This article cites 117 articles, 43 of which can be accessed free at: (2009)
Takayuki Harada, Chikako Harada, Luis F. Parada, Takayuki Harada, Chikako Harada, Luis F. Parada
service
Zhou, Jing, Brugarolas, James, Parada, Luis F.
Tuberous sclerosis complex (TSC) is a genetic disorder linked to mutations of either the TSC1 or TSC2 gene, which encode proteins that form a complex to negatively regulate mammalian target of...
NF1 loss disrupts Schwann cell-axonal interactions: a novel role for semaphorin 4F (2008)
Parrinello, Simona, Noon, Luke A., Harrisingh, Marie C., Digby, Patrick Wingfield, Rosenberg, Laura H., Cremona, Catherine A., ...
Neurofibromatosis type 1 (NF1) patients develop neurofibromas, tumors of Schwann cell origin, as a result of loss of the Ras-GAP neurofibromin. In normal nerves, Schwann cells are found tightly...
Multiple roles for neurofibromin in skeletal development and growth. (2007)
Kolanczyk, Mateusz, Kossler, Nadine, Kühnisch, Jirko, Lavitas, Liron, Stricker, Sigmar, Wilkening, Ulrich, ...
Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder primarily characterized by the formation of neurofibromas, café-au-lait spots and freckling. Skeletal abnormalities such as short...
Molecular regulation of visual system development: more than meets the eye (2007)
Harada, Takayuki, Harada, Chikako, Parada, Luis F.
Vertebrate eye development has been an excellent model system to investigate basic concepts of developmental biology ranging from mechanisms of tissue induction to the complex patterning and...
Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-{beta} signaling (2006)
Yang, Feng-Chun, Chen, Shi, Clegg, Travis, Li, Xiaohong, Morgan, Trent, Estwick, Selina A., ...
Neurofibromas are common tumors found in neurofibromatosis type 1 (NF1) patients. These complex tumors are composed of Schwann cells, mast cells, fibroblasts and perineurial cells embedded in...
Nf1+/- mast cells induce neurofibroma like phenotypes through secreted TGF-{beta} signaling (2006)
Yang, Feng-Chun, Chen, Shi, Clegg, Travis, Li, Xiaohong, Morgan, Trent, Estwick, Selina A., ...
Neurofibromas are common tumors found in neurofibromatosis type 1 patients (NF1). These complex tumors are composed of Schwann cells, mast cells, fibroblasts and perineurial cells embedded in...
Lei, Lei, Laub, Friedrich, Lush, Mark, Romero, Mario, Zhou, Jing, Luikart, Bryan, ...
TrkA, the high affinity receptor for nerve growth factor (NGF), is essential for the development of nociceptive sensory and sympathetic neurons. The zinc finger transcription factor Klf7 interacts...
Schonhoff, Christopher M., Bulseco, Dylan A., Brancho, Deborah Marie, Parada, Luis F., Ross, Alonzo H.
We have studied the role of MAP kinase pathways in neuronal nitric oxide synthase (nNOS) induction during the differentiation of PC12 cells. In nerve growth factor (NGF)-treated PC12 cells, we find...
Zhu, Yuan, Romero, Mario I., Ghosh, Pritam, Ye, Zhengyi, Charnay, Patrick, Rushing, Elizabeth J., ...
In Vivo Models of NF-1: The Nervous System and Tumorigenesis. (1998)
It is believed that the primary function of the protein encoded by the NF-1 gene is as a negative regulator of the ras protooncogene. Mutation of the NF-1 gene therefore releases ras function from...
In Vivo Models of NF-1: The Nervous System and Tumorigenesis (1998)
The present document summarizes the work of three years in which we have endeavored to better understand the mechanisms that lead to NF1 and the relationship between NFl and the related rasGap gene....
Liebl, Daniel J., Klesse, Laura J., Tessarollo, Lino, Wohlman, Todd, Parada, Luis F.
Peripheral ganglion neurons confer sensory information including touch, pain, temperature, and proprioception. Sensory modality is linked to specific neurotrophin (NTF) requirements. NT-3 supports...
Tessarollo, Lino, Tsoulfas, Pantelis, Donovan, Michael J., Palko, Mary Ellen, Blair-Flynn, Janet, Hempstead, Barbara L., ...
