Ribofuranose as a carrier of tetraoxane and 4-aminoquinoline antimalarial pharmacophores (2008)
IGOR M. OPSENICA, KIRSTEN K. SMITH, LUCIA GERENA, SANDRA GAICA, BOGDAN A. SOLAJA
Several tetraoxane and 4-aminoquinoline molecules were prepared in order to examine the influence of ribofuranose as a carrier molecule on the antimalarial activity of test compounds. The synthesized...
Antimalarial Activities in New Pyrrolo(3,2-f)Quinazoline-1,3-Diamine Derivatives (1998)
Guan, Jian, Zhang, Quan, O'Neil, Michael, Obaldia III, Nicanor, Ager, Arba, Gerena, Lucia, ...
WR227825 is an antimalarial pyrroloquinazolinediamine derivative with a high potency but a low therapeutic index. A series of carbamate, carboxamide, succinimide, and alkylamine derivatives of...
Vennerstrom, Jonathan L., Nuzum, Edwin O., Miller, Robert E., Dorn, Arnulf, Gerena, Lucia, Dande, Prasad A., ...
From the Walter Reed Army Institute of Research (WRAIR) inventory, thirteen 8-aminoquinoline analogs of primaquine were selected for screening against a panel of seven Plasmodium falciparum clones...
Jiang, Suping, Prigge, Sean T., Wei, Lan, Gao, Yu-e, Hudson, Thomas H., Gerena, Lucia, ...
Malarial parasites rely on aspartic proteases called plasmepsins to digest hemoglobin during the intraerythrocytic stage. Plasmepsins from Plasmodium falciparum and Plasmodium vivax have been cloned...
Dow, Geoffrey S., Koenig, Michael L., Wolf, Lesley, Gerena, Lucia, Lopez-Sanchez, Miriam, Hudson, Thomas H., ...
The clinical potential of mefloquine has been compromised by reports of adverse neurological effects. A series of 4-quinolinecarbinolamines were compared in terms of neurotoxicity and antimalarial...
Antimalarial Activities of New Pyrrolo[3,2-f]Quinazoline-1,3-Diamine Derivatives†
Guan, Jian, Zhang, Quan, O'Neil, Michael, Obaldia, Nicanor, Ager, Arba, Gerena, Lucia, ...
WR227825 is an antimalarial pyrroloquinazolinediamine derivative with a high potency but a low therapeutic index. A series of carbamate, carboxamide, succinimide, and alkylamine derivatives of...
Vennerstrom, Jonathan L., Nuzum, Edwin O., Miller, Robert E., Dorn, Arnulf, Gerena, Lucia, Dande, Prasad A., ...
From the Walter Reed Army Institute of Research (WRAIR) inventory, thirteen 8-aminoquinoline analogs of primaquine were selected for screening against a panel of seven Plasmodium falciparum clones...
Jiang, Suping, Prigge, Sean T., Wei, Lan, Gao, Yu-e, Hudson, Thomas H., Gerena, Lucia, ...
Malarial parasites rely on aspartic proteases called plasmepsins to digest hemoglobin during the intraerythrocytic stage. Plasmepsins from Plasmodium falciparum and Plasmodium vivax have been cloned...
Dow, Geoffrey S., Koenig, Michael L., Wolf, Lesley, Gerena, Lucia, Lopez-Sanchez, Miriam, Hudson, Thomas H., ...
The clinical potential of mefloquine has been compromised by reports of adverse neurological effects. A series of 4-quinolinecarbinolamines were compared in terms of neurotoxicity and antimalarial...
Antimalarial Activities of New Pyrrolo[3,2-f]Quinazoline-1,3-Diamine Derivatives†
Guan, Jian, Zhang, Quan, O'Neil, Michael, Obaldia, Nicanor, Ager, Arba, Gerena, Lucia, ...
WR227825 is an antimalarial pyrroloquinazolinediamine derivative with a high potency but a low therapeutic index. A series of carbamate, carboxamide, succinimide, and alkylamine derivatives of...
Johnson, Jacob D., Dennull, Richard A., Gerena, Lucia, Lopez-Sanchez, Miriam, Roncal, Norma E., Waters, Norman C.
Several new fluorescence malaria in vitro drug susceptibility microtiter plate assays that detect the presence of malarial DNA in infected erythrocytes have recently been reported, in contrast to...