Habib Dakir, EL, Feigenbaum, Lionel, Linnoila, R. Ilona
Squamous cell carcinoma accounts for 20% of all human lung cancers and is strongly linked to cigarette smoking. It develops through premalignant changes that are characterized by high levels of...
Effect of Lapatinib on the Outgrowth of Metastatic Breast Cancer Cells to the Brain (2008)
Gril, Brunilde, Palmieri, Diane, Bronder, Julie L., Herring, Jeanne M., Vega-Valle, Eleazar, Feigenbaum, Lionel, ...
Background The brain is increasingly being recognized as a sanctuary site for metastatic tumor cells in women with HER2-overexpressing breast cancer who receive trastuzumab therapy. There are no...
Carlson, Bradley A., Moustafa, Mohamed E., Sengupta, Aniruddha, Schweizer, Ulrich, Shrimali, Rajeev, Rao, Mahadev, ...
Novel mouse models were developed in which the hepatic selenoprotein population was targeted for removal by disrupting the selenocysteine (Sec) tRNA [Ser]Sec gene (trsp) and then selenoprotein...
IFN-{gamma} gene expression is controlled by the architectural transcription factor HMGA1 (2005)
Chau, Kai-Yin, Keane-Myers, Andrea M., Fedele, Monica, Ikeda, Yasuhiro, Creusot, Remi J., Menozzi, Lisa, ...
We report for the first time that IFNG gene expression requires high mobility group (HMG)A1, the architectural transcription factor mediating enhanceosome formation. This finding is supported by our...
IFN-gamma gene expression is controlled by the architectural transcription factor HMGA1 (2005)
Chau, Kai-Yin, Keane-Myers, Andrea M., Fedele, Monica, Ikeda, Yasuhiro, Creusot, Remi J., Menozzi, Lisa, ...
We report for the first time that IFNG gene expression requires high mobility group (HMG)A1, the architectural transcription factor mediating enhanceosome formation. This finding is supported by our...
IFN-{gamma} gene expression is controlled by the architectural transcription factor HMGA1 (2005)
Chau, Kai-Yin, Keane-Myers, Andrea M., Fedele, Monica, Ikeda, Yasuhiro, Creusot, Remi J., Menozzi, Lisa, ...
We report for the first time that IFNG gene expression requires high mobility group (HMG)A1, the architectural transcription factor mediating enhanceosome formation. This finding is supported by our...
Moustafa, Mohamed E., Carlson, Bradley A., El-Saadani, Muhammed A., Kryukov, Gregory V., Sun, Qi-An, Harney, John W., ...
Selenocysteine (Sec) tRNA (tRNA [Ser]Sec) serves as both the site of Sec biosynthesis and the adapter molecule for donation of this amino acid to protein. The consequences on selenoprotein...
Life without white fat: a transgenic mouse (1998)
Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...
The human JC virus :--gene expression and pathogenesis /--by Lionel Feigenbaum. (1989)
Thesis (Ph. D.)--University of Maryland at College Park, 1989.
IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice
Marks-Konczalik, Joanna, Dubois, Sigrid, Losi, Jacqueline M., Sabzevari, Helen, Yamada, Nobuo, Feigenbaum, Lionel, ...
A transgenic (Tg) mouse expressing human IL-15 was generated to define the role of IL-15 in the normal immune response. Overexpression of IL-15 resulted in an increase of NK, CD44hiCD8 memory T...
Moustafa, Mohamed E., Carlson, Bradley A., El-Saadani, Muhammad A., Kryukov, Gregory V., Sun, Qi-An, Harney, John W., ...
Selenocysteine (Sec) tRNA (tRNA[Ser]Sec) serves as both the site of Sec biosynthesis and the adapter molecule for donation of this amino acid to protein. The consequences on selenoprotein...
Life without white fat: a transgenic mouse
Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...
We have generated a transgenic mouse with no white fat tissue throughout life. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2...
Chiang, Y. Jeffrey, Hemann, Michael T., Hathcock, Karen S., Tessarollo, Lino, Feigenbaum, Lionel, Hahn, William C., ...