We have generated null mutant mice that lack expression of all isoforms encoded by the trkC locus. These mice display a behavioral phenotype characterized by a loss of proprioceptive neurons....
Gonzalez-Zulueta, Mirella, Feldman, Alicia B., Klesse, Laura J., Kalb, Robert G., Dillman, James F., Parada, Luis F., ...
The mechanisms underlying neuronal ischemic preconditioning, a phenomenon in which brief episodes of ischemia protect against the lethal effects of subsequent periods of prolonged ischemia, are...
Kitamura, Tadahiro, Kido, Yoshiaki, Nef, Serge, Merenmies, Jussi, Parada, Luis F., Accili, Domenico
Receptors of the insulin/insulinlike growth factor (IGF) family have been implicated in the regulation of pancreatic β-cell growth and insulin secretion. The insulin receptor-related receptor (IRR)...
Bajenaru, Michaela Livia, Zhu, Yuan, Hedrick, Nicolé M., Donahoe, Jessica, Parada, Luis F., Gutmann, David H.
Individuals with the neurofibromatosis 1 (NF1) inherited tumor syndrome develop low-grade gliomas (astrocytomas) at an increased frequency, suggesting that the NF1 gene is a critical growth regulator...
BDNF regulates eating behavior and locomotor activity in mice
Kernie, Steven G., Liebl, Daniel J., Parada, Luis F.
Brain-derived neurotrophic factor (BDNF) was studied initially for its role in sensory neuron development. Ablation of this gene in mice leads to death shortly after birth, and abnormalities have...
Ma, Long, Reis, Gerald, Parada, Luis F., Schuman, Erin M.
Neurotrophic factors, including BDNF and NT-3, have been implicated in the regulation of synaptic transmission and plasticity. Previous attempts to analyze synaptic transmission and plasticity in...
Lei, Lei, Laub, Friedrich, Lush, Mark, Romero, Mario, Zhou, Jing, Luikart, Bryan, ...
TrkA, the high affinity receptor for nerve growth factor (NGF), is essential for the development of nociceptive sensory and sympathetic neurons. The zinc finger transcription factor Klf7 interacts...
Laub, Friedrich, Lei, Lei, Sumiyoshi, Hideaki, Kajimura, Daisuke, Dragomir, Cecilia, Smaldone, Silvia, ...
The Krüppel-like transcription factors (KLFs) are important regulators of cell proliferation and differentiation in several different organ systems. The mouse Klf7 gene is strongly active in...
Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth
Benson, M. Douglas, Romero, Mario I., Lush, Mark E., Lu, Q. Richard, Henkemeyer, Mark, Parada, Luis F.
The inability of CNS axons to regenerate after traumatic spinal cord injury is due, in part, to the inhibitory effects of myelin. The three major previously identified constituents of this activity...
Zhu, Yuan, Romero, Mario I., Ghosh, Pritam, Ye, Zhengyi, Charnay, Patrick, Rushing, Elizabeth J., ...
Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder that affects growth properties of neural-crest-derived cell populations. In addition, approximately one-half of NF1 patients exhibit...
Liebl, Daniel J., Klesse, Laura J., Tessarollo, Lino, Wohlman, Todd, Parada, Luis F.
Peripheral ganglion neurons confer sensory information including touch, pain, temperature, and proprioception. Sensory modality is linked to specific neurotrophin (NTF) requirements. NT-3 supports...
Tessarollo, Lino, Tsoulfas, Pantelis, Donovan, Michael J., Palko, Mary Ellen, Blair-Flynn, Janet, Hempstead, Barbara L., ...
We have generated null mutant mice that lack expression of all isoforms encoded by the trkC locus. These mice display a behavioral phenotype characterized by a loss of proprioceptive neurons....
Gonzalez-Zulueta, Mirella, Feldman, Alicia B., Klesse, Laura J., Kalb, Robert G., Dillman, James F., Parada, Luis F., ...
The mechanisms underlying neuronal ischemic preconditioning, a phenomenon in which brief episodes of ischemia protect against the lethal effects of subsequent periods of prolonged ischemia, are...
