Chagas Disease, Adipose Tissue and the Metabolic Syndrome (2009)
Nagajyothi, Fnu, Desruisseaux, Mahalia S., Weiss, Louis M., Chua, Streamson, Albanese, Chris, Machado, Fabiana S., ...
Trypanosomacruzi infection of the adipose tissue of mice triggers the local expression of inflammatory mediators and a reduction in the expression of the adipokine adiponectin. T. cruzi can be...
EPIC-DB: a proteomics database for studying Apicomplexan organisms (2009)
Madrid-Aliste, Carlos J, Dybas, Joseph M, Angeletti, Ruth, Weiss, Louis M, Kim, Kami, Simon, Istvan, ...
Abstract Background High throughput proteomics experiments are useful for analyzing the protein expression of an organism, identifying the correct gene structure of a genome, or locating possible...
Genomic survey of the non-cultivatable opportunistic human pathogen, Enterocytozoon bieneusi (2009)
Akiyoshi, Donna E., Morrison, Hilary G., Lei, Shi, Feng, Xiaochuan, Zhang, Quanshun, Corradi, Nicolas, ...
© 2009 The Authors. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in PLoS Pathogens 5 (2009): e1000261,...
Molecular Diagnostic Tests for Microsporidia (2009)
The Microsporidia are a ubiquitous group of eukaryotic obligate intracellular parasites which were recognized over 100 years ago with the description of Nosema bombycis, a parasite of silkworms. It...
Molecular Diagnostic Tests for Microsporidia (2009)
The Microsporidia are a ubiquitous group of eukaryotic obligate intracellular parasites which were recognized over 100 years ago with the description of Nosema bombycis, a parasite of silkworms. It...
Williams, Bryony AP, Lee, Renny CH, Becnel, James J, Weiss, Louis M, Fast, Naomi M, Keeling, Patrick J
Abstract Background Microsporidia are well known models of extreme nuclear genome reduction and compaction. The smallest microsporidian genomes have received the most attention, but genomes of...
ANN CALI, LOUIS M. WEISS, PETER M. TAKVORIAN
The genus Brachiola is the newest microsporidian genus established for a human infection with the type species being B. vesicularum in skeletal muscle. Subsequently, the microsporidium, Nosema...
Chagas' disease and AIDS (2004)
Vaidian, Anil K, Weiss, Louis M, Tanowitz, Herbert B
Abstract Chagas' disease caused by Trypanosoma cruzi is an opportunistic infection in the setting of HIV/AIDS. Some individuals with HIV and chronic T. cruzi infection may experience a reactivation,...
An investigation of microsporidian polar tube / (2004)
Advisor: Louis M. Weiss.
Rivera, Johanna, Mukherjee, Jean, Weiss, Louis M., Casadevall, Arturo
We investigated the pathogenesis of pulmonary Cryptococcus neoformans infection and passive Ab efficacy in mice deficient in inducible NO synthase (NOS2(-/-)) and the parental strain. Parental mice...
ANN CALI, LOUIS M. WEISS, PETER M. TAKVORIAN
The microsporidial genus, Brachiola, contains three species: the type species Brachiola vesicularum (identified from an AIDS patient) and two species transferred from the genus Nosema, becoming...
Polyamine Synthesis and Interconversion by the Microsporidian Encephalitozoon cuniculi (2001)
CYRUS J. BACCHI, SCHENNELLA LANE, LOUIS M. WEISS, NIGEL YARLETT, PETER TAKVORIAN, MURRAY WITTNER
Polyamines are small cationic molecules necessary for growth and differentiation in all cells. Although mammalian cells have been studied extensively, particularly as targets of polyamine...
Nucleotide sequence of the small subunit rRNA of Ameson michaelis (1993)
Zhu, Xiaolong, Wittner, Murray, Tanowitz, Herbet B., Cali, Ann, Weiss, Louis M.
Nucleotide sequence of the small ribosomal RNA of Encephalitozoon cuniculi (1993)
Zhu, Xiaolong, Winner, Murray, Tanowitz, Herbert B., Cali, Ann, Weiss, Louis M.
A dual-specificity aminoacyl-tRNA synthetase in the deep-rooted eukaryote Giardia lamblia
Bunjun, Shipra, Stathopoulos, Constantinos, Graham, David, Min, Bokkee, Kitabatake, Makoto, Wang, Alice L., ...