Telomerase consists of two essential components, the telomerase RNA template (TR) and telomerase reverse transcriptase (TERT). The haplo-insufficiency of TR was recently shown to cause one form of...
Yu, Zhiya, Theoret, Marc R., Touloukian, Christopher E., Surman, Deborah R., Garman, Scott C., Feigenbaum, Lionel, ...
Understanding the mechanisms underlying the poor immunogenicity of human self/tumor antigens is challenging because of experimental limitations in humans. Here, we developed a human-mouse chimeric...
Horikawa, Izumi, Chiang, Y. Jeffrey, Patterson, Tricia, Feigenbaum, Lionel, Leem, Sun-Hee, Michishita, Eriko, ...
In vivo expression of human telomerase is significantly different from that of mouse telomerase. To assess the basis for this difference, a bacterial artificial chromosome clone containing the entire...
IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice
Marks-Konczalik, Joanna, Dubois, Sigrid, Losi, Jacqueline M., Sabzevari, Helen, Yamada, Nobuo, Feigenbaum, Lionel, ...
A transgenic (Tg) mouse expressing human IL-15 was generated to define the role of IL-15 in the normal immune response. Overexpression of IL-15 resulted in an increase of NK, CD44hiCD8 memory T...
Moustafa, Mohamed E., Carlson, Bradley A., El-Saadani, Muhammad A., Kryukov, Gregory V., Sun, Qi-An, Harney, John W., ...
Selenocysteine (Sec) tRNA (tRNA[Ser]Sec) serves as both the site of Sec biosynthesis and the adapter molecule for donation of this amino acid to protein. The consequences on selenoprotein...
Life without white fat: a transgenic mouse
Moitra, Jaideep, Mason, Mark M., Olive, Michelle, Krylov, Dmitry, Gavrilova, Oksana, Marcus-Samuels, Bernice, ...
We have generated a transgenic mouse with no white fat tissue throughout life. These mice express a dominant-negative protein, termed A-ZIP/F, under the control of the adipose-specific aP2...
Chiang, Y. Jeffrey, Hemann, Michael T., Hathcock, Karen S., Tessarollo, Lino, Feigenbaum, Lionel, Hahn, William C., ...
Telomerase consists of two essential components, the telomerase RNA template (TR) and telomerase reverse transcriptase (TERT). The haplo-insufficiency of TR was recently shown to cause one form of...
Yu, Zhiya, Theoret, Marc R., Touloukian, Christopher E., Surman, Deborah R., Garman, Scott C., Feigenbaum, Lionel, ...
Understanding the mechanisms underlying the poor immunogenicity of human self/tumor antigens is challenging because of experimental limitations in humans. Here, we developed a human-mouse chimeric...
Horikawa, Izumi, Chiang, Y. Jeffrey, Patterson, Tricia, Feigenbaum, Lionel, Leem, Sun-Hee, Michishita, Eriko, ...
In vivo expression of human telomerase is significantly different from that of mouse telomerase. To assess the basis for this difference, a bacterial artificial chromosome clone containing the entire...
Sun, Youping, Strizzi, Luigi, Raafat, Ahmed, Hirota, Morihisa, Bianco, Caterina, Feigenbaum, Lionel, ...
Overexpression of Cripto-1 has been reported in several types of human cancers including breast cancer. To investigate the role of human Cripto-1 (CR-1) in mammary gland development and...
Yu, Qing, Park, Jung-Hyun, Doan, Loretta L., Erman, Batu, Feigenbaum, Lionel, Singer, Alfred
Death by neglect requires that CD4+8+ double-positive (DP) thymocytes avoid cytokine-mediated survival signals, which is presumably why DP thymocytes normally extinguish IL-7R gene expression. We...
Regulation of AID expression in the immune response
Crouch, Elizabeth E., Li, Zhiyu, Takizawa, Makiko, Fichtner-Feigl, Stefan, Gourzi, Polyxeni, Montaño, Carolina, ...
