Lyn Griffiths

SHOX gene is expressed in vertebral body growth plates in idiopathic and congenital scoliosis: Implications for the etiology of scoliosis in Turner syndrome (2009)

Day, Gregory, Szvetko, Attila, Griffiths, Lyn, McPhee, I. Bruce, Tuffley, John, LaBrom, Robert, ...

Reduced SHOX gene expression has been demonstrated to be associated with all skeletal abnormalities in Turner syndrome, other than scoliosis (and kyphosis). There is evidence to suggest that Turner...

SHOX gene is expressed in vertebral body growth plates in idiopathic and congenital scoliosis: Implications for the etiology of scoliosis in Turner syndrome (2009)

Day, Gregory, Szvetko, Attila, Griffiths, Lyn, McPhee, I. Bruce, Tuffley, John, LaBrom, Robert, ...

Reduced SHOX gene expression has been demonstrated to be associated with all skeletal abnormalities in Turner syndrome, other than scoliosis (and kyphosis). There is evidence to suggest that Turner...

Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material (2008)

Haupt, Larisa, Irving, Rachel, Weinstein, Stephen Rudolph, Irving, Michael G., Griffiths, Lyn

Utilising archival human breast cancer biopsy material we examined the stromal/epithelial interactions of several matrix metalloproteinases (MMPs) using in situ-RT-PCR (IS-RT-PCR). In breast cancer,...

Novel NOD2 haplotype strengthens the association between TLR4 Asp299Gly and Crohn's disease in an Australian population. (2008)

Hume, Georgia E., Fowler, Elizabeth V., Doecke, James, Simms, Lisa A, Huang, Nina, Palmieri, Orazio, ...

Background: The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and other pattern recognition receptors in the pathogenesis of this chronic,...

Novel NOD2 haplotype strengthens the association between TLR4 Asp299Gly and Crohn's disease in an Australian population. (2008)

Hume, Georgia E., Fowler, Elizabeth V., Doecke, James, Simms, Lisa A, Huang, Nina, Palmieri, Orazio, ...

Background: The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and other pattern recognition receptors in the pathogenesis of this chronic,...

Linkage disequilibrium analysis in the genetically isolated Norfolk Island population (2008)

Bellis, Claire, Cox, Hannah, Ovcaric, Micky, Begley, Kimberly Nina, Lea, Rodney Arthur, Quinlan, Sharon Anne, ...

Norfolk Island is a human genetic isolate, possessing unique population characteristics that could be utilized for complex disease gene localization. Our intention was to evaluate the extent and...

Investigation of the NOTCH3 and TNFSF7 Genes on C19p13 as Candidates for Migraine (2008)

Smith, Robert Anthony, Curtain, Rob, Ovcaric, Micky, Tajouri, Lotfi, MacMillan, John, Griffiths, Lyn

To investigate the migraine locus around the C19p13 region through analysis of the NOTCH3 gene (C19p13.2- p13.1), previously shown to be a gene involved in CADASIL and the TNFSF7 gene (C19p13),...

Polymorphisms of the VDR gene are associated with presence of solar keratoses on the skin (2008)

Carless, Melanie, Kraska, Troy Morgan, Lintell, Nicholas, Neale, R.E., Green, A.C., Griffiths, Lyn

Background Vitamin D has a range of biological effects including antiproliferative functions that are mediated through its receptors, encoded by the VDR gene. Objectives We investigated polymorphisms...

Immunodeficiency-associated lymphomas (2008)

Tran, Huy, Nourse, Jamie, Hall, Sara, Green, Michael Richard, Griffiths, Lyn, Gandhi, Maher K

This article covers lymphoproliferative disorders in patients with primary or acquired immunodeficiencies. Primary immunodeficiences include Ataxia Telangiectasia and X-linked disorders such as...

Investigation between the S377G3 GATA-4 polymorphism and migraine (2008)

Chikhani, Sherin, Fernandez, Francesca, Karl, Poetter, Brendan, Toohey, Harvey, Richard, Griffiths, Lyn

Migraine is a common and painful neurological disorder, with genetic and environmental components. Several conditions have been shown to be comorbid with migraine, notably a cardiac malformation...

Linkage mapping of CVD risk traits in the isolated Norfolk Island population (2008)

Bellis, Claire, Cox, Hannah, Dyer, T. D., Charlesworth, J. C., Begley, Kimberly Nina, Quinlan, Sharon Anne, ...

To understand the underlying genetic architecture of cardiovascular disease (CVD) risk traits, we undertook a genome-wide linkage scan to identify CVD quantitative trait loci (QTLs) in 377...

Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility (2008)

Fernandez, Francesca, Esposito, Teresa, Lea, Rodney Arthur, Colson, Natalie Jane, Ciccodicola, Alfredo, Gianfrancesco, Fernando, ...

Background: Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong...

Linkage disequilibrium analysis in the genetically isolated Norfolk Island population (2008)

Bellis, Claire, Cox, Hannah, Ovcaric, Micky, Begley, Kimberly Nina, Lea, Rodney Arthur, Quinlan, Sharon Anne, ...

Norfolk Island is a human genetic isolate, possessing unique population characteristics that could be utilized for complex disease gene localization. Our intention was to evaluate the extent and...

Investigation of the NOTCH3 and TNFSF7 Genes on C19p13 as Candidates for Migraine (2008)

Smith, Robert Anthony, Curtain, Rob, Ovcaric, Micky, Tajouri, Lotfi, MacMillan, John, Griffiths, Lyn

To investigate the migraine locus around the C19p13 region through analysis of the NOTCH3 gene (C19p13.2- p13.1), previously shown to be a gene involved in CADASIL and the TNFSF7 gene (C19p13),...

