Lionel Piroth

Development of a New Experimental Model of Penicillin-Resistant Streptococcus pneumoniae Pneumonia and Amoxicillin Treatment by Reproducing Human Pharmacokinetics

Piroth, Lionel, Martin, Laurent, Coulon, Alexis, Lequeu, Catherine, Duong, Michel, Buisson, Marielle, ...

The increase of penicillin-resistant Streptococcus pneumoniae (PRSP) pneumonia results in a greater risk of antibiotic treatment failure. In vitro data are not sufficient predictors of clinical...

Fractional Maximal Effect Method for In Vitro Synergy between Amoxicillin and Ceftriaxone and between Vancomycin and Ceftriaxone against Enterococcus faecalis and Penicillin-Resistant Streptococcus pneumoniae

Desbiolles, Norbert, Piroth, Lionel, Lequeu, Catherine, Neuwirth, Catherine, Portier, Henri, Chavanet, Pascal

In the present study we assessed the use of a new in vitro testing method and graphical representation of the results to investigate the potential effectiveness of combinations of amoxicillin (AMZ)...

Rotavirus 2/6 Virus-Like Particles Administered Intranasally in Mice, with or without the Mucosal Adjuvants Cholera Toxin and Escherichia coli Heat-Labile Toxin, Induce a Th1/Th2-Like Immune Response

Fromantin, Catherine, Jamot, Béatrice, Cohen, Jean, Piroth, Lionel, Pothier, Pierre, Kohli, Evelyne

We investigated the rotavirus-specific lymphocyte responses induced by intranasal immunization of adult BALB/c mice with rotavirus 2/6 virus-like particles (2/6-VLPs) of the bovine RF strain, by...

Mutant Selection Window in Levofloxacin and Moxifloxacin Treatments of Experimental Pneumococcal Pneumonia in a Rabbit Model of Human Therapy

Croisier, Delphine, Etienne, Manuel, Bergoin, Emilie, Charles, Pierre-Emmanuel, Lequeu, Catherine, Piroth, Lionel, ...

For some pneumococci the fluoroquinolone MICs are low but the mutant prevention concentrations (MPCs) are high; this difference defines in vitro the mutant selection window (MSW). We investigated in...

Development of a New Experimental Model of Penicillin-Resistant Streptococcus pneumoniae Pneumonia and Amoxicillin Treatment by Reproducing Human Pharmacokinetics

Piroth, Lionel, Martin, Laurent, Coulon, Alexis, Lequeu, Catherine, Duong, Michel, Buisson, Marielle, ...

The increase of penicillin-resistant Streptococcus pneumoniae (PRSP) pneumonia results in a greater risk of antibiotic treatment failure. In vitro data are not sufficient predictors of clinical...

Fractional Maximal Effect Method for In Vitro Synergy between Amoxicillin and Ceftriaxone and between Vancomycin and Ceftriaxone against Enterococcus faecalis and Penicillin-Resistant Streptococcus pneumoniae

Desbiolles, Norbert, Piroth, Lionel, Lequeu, Catherine, Neuwirth, Catherine, Portier, Henri, Chavanet, Pascal

In the present study we assessed the use of a new in vitro testing method and graphical representation of the results to investigate the potential effectiveness of combinations of amoxicillin (AMZ)...

Rotavirus 2/6 Virus-Like Particles Administered Intranasally in Mice, with or without the Mucosal Adjuvants Cholera Toxin and Escherichia coli Heat-Labile Toxin, Induce a Th1/Th2-Like Immune Response

Fromantin, Catherine, Jamot, Béatrice, Cohen, Jean, Piroth, Lionel, Pothier, Pierre, Kohli, Evelyne

We investigated the rotavirus-specific lymphocyte responses induced by intranasal immunization of adult BALB/c mice with rotavirus 2/6 virus-like particles (2/6-VLPs) of the bovine RF strain, by...

Mutant Selection Window in Levofloxacin and Moxifloxacin Treatments of Experimental Pneumococcal Pneumonia in a Rabbit Model of Human Therapy

Croisier, Delphine, Etienne, Manuel, Bergoin, Emilie, Charles, Pierre-Emmanuel, Lequeu, Catherine, Piroth, Lionel, ...

For some pneumococci the fluoroquinolone MICs are low but the mutant prevention concentrations (MPCs) are high; this difference defines in vitro the mutant selection window (MSW). We investigated in...

Fibrinogen and fibronectin binding cooperate for valve infection and invasion in Staphylococcus aureus experimental endocarditis

Que, Yok-Ai, Haefliger, Jacques-Antoine, Piroth, Lionel, François, Patrice, Widmer, Eleonora, Entenza, José M., ...

The expression of Staphylococcus aureus adhesins in Lactococcus lactis identified clumping factor A (ClfA) and fibronectin-binding protein A (FnBPA) as critical for valve colonization in rats with...

The Fibrinogen- and Fibronectin-Binding Domains of Staphylococcus aureus Fibronectin-Binding Protein A Synergistically Promote Endothelial Invasion and Experimental Endocarditis▿ †

Piroth, Lionel, Que, Yok-Ai, Widmer, Eleonora, Panchaud, Alexandre, Piu, Stéphane, Entenza, José M., ...

Staphylococcus aureus experimental endocarditis relies on sequential fibrinogen binding (for valve colonization) and fibronectin binding (for endothelial invasion) conferred by peptidoglycan-attached...