Lindsay Brown

Evaluation of the chronic complications of diabetes in a high fructose diet in rats (2009)

Patel, Jatin, Iyer, Abishek, Brown, Lindsay

The increasing prevalence of type 2 diabetes is associated with increasing health costs, especially for the treatment of cardiovascular disease. The development of new treatment modalities requires...

The effects of generalized joint laxity and shoulder joint laxity on shoulder joint ROM in swimmers (2008)

Baril, Beth, Bivens, Brenda, Brown, Lindsay, Travis, Janette

Paper presented to the 4th Annual Symposium on Graduate Research and Scholarly Projects (GRASP) held at the Hughes Metropolitan Complex, Wichita State University, April 25, 2008.

Prevention of hypertension in DOCA-salt rats by an inhibitor of soluble epoxide hydrolase (2007)

Loch, David, Hoey, Andrew, Morisseau, Christophe, Hammock, Bruce O., Brown, Lindsay

Cyclooxygenase and lipoxygenase metabolism of arachidonic acid produces compounds important in cardiovascular control. Further, arachidonic acid can be metabolised by cytochrome p450 to produce...

Attentuation of cardiovascular remodelling in DOCA-Salt rats by the Vasopeptidase inhibitor, Omapatrilat (2006)

Loch, David, Hoey, Andrew, Brown, Lindsay

Omapatrilat, a vasopeptidase inhibitor, inhibits both neutral endopeptidase and angiotensin- converting enzyme with similar potency. The aim of this study was to investigate whether omapatrilat...

Attentuation of cardiovascular remodelling in DOCA-Salt rats by the Vasopeptidase inhibitor, Omapatrilat (2006)

Loch, David, Hoey, Andrew, Brown, Lindsay

Omapatrilat, a vasopeptidase inhibitor, inhibits both neutral endopeptidase and angiotensin-converting enzyme with similar potency. The aim of this study was to investigate whether omapatrilat...

Attentuation of cardiovascular remodelling in DOCA-Salt rats by the Vasopeptidase inhibitor, Omapatrilat (2006)

Loch, David, Hoey, Andrew, Brown, Lindsay

Omapatrilat, a vasopeptidase inhibitor, inhibits both neutral endopeptidase and angiotensin- converting enzyme with similar potency. The aim of this study was to investigate whether omapatrilat...

Attentuation of cardiovascular remodelling in DOCA-Salt rats by the Vasopeptidase inhibitor, Omapatrilat (2006)

Loch, David, Hoey, Andrew, Brown, Lindsay

Omapatrilat, a vasopeptidase inhibitor, inhibits both neutral endopeptidase and angiotensin-converting enzyme with similar potency. The aim of this study was to investigate whether omapatrilat...

Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats (2006)

Chan, Vincent, Hoey, Andrew, Brown, Lindsay

[Summary]: 1. The ability of aminoguanidine, an inhibitor of collagen cross-linking, to prevent changes in cardiac and vascular structure and function has been determined in the DOCA-salt...

Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats (2006)

Chan, Vincent, Hoey, Andrew, Brown, Lindsay

[Summary]: 1. The ability of aminoguanidine, an inhibitor of collagen cross-linking, to prevent changes in cardiac and vascular structure and function has been determined in the DOCA-salt...

Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats (2006)

Chan, Vincent, Hoey, Andrew, Brown, Lindsay

[Summary]: 1. The ability of aminoguanidine, an inhibitor of collagen cross-linking, to prevent changes in cardiac and vascular structure and function has been determined in the DOCA-salt...

Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats (2006)

Chan, Vincent, Hoey, Andrew, Brown, Lindsay

[Summary]: 1. The ability of aminoguanidine, an inhibitor of collagen cross-linking, to prevent changes in cardiac and vascular structure and function has been determined in the DOCA-salt...

Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle (2006)

Woolf, Peter James, Lu, Sai, Cornford-Nairn, Renee A., Watson, Michael, Xiao, Xiao-Hui, Holroyd, Sean, ...

The deficiency of dystrophin, a critical membrane stabilising protein, in the mdx mouse causes an elevation in intracellular calcium in myocytes. One mechanism that could elicit increases in...

Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle (2006)

Woolf, Peter James, Lu, Sai, Cornford-Nairn, Renee A., Watson, Michael, Xiao, Xiao-Hui, Holroyd, Sean, ...

The deficiency of dystrophin, a critical membrane stabilising protein, in the mdx mouse causes an elevation in intracellular calcium in myocytes. One mechanism that could elicit increases in...

Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle (2006)

Woolf, Peter James, Lu, Sai, Cornford-Nairn, Renee A., Watson, Michael, Xiao, Xiao-Hui, Holroyd, Sean, ...

The deficiency of dystrophin, a critical membrane stabilising protein, in the mdx mouse causes an elevation in intracellular calcium in myocytes. One mechanism that could elicit increases in...

Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle (2006)

Woolf, Peter James, Lu, Sai, Cornford-Nairn, Renee A., Watson, Michael, Xiao, Xiao-Hui, Holroyd, Sean, ...

The deficiency of dystrophin, a critical membrane stabilising protein, in the mdx mouse causes an elevation in intracellular calcium in myocytes. One mechanism that could elicit increases in...

Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats (2006)

Loch, David, Levick, Scott, Hoey, Andrew, Brown, Lindsay

The pleiotropic effects of statins represent potential mechanisms for the treatment of end-organ damage in hypertension. This study has investigated the effects of rosuvastatin in a model of...

Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats (2006)

Loch, David, Levick, Scott, Hoey, Andrew, Brown, Lindsay

The pleiotropic effects of statins represent potential mechanisms for the treatment of end-organ damage in hypertension. This study has investigated the effects of rosuvastatin in a model of...

Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats (2006)

Loch, David, Levick, Scott, Hoey, Andrew, Brown, Lindsay

The pleiotropic effects of statins represent potential mechanisms for the treatment of end-organ damage in hypertension. This study has investigated the effects of rosuvastatin in a model of...

Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats (2006)

Loch, David, Levick, Scott, Hoey, Andrew, Brown, Lindsay

The pleiotropic effects of statins represent potential mechanisms for the treatment of end-organ damage in hypertension. This study has investigated the effects of rosuvastatin in a model of...

Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle (2006)

Woolf, Peter James, Lu, Sai, Cornford-Nairn, Renee A., Watson, Michael, Xiao, Xiao-Hui, Holroyd, Sean, ...

The deficiency of dystrophin, a critical membrane stabilising protein, in the mdx mouse causes an elevation in intracellular calcium in myocytes. One mechanism that could elicit increases in...

Attentuation of cardiovascular remodelling in DOCA-Salt rats by the Vasopeptidase inhibitor, Omapatrilat (2006)

Loch, David, Hoey, Andrew, Brown, Lindsay

Omapatrilat, a vasopeptidase inhibitor, inhibits both neutral endopeptidase and angiotensin- converting enzyme with similar potency. The aim of this study was to investigate whether omapatrilat...

Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats (2006)

Chan, Vincent, Hoey, Andrew, Brown, Lindsay

[Summary]: 1. The ability of aminoguanidine, an inhibitor of collagen cross-linking, to prevent changes in cardiac and vascular structure and function has been determined in the DOCA-salt...

Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats (2006)

Loch, David, Levick, Scott, Hoey, Andrew, Brown, Lindsay

The pleiotropic effects of statins represent potential mechanisms for the treatment of end-organ damage in hypertension. This study has investigated the effects of rosuvastatin in a model of...

Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A(2) in young spontaneously hypertensive rats (2006)

Levick, Scott, Loch, David, Rolfe, Barbara, Reid, Robert C., Fairlie, David P., Taylor, Stephan M., ...

The development of fibrosis in the chronically hypertensive heart is associated with infiltration of inflammatory cells and cardiac hypertrophy. In this study, an inhibitor of the proinflammatory...

Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A(2) in young spontaneously hypertensive rats (2006)

Levick, Scott, Loch, David, Rolfe, Barbara, Reid, Robert C., Fairlie, David P., Taylor, Stephan M., ...

The development of fibrosis in the chronically hypertensive heart is associated with infiltration of inflammatory cells and cardiac hypertrophy. In this study, an inhibitor of the proinflammatory...

