Luda Diatchenko

Expansion of the human {micro}-opioid receptor gene architecture: novel functional variants (2009)

Shabalina, Svetlana A., Zaykin, Dmitri V., Gris, Pavel, Ogurtsov, Aleksey Y., Gauthier, Josee, Shibata, Kyoko, ...

The μ-opioid receptor (OPRM1) is the principal receptor target for both endogenous and exogenous opioid analgesics. There are substantial individual differences in human responses to painful stimuli...

Influence of psychological factors on risk of temporomandibular disorders (2007)

Slade, Gary Douglas, Diatchenko, Luda, Bhalang, Konakporn, Sigurdsson, Asgeir, Fillingim, Roger, Belfer, Inna, ...

Psychological characteristics potentially may be a cause or consequence of temporomandibular disorder (TMD). We hypothesized that psychological characteristics associated with pain sensitivity would...

Influence of psychological factors on risk of temporomandibular disorders (2007)

Slade, Gary Douglas, Diatchenko, Luda, Bhalang, Konakporn, Sigurdsson, Asgeir, Fillingim, Roger, Belfer, Inna, ...

Psychological characteristics potentially may be a cause or consequence of temporomandibular disorder (TMD). We hypothesized that psychological characteristics associated with pain sensitivity would...

Genetic basis for individual variations in pain perception and the development of a chronic pain condition (2005)

Diatchenko, Luda, Slade, Gary D., Nackley, Andrea G., Bhalang, Konakporn, Sigurdsson, Asgeir, Belfer, Inna, ...

Pain sensitivity varies substantially among humans. A significant part of the human population develops chronic pain conditions that are characterized by heightened pain sensitivity. We identified...

Genetic basis for individual variations in pain perception and the development of a chronic pain condition (2004)

Diatchenko, Luda, Slade, Gary D., Nackley, Andrea G., Bhalang, Konakporn, Sigurdsson, Asgeir, Belfer, Inna, ...

Pain sensitivity varies substantially among humans. A significant part of the human population develops chronic pain conditions that are characterized by heightened pain sensitivity. We identified...

Genetic basis for individual variations in pain perception and the development of a chronic pain condition (2004)

Diatchenko, Luda, Slade, Gary D., Nackley, Andrea G., Bhalang, Konakporn, Sigurdsson, Asgeir, Belfer, Inna, ...

Pain sensitivity varies substantially among humans. A significant part of the human population develops chronic pain conditions that are characterized by heightened pain sensitivity. We identified...

PCR-based subtractive hybridization and differences in gene content among strains of Helicobacter pylori

Akopyants, Natalia S., Fradkov, Arkady, Diatchenko, Luda, Hill, Jason E., Siebert, Paul D., Lukyanov, Sergey A., ...

Genes that are characteristic of only certain strains of a bacterial species can be of great biologic interest. Here we describe a PCR-based subtractive hybridization method for efficiently detecting...

PCR-based subtractive hybridization and differences in gene content among strains of Helicobacter pylori

Akopyants, Natalia S., Fradkov, Arkady, Diatchenko, Luda, Hill, Jason E., Siebert, Paul D., Lukyanov, Sergey A., ...

Genes that are characteristic of only certain strains of a bacterial species can be of great biologic interest. Here we describe a PCR-based subtractive hybridization method for efficiently detecting...

Caveolin-1 Is Down-Regulated in Human Ovarian Carcinoma and Acts as a Candidate Tumor Suppressor Gene

Wiechen, Kai, Diatchenko, Luda, Agoulnik, Alexander, Scharff, K. Michael, Schober, Hagen, Arlt, Katharina, ...

To identify novel markers differentially expressed in ovarian cancer versus normal ovary, we hybridized microarrays with cDNAs derived from normal human ovaries and advanced stage ovarian carcinomas....

Low Enzymatic Activity Haplotypes of the Human Catechol-O-Methyltransferase Gene: Enrichment for Marker SNPs

Nackley, Andrea G., Shabalina, Svetlana A., Lambert, Jason E., Conrad, Mathew S., Gibson, Dustin G., Spiridonov, Alexey N., ...

Catechol-O-methyltransferase (COMT) is an enzyme that plays a key role in the modulation of catechol-dependent functions such as cognition, cardiovascular function, and pain processing. Three common...

Expansion of the human μ-opioid receptor gene architecture: novel functional variants

Shabalina, Svetlana A., Zaykin, Dmitri V., Gris, Pavel, Ogurtsov, Aleksey Y., Gauthier, Josee, Shibata, Kyoko, ...

The μ-opioid receptor (OPRM1) is the principal receptor target for both endogenous and exogenous opioid analgesics. There are substantial individual differences in human responses to painful stimuli...