Lowell S. Kappmeyer

Conservation in the face of diversity: multistrain analysis of an intracellular bacterium (2009)

Dark, Michael J, Herndon, David R, Kappmeyer, Lowell S, Gonzales, Mikel P, Nordeen, Elizabeth, Palmer, Guy H, ...

Abstract Background With the recent completion of numerous sequenced bacterial genomes, notable advances have been made in understanding the level of conservation between various species. However,...

Transmission of Babesia caballi by Dermacentor nitens (Acari: Ixodidae) Is Restricted to One Generation in the Absence of Alimentary Reinfection on a Susceptible Equine Host (2008)

O. Nicolas Schwint, Donald P. Knowles, Massaro W. Ueti, Lowell S. Kappmeyer, Glen A. Scoles

The tropical horse tick, Dermacentor nitens, is a natural vector of Babesia caballi in the Americas. B. caballi, one of the etiologic agents of equine piroplasmosis, occurs widely throughout the...

Genome Sequence of Babesia bovis and Comparative Analysis of Apicomplexan Hemoprotozoa (2007)

Kelly A. Brayton, David R. Herndon, Linda Hannick, Lowell S. Kappmeyer, Shawn J. Berens, ...

Babesia bovis is an apicomplexan tick-transmitted pathogen of cattle imposing a global risk and severe constraints to livestock health and economic development. The complete genome sequence was...

Detection of Equine Antibodies to Babesia caballi by Recombinant B. caballi Rhoptry-Associated Protein 1 in a Competitive-Inhibition Enzyme-Linked Immunosorbent Assay

Kappmeyer, Lowell S., Perryman, Lance E., Hines, Stephen A., Baszler, Timothy V., Katz, Jonathan B., Hennager, Steven G., ...

A competitive-inhibition enzyme-linked immunosorbent assay (cELISA) was developed for detection of equine antibodies specific for Babesia caballi. The assay used recombinant B. caballi...

Conformational Dependence and Conservation of an Immunodominant Epitope within the Babesia equi Erythrocyte-Stage Surface Protein Equi Merozoite Antigen 1

Cunha, Cristina W., Kappmeyer, Lowell S., McGuire, Travis C., Dellagostin, Odir A., Knowles, Donald P.

Equi merozoite antigen 1 (EMA-1) is an immunodominant Babesia equi erythrocyte-stage surface protein. A competitive enzyme-linked immunosorbent assay (ELISA), based on inhibition of monoclonal...

Expression of Equi Merozoite Antigen 2 during Development of Babesia equi in the Midgut and Salivary Gland of the Vector Tick Boophilus microplus

Ueti, Massaro W., Palmer, Guy H., Kappmeyer, Lowell S., Scoles, Glen A., Knowles, Donald P.

Equi merozoite antigens 1 and 2 (EMA-1 and EMA-2) are Babesia equi proteins expressed on the parasite surface during infection in horses and are orthologues of proteins in Theileria spp., which are...

Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins

Brayton, Kelly A., Kappmeyer, Lowell S., Herndon, David R., Dark, Michael J., Tibbals, David L., Palmer, Guy H., ...

The rickettsia Anaplasma marginale is the most prevalent tick-borne livestock pathogen worldwide and is a severe constraint to animal health. A. marginale establishes lifelong persistence in infected...

Ability of the Vector Tick Boophilus microplus To Acquire and Transmit Babesia equi following Feeding on Chronically Infected Horses with Low-Level Parasitemia

Ueti, Massaro W., Palmer, Guy H., Kappmeyer, Lowell S., Statdfield, Mary, Scoles, Glen A., Knowles, Donald P.

The protozoan parasite Babesia equi replicates within erythrocytes. During the acute phase of infection, B. equi can reach high levels of parasitemia, resulting in a hemolytic crisis. Horses that...

Development of Specific Immunoglobulin Ga (IgGa) and IgGb Antibodies Correlates with Control of Parasitemia in Babesia equi Infection

Cunha, Cristina W., McGuire, Travis C., Kappmeyer, Lowell S., Hines, Stephen A., Lopez, A. Marianela, Dellagostin, Odir A., ...

