APC truncation and increased {beta}-catenin levels in a human breast cancer cell line (2000)
Schlosshauer, Peter W., Brown, Stephen A., Eisinger, Katarina, Yan, Qingyou, Guglielminetti, Enrica R., Parsons, Ramon, ...
Mutations in the Adenomatous Polyposis Coli (APC) tumor suppressor gene or the β-catenin gene are present in most colon cancers and less frequently in other tumor types. In this study, we screened...
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
Podsypanina, Katrina, Ellenson, Lora Hedrick, Nemes, Adriana, Gu, Jianguo, Tamura, Masahito, Yamada, Kenneth M., ...
Pten/Mmac1+/− heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type allele was...
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
Podsypanina, Katrina, Ellenson, Lora Hedrick, Nemes, Adriana, Gu, Jianguo, Tamura, Masahito, Yamada, Kenneth M., ...
Pten/Mmac1+/− heterozygous mice exhibited neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus. Loss of the wild-type allele was...
DNA Mismatch Repair Deficiency Accelerates Endometrial Tumorigenesis in Pten Heterozygous Mice
Wang, Hong, Douglas, Wayne, Lia, Marie, Edelmann, Winfried, Kucherlapati, Raju, Podsypanina, Katrina, ...
PTEN mutation and microsatellite instability are two of the most common genetic alterations in uterine endometrioid carcinoma. Furthermore, previous studies have suggested an association between the...