Lisa A. Simms

Novel NOD2 haplotype strengthens the association between TLR4 Asp299Gly and Crohn's disease in an Australian population. (2008)

Hume, Georgia E., Fowler, Elizabeth V., Doecke, James, Simms, Lisa A, Huang, Nina, Palmieri, Orazio, ...

Background: The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and other pattern recognition receptors in the pathogenesis of this chronic,...

Novel NOD2 haplotype strengthens the association between TLR4 Asp299Gly and Crohn's disease in an Australian population. (2008)

Hume, Georgia E., Fowler, Elizabeth V., Doecke, James, Simms, Lisa A, Huang, Nina, Palmieri, Orazio, ...

Background: The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and other pattern recognition receptors in the pathogenesis of this chronic,...

Novel NOD2 haplotype strengthens the association between TLR4 Asp299Gly and Crohn's disease in an Australian population. (2008)

Hume, Georgia E., Fowler, Elizabeth V., Doecke, James, Simms, Lisa A, Huang, Nina, Palmieri, Orazio, ...

Background: The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and other pattern recognition receptors in the pathogenesis of this chronic,...

SnoNexpression is differently regulated in microsatellite unstable compared with microsatellite stable colorectal cancers (2006)

Chia, June A, Simms, Lisa A, Cozzi, Sarah-Jane, Young, Joanne, Jass, Jeremy R, Walsh, Michael D, ...

Abstract Background SnoN is an important regulator of the transforming growth factor beta (TGFβ) signalling pathway and has been shown to exhibit both tumour promotion and suppression activity....

The PCNA-associated factor KIAA0101/p15(PAF) binds the portnetial tumor suppresoor product p33ING1b (2006)

Simpson-Fraser, Fiona, Lammerts Van Bueren, Kelly L., Butterfield, Natalie, Bennetts, Jennifer S., Bowles, Josephine, Adolphe, Christelle, ...

The KIAA0101/p15(PAF)/OEATC-1 protein was initially isolated in a yeast two-hybrid screen for proliferating cell nuclear antigen (PCNA) binding partners, and was shown to bind PCNA competitively with...

High Prevalence of Sessile Serrated Adenomas With BRAF Mutations: A Prospective Study of Patients Undergoing Colonoscopy (2006)

Spring, Kevin J., Zhao, Zhen Zhen, Karamatic, Rozemary, Walsh, Michael D., Whitehall, Vicki L. J., Pike, Tanya, ...

Background & Aims: Sporadic colorectal cancers with a high degree of microsatellite instability are a clinically distinct subgroup with a high incidence of BRAF mutation and are widely considered to...

High Prevalence of Sessile Serrated Adenomas With BRAF Mutations: A Prospective Study of Patients Undergoing Colonoscopy (2006)

Spring, Kevin J., Zhao, Zhen Zhen, Karamatic, Rozemary, Walsh, Michael D., Whitehall, Vicki L. J., Pike, Tanya, ...

Background & Aims: Sporadic colorectal cancers with a high degree of microsatellite instability are a clinically distinct subgroup with a high incidence of BRAF mutation and are widely considered to...

The PCNA-associated factor KIAA0101/p15(PAF) binds the portnetial tumor suppresoor product p33ING1b (2006)

Simpson-Fraser, Fiona, Lammerts Van Bueren, Kelly L., Butterfield, Natalie, Bennetts, Jennifer S., Bowles, Josephine, Adolphe, Christelle, ...

The KIAA0101/p15(PAF)/OEATC-1 protein was initially isolated in a yeast two-hybrid screen for proliferating cell nuclear antigen (PCNA) binding partners, and was shown to bind PCNA competitively with...

HPP1: A transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers

Young, Joanne, Biden, Kelli G., Simms, Lisa A., Huggard, Phillip, Karamatic, Rozemary, Eyre, Helen J., ...

Adenomas are the precursors of most colorectal cancers. Hyperplastic polyps have been linked to the subset of colorectal cancers showing DNA microsatellite instability, but little is known of their...

HPP1: A transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers

Young, Joanne, Biden, Kelli G., Simms, Lisa A., Huggard, Phillip, Karamatic, Rozemary, Eyre, Helen J., ...

Adenomas are the precursors of most colorectal cancers. Hyperplastic polyps have been linked to the subset of colorectal cancers showing DNA microsatellite instability, but little is known of their...

Features of Colorectal Cancers with High-Level Microsatellite Instability Occurring in Familial and Sporadic Settings : Parallel Pathways of Tumorigenesis

Young, Joanne, Simms, Lisa A., Biden, Kelli G., Wynter, Coral, Whitehall, Vicki, Karamatic, Rozemary, ...

High-level microsatellite instability (MSI-H) is demonstrated in 10 to 15% of sporadic colorectal cancers and in most cancers presenting in the inherited condition hereditary nonpolyposis colorectal...