Conversion of a Large Animal Inhalational Anesthesia Machine to One for Small Animal Use (1998)
Leon, Lisa R., Blaha, Michael D., DuBose, David A., Walker, Larry D.
The use of injectable anesthesia in animal research practices has the disadvantage of uncontrollable anesthesia depth, which leads to toxicity and at times death. This adversely influences research...
Biotelemetry Transmitter Implantation in Rodents: Impact on Growth and Circadian Rhythms (1998)
Leon, Lisa R., Walker, Larry D., DuBose, David A., Stephenson, Lou A.
The implantation of a biotelemetry transmitter for core body temperature (Tc) and motor activity (MA) measurements is hypothesized to have effects on growth and circadian rhythmicity depending on...
Heat Stress Induces a Biphasic Thermoregulatory Response in Mice (1998)
Leon, Lisa R., Dubose, David A., Mason, Clifford W.
Previous animal models of heat stress have been compromised by methodologies such as restraint and anesthesia that confound our understanding of the core temperature (Tc) responses elicited by heat...
The Use of Gene Knockout Mice in Thermoregulation Studies (1998)
As the use of gene knockout models in thermoregulation studies has gained popularity, the reported incidence of redundant or discrepant phenotypes between studies has also increased, Several gene...
Development of a Rat Model of Hypothermia (1998)
DuBose, David A., Morehouse, David H., Rufolo, Dennis, Blaha, Michael, Leon, Lisa R.
Hypothermia can significantly impact the outcome of military missions, since it is a seasonal and geographic pervasive physiological phenomenon that reduces not only soldier performance, but may lead...
Thermal Stress and the Physiological Response to Environmental Toxicants (1998)
Gordon, Christopher J., Leon, Lisa R.
Most toxicological and pharmacological studies are performed in laboratory animals maintained under comfortable environmental conditions. Yet, the exposure to environmental toxicants as well as to...
Torpor in mice is induced by both leptin-dependent and -independent mechanisms
Gavrilova, Oksana, Leon, Lisa R., Marcus-Samuels, Bernice, Mason, Mark M., Castle, Arthur L., Refetoff, Samuel, ...
We tested the effect of chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and ob/ob mice. A-ZIP/F-1 mice have virtually no white adipose tissue and low leptin levels,...
Torpor in mice is induced by both leptin-dependent and -independent mechanisms
Gavrilova, Oksana, Leon, Lisa R., Marcus-Samuels, Bernice, Mason, Mark M., Castle, Arthur L., Refetoff, Samuel, ...
We tested the effect of chronic leptin treatment on fasting-induced torpor in leptin-deficient A-ZIP/F-1 and ob/ob mice. A-ZIP/F-1 mice have virtually no white adipose tissue and low leptin levels,...
Effects of Indomethacin and Buprenorphine Analgesia on the Postoperative Recovery of Mice
Blaha, Michael D, Leon, Lisa R
Buprenorphine (Bup) is the most commonly used analgesic in mice, yet few objective assessments address its superiority for postsurgical recovery. In mice, IP implantation of a radiotelemetry device...