In this study, the kinetics of specific immunoglobulin G (IgG) isotypes were characterized in Babesia equi (Theileria equi)-infected horses. IgGa and IgGb developed during acute infection, whereas...

Detection of Equine Antibodies to Babesia caballi by Recombinant B. caballi Rhoptry-Associated Protein 1 in a Competitive-Inhibition Enzyme-Linked Immunosorbent Assay

Kappmeyer, Lowell S., Perryman, Lance E., Hines, Stephen A., Baszler, Timothy V., Katz, Jonathan B., Hennager, Steven G., ...

A competitive-inhibition enzyme-linked immunosorbent assay (cELISA) was developed for detection of equine antibodies specific for Babesia caballi. The assay used recombinant B. caballi...

Conformational Dependence and Conservation of an Immunodominant Epitope within the Babesia equi Erythrocyte-Stage Surface Protein Equi Merozoite Antigen 1

Cunha, Cristina W., Kappmeyer, Lowell S., McGuire, Travis C., Dellagostin, Odir A., Knowles, Donald P.

Equi merozoite antigen 1 (EMA-1) is an immunodominant Babesia equi erythrocyte-stage surface protein. A competitive enzyme-linked immunosorbent assay (ELISA), based on inhibition of monoclonal...

Expression of Equi Merozoite Antigen 2 during Development of Babesia equi in the Midgut and Salivary Gland of the Vector Tick Boophilus microplus

Ueti, Massaro W., Palmer, Guy H., Kappmeyer, Lowell S., Scoles, Glen A., Knowles, Donald P.

Equi merozoite antigens 1 and 2 (EMA-1 and EMA-2) are Babesia equi proteins expressed on the parasite surface during infection in horses and are orthologues of proteins in Theileria spp., which are...

Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins

Brayton, Kelly A., Kappmeyer, Lowell S., Herndon, David R., Dark, Michael J., Tibbals, David L., Palmer, Guy H., ...

The rickettsia Anaplasma marginale is the most prevalent tick-borne livestock pathogen worldwide and is a severe constraint to animal health. A. marginale establishes lifelong persistence in infected...

Ability of the Vector Tick Boophilus microplus To Acquire and Transmit Babesia equi following Feeding on Chronically Infected Horses with Low-Level Parasitemia

Ueti, Massaro W., Palmer, Guy H., Kappmeyer, Lowell S., Statdfield, Mary, Scoles, Glen A., Knowles, Donald P.

The protozoan parasite Babesia equi replicates within erythrocytes. During the acute phase of infection, B. equi can reach high levels of parasitemia, resulting in a hemolytic crisis. Horses that...

Development of Specific Immunoglobulin Ga (IgGa) and IgGb Antibodies Correlates with Control of Parasitemia in Babesia equi Infection

Cunha, Cristina W., McGuire, Travis C., Kappmeyer, Lowell S., Hines, Stephen A., Lopez, A. Marianela, Dellagostin, Odir A., ...

In this study, the kinetics of specific immunoglobulin G (IgG) isotypes were characterized in Babesia equi (Theileria equi)-infected horses. IgGa and IgGb developed during acute infection, whereas...

Genome Sequence of Babesia bovis and Comparative Analysis of Apicomplexan Hemoprotozoa

Brayton, Kelly A, Lau, Audrey O. T, Herndon, David R, Hannick, Linda, Kappmeyer, Lowell S, Berens, Shawn J, ...

Babesia bovis is an apicomplexan tick-transmitted pathogen of cattle imposing a global risk and severe constraints to livestock health and economic development. The complete genome sequence was...

Persistently Infected Horses Are Reservoirs for Intrastadial Tick-Borne Transmission of the Apicomplexan Parasite Babesia equi▿

Ueti, Massaro W., Palmer, Guy H., Scoles, Glen A., Kappmeyer, Lowell S., Knowles, Donald P.

Tick-borne pathogens may be transmitted intrastadially and transstadially within a single vector generation as well as vertically between generations. Understanding the mode and relative efficiency...