Lothar H. Wieler

Sex and virulence in Escherichia coli: an evolutionary perspective (2006)

Wirth, Thierry, Falush, Daniel, Lan, Ruiting, Colles, Frances, Mensa, Patience, Wieler, Lothar H., ...

Pathogenic Escherichia coli cause over 160 million cases of dysentery and one million deaths per year, whereas non-pathogenic E. coli constitute part of the normal intestinal flora of healthy mammals...

Rapid Detection of Virulence-Associated Genes in Avian Pathogenic Escherichia coli by Multiplex Polymerase Chain Reaction (2005)

Christa Ewers, Traute Janßen, Sabine Kießling, Hans-C. Philipp, Lothar H. Wieler

Based on recently published prevalence data of virulence-associated factors in avian pathogenic Escherichia coli (APEC) and their roles in the pathogenesis of colibacillosis, we developed a multiplex...

Enterohemorrhagic Escherichia coli (EHEC) Strains of Serogroup O118 Display Three Distinctive Clonal Groups of EHEC Pathogens

Wieler, Lothar H., Busse, Barbara, Steinrück, Hartmut, Beutin, Lothar, Weber, Albert, Karch, Helge, ...

A recent case report of a child infected with enterohemorrhagic Escherichia coli (EHEC) of serotype O118:H16 in Bavaria, in association with the isolation of a bovine O118 strain on the same farm (A....

A New Shiga Toxin 2 Variant (Stx2f) from Escherichia coli Isolated from Pigeons

Schmidt, Herbert, Scheef, Jürgen, Morabito, Stefano, Caprioli, Alfredo, Wieler, Lothar H., Karch, Helge

We have isolated Shiga toxin (Stx)-producing Escherichia coli (STEC) strains from the feces of feral pigeons which contained a new Stx2 variant gene designated stx2f. This gene is most similar to...

Naturally Occurring Clostridium perfringens Nontoxic Alpha-Toxin Variant as a Potential Vaccine Candidate against Alpha-Toxin-Associated Diseases

Schoepe, Heike, Pache, Christian, Neubauer, Axel, Potschka, Heidrun, Schlapp, Tobias, Wieler, Lothar H., ...

Clostridium perfringens mutant strain 121A/91 shows neither enzymatic (phospholipase C) nor hemolytic activity. Nevertheless, the cpa gene and the corresponding alpha-toxin variant are detectable....

Identification of Genes Required for Avian Escherichia coli Septicemia by Signature-Tagged Mutagenesis

Li, Ganwu, Laturnus, Claudia, Ewers, Christa, Wieler, Lothar H.

Infections with avian pathogenic Escherichia coli (APEC) cause colibacillosis, an acute and largely systemic disease resulting in significant economic losses in poultry industry worldwide. Although...

Shiga Toxin 2e-Producing Escherichia coli Isolates from Humans and Pigs Differ in Their Virulence Profiles and Interactions with Intestinal Epithelial Cells

Sonntag, Anne-Katharina, Bielaszewska, Martina, Mellmann, Alexander, Dierksen, Nadine, Schierack, Peter, Wieler, Lothar H., ...

Thirteen Escherichia coli strains harboring stx2e were isolated from 11,056 human stools. This frequency corresponded to the presence of the stx2e allele in 1.7% of all Shiga toxin-producing E. coli...

Sex and virulence in Escherichia coli: an evolutionary perspective

Wirth, Thierry, Falush, Daniel, Lan, Ruiting, Colles, Frances, Mensa, Patience, Wieler, Lothar H, ...

Pathogenic Escherichia coli cause over 160 million cases of dysentery and one million deaths per year, whereas non-pathogenic E. coli constitute part of the normal intestinal flora of healthy mammals...

Enterohemorrhagic Escherichia coli (EHEC) Strains of Serogroup O118 Display Three Distinctive Clonal Groups of EHEC Pathogens

Wieler, Lothar H., Busse, Barbara, Steinrück, Hartmut, Beutin, Lothar, Weber, Albert, Karch, Helge, ...

A recent case report of a child infected with enterohemorrhagic Escherichia coli (EHEC) of serotype O118:H16 in Bavaria, in association with the isolation of a bovine O118 strain on the same farm (A....

A New Shiga Toxin 2 Variant (Stx2f) from Escherichia coli Isolated from Pigeons

Schmidt, Herbert, Scheef, Jürgen, Morabito, Stefano, Caprioli, Alfredo, Wieler, Lothar H., Karch, Helge

We have isolated Shiga toxin (Stx)-producing Escherichia coli (STEC) strains from the feces of feral pigeons which contained a new Stx2 variant gene designated stx2f. This gene is most similar to...

Naturally Occurring Clostridium perfringens Nontoxic Alpha-Toxin Variant as a Potential Vaccine Candidate against Alpha-Toxin-Associated Diseases

Schoepe, Heike, Pache, Christian, Neubauer, Axel, Potschka, Heidrun, Schlapp, Tobias, Wieler, Lothar H., ...

Clostridium perfringens mutant strain 121A/91 shows neither enzymatic (phospholipase C) nor hemolytic activity. Nevertheless, the cpa gene and the corresponding alpha-toxin variant are detectable....

Identification of Genes Required for Avian Escherichia coli Septicemia by Signature-Tagged Mutagenesis

Li, Ganwu, Laturnus, Claudia, Ewers, Christa, Wieler, Lothar H.

Infections with avian pathogenic Escherichia coli (APEC) cause colibacillosis, an acute and largely systemic disease resulting in significant economic losses in poultry industry worldwide. Although...

Shiga Toxin 2e-Producing Escherichia coli Isolates from Humans and Pigs Differ in Their Virulence Profiles and Interactions with Intestinal Epithelial Cells

Sonntag, Anne-Katharina, Bielaszewska, Martina, Mellmann, Alexander, Dierksen, Nadine, Schierack, Peter, Wieler, Lothar H., ...

Thirteen Escherichia coli strains harboring stx2e were isolated from 11,056 human stools. This frequency corresponded to the presence of the stx2e allele in 1.7% of all Shiga toxin-producing E. coli...

Sex and virulence in Escherichia coli: an evolutionary perspective

Wirth, Thierry, Falush, Daniel, Lan, Ruiting, Colles, Frances, Mensa, Patience, Wieler, Lothar H, ...

Pathogenic Escherichia coli cause over 160 million cases of dysentery and one million deaths per year, whereas non-pathogenic E. coli constitute part of the normal intestinal flora of healthy mammals...