Human Dna2 is a nuclear and mitochondrial DNA maintenance protein (2009)
Duxin, Julien P., Dao, Benjamin, Martinsson, Peter, Rajala, Nina, Guittat, Lionel, Campbell, Judith L., ...
Dna2 is a highly conserved helicase/nuclease that in yeast participates in Okazaki fragment processing, DNA repair, and telomere maintenance. Here, we investigated the biological function of human...
DNA and RNA Quadruplex ligands (2008)
De Cian, Anne, Gros, Julien, Guédin, Aurore, Haddi, Meriem, Lyonnais, Sébastien, Guittat, Lionel, ...
Guanine-rich nucleic acids can adopt unusual structures called guanine quadruplexes (G4) based on stacked guanine quartets. Both RNA and DNA backbones are compatible with G4 formation. As RNA and DNA...
Ascididemin and meridine stabilise G-quadruplexes and inhibit telomerase in vitro (2005)
Guittat, Lionel, De Cian, Anne, Rosu, Frédéric, Gabelica, Valérie, De Pauw, Edwin, Delfourne, Evelyne, ...
Ascididemin and Meridine are two marine compounds with pyridoacridine skeletons known to exhibit interesting antitumour activities. These molecules have been reported to behave like DNA...
Affinity and selectivity of G4 ligands measured by FRET (2005)
De Cian, Anne, Guittat, Lionel, Shin-ya, Kazuo, Riou, Jean-François, Mergny, Jean-Louis
The telomeric G-rich single-stranded DNA can adopt in vitro an intramolecular quadruplex structure, which has been shown to directly inhibit telomerase activity. The reactivation of this enzyme in...
Interactions of cryptolepine and neocryptolepine with unusual DNA structures (2003)
Guittat, Lionel, Alberti, Patrizia, Rosu, Frédéric, Van Miert, Sabine, Thetiot, Emilie, Pieters, Luc, ...
Cryptolepine, the main alkaloid present in the roots of Cryptolepis sanguinolenta, presents a large spectrum of biological properties. It has been reported to behave like a DNA intercalator with a...
Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay
Mergny, Jean-Louis, Lacroix, Laurent, Teulade-Fichou, Marie-Paule, Hounsou, Candide, Guittat, Lionel, Hoarau, Magali, ...
The reactivation of telomerase activity in most cancer cells supports the concept that telomerase is a relevant target in oncology, and telomerase inhibitors have been proposed as new potential...
Telomerase inhibitors based on quadruplex ligands selected by a fluorescence assay
Mergny, Jean-Louis, Lacroix, Laurent, Teulade-Fichou, Marie-Paule, Hounsou, Candide, Guittat, Lionel, Hoarau, Magali, ...
The reactivation of telomerase activity in most cancer cells supports the concept that telomerase is a relevant target in oncology, and telomerase inhibitors have been proposed as new potential...
Temime-Smaali, Nassima, Guittat, Lionel, Wenner, Thomas, Bayart, Emilie, Douarre, Céline, Gomez, Dennis, ...
Topoisomerase (Topo) IIIα associates with BLM helicase, which is proposed to be important in the alternative lengthening of telomeres (ALT) pathway that allows telomere recombination in the absence...
Temime-Smaali, Nassima, Guittat, Lionel, Sidibe, Assitan, Shin-ya, Kazuo, Trentesaux, Chantal, Riou, Jean-François
In Alternative Lengthening of Telomeres (ALT) cell lines, specific nuclear bodies called APBs (ALT-associated PML bodies) concentrate telomeric DNA, shelterin components and recombination factors...