Alterations in dihydropyridine receptors in dystrophin-deficient cardiac muscle (2006)

Woolf, Peter James, Lu, Sai, Cornford-Nairn, Renee A., Watson, Michael, Xiao, Xiao-Hui, Holroyd, Sean, ...

The deficiency of dystrophin, a critical membrane stabilising protein, in the mdx mouse causes an elevation in intracellular calcium in myocytes. One mechanism that could elicit increases in...

Attentuation of cardiovascular remodelling in DOCA-Salt rats by the Vasopeptidase inhibitor, Omapatrilat (2006)

Loch, David, Hoey, Andrew, Brown, Lindsay

Omapatrilat, a vasopeptidase inhibitor, inhibits both neutral endopeptidase and angiotensin- converting enzyme with similar potency. The aim of this study was to investigate whether omapatrilat...

Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats (2006)

Chan, Vincent, Hoey, Andrew, Brown, Lindsay

[Summary]: 1. The ability of aminoguanidine, an inhibitor of collagen cross-linking, to prevent changes in cardiac and vascular structure and function has been determined in the DOCA-salt...

Rosuvastatin attenuates hypertension-induced cardiovascular remodeling without affecting blood pressure in DOCA-salt hypertensive rats (2006)

Loch, David, Levick, Scott, Hoey, Andrew, Brown, Lindsay

The pleiotropic effects of statins represent potential mechanisms for the treatment of end-organ damage in hypertension. This study has investigated the effects of rosuvastatin in a model of...

Reversal of cardiac dysfunction by selective ET-A receptor antagonism (2005)

Allan, Anthony, Fenning, Andrew, Levick, Scott, Hoey, Andrew, Brown, Lindsay

1. The effectiveness of a selective endothelin receptor-A (ET-A) antagonist, A-127722 (approximately 10 mg kg-1 day-1 as 200 mg kg-1 powdered food), to reverse existing cardiac remodelling and...

Reversal of cardiac dysfunction by selective ET-A receptor antagonism (2005)

Allan, Anthony, Fenning, Andrew, Levick, Scott, Hoey, Andrew, Brown, Lindsay

1. The effectiveness of a selective endothelin receptor-A (ET-A) antagonist, A-127722 (approximately 10 mg kg-1 day-1 as 200 mg kg-1 powdered food), to reverse existing cardiac remodelling and...

Reversal of cardiac dysfunction by selective ET-A receptor antagonism (2005)

Allan, Anthony, Fenning, Andrew, Levick, Scott, Hoey, Andrew, Brown, Lindsay

1. The effectiveness of a selective endothelin receptor-A (ET-A) antagonist, A-127722 (approximately 10 mg kg-1 day-1 as 200 mg kg-1 powdered food), to reverse existing cardiac remodelling and...

Reversal of cardiac dysfunction by selective ET-A receptor antagonism (2005)

Allan, Anthony, Fenning, Andrew, Levick, Scott, Hoey, Andrew, Brown, Lindsay

1. The effectiveness of a selective endothelin receptor-A (ET-A) antagonist, A-127722 (approximately 10 mg kg-1 day-1 as 200 mg kg-1 powdered food), to reverse existing cardiac remodelling and...

L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats (2005)

Hoey, Andrew, Fenning, Andrew, Harrison, Glenn, Rose Meyer, Roselyn, Brown, Lindsay

Nitric oxide (NO) is essential for normal function of the cardiovascular system. This study has determined whether chronic administration of L-arginine, the biological precursor of NO, attenuates the...

L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats (2005)

Hoey, Andrew, Fenning, Andrew, Harrison, Glenn, Rose Meyer, Roselyn, Brown, Lindsay

Nitric oxide (NO) is essential for normal function of the cardiovascular system. This study has determined whether chronic administration of L-arginine, the biological precursor of NO, attenuates the...

L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats (2005)

Hoey, Andrew, Fenning, Andrew, Harrison, Glenn, Rose Meyer, Roselyn, Brown, Lindsay

Nitric oxide (NO) is essential for normal function of the cardiovascular system. This study has determined whether chronic administration of L-arginine, the biological precursor of NO, attenuates the...

