Torrens, Christopher, Snelling, Tristram H., Chau, Ryan, Shanmuganathan, Meena, Cleal, Jane K., Poore, Kirsten R., ...
The nutritional environment during development and even prior to conception may contribute to cardiovascular risk. In mature adult female sheep, we investigated the effect of preconceptional and...
Cleal, Jane K., Poore, Kirsten R., Boullin, Julian P., Khan, Omar, Chau, Ryan, Hambidge, Oliver, ...
The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit...
Cleal, Jane K., Poore, Kirsten R., Boullin, Julian P., Khan, Omar, Chau, Ryan, Hambidge, Oliver, ...
The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit...
Torrens, Christopher, Brawley, Lee, Anthony, Frederick W., Dance, Caroline S., Dunn, Rebecca, Jackson, Alan A., ...
Dietary protein restriction in the rat compromises the maternal cardiovascular adaptations to pregnancy and leads to raised blood pressure and endothelial dysfunction in the offspring. In this study...
Jauniaux, Eric, Poston, Lucilla, Burton, Graham J.
Miscarriage and pre-eclampsia are the most common disorders of human pregnancy. Both are placental-related and exceptional in other mammalian species. Ultrasound imaging has enabled events during...
Jauniaux, Eric, Poston, Lucilla, Burton, Graham J.
Miscarriage and pre-eclampsia are the most common disorders of human pregnancy. Both are placental-related and exceptional in other mammalian species. Ultrasound imaging has enabled events during...
Khan, Omar A., Torrens, Christopher, Noakes, David E., Poston, Lucilla, Hanson, Mark A., Green, Lucy R., ...
Objective: Previous studies in humans and animals have suggested that undernutrition in utero and in early post-natal life may lead to altered vascular function in a number of peripheral arteries. We...
Diet-induced obesity in the rat: a model for gestational diabetes mellitus (2004)
Poston, Lucilla, Van Assche, F André
OBJECTIVES: Obesity is one of the most important risk factors for the development of gestational diabetes mellitus (GDM). However, in obese women, it is difficult to disentangle the genetic and...
Khan, Imran, Dekou, Vasia, Hanson, Mark A., Poston, Lucilla, Taylor, Paul
Background— Population-based studies suggest that fetal adaptive responses to maternal dietary imbalance confer survival benefit when the postnatal diet remains suboptimal but increase...
Rachel M. Tribe, Patrick Moriarty, Annette Dalrymple, Abdul A. Hassoni, Lucilla Poston
We have previously reported increased protein expression of sarcoplasmic reticulum calcium ATPase (SERCA) 2b in myometrium from women in labor at term, but the stimulus for this change is unknown....
Brawley, Lee, Itoh, Shigeru, Torrens, Christopher, Barker, Alison, Bertram, Caroline, Poston, Lucilla, ...
It is established that dietary protein restriction of pregnant rats results in their offspring developing hypertension. However, to date no studies have investigated peripheral vascular function of...
Nishina, Hidenori, Green, Lucy R., McGarrigle, Hugh H.G., Noakes, David E., Poston, Lucilla, Hanson, Mark A.
Unbalanced maternal nutrition affects fetal endocrine and cardiovascular systems, sometimes accompanied by changes in growth, although this is usually in late gestation. We determined the effect of...
Gender-linked hypertension in offspring of lard-fed pregnant rats (2003)
Khan, Imran Y., Taylor, Paul D., Dekou, Vasia, Seed, Paul T., Lakasing, Lorin, Graham, Delyth, ...
Epidemiological studies suggest an association between maternal nutrition and offspring cardiovascular disease. We previously demonstrated endothelial dysfunction and abnormal aortic fatty acid...
Torrens, Christopher, Brawley, Lee, Barker, Alison C., Itoh, Shigeru, Poston, Lucilla, Hanson, Mark A.
Dietary protein restriction during gestation has been shown to produce vascular dysfunction in pregnant rats and hypertension in their offspring. However, no studies have to date examined the effects...
Low-protein diet impairs vascular relaxation in virgin and pregnant rats (2002)
Koumentaki, Angeliki, Anthony, Frederick, Poston, Lucilla, Wheeler, Timothy
Pregnancy is associated with increases in maternal cardiac output and plasma volume and a reduction in peripheral vascular resistance. Cardiac output and plasma volume are substantially reduced in...
Itoh, Shigeru, Brawley, Lee, Wheeler, Timothy, Anthony, Frederick W., Poston, Lucilla, Hanson, Mark A.
Pregnancy is associated with a substantial increase in uterine artery blood flow, which may in part result from dilation in response to vascular endothelial growth factor (VEGF). Uterine blood flow...
Belevych, Andriy E., Beck, Richard, Tammaro, Paolo, Poston, Lucilla, Smirnov, Sergey V.
Objective: Active control of the arterial diameter by vascular smooth muscle is one of the principle mechanisms by which vessels adapt to a significant rise in blood pressure after birth. Although...
Expression of cyclo-oxygenase types-1 and -2 in human myometrium throughout pregnancy (1999)
Slater, Donna M., Dennes, William J.B., Campa, Juan S., Poston, Lucilla, Bennett, Phillip R.
Human labour is associated with increased prostaglandin synthesis within the uterus. The aim of this study was to examine the expression of the two isoforms of the central prostaglandin synthetic...
British Hypertension Society guidelines for hypertension management 1999: summary
Ramsay, Lawrence E, Williams, Bryan, Johnston, G Dennis, MacGregor, Graham A, Poston, Lucilla, Potter, John F, ...