Kitamura, Tadahiro, Kido, Yoshiaki, Nef, Serge, Merenmies, Jussi, Parada, Luis F., Accili, Domenico
Receptors of the insulin/insulinlike growth factor (IGF) family have been implicated in the regulation of pancreatic β-cell growth and insulin secretion. The insulin receptor-related receptor (IRR)...
Bajenaru, Michaela Livia, Zhu, Yuan, Hedrick, Nicolé M., Donahoe, Jessica, Parada, Luis F., Gutmann, David H.
Individuals with the neurofibromatosis 1 (NF1) inherited tumor syndrome develop low-grade gliomas (astrocytomas) at an increased frequency, suggesting that the NF1 gene is a critical growth regulator...
BDNF regulates eating behavior and locomotor activity in mice
Kernie, Steven G., Liebl, Daniel J., Parada, Luis F.
Brain-derived neurotrophic factor (BDNF) was studied initially for its role in sensory neuron development. Ablation of this gene in mice leads to death shortly after birth, and abnormalities have...
Ma, Long, Reis, Gerald, Parada, Luis F., Schuman, Erin M.
Neurotrophic factors, including BDNF and NT-3, have been implicated in the regulation of synaptic transmission and plasticity. Previous attempts to analyze synaptic transmission and plasticity in...
Zhu, Yuan, Romero, Mario I., Ghosh, Pritam, Ye, Zhengyi, Charnay, Patrick, Rushing, Elizabeth J., ...
Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder that affects growth properties of neural-crest-derived cell populations. In addition, approximately one-half of NF1 patients exhibit...
Lei, Lei, Laub, Friedrich, Lush, Mark, Romero, Mario, Zhou, Jing, Luikart, Bryan, ...
TrkA, the high affinity receptor for nerve growth factor (NGF), is essential for the development of nociceptive sensory and sympathetic neurons. The zinc finger transcription factor Klf7 interacts...
Laub, Friedrich, Lei, Lei, Sumiyoshi, Hideaki, Kajimura, Daisuke, Dragomir, Cecilia, Smaldone, Silvia, ...
The Krüppel-like transcription factors (KLFs) are important regulators of cell proliferation and differentiation in several different organ systems. The mouse Klf7 gene is strongly active in...
Ephrin-B3 is a myelin-based inhibitor of neurite outgrowth
Benson, M. Douglas, Romero, Mario I., Lush, Mark E., Lu, Q. Richard, Henkemeyer, Mark, Parada, Luis F.
The inability of CNS axons to regenerate after traumatic spinal cord injury is due, in part, to the inhibitory effects of myelin. The three major previously identified constituents of this activity...
β common receptor inactivation attenuates myeloproliferative disease in Nf1 mutant mice
Kim, Andrew, Morgan, Kelly, Hasz, Diane E., Wiesner, Stephen M., Lauchle, Jennifer O., Geurts, Jennifer L., ...
Neurofibromatosis type 1 (NF1) syndrome is caused by germline mutations in the NF1 tumor suppressor, which encodes neurofibromin, a GTPase activating protein for Ras. Children with NF1 are...
NF1 loss disrupts Schwann cell–axonal interactions: a novel role for semaphorin 4F
Parrinello, Simona, Noon, Luke A., Harrisingh, Marie C., Digby, Patrick Wingfield, Rosenberg, Laura H., Cremona, Catherine A., ...
Neurofibromatosis type 1 (NF1) patients develop neurofibromas, tumors of Schwann cell origin, as a result of loss of the Ras-GAP neurofibromin. In normal nerves, Schwann cells are found tightly...
Farassati, Faris, Pan, Weihong, Yamoutpour, Farnaz, Henke, Susann, Piedra, Mark, Frahm, Silke, ...
Lack of expression of neurofibromin in neurofibromatosis 1 and its lethal derivative, malignant peripheral nerve sheath tumors (MPNSTs), is thought to result in the overactivation of the Ras...
PTEN dosage is essential for neurofibroma development and malignant transformation
Gregorian, Caroline, Nakashima, Jonathan, Dry, Sarah M., Nghiemphu, P. Leia, Smith, Kate Barzan, Ao, Yan, ...
Patients with neurofibromatosis type 1 (NF1) carry approximately a 10% lifetime risk of developing a malignant peripheral nerve sheath tumor (MPNST). Although the molecular mechanisms underlying NF1...