natasha J., Lord, Christopher J., ...
Type 1 diabetes in the nonobese diabetic (NOD) mouse arises as a consequence of T cell-mediated destruction of the insulin-producing β cells of the pancreas. Although little is known of the events...
T1DBase, a community web-based resource for type 1 diabetes research
Smink, Luc J., Helton, Erin M., Healy, Barry C., Cavnor, Christopher C., Lam, Alex C., Flamez, Daisy, ...
T1DBase (http://T1DBase.org) is a public website and database that supports the type 1 diabetes (T1D) research community. The site is currently focused on the molecular genetics and biology of T1D...
Genetic Control of Susceptibility to Cryptococcus neoformans in Mice
Rhodes, Judith C., Wicker, Linda S., Urba, Walter J.
Inbred mice injected intravenously with 5 × 106 cells of Cryptococcus neoformans showed two patterns of survival: sensitive (A/WySn, A.BY, A/J, DBA/2J, NZB/B1NJ, and SWR/J) and resistant...
Maier, Lisa M, Smyth, Deborah J, Vella, Adrian, Payne, Felicity, Cooper, Jason D, Pask, Rebecca, ...
Taniguchi, Hidenori, Lowe, Christopher E, Cooper, Jason D, Smyth, Deborah J, Bailey, Rebecca, Nutland, Sarah, ...
T1DBase: integration and presentation of complex data for type 1 diabetes research
Hulbert, Erin M., Smink, Luc J., Adlem, Ellen C., Allen, James E., Burdick, David B., Burren, Oliver S., ...
T1DBase () [Smink et al. (2005) Nucleic Acids Res., 33, D544–D549; Burren et al. (2004) Hum. Genomics, 1, 98–109] is a public website and database that supports the type 1 diabetes (T1D) research...
Irie, Junichiro, Wu, Yuehong, Wicker, Linda S., Rainbow, Daniel, Nalesnik, Michael A., Hirsch, Raphael, ...
Primary biliary cirrhosis (PBC) is an autoimmune disease with a strong genetic component characterized by biliary ductular inflammation with eventual liver cirrhosis. The serologic hallmark of PBC is...
Allelic variant in CTLA4 alters T cell phosphorylation patterns
Maier, Lisa M., Anderson, David E., De Jager, Philip L., Wicker, Linda S., Hafler, David A.
Little is known regarding the functional effects of common autoimmune susceptibility variants on human immune cells. The SNP CT60 (rs3087243; A/G) located in the 3′ UTR of the CTLA4 gene has been...
Maier, Lisa M., Lowe, Christopher E., Cooper, Jason, Downes, Kate, Anderson, David E., Severson, Christopher, ...
Multiple sclerosis (MS) and type 1 diabetes (T1D) are organ-specific autoimmune disorders with significant heritability, part of which is conferred by shared alleles. For decades, the Human Leukocyte...
Kamanaka, Masahito, Rainbow, Dan, Schuster-Gossler, Karin, Eynon, Elizabeth E., Chervonsky, Alexander V., Wicker, Linda S., ...
Idd3 is one of many gene regions that affect the development of type 1 diabetes (T1D) in the nonobese diabetic (NOD) mouse. Idd3 has been localized to a 650-kb region on chromosome 3 containing the...