Louis Sokoloff

Effects of anesthesia on functional activation of cerebral blood flow and metabolism

Nakao, Yasuaki, Itoh, Yoshiaki, Kuang, Tang-Yong, Cook, Michelle, Jehle, Jane, Sokoloff, Louis

Functional brain mapping based on changes in local cerebral blood flow (lCBF) or glucose utilization (lCMRglc) induced by functional activation is generally carried out in animals under anesthesia,...

Brain glucose utilization in mice with a targeted mutation in the thyroid hormone α or β receptor gene

Itoh, Yoshiaki, Esaki, Takanori, Kaneshige, Masahiro, Suzuki, Hideyo, Cook, Michelle, Sokoloff, Louis, ...

Brain glucose utilization is markedly depressed in adult rats made cretinous after birth. To ascertain which subtype of thyroid hormone (TH) receptors, TRα1 or TRβ, is involved in the regulation of...

Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo

Itoh, Yoshiaki, Esaki, Takanori, Shimoji, Kazuaki, Cook, Michelle, Law, Mona J., Kaufman, Elaine, ...

Neuronal cultures in vitro readily oxidized both D-[14C]glucose and l-[14C]lactate to 14CO2, whereas astroglial cultures oxidized both substrates sparingly and metabolized glucose predominantly to...

Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice

Esaki, Takanori, Cook, Michelle, Shimoji, Kazuaki, Murphy, Dennis L., Sokoloff, Louis, Holmes, Andrew

There is growing evidence that serotonin (5-hydroxtryptamine, 5-HT) has major influences on brain development in mammals. Genetic and pharmacological disruption of 5-HT signaling during early...

Metabolic mapping of neural pathways involved in gastrosecretory response to insulin hypoglycaemia in the rat

Kadekaro, Massako, Savaki, Helen, Sokoloff, Louis

1. The central nervous structures involved in the gastrosecretory effect of insulin hypoglycaemia were investigated in twenty urethane-anaesthetized rats, previously provided with a chronic gastric...

Effects of anesthesia on functional activation of cerebral blood flow and metabolism

Nakao, Yasuaki, Itoh, Yoshiaki, Kuang, Tang-Yong, Cook, Michelle, Jehle, Jane, Sokoloff, Louis

Functional brain mapping based on changes in local cerebral blood flow (lCBF) or glucose utilization (lCMRglc) induced by functional activation is generally carried out in animals under anesthesia,...

Brain glucose utilization in mice with a targeted mutation in the thyroid hormone α or β receptor gene

Itoh, Yoshiaki, Esaki, Takanori, Kaneshige, Masahiro, Suzuki, Hideyo, Cook, Michelle, Sokoloff, Louis, ...

Brain glucose utilization is markedly depressed in adult rats made cretinous after birth. To ascertain which subtype of thyroid hormone (TH) receptors, TRα1 or TRβ, is involved in the regulation of...

Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo

Itoh, Yoshiaki, Esaki, Takanori, Shimoji, Kazuaki, Cook, Michelle, Law, Mona J., Kaufman, Elaine, ...

Neuronal cultures in vitro readily oxidized both D-[14C]glucose and l-[14C]lactate to 14CO2, whereas astroglial cultures oxidized both substrates sparingly and metabolized glucose predominantly to...

Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice

Esaki, Takanori, Cook, Michelle, Shimoji, Kazuaki, Murphy, Dennis L., Sokoloff, Louis, Holmes, Andrew

There is growing evidence that serotonin (5-hydroxtryptamine, 5-HT) has major influences on brain development in mammals. Genetic and pharmacological disruption of 5-HT signaling during early...

Metabolic mapping of neural pathways involved in gastrosecretory response to insulin hypoglycaemia in the rat

Kadekaro, Massako, Savaki, Helen, Sokoloff, Louis

1. The central nervous structures involved in the gastrosecretory effect of insulin hypoglycaemia were investigated in twenty urethane-anaesthetized rats, previously provided with a chronic gastric...

The physiological and biochemical bases of functional brain imaging

Sokoloff, Louis

Functional brain imaging is based on the display of computer-derived images of changes in physiological and/or biochemical functions altered by activation or depression of local functional activities...