Cysteinyl-tRNA (Cys-tRNA) is essential for protein synthesis. In most organisms the enzyme responsible for the formation of Cys-tRNA is cysteinyl-tRNA synthetase (CysRS). The only known exceptions...
Serological Evidence of Human Infection with the Protozoan Neospora caninum
Tranas, Jennifer, Heinzen, Robert A., Weiss, Louis M., McAllister, Milton M.
Neospora caninum is a protozoan parasite that is closely related to Toxoplasma gondii. Dogs are a definitive host. Prior to its discovery in 1988, N. caninum infection in animals was often mistakenly...
Huang, Huan, Calderon, Tina M., Berman, Joan W., Braunstein, Vicki L., Weiss, Louis M., Wittner, Murray, ...
Transcriptional activation of vascular adhesion molecule expression, a major component of an inflammatory response, is regulated, in part, by the nuclear factor-κB/Rel (NF-κB) family of...
Orr, George A., Werner, Craig, Xu, Jun, Bennett, Marcia, Weiss, Louis M., Takvorkan, Peter, ...
We cloned two novel Trypanosoma cruzi proteins by using degenerate oligonucleotide primers prepared against conserved domains in mammalian serine/threonine protein phosphatases 1, 2A, and 2B. The...
Halonen, Sandra K., Weiss, Louis M.
Toxoplasma gondii is an obligate intracellular parasite that is a common opportunistic pathogen of the central nervous system in AIDS patients. Gamma interferon (IFN-γ) alone or in combination with...
Cyclic Nucleotide Signaling in Toxoplasma gondii Bradyzoite Differentiation
Kirkman, Laura A., Weiss, Louis M., Kim, Kami
The ability of Toxoplasma gondii tachyzoites to differentiate into latent bradyzoite forms is essential for pathogenesis of clinical disease. We examined the effects of cyclic nucleotides on T....
Initial Characterization of CST1, a Toxoplasma gondii Cyst Wall Glycoprotein
Zhang, Yi Wei, Halonen, Sandra K., Ma, Yan Fen, Wittner, Murray, Weiss, Louis M.
Toxoplasma gondii is an important protozoan pathogen of humans that can cause encephalitis in immunocompromised individuals such as those with AIDS. This encephalitis is due to reactivation of latent...
Herbst, Lawrence H., Costa, Sylvia F., Weiss, Louis M., Johnson, Linda K., Bartell, John, Davis, Raymond, ...
An outbreak of granulomatous dermatitis was investigated in a captive population of moray eels. The affected eels had florid skin nodules concentrated around the head and trunk. Histopathological...
Gamma Interferon-Induced Inhibition of Toxoplasma gondii in Astrocytes Is Mediated by IGTP
Halonen, Sandra K., Taylor, Gregory A., Weiss, Louis M.
Toxoplasma gondii is an important pathogen in the central nervous system, causing a severe and often fatal encephalitis in patients with AIDS. Gamma interferon (IFN-γ) is the main cytokine...
Bradyzoite Development in Toxoplasma gondii and the hsp70 Stress Response
Weiss, Louis M., Ma, Yan Fen, Takvorian, Peter M., Tanowitz, Herbert B., Wittner, Murray
Toxoplasma gondii is a well-described ubiquitous Apicomplexan protozoan parasite that is an important opportunistic pathogen. The factors affecting the transition of tachyzoites to the latent...
Bacchi, Cyrus J., Weiss, Louis M., Lane, Schenella, Frydman, Benjamin, Valasinas, Aldonia, Reddy, Venodhar, ...
Microsporidia are eukaryotic obligate intracellular protists that are emerging pathogens in immunocompromised hosts, such as patients with AIDS or patients who have undergone organ transplantation....
Activation of Transcription Factors AP-1 and NF-κB in Murine Chagasic Myocarditis
Huang, Huan, Petkova, Stefka B., Cohen, Alex W., Bouzahzah, Boumediene, Chan, John, Zhou, Jian-nian, ...
The myocardium of CD1 mice was examined for the activation of signal transduction pathways leading to cardiac inflammation and subsequent remodeling during Trypanosoma cruzi infection (Brazil...
Levi, Michael H., Bartell, John, Gandolfo, Leanne, Smole, Sandra C., Costa, Sylvia F., Weiss, Louis M., ...
