Lodewijk Spanjaard

Hyperglycemia in bacterial meningitis: a prospective cohort study (2009)

Schut, Ewout S, Westendorp, Willeke F, De Gans, Jan, Kruyt, Nyika D, Spanjaard, Lodewijk, Reitsma, Johannes B, ...

Abstract Background Hyperglycemia has been associated with unfavorable outcome in several disorders, but few data are available in bacterial meningitis. We assessed the incidence and significance of...

Improved survival of children with sepsis and purpura: effects of age, gender, and era (2007)

Maat, Martine, Buysse, Corinne MP, Emonts, Marieke, Spanjaard, Lodewijk, Joosten, Koen FM, De Groot, Ronald, ...

Abstract Background To gain insight into factors that might affect results of future case-control studies, we performed an analysis of children with sepsis and purpura admitted to the paediatric...

Attenuated cerebrospinal fluid leukocyte count and sepsis in adults with pneumococcal meningitis: a prospective cohort study (2006)

Weisfelt, Martijn, Van De Beek, Diederik, Spanjaard, Lodewijk, Reitsma, Johannes B, De Gans, Jan

Abstract Background A low cerebrospinal fluid (CSF) white-blood cell count (WBC) has been identified as an independent risk factor for adverse outcome in adults with bacterial meningitis. Whereas a...

Arthritis in adults with community-acquired bacterial meningitis: a prospective cohort study (2006)

Weisfelt, Martijn, Van De Beek, Diederik, Spanjaard, Lodewijk, De Gans, Jan

Abstract Background Although the coexistence of bacterial meningitis and arthritis has been noted in several studies, it remains unclear how often both conditions occur simultaneously. Methods We...

Antibiotic guidelines and antibiotic use in adult bacterial meningitis in The Netherlands (2002)

Van De Beek, Diederik, De Gans, Jan, Spanjaard, Lodewijk, Vermeulen, Marinus, Dankert, Jacob

In The Netherlands, national guidelines for the treatment of adult patients with bacterial meningitis were introduced in October 1997. In 1998 we began a prospective, nationwide study to evaluate the...

First Trimester Listeria monocytogenes Septicemia (1997)

Mariëtte Goddijn, Hans G. Schipper, Lodewijk Spanjaard, Hans Wolf

Background: Little is known about fetal outcome after Listeria monocytogenes septicemia in the first trimester of pregnancy.Case: A primigravida with L. monocytogenes septicemia at 9 weeks gestation...

PCR Assessment of Chlamydia trachomatis Infection of Semen Specimens Processed for Artificial Insemination

Pannekoek, Yvonne, Westenberg, Steven M., De Vries, Jan, Repping, Sjoerd, Spanjaard, Lodewijk, Eijk, Paul P., ...

In order to ascertain the microbiological quality of stored semen specimens processed for artificial insemination by a donor (AID), we developed a PCR assay targeting the chlamydial plasmid to detect...

Molecular Typing of Borrelia burgdorferi Sensu Lato by Randomly Amplified Polymorphic DNA Fingerprinting Analysis

Wang, Guiqing, Van Dam, Alje P., Spanjaard, Lodewijk, Dankert, Jacob

To study whether pathogenic clusters of Borrelia burgdorferi sensu lato strains occur, we typed 136 isolates, cultured from specimens from patients (n = 49) with various clinical entities and from...

Interlaboratory Comparison of Agar Dilution and Etest Methods for Determining the MICs of Antibiotics Used in Management of Neisseria meningitidis Infections

Vázquez, Julio A., Arreaza, Luisa, Block, Colin, Ehrhard, Ingrid, Gray, Stephen J., Heuberger, Sigrid, ...

Previous studies have shown that there is considerable variation in the methods and media used to determine the susceptibility of Neisseria meningitidis to antimicrobial agents in different...

Increase in Genetic Diversity of Haemophilus influenzae Serotype b (Hib) Strains after Introduction of Hib Vaccination in The Netherlands

Schouls, Leo M., Van Der Ende, Arie, Van De Pol, Ingrid, Schot, Corrie, Spanjaard, Lodewijk, Vauterin, Paul, ...

Recently, there has been an increase in The Netherlands in the number of cases of invasive disease caused by Haemophilus influenzae serotype b (Hib). To study a possible change in the Hib population...

Widespread Transfer of Resistance Genes between Bacterial Species in an Intensive Care Unit: Implications for Hospital Epidemiology

Naiemi, Nashwan Al, Duim, Birgitta, Savelkoul, Paul H. M., Spanjaard, Lodewijk, De Jonge, Evert, Bart, Aldert, ...

