Lois A. Salamonsen

Expression of nodal signalling components in cycling human endometrium and in endometrial cancer (2009)

Papageorgiou, Irene, Nicholls, Peter K, Wang, Fang, Lackmann, Martin, Makanji, Yogeshwar, Salamonsen, Lois A, ...

Abstract Background The human endometrium is unique in its capacity to remodel constantly throughout adult reproductive life. Although the processes of tissue damage and breakdown in the endometrium...

HTRA3 expression in non-pregnant rhesus monkey ovary and endometrium, and at the maternal-fetal interface during early pregnancy (2008)

Bowden, Marissa A, Li, Ying, Liu, Yi-Xun, Findlay, Jock K, Salamonsen, Lois A, Nie, Guiying

Abstract Background HTRA3 is a recently identified member of the mammalian serine protease family HTRA (high temperature requirement factor A). In both the rodent and the human HTRA3 is transcribed...

Leukemia inhibitory factor promotes human first trimester extravillous trophoblast adhesion to extracellular matrix and secretion of tissue inhibitor of metalloproteinases-1 and -2 (2008)

Tapia, Alejandro, Salamonsen, Lois A., Manuelpillai, Ursula, Dimitriadis, Evdokia

BACKGROUND Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that is essential for blastocyst implantation in mice. It has been suggested that LIF may play a role in human first trimester...

A distinct cohort of the TGF{beta} superfamily members expressed in human endometrium regulate decidualization (2008)

Stoikos, Chelsea J., Harrison, Craig A., Salamonsen, Lois A., Dimitriadis, Evdokia

BACKGROUND Successful blastocyst implantation requires the differentiation of human endometrial stromal cells (HESC), a process known as decidualization. Activin A, a transforming growth factor β...

Immunolocalisation of phosphorylated STAT3, interleukin 11 and leukaemia inhibitory factor in endometrium of women with unexplained infertility during the implantation window (2007)

Dimitriadis, Evdokia, Sharkey, Andrew M, Tan, Yee, Salamonsen, Lois A, Sherwin, J Robert A

Abstract Background Uterine receptivity and embryo implantation are critical in the establishment of pregnancy. The diagnosis of endometrial fertility requires more precise measurements of...

Laser capture microdissection and cDNA array analysis of endometrium identify CCL16 and CCL21 as epithelial-derived inflammatory mediators associated with endometriosis (2007)

Chand, Ashwini L, Murray, Andrew S, Jones, Rebecca L, Hannan, Natalie J, Salamonsen, Lois A, Rombauts, Luk

Abstract Background Understanding the pathophysiology of chemokine secretion in endometriosis may offer a novel area of therapeutic intervention. This study aimed to identify chemokines...

Serine Peptidase HTRA3 Is Closely Associated with Human Placental Development and Is Elevated in Pregnancy Serum1 (2006)

Guiying Nie, Ying Li, Kathryn Hale, Hidetaka Okada, Ursula Manuelpillai, Euan M. Wallace, ...

HTRA3 is a newly identified serine peptidase of the mammalian HTRA (high-temperature requirement factor A) family, that is upregulated dramatically during mouse placental development. The current...

Matrix Metalloproteinases in Endometrial Breakdown and Repair: Functional Significance in a Mouse Model1 (2005)

Tu'uhevaha J. Kaitu'u, Jun Shen, Jin Zhang, Naomi B. Morison, Lois A. Salamonsen

Considerable correlative evidence suggests an important role for matrix metalloproteinases (MMPs) in menstruation, a process which occurs naturally in very few species. In this study, MMP expression...

Inhibiting Uterine PC6 Blocks Embryo Implantation: An Obligatory Role for a Proprotein Convertase in Fertility1 (2005)

Guiying Nie, Ying Li, Min Wang, Yi Xun Liu, Jock K. Findlay, Lois A. Salamonsen

Successful embryo implantation involves complex interactions between the embryo and the uterus and is critical in establishing pregnancy. Proprotein convertase (PC) 6 (PC6) is one of the PC...

Chemokine expression is dysregulated in the endometrium of women using progestin-only contraceptives and correlates to elevated recruitment of distinct leukocyte populations (2005)

Jones, Rebecca L., Morison, Naomi B., Hannan, Natalie J., Critchley, Hilary O.D., Salamonsen, Lois A.

BACKGROUND: Breakthrough bleeding (BTB) is the most common reason for discontinuation of progestin-only (p-only) contraceptives, yet the causes are unknown. Use of p-only contraceptives is associated...

Chemokine expression is dysregulated in the endometrium of women using progestin-only contraceptives and correlates to elevated recruitment of distinct leukocyte populations (2005)

Jones, Rebecca L., Morison, Naomi B., Hannan, Natalie J., Critchley, Hilary O.D., Salamonsen, Lois A.

Breakthrough bleeding (BTB) is the most common reason for discontinuation of progestin-only (p-only) contraceptives, yet the causes are unknown. Use of p-only contraceptives is associated with...