L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats (2005)

Hoey, Andrew, Fenning, Andrew, Harrison, Glenn, Rose Meyer, Roselyn, Brown, Lindsay

Nitric oxide (NO) is essential for normal function of the cardiovascular system. This study has determined whether chronic administration of L-arginine, the biological precursor of NO, attenuates the...

L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats. (2005)

Fenning, Andrew, Harrison, Glenn, Rose'Meyer, Roselyn, Hoey, Andrew, Brown, Lindsay

Nitric oxide (NO) is essential for the normal functioning of the cardiovascular system. This study has determined whether chronic administration of L-arginine, the biological precursor of NO,...

Reversal of cardiac dysfunction by selective ET-A receptor antagonism (2005)

Allan, Anthony, Fenning, Andrew, Levick, Scott, Hoey, Andrew, Brown, Lindsay

1. The effectiveness of a selective endothelin receptor-A (ET-A) antagonist, A-127722 (approximately 10 mg kg-1 day-1 as 200 mg kg-1 powdered food), to reverse existing cardiac remodelling and...

L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats (2005)

Hoey, Andrew, Fenning, Andrew, Harrison, Glenn, Rose Meyer, Roselyn, Brown, Lindsay

Nitric oxide (NO) is essential for normal function of the cardiovascular system. This study has determined whether chronic administration of L-arginine, the biological precursor of NO, attenuates the...

L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats. (2005)

Fenning, Andrew, Harrison, Glenn, Rose'Meyer, Roselyn, Hoey, Andrew, Brown, Lindsay

Nitric oxide (NO) is essential for the normal functioning of the cardiovascular system. This study has determined whether chronic administration of L-arginine, the biological precursor of NO,...

L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats. (2005)

Fenning, Andrew, Harrison, Glenn, Rose'Meyer, Roselyn, Hoey, Andrew, Brown, Lindsay

Nitric oxide (NO) is essential for the normal functioning of the cardiovascular system. This study has determined whether chronic administration of L-arginine, the biological precursor of NO,...

Genomic Instability of Human Mammary Epithelial Cells Overexpressing a Truncated Form of EMSY (2005)

Raouf, Afshin, Brown, Lindsay, Vrcelj, Nikoleta, To, Karen, Kwok, Winnie, Huntsman, David, ...

The EMSY gene encodes a protein that interacts with Brca2 and is amplified in some sporadic cases of human breast cancer. To examine whether overexpression of EMSY would mimic the chromosome...

Reversal of cardiac dysfunction by selective ET-A receptor antagonism (2005)

Allan, Anthony, Fenning, Andrew, Levick, Scott, Hoey, Andrew, Brown, Lindsay

1. The effectiveness of a selective endothelin receptor-A (ET-A) antagonist, A-127722 (approximately 10 mg kg-1 day-1 as 200 mg kg-1 powdered food), to reverse existing cardiac remodelling and...

L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats (2005)

Hoey, Andrew, Fenning, Andrew, Harrison, Glenn, Rose Meyer, Roselyn, Brown, Lindsay

Nitric oxide (NO) is essential for normal function of the cardiovascular system. This study has determined whether chronic administration of L-arginine, the biological precursor of NO, attenuates the...

The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes (2003)

Wei, Michael, Ong, Leslie, Smith, Maree, Ross, Fraser B., Schmid, Katrina, Hoey, Andrew, ...

Background: Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes...

The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes (2003)

Wei, Michael, Ong, Leslie, Smith, Maree, Ross, Fraser B., Schmid, Katrina, Hoey, Andrew, ...

Background: Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes...

The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes (2003)

Wei, Michael, Ong, Leslie, Smith, Maree, Ross, Fraser B., Schmid, Katrina, Hoey, Andrew, ...

Background: Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes...

The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes (2003)

Wei, Michael, Ong, Leslie, Smith, Maree, Ross, Fraser B., Schmid, Katrina, Hoey, Andrew, ...

Background: Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes...

The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes (2003)

Wei, Michael, Ong, Leslie, Smith, Maree, Ross, Fraser B., Schmid, Katrina, Hoey, Andrew, ...