Armitage, James A, Taylor, Paul D, Poston, Lucilla
Studies in both humans and experimental animals addressing the ‘Fetal Origins of Adult Disease’ hypothesis have established a relationship between an adverse intrauterine environment and...
Armitage, James A, Lakasing, Lorin, Taylor, Paul D, Balachandran, Aswini A, Jensen, Runa I, Dekou, Vasia, ...
Evidence from human and animal studies suggests that maternal nutrition can induce developmental programming of adult hypertension in offspring. We have previously described a model of maternal...
Armitage, James A, Khan, Imran Y, Taylor, Paul D, Nathanielsz, Peter W, Poston, Lucilla
The incidence of the metabolic syndrome, a cluster of abnormalities focusing on insulin resistance and associated with high risk for cardiovascular disease and diabetes, is reaching epidemic...
British Hypertension Society guidelines for hypertension management 1999: summary
Ramsay, Lawrence E, Williams, Bryan, Johnston, G Dennis, MacGregor, Graham A, Poston, Lucilla, Potter, John F, ...
Armitage, James A, Taylor, Paul D, Poston, Lucilla
Studies in both humans and experimental animals addressing the ‘Fetal Origins of Adult Disease’ hypothesis have established a relationship between an adverse intrauterine environment and...
Armitage, James A, Lakasing, Lorin, Taylor, Paul D, Balachandran, Aswini A, Jensen, Runa I, Dekou, Vasia, ...
Evidence from human and animal studies suggests that maternal nutrition can induce developmental programming of adult hypertension in offspring. We have previously described a model of maternal...
Armitage, James A, Khan, Imran Y, Taylor, Paul D, Nathanielsz, Peter W, Poston, Lucilla
The incidence of the metabolic syndrome, a cluster of abnormalities focusing on insulin resistance and associated with high risk for cardiovascular disease and diabetes, is reaching epidemic...
Cleal, Jane K., Poore, Kirsten R., Boullin, Julian P., Khan, Omar, Chau, Ryan, Hambidge, Oliver, ...
The early life environment has long-term implications for the risk of developing cardiovascular (CV) disease in adulthood. Fetal responses to changes in maternal nutrition may be of immediate benefit...
Sawdy, Robert, Knock, Gregory A, Bennett, Philip R, Poston, Lucilla, Aaronson, Philip I
The non-steroidal anti-inflammatory drug (NSAID) indomethacin inhibits both constitutive and inducible forms of cyclo-oxygenase (COX-1 and COX-2, respectively), while nimesulide is a selective COX-2...
Activation of nitric oxide synthase by β2-adrenoceptors in human umbilical vein endothelium in vitro
Ferro, Albert, Queen, Lindsay R, Priest, Rachel M, Xu, Biao, Ritter, James M, Poston, Lucilla, ...
Some animal studies suggest that β-adrenoceptor-mediated vasorelaxation is in part mediated through nitric oxide (NO) release. Furthermore, in humans, we have recently shown that forearm blood flow...
Luksha, Leonid, Poston, Lucilla, Gustafsson, Jan-Åke, Hultenby, Kjell, Kublickiene, Karolina
Sex related differences in cardiovascular function have been reported in oestrogen receptor β knockout (ERβKO) mice. In this study we examined the role of endothelium-derived hyperpolarizing factor...
Gerber, Robert T, Holemans, Kathleen, O'Brien-Coker, Ivan, Mallet, Anthony I, Van Bree, Rita, Van Assche, F André, ...
Western diets high in saturated fat are associated with an increased incidence of cardiovascular diseases. In this study we have evaluated vascular endothelial function and oxidative stress in virgin...
Expression of nitric oxide synthase isoforms in pregnant human myometrium
Bartlett, Simon R, Bennett, Phillip R, Campa, Juan S, Dennes, William J B, Slater, Donna M, Mann, Giovanni E, ...
Endogenous nitric oxide has been proposed to play a role in the control of myometrial contractility in pregnancy. In this study, the expression, localisation and regulation of nitric oxide synthase...
Torrens, Christopher, Brawley, Lee, Barker, Alison C, Itoh, Shigeru, Poston, Lucilla, Hanson, Mark A
Dietary protein restriction during gestation has been shown to produce vascular dysfunction in pregnant rats and hypertension in their offspring. However, no studies have to date examined the effects...
Nishina, Hidenori, Green, Lucy R, McGarrigle, Hugh H G, Noakes, David E, Poston, Lucilla, Hanson, Mark A
Unbalanced maternal nutrition affects fetal endocrine and cardiovascular systems, sometimes accompanied by changes in growth, although this is usually in late gestation. We determined the effect of...
Igosheva, Natalia, Taylor, Paul D, Poston, Lucilla, Glover, Vivette
We have shown previously that stress in the pregnant rat leads to a heightened cardiovascular response to restraint in adult offspring. The present study was undertaken to explore further the...
Kirk, Shona L., Samuelsson, Anne-Maj, Argenton, Marco, Dhonye, Hannah, Kalamatianos, Theodosis, Poston, Lucilla, ...
Hypothalamic systems which regulate appetite may be permanently modified during early development. We have previously reported hyperphagia and increased adiposity in the adult offspring of rodents...
Armitage, James A, Gupta, Sanjana, Wood, Caroline, Jensen, Runa I, Samuelsson, Anne-Maj, Fuller, William, ...
In rats, a maternal diet rich in lard is associated with reduced Na+,K+-ATPase activity in adult offspring kidney. We have addressed the role of different fatty acids by evaluating Na+,K+-ATPase...