Lingjun Zuo

Recessive genetic mode of an ADH4variant in substance dependence in African-Americans: A model of utility of the HWD test (2008)

Luo, Xingguang, Zuo, Lingjun, Kranzler, Henry R, Wang, Shuang, Anton, Raymond F, Gelernter, Joel

Abstract Background In our previous studies, we reported positive associations between seven ADH4 polymorphisms and substance dependence [i.e., alcohol dependence (AD) and/or drug dependence (DD)] in...

CHRM2 variation predisposes to personality traits of agreeableness and conscientiousness (2007)

Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Zhang, Huiping, Wang, Shuang, Gelernter, Joel

Personality traits are among the most complex quantitative traits. Certain personality traits have been postulated to be part of the inherited component of substance dependence (SD) risk. Association...

Multiple ADH genes modulate risk for drug dependence in both African- and European-Americans (2007)

Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Schork, Nicholas J., Gelernter, Joel

Drug dependence (DD) is commonly co-morbid with alcohol dependence (AD). Many studies have also shown common genetic risk factors for these disorders. We previously reported associations of AD with...

Variation at APOE and STH loci and Alzheimer's disease. (2006)

Zuo, Lingjun, Van Dyck, Christopher, Luo, Xingguang, Kranzler, Henry, Yang, Bao-Zhu, Gelernter, Joel

ABSTRACT: BACKGROUND: The apolipoprotein E (APOE) and tau proteins play important roles in the pathological development of Alzheimer's disease (AD). Many studies have shown an association between the...

Variation at APOEand STHloci and Alzheimer's disease (2006)

Zuo, Lingjun, Van Dyck, Christopher H, Luo, Xingguang, Kranzler, Henry R, Yang, Bao-zhu, Gelernter, Joel

Abstract Background The apolipoprotein E (APOE) and tau proteins play important roles in the pathological development of Alzheimer's disease (AD). Many studies have shown an association between the...

Multiple ADH genes modulate risk for drug dependence (2006)

Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Schork, Nicholas J., Gelernter, Joel

Drug dependence (DD) is commonly co-morbid with alcohol dependence (AD). Many studies have also shown common genetic risk factors for these disorders. We previously reported associations of AD with...

CHRM2 gene predisposes to alcohol dependence, drug dependence, and affective disorders: results from an extended case-control structured association study (2005)

Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Blumberg, Hilary P., Gelernter, Joel

Cholinergic muscarinic 2 receptor (CHRM2) is implicated in memory and cognition, functions impaired in many neuropsychiatric disorders. Wang et al. (2004) reported that variation in CHRM2 gene...

CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study (2005)

Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Blumberg, Hilary P., Gelernter, Joel

Cholinergic muscarinic 2 receptor (CHRM2) is implicated in memory and cognition, functions impaired in many neuropsychiatric disorders. Wang et al. [Wang, J.C., Hinrichs, A.L., Stock, H., Budde, J.,...

Diplotype Trend Regression Analysis of the ADH Gene Cluster and the ALDH2 Gene: Multiple Significant Associations with Alcohol Dependence

Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Schork, Nicholas J., Gelernter, Joel

The set of alcohol-metabolizing enzymes has considerable genetic and functional complexity. The relationships between some alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes and...

Diplotype Trend Regression Analysis of the ADH Gene Cluster and the ALDH2 Gene: Multiple Significant Associations with Alcohol Dependence

Luo, Xingguang, Kranzler, Henry R., Zuo, Lingjun, Wang, Shuang, Schork, Nicholas J., Gelernter, Joel

The set of alcohol-metabolizing enzymes has considerable genetic and functional complexity. The relationships between some alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) genes and...