Uterine extracellular matrix components are altered during defective decidualization in interleukin-11 receptor α deficient mice (2004)

White, Christine A, Robb, Lorraine, Salamonsen, Lois A

Abstract Background Implantation of the embryo and successful pregnancy are dependent on the differentiation of endometrial stromal cells into decidual cells. Female interleukin-11 receptor α...

Reproductive Biology and (2004)

Biomed Central, Christine A White, Lorraine Robb, Lois A Salamonsen, Open Access, Lois A Salamonsen

Uterine extracellular matrix components are altered during defective decidualization in interleukin-11 receptor α deficient mice

Specific and Transient Up-Regulation of Proprotein Convertase 6 at the Site of Embryo Implantation and Identification of a Unique Transcript in Mouse Uterus During Early Pregnancy1 (2003)

Gui-Ying Nie, Ying Li, Hiroyuki Minoura, Jock K. Findlay, Lois A. Salamonsen

The present investigation was conducted to identify and characterize an mRNA that was found by RNA differential display to be uniquely regulated at the sites of embryo implantation in mouse uterus....

Expression of activin receptors, follistatin and betaglycan by human endometrial stromal cells; consistent with a role for activins during decidualization (2002)

Jones, Rebecca L., Salamonsen, Lois A., Zhao, Yi Chen, Ethier, Jean-Franciois, Drummond, Ann E., Findlay, Jock K.

Decidualization of the human endometrium is critical for implantation, but the mechanisms involved are largely unknown. Activin subunits are expressed in endometrium during decidualization. From its...

Uterine expression of alternatively spliced mRNAs of mouse splicing factor SC35 during early pregnancy (2000)

Nie, Gui-Ying, Li, Ying, Batten, Leigh, Griffiths, Belinda, Wang, Jian, Findlay, Jock K., ...

RNA differential display was applied to identify genes critical for the establishment of pregnancy in the mouse. One of the gene fragments identified was homologous to human SC35 splicing factor; the...

Endometrial leukocytes and menstruation (2000)

Salamonsen, Lois A., Lathbury, Louise J.

This review examines evidence supporting the concept that menstruation occurs as a result of an inflammatory process. In the endometrium, leukocyte numbers rise in the late secretory phase following...

In-vitro studies of the potential role of neutrophils in the process of menstruation (2000)

Lathbury, Louise J., Salamonsen, Lois A.

Significant numbers of neutrophils are found extravascularly within the endometrium only during the immediate premenstrual and menstrual phases of the cycle. In this study we investigated the effect...

Uterine Dysfunction and Genetic Modifiers in Centromere Protein B-deficient Mice

Fowler, Kerry J., Hudson, Damien F., Salamonsen, Lois A., Edmondson, Stephanie R., Earle, Elizabeth, Sibson, Mandy C., ...

Centromere protein B (CENP-B) binds constitutively to mammalian centromere repeat DNA and is highly conserved between humans and mouse. Cenpb null mice appear normal but have lower body and testis...

Endometrial calbindins are critical for embryo implantation: Evidence from in vivo use of morpholino antisense oligonucleotides

Luu, Kien C., Nie, Gui Ying, Salamonsen, Lois A.

The endometrium is receptive to embryo implantation only for a short period in each reproductive cycle: development of receptivity requires alterations in endometrial gene expression. Calbindin...

Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2.

Nie, Gui-Ying, Hampton, Anne, Li, Ying, Findlay, Jock K, Salamonsen, Lois A

In the present study, we identified an additional member of the human high-temperature requirement factor A (HtrA) protein family, called pregnancy-related serine protease or HtrA3, which was most...

Uterine Dysfunction and Genetic Modifiers in Centromere Protein B-deficient Mice

Fowler, Kerry J., Hudson, Damien F., Salamonsen, Lois A., Edmondson, Stephanie R., Earle, Elizabeth, Sibson, Mandy C., ...

Centromere protein B (CENP-B) binds constitutively to mammalian centromere repeat DNA and is highly conserved between humans and mouse. Cenpb null mice appear normal but have lower body and testis...

Endometrial calbindins are critical for embryo implantation: Evidence from in vivo use of morpholino antisense oligonucleotides

Luu, Kien C., Nie, Gui Ying, Salamonsen, Lois A.

The endometrium is receptive to embryo implantation only for a short period in each reproductive cycle: development of receptivity requires alterations in endometrial gene expression. Calbindin...

Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2.

Nie, Gui-Ying, Hampton, Anne, Li, Ying, Findlay, Jock K, Salamonsen, Lois A

In the present study, we identified an additional member of the human high-temperature requirement factor A (HtrA) protein family, called pregnancy-related serine protease or HtrA3, which was most...

Blocking LIF action in the uterus by using a PEGylated antagonist prevents implantation: A nonhormonal contraceptive strategy

White, Christine A., Zhang, Jian-Guo, Salamonsen, Lois A., Baca, Manuel, Fairlie, W. Douglas, Metcalf, Donald, ...

Blastocyst implantation is a critical stage in the establishment of pregnancy. Leukemia inhibitory factor (LIF) is essential for mouse blastocyst implantation and also plays a role in human...