The characterization of a novel Mycobacterium sp. isolated from granulomatous skin lesions of moray eels is reported. Analysis of the hsp65 gene, small-subunit rRNA gene, rRNA spacer region, and...
Vaidian, Anil K, Weiss, Louis M, Tanowitz, Herbert B
Chagas' disease caused by Trypanosoma cruzi is an opportunistic infection in the setting of HIV/AIDS. Some individuals with HIV and chronic T. cruzi infection may experience a reactivation, which is...
Mukherjee, Shankar, Huang, Huan, Petkova, Stefka B., Albanese, Chris, Pestell, Richard G., Braunstein, Vicki L., ...
Trypanosoma cruzi infection causes cardiomyopathy and vasculopathy. We examined the consequence of this infection for the mitogen-activated protein kinase (MAPK) pathways, which regulate cell...
Xu, Yanji, Takvorian, Peter M., Cali, Ann, Orr, George, Weiss, Louis M.
The microsporidia are ubiquitous, obligate intracellular eukaryotic spore-forming parasites infecting a wide range of invertebrates and vertebrates, including humans. The defining structure of...
Role of Endothelin 1 in the Pathogenesis of Chronic Chagasic Heart Disease
Tanowitz, Herbert B., Huang, Huan, Jelicks, Linda A., Chandra, Madhulika, Loredo, Maria L., Weiss, Louis M., ...
On the basis of previous observations, endothelin 1 (ET-1) has been suggested as contributing to the pathogenesis of Chagasic cardiomyopathy. Therefore, ET-1flox/flox;α-MHC-Cre(+) mice in which the...
Identification of a New Spore Wall Protein from Encephalitozoon cuniculi
Xu, Yanji, Takvorian, Peter, Cali, Ann, Wang, Fang, Zhang, Hong, Orr, George, ...
Microsporidia form environmentally resistant spores that are critical for their host-to-host transmission and persistence in the environment. The spore walls of these organisms are composed of two...
Trypanosoma cruzi Infection Induces Proliferation of Vascular Smooth Muscle Cells
Hassan, Ghada S., Mukherjee, Shankar, Nagajyothi, Fnu, Weiss, Louis M., Petkova, Stefka B., De Almeida, Cecilia J., ...
Trypanosoma cruzi infection causes cardiomyopathy and vasculopathy. Previous studies have demonstrated that infection of human umbilical vein endothelial and smooth muscle cells resulted in...
A dual-specificity aminoacyl-tRNA synthetase in the deep-rooted eukaryote Giardia lamblia
Bunjun, Shipra, Stathopoulos, Constantinos, Graham, David, Min, Bokkee, Kitabatake, Makoto, Wang, Alice L., ...
Cysteinyl-tRNA (Cys-tRNA) is essential for protein synthesis. In most organisms the enzyme responsible for the formation of Cys-tRNA is cysteinyl-tRNA synthetase (CysRS). The only known exceptions...
Serological Evidence of Human Infection with the Protozoan Neospora caninum
Tranas, Jennifer, Heinzen, Robert A., Weiss, Louis M., McAllister, Milton M.
Neospora caninum is a protozoan parasite that is closely related to Toxoplasma gondii. Dogs are a definitive host. Prior to its discovery in 1988, N. caninum infection in animals was often mistakenly...
Huang, Huan, Calderon, Tina M., Berman, Joan W., Braunstein, Vicki L., Weiss, Louis M., Wittner, Murray, ...
Transcriptional activation of vascular adhesion molecule expression, a major component of an inflammatory response, is regulated, in part, by the nuclear factor-κB/Rel (NF-κB) family of...
Orr, George A., Werner, Craig, Xu, Jun, Bennett, Marcia, Weiss, Louis M., Takvorkan, Peter, ...
We cloned two novel Trypanosoma cruzi proteins by using degenerate oligonucleotide primers prepared against conserved domains in mammalian serine/threonine protein phosphatases 1, 2A, and 2B. The...
Halonen, Sandra K., Weiss, Louis M.
Toxoplasma gondii is an obligate intracellular parasite that is a common opportunistic pathogen of the central nervous system in AIDS patients. Gamma interferon (IFN-γ) alone or in combination with...
Cyclic Nucleotide Signaling in Toxoplasma gondii Bradyzoite Differentiation
Kirkman, Laura A., Weiss, Louis M., Kim, Kami
The ability of Toxoplasma gondii tachyzoites to differentiate into latent bradyzoite forms is essential for pathogenesis of clinical disease. We examined the effects of cyclic nucleotides on T....