A transferable plasmid encoding SHV-12 extended-spectrum β-lactamase, TEM-116, and aminoglycoside resistance was responsible for two sequential clonal outbreaks of Enterobacter cloacae and...

PCR Assessment of Chlamydia trachomatis Infection of Semen Specimens Processed for Artificial Insemination

Pannekoek, Yvonne, Westenberg, Steven M., De Vries, Jan, Repping, Sjoerd, Spanjaard, Lodewijk, Eijk, Paul P., ...

In order to ascertain the microbiological quality of stored semen specimens processed for artificial insemination by a donor (AID), we developed a PCR assay targeting the chlamydial plasmid to detect...

Molecular Typing of Borrelia burgdorferi Sensu Lato by Randomly Amplified Polymorphic DNA Fingerprinting Analysis

Wang, Guiqing, Van Dam, Alje P., Spanjaard, Lodewijk, Dankert, Jacob

To study whether pathogenic clusters of Borrelia burgdorferi sensu lato strains occur, we typed 136 isolates, cultured from specimens from patients (n = 49) with various clinical entities and from...

Interlaboratory Comparison of Agar Dilution and Etest Methods for Determining the MICs of Antibiotics Used in Management of Neisseria meningitidis Infections

Vázquez, Julio A., Arreaza, Luisa, Block, Colin, Ehrhard, Ingrid, Gray, Stephen J., Heuberger, Sigrid, ...

Previous studies have shown that there is considerable variation in the methods and media used to determine the susceptibility of Neisseria meningitidis to antimicrobial agents in different...

Increase in Genetic Diversity of Haemophilus influenzae Serotype b (Hib) Strains after Introduction of Hib Vaccination in The Netherlands

Schouls, Leo M., Van Der Ende, Arie, Van De Pol, Ingrid, Schot, Corrie, Spanjaard, Lodewijk, Vauterin, Paul, ...

Recently, there has been an increase in The Netherlands in the number of cases of invasive disease caused by Haemophilus influenzae serotype b (Hib). To study a possible change in the Hib population...

Widespread Transfer of Resistance Genes between Bacterial Species in an Intensive Care Unit: Implications for Hospital Epidemiology

Naiemi, Nashwan Al, Duim, Birgitta, Savelkoul, Paul H. M., Spanjaard, Lodewijk, De Jonge, Evert, Bart, Aldert, ...

A transferable plasmid encoding SHV-12 extended-spectrum β-lactamase, TEM-116, and aminoglycoside resistance was responsible for two sequential clonal outbreaks of Enterobacter cloacae and...

Escherichia coli K1-Specific Bacteriophage CUS-3 Distribution and Function in Phase-Variable Capsular Polysialic Acid O Acetylation▿ †

King, Michael R., Vimr, Ross P., Steenbergen, Susan M., Spanjaard, Lodewijk, Plunkett, Guy, Blattner, Frederick R., ...

Escherichia coli K1 is the leading cause of human neonatal sepsis and meningitis and is important in other clinical syndromes of both humans and domestic animals; in this strain the polysialic acid...

Combination Vaccine Against Invasive Meningococcal B and Pneumococcal Infections: Potential Epidemiological and Economic Impact in The Netherlands

Jasper M. Bos, Hans C. Rumke, Robert Welte, Lodewijk Spanjaard, Loek Van Alphen, Maarten J. Postma

Background: Streptococcus pneumoniae and Neisseria meningitidis group B are among the main causes of invasive bacterial meningitis infections in infants. Worldwide, these diseases lead to significant...

First Trimester Listeria monocytogenes Septicemia

Goddijn, Mariëtte, Schipper, Hans G., Spanjaard, Lodewijk, Wolf, Hans

Background: Little is known about fetal outcome after Listeria monocytogenes septicemia in the first trimester of pregnancy.

Activity of Daptomycin against Listeria monocytogenes Isolates from Cerebrospinal Fluid▿

Spanjaard, Lodewijk

We tested the activity of daptomycin against 76 Listeria monocytogenes isolates from cerebrospinal fluid by broth dilution and Etest methods. For the broth dilution method, the MIC range was 1.0 to...

Comparison of Extraintestinal Pathogenic Escherichia coli Strains from Human and Avian Sources Reveals a Mixed Subset Representing Potential Zoonotic Pathogens▿

Johnson, Timothy J., Wannemuehler, Yvonne, Johnson, Sara J., Stell, Adam L., Doetkott, Curt, Johnson, James R., ...

Since extraintestinal pathogenic Escherichia coli (ExPEC) strains from human and avian hosts encounter similar challenges in establishing infection in extraintestinal locations, they may share...