Background: Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes...

Leukaemia inhibitory factor retards the progression of atherosclerosis (2003)

Rolfe, Barbara E., Stamatiou, Steve, World, Cameron J., Brown, Lindsay, Thomas, Anita C., Bingley, John A., ...

Objective: Our previous studies showed that the pleiotropic cytokine leukaemia inhibitory factor (LIF) inhibits the de novo formation of experimental atherosclerotic lesions. The present study...

The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes (2003)

Wei, Michael, Ong, Leslie, Smith, Maree, Ross, Fraser B., Schmid, Katrina, Hoey, Andrew, ...

Background: Diabetes in humans induces chronic complications such as cardiovascular damage, cataracts and retinopathy, nephropathy and polyneuropathy. The most common animal model of human diabetes...

Renal impairment in deoxycorticosterone acetate-salt hypertensive rats (2000)

Dallemagne, Catherine, Ooi, Sze-Yuan, Brown, Lindsay, Gobe, Glenda, Endre, Zoltan

This study has compared renal function in deoxycorticosterone (DOCA)-salt hypertensive Wistar rats (uninephrectomy followed by administration of DOCA 25 mg subcutaneously every fourth day and 1% NaCl...

On the Performance Potential of Dynamic Cache Line Sizes (1999)

Eric Anderson, Peter Van Vleet, Lindsay Brown, Jean-loup Baer, Anna R. Karlin

In this paper we present offline algorithms for determining the optimal sequence of loads, superloads and bypasses for direct-mapped caches. We evaluate potential gains in terms of miss rate and...

Reduced positive inotropic effects in diseased human ventricular myocardium (1986)

BROWN, LINDSAY, LORENZ, BERNHARD, ERDMANN, ERLAND

In isolated contracting human ventricular myocardium taken from patients undergoing mitral valve replacement the positive inotropic effects of calcium, isoprenaline, dobutamine, dopamine, histamine,...

Ouabain binding and inotropy in acute potassium depletion in guinea pigs (1986)

BROWN, LINDSAY, WAGNER, GERHARD, HUG, EUGEN, ERDMANN, ERLAND

In hypokalaemia the incidence of cardiac toxicity with digitalis is increased, possibly through changes in the affinity or capacity of the digitalis receptor in the heart. Previous studies have...

Concentration-response curves of positive inotropic agents before and after ouabain pretreatment (1985)

BROWN, LINDSAY, ERDMANN, ERLAND

Current therapy for congestive heart failure (diuretics, digitalis, vasodilators) may be insufficient. Addition of a second positive inotropic substance to digitalised patients has been previously...

Reversal of cardiac and renal fibrosis by pirfenidone and spironolactone in streptozotocin-diabetic rats

Miric, Goran, Dallemagne, Catherine, Endre, Zoltan, Margolin, Solomon, Taylor, Stephen M, Brown, Lindsay

Fibrosis leads to chronic impairment of cardiac and renal function and thus reversal of existing fibrosis may improve function and survival. This project has determined whether pirfenidone, a new...

Attenuation of cardiac fibrosis by pirfenidone and amiloride in DOCA-salt hypertensive rats

Mirkovic, Stevo, Seymour, Anne-Marie L, Fenning, Andrew, Strachan, Anna, Margolin, Solomon B, Taylor, Stephen M, ...

This study has administered pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone) or amiloride to attenuate the remodelling and associated functional changes, especially an increased cardiac stiffness, in...

Reversal of cardiac dysfunction by selective ET-A receptor antagonism

Allan, Anthony, Fenning, Andrew, Levick, Scott, Hoey, Andrew, Brown, Lindsay

The effectiveness of a selective endothelin receptor-A (ET-A) antagonist, A-127722 (approximately 10 mg kg−1 day−1 as 200 mg kg−1 powdered food), to reverse existing cardiac...

Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats

Chan, Vincent, Hoey, Andrew, Brown, Lindsay

The ability of aminoguanidine (AG), an inhibitor of collagen crosslinking, to prevent changes in cardiac and vascular structure and function has been determined in the deoxycorticosterone acetate...