Lucy R. Wedderburn

Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis (2009)

Nistala, Kiran, Wedderburn, Lucy R.

Inflammatory T cells are thought to be central to the pathology of autoimmune arthritis. Th17 cells, CD4 T cells that secrete the pro-inflammatory cytokine IL-17 play a critical role in murine models...

HLA-DPB1 associations differ between DRB1*03 positive anti-Jo-1 and anti-PM-Scl antibody positive idiopathic inflammatory myopathy (2009)

Chinoy, Hector, Payne, Debbie, Poulton, Kate V., Fertig, Noreen, Betteridge, Zoe, Gunawardena, Harsha, ...

Objective. The HLA 8.1 ancestral haplotype (HLA-B*08/DRB1*03/DQA1*05/DQB1*02) is associated with adult/juvenile idiopathic inflammatory myopathy (IIM), but confers a greater strength of association...

Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells (2006)

Pharoah, Daniel S, Varsani, Hemlata, Tatham, Richard W, Newton, Katy R, De Jager, Wilco, Prakken, Berent J, ...

Abstract This study focuses upon three chemokines, namely CCL5, CXCL10 and CCL3, which are potential novel therapeutic targets in arthritis. The aim of the study was to analyse the expression and...

Divergence in the degree of clonal expansions in inflammatory T cell subpopulations mirrors HLA-associated risk alleles in genetically and clinically distinct subtypes of childhood arthritis (2001)

Wedderburn, Lucy R., Patel, Alka, Varsani, Hemlata, Woo, Patricia

Clinically distinct forms of childhood arthritis are associated with different risk alleles of polymorphic loci within the MHC, which code for the antigen-presenting class I or class II molecules. We...

Molecular fingerprinting reveals non-overlapping T cell oligoclonality between an inflamed site and peripheral blood (1999)

Wedderburn, Lucy R., Maini, Mala K., Patel, Alka, Beverley, Peter C. L., Woo, Patricia

We have demonstrated a stable expansion of CD8+ T cells in the peripheral blood of a child with chronic arthritis. The expanded TCRBV family (TCRBV14) was enriched for CD57hiCD28– T cells....

Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells

Pharoah, Daniel S, Varsani, Hemlata, Tatham, Richard W, Newton, Katy R, De Jager, Wilco, Prakken, Berent J, ...

This study focuses upon three chemokines, namely CCL5, CXCL10 and CCL3, which are potential novel therapeutic targets in arthritis. The aim of the study was to analyse the expression and production...

Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells

Pharoah, Daniel S, Varsani, Hemlata, Tatham, Richard W, Newton, Katy R, De Jager, Wilco, Prakken, Berent J, ...

This study focuses upon three chemokines, namely CCL5, CXCL10 and CCL3, which are potential novel therapeutic targets in arthritis. The aim of the study was to analyse the expression and production...

Interleukin-17–producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers

Nistala, Kiran, Moncrieffe, Halima, Newton, Katy R, Varsani, Hemlata, Hunter, Patricia, Wedderburn, Lucy R