Initial Characterization of CST1, a Toxoplasma gondii Cyst Wall Glycoprotein
Zhang, Yi Wei, Halonen, Sandra K., Ma, Yan Fen, Wittner, Murray, Weiss, Louis M.
Toxoplasma gondii is an important protozoan pathogen of humans that can cause encephalitis in immunocompromised individuals such as those with AIDS. This encephalitis is due to reactivation of latent...
Herbst, Lawrence H., Costa, Sylvia F., Weiss, Louis M., Johnson, Linda K., Bartell, John, Davis, Raymond, ...
An outbreak of granulomatous dermatitis was investigated in a captive population of moray eels. The affected eels had florid skin nodules concentrated around the head and trunk. Histopathological...
Gamma Interferon-Induced Inhibition of Toxoplasma gondii in Astrocytes Is Mediated by IGTP
Halonen, Sandra K., Taylor, Gregory A., Weiss, Louis M.
Toxoplasma gondii is an important pathogen in the central nervous system, causing a severe and often fatal encephalitis in patients with AIDS. Gamma interferon (IFN-γ) is the main cytokine...
Bradyzoite Development in Toxoplasma gondii and the hsp70 Stress Response
Weiss, Louis M., Ma, Yan Fen, Takvorian, Peter M., Tanowitz, Herbert B., Wittner, Murray
Toxoplasma gondii is a well-described ubiquitous Apicomplexan protozoan parasite that is an important opportunistic pathogen. The factors affecting the transition of tachyzoites to the latent...
Bacchi, Cyrus J., Weiss, Louis M., Lane, Schenella, Frydman, Benjamin, Valasinas, Aldonia, Reddy, Venodhar, ...
Microsporidia are eukaryotic obligate intracellular protists that are emerging pathogens in immunocompromised hosts, such as patients with AIDS or patients who have undergone organ transplantation....
Activation of Transcription Factors AP-1 and NF-κB in Murine Chagasic Myocarditis
Huang, Huan, Petkova, Stefka B., Cohen, Alex W., Bouzahzah, Boumediene, Chan, John, Zhou, Jian-nian, ...
The myocardium of CD1 mice was examined for the activation of signal transduction pathways leading to cardiac inflammation and subsequent remodeling during Trypanosoma cruzi infection (Brazil...
Levi, Michael H., Bartell, John, Gandolfo, Leanne, Smole, Sandra C., Costa, Sylvia F., Weiss, Louis M., ...
The characterization of a novel Mycobacterium sp. isolated from granulomatous skin lesions of moray eels is reported. Analysis of the hsp65 gene, small-subunit rRNA gene, rRNA spacer region, and...
Vaidian, Anil K, Weiss, Louis M, Tanowitz, Herbert B
Chagas' disease caused by Trypanosoma cruzi is an opportunistic infection in the setting of HIV/AIDS. Some individuals with HIV and chronic T. cruzi infection may experience a reactivation, which is...
Mukherjee, Shankar, Huang, Huan, Petkova, Stefka B., Albanese, Chris, Pestell, Richard G., Braunstein, Vicki L., ...
Trypanosoma cruzi infection causes cardiomyopathy and vasculopathy. We examined the consequence of this infection for the mitogen-activated protein kinase (MAPK) pathways, which regulate cell...
Xu, Yanji, Takvorian, Peter M., Cali, Ann, Orr, George, Weiss, Louis M.
The microsporidia are ubiquitous, obligate intracellular eukaryotic spore-forming parasites infecting a wide range of invertebrates and vertebrates, including humans. The defining structure of...
Role of Endothelin 1 in the Pathogenesis of Chronic Chagasic Heart Disease
Tanowitz, Herbert B., Huang, Huan, Jelicks, Linda A., Chandra, Madhulika, Loredo, Maria L., Weiss, Louis M., ...
On the basis of previous observations, endothelin 1 (ET-1) has been suggested as contributing to the pathogenesis of Chagasic cardiomyopathy. Therefore, ET-1flox/flox;α-MHC-Cre(+) mice in which the...
Identification of a New Spore Wall Protein from Encephalitozoon cuniculi
Xu, Yanji, Takvorian, Peter, Cali, Ann, Wang, Fang, Zhang, Hong, Orr, George, ...