The B cell–specific enzyme activation-induced cytidine deaminase (AID) has been shown to be essential for isotype switching and affinity maturation of antibody genes during the immune response....
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis
Difilippantonio, Simone, Celeste, Arkady, Kruhlak, Michael J., Lee, Youngsoo, Difilippantonio, Michael J., Feigenbaum, Lionel, ...
The chromosomal instability syndromes Nijmegen breakage syndrome (NBS) and ataxia telangiectasia (AT) share many overlapping phenotypes, including cancer predisposition, radiation sensitivity,...
Jenkinson, S. Rhiannon, Intlekofer, Andrew M., Sun, Guangping, Feigenbaum, Lionel, Reiner, Steven L., Bosselut, Rémy
Most T cells belong to either of two lineages defined by the mutually exclusive expression of CD4 and CD8 coreceptors: CD4 T cells are major histocompatibility complex (MHC) II restricted and have...
Yu, Qing, Erman, Batu, Park, Jung-Hyun, Feigenbaum, Lionel, Singer, Alfred
Intrathymic T cell development depends on signals transduced by both T cell receptor and cytokine receptors. Early CD4−CD8− (double negative) thymocytes require interleukin (IL)-7 receptor...
Liu, Xiaolong, Adams, Anthony, Wildt, Kathryn F., Aronow, Bruce, Feigenbaum, Lionel, Bosselut, Rémy
Although T cell receptor (TCR) signals are essential for intrathymic T cell–positive selection, it remains controversial whether they only serve to initiate this process, or whether they are...
Overwijk, Willem W., Theoret, Marc R., Finkelstein, Steven E., Surman, Deborah R., De Jong, Laurina A., Vyth-Dreese, Florry A., ...
Many tumor-associated antigens are derived from nonmutated “self” proteins. T cells infiltrating tumor deposits recognize self-antigens presented by tumor cells and can be expanded in vivo with...
Kovalchuk, Alexander L., Qi, Chen-Feng, Torrey, Ted A., Taddesse-Heath, Lekidelu, Feigenbaum, Lionel, Park, Sung Sup, ...
Chromosomal translocations juxtaposing the MYC protooncogene with regulatory sequences of immunoglobulin (Ig) H chain or kappa (Igκ) or lambda (Igλ) L chain genes and effecting deregulated...
Habib Dakir, EL, Feigenbaum, Lionel, Linnoila, R. Ilona
Squamous cell carcinoma accounts for 20% of all human lung cancers and is strongly linked to cigarette smoking. It develops through premalignant changes that are characterized by high levels of...
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo
Daniel, Jeremy A., Pellegrini, Manuela, Lee, Ji-Hoon, Paull, Tanya T., Feigenbaum, Lionel, Nussenzweig, André
Cellular responses to both physiological and pathological DNA double-strand breaks are initiated through activation of the evolutionarily conserved ataxia telangiectasia mutated (ATM) kinase. Upon...
Tumor-specific Th17-polarized cells eradicate large established melanoma
Muranski, Pawel, Boni, Andrea, Antony, Paul A., Cassard, Lydie, Irvine, Kari R., Kaiser, Andrew, ...
CD4+ T cells can differentiate into multiple effector subsets, but the potential roles of these subsets in anti-tumor immunity have not been fully explored. Seeking to study the impact of CD4+ T cell...
Effect of Lapatinib on the Outgrowth of Metastatic Breast Cancer Cells to the Brain
Gril, Brunilde, Palmieri, Diane, Bronder, Julie L., Herring, Jeanne M., Vega-Valle, Eleazar, Feigenbaum, Lionel, ...
Visualization and Identification of IL-7 Producing Cells in Reporter Mice
Mazzucchelli, Renata I., Warming, Søren, Lawrence, Scott M., Ishii, Masaru, Abshari, Mehrnoosh, Washington, A. Valance, ...
Interleukin-7 (IL-7) is required for lymphocyte development and homeostasis although the actual sites of IL-7 production have never been clearly identified. We produced a bacterial artificial...