Microsporidia form environmentally resistant spores that are critical for their host-to-host transmission and persistence in the environment. The spore walls of these organisms are composed of two...
Trypanosoma cruzi Infection Induces Proliferation of Vascular Smooth Muscle Cells
Hassan, Ghada S., Mukherjee, Shankar, Nagajyothi, Fnu, Weiss, Louis M., Petkova, Stefka B., De Almeida, Cecilia J., ...
Trypanosoma cruzi infection causes cardiomyopathy and vasculopathy. Previous studies have demonstrated that infection of human umbilical vein endothelial and smooth muscle cells resulted in...
Upadhya, Rajendra, Zhang, Hong Shan, Weiss, Louis M.
Microsporidia are parasitic protists of all classes of vertebrates and most invertebrates. They recently emerged as important infections in various immunosuppressed and immunocompetent patient...
Fas–FasL interaction modulates nitric oxide production in Trypanosoma cruzi-infected mice
MARTINS, GISLâINE A, PETKOVA, STEFKA B, MACHADO, FABIANA S, KITSIS, RICHARD N, WEISS, LOUIS M, WITTNER, MURRAY, ...
During acute Trypanosoma cruzi infection in mice, many leucocytes undergo apoptosis. Although apoptosis has been ascribed to increased levels of nitric oxide (NO) and Fas–FasL interaction, the...
Park, David S., Woodman, Scott E., Schubert, William, Cohen, Alex W., Frank, Philippe G., Chandra, Madhulika, ...
The caveolin gene family consists of caveolins 1, 2, and 3. Caveolins 1 and 2 are co-expressed in many cell types, such as endothelial cells, fibroblasts, smooth muscle cells and adipocytes, where...
Corradi, Nicolas, Akiyoshi, Donna E., Morrison, Hilary G., Feng, Xiaochuan, Weiss, Louis M., Tzipori, Saul, ...
Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection
Ashton, Anthony W., Mukherjee, Shankar, Nagajyothi, FNU, Huang, Huan, Braunstein, Vicki L., Desruisseaux, Mahalia S., ...
Chagas' disease is caused by infection with the parasite Trypanosoma cruzi. We report that infected, but not uninfected, human endothelial cells (ECs) released thromboxane A2 (TXA2). Physical...
Williams, Bryony AP, Lee, Renny CH, Becnel, James J, Weiss, Louis M, Fast, Naomi M, Keeling, Patrick J
Khan, Imtiaz A., Hakak, Rubeena, Eberle, Karen, Sayles, Peter, Weiss, Louis M., Urban, Joseph F.
CD8+ T-cell immunity is important for long-term protection against Toxoplasma gondii infection. However, a Th1 cytokine environment, especially the presence of gamma interferon (IFN-γ), is essential...
Genomic Survey of the Non-Cultivatable Opportunistic Human Pathogen, Enterocytozoon bieneusi
Akiyoshi, Donna E., Morrison, Hilary G., Lei, Shi, Feng, Xiaochuan, Zhang, Quanshun, Corradi, Nicolas, ...
Enterocytozoon bieneusi is the most common microsporidian associated with human disease, particularly in the immunocompromised population. In the setting of HIV infection, it is associated with...
EPIC-DB: a proteomics database for studying Apicomplexan organisms
Madrid-Aliste, Carlos J, Dybas, Joseph M, Angeletti, Ruth Hogue, Weiss, Louis M, Kim, Kami, Simon, Istvan, ...
Role of Protein Kinase A in Trypanosoma cruzi▿ †
Bao, Yi, Weiss, Louis M., Braunstein, Vicki L., Huang, Huan
Protein kinase A (PKA) is an important mediator of many signal transduction pathways that occur in eukaryotic cells, and it has been implicated as a regulator of stage differentiation in Trypanosoma...
Molecular Diagnostic Tests for Microsporidia
The Microsporidia are a ubiquitous group of eukaryotic obligate intracellular parasites which were recognized over 100 years ago with the description of Nosema bombycis, a parasite of silkworms. It...
Lee, Soo Chan, Weiss, Louis M, Heitman, Joseph
Microsporidia are obligate intracellular pathogens mainly infecting both vertebrate and invertebrate hosts. The group comprises approximately 150 genera with 1,200 species. Due to sequence divergence...