Polymorphisms of the VDR gene are associated with presence of solar keratoses on the skin (2008)

Carless, Melanie, Kraska, Troy Morgan, Lintell, Nicholas, Neale, R.E., Green, A.C., Griffiths, Lyn

Background Vitamin D has a range of biological effects including antiproliferative functions that are mediated through its receptors, encoded by the VDR gene. Objectives We investigated polymorphisms...

Immunodeficiency-associated lymphomas (2008)

Tran, Huy, Nourse, Jamie, Hall, Sara, Green, Michael Richard, Griffiths, Lyn, Gandhi, Maher K

This article covers lymphoproliferative disorders in patients with primary or acquired immunodeficiencies. Primary immunodeficiences include Ataxia Telangiectasia and X-linked disorders such as...

Investigation between the S377G3 GATA-4 polymorphism and migraine (2008)

Chikhani, Sherin, Fernandez, Francesca, Karl, Poetter, Brendan, Toohey, Harvey, Richard, Griffiths, Lyn

Migraine is a common and painful neurological disorder, with genetic and environmental components. Several conditions have been shown to be comorbid with migraine, notably a cardiac malformation...

Linkage mapping of CVD risk traits in the isolated Norfolk Island population (2008)

Bellis, Claire, Cox, Hannah, Dyer, T. D., Charlesworth, J. C., Begley, Kimberly Nina, Quinlan, Sharon Anne, ...

To understand the underlying genetic architecture of cardiovascular disease (CVD) risk traits, we undertook a genome-wide linkage scan to identify CVD quantitative trait loci (QTLs) in 377...

Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility (2008)

Fernandez, Francesca, Esposito, Teresa, Lea, Rodney Arthur, Colson, Natalie Jane, Ciccodicola, Alfredo, Gianfrancesco, Fernando, ...

Background: Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong...

Matrix metalloproteinase localisation by in situ-RT-PCR in archival human breast biopsy material (2008)

Haupt, Larisa, Irving, Rachel, Weinstein, Stephen Rudolph, Irving, Michael G., Griffiths, Lyn

Utilising archival human breast cancer biopsy material we examined the stromal/epithelial interactions of several matrix metalloproteinases (MMPs) using in situ-RT-PCR (IS-RT-PCR). In breast cancer,...

Novel NOD2 haplotype strengthens the association between TLR4 Asp299Gly and Crohn's disease in an Australian population. (2008)

Hume, Georgia E., Fowler, Elizabeth V., Doecke, James, Simms, Lisa A, Huang, Nina, Palmieri, Orazio, ...

Background: The first major Crohn's disease (CD) susceptibility gene, NOD2, implicates the innate intestinal immune system and other pattern recognition receptors in the pathogenesis of this chronic,...

Linkage disequilibrium analysis in the genetically isolated Norfolk Island population (2008)

Bellis, Claire, Cox, Hannah, Ovcaric, Micky, Begley, Kimberly Nina, Lea, Rodney Arthur, Quinlan, Sharon Anne, ...

Norfolk Island is a human genetic isolate, possessing unique population characteristics that could be utilized for complex disease gene localization. Our intention was to evaluate the extent and...

Investigation of the NOTCH3 and TNFSF7 Genes on C19p13 as Candidates for Migraine (2008)

Smith, Robert Anthony, Curtain, Rob, Ovcaric, Micky, Tajouri, Lotfi, MacMillan, John, Griffiths, Lyn

To investigate the migraine locus around the C19p13 region through analysis of the NOTCH3 gene (C19p13.2- p13.1), previously shown to be a gene involved in CADASIL and the TNFSF7 gene (C19p13),...

Polymorphisms of the VDR gene are associated with presence of solar keratoses on the skin (2008)

Carless, Melanie, Kraska, Troy Morgan, Lintell, Nicholas, Neale, R.E., Green, A.C., Griffiths, Lyn

Background Vitamin D has a range of biological effects including antiproliferative functions that are mediated through its receptors, encoded by the VDR gene. Objectives We investigated polymorphisms...

Immunodeficiency-associated lymphomas (2008)

Tran, Huy, Nourse, Jamie, Hall, Sara, Green, Michael Richard, Griffiths, Lyn, Gandhi, Maher K

This article covers lymphoproliferative disorders in patients with primary or acquired immunodeficiencies. Primary immunodeficiences include Ataxia Telangiectasia and X-linked disorders such as...

Investigation between the S377G3 GATA-4 polymorphism and migraine (2008)

Chikhani, Sherin, Fernandez, Francesca, Karl, Poetter, Brendan, Toohey, Harvey, Richard, Griffiths, Lyn

Migraine is a common and painful neurological disorder, with genetic and environmental components. Several conditions have been shown to be comorbid with migraine, notably a cardiac malformation...

Linkage mapping of CVD risk traits in the isolated Norfolk Island population (2008)

Bellis, Claire, Cox, Hannah, Dyer, T. D., Charlesworth, J. C., Begley, Kimberly Nina, Quinlan, Sharon Anne, ...

To understand the underlying genetic architecture of cardiovascular disease (CVD) risk traits, we undertook a genome-wide linkage scan to identify CVD quantitative trait loci (QTLs) in 377...

Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility (2008)

Fernandez, Francesca, Esposito, Teresa, Lea, Rodney Arthur, Colson, Natalie Jane, Ciccodicola, Alfredo, Gianfrancesco, Fernando, ...

Background: Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong...

Allelic variation investigation of the estrogen receptor within an Australian multiple sclerosis population (2007)

Tajouri, Lotfi, Fernandez, Francesca, Tajouri, Sophie, Detriche, Geraldine, Szvetko, Attila Laszlo, Colson, Natalie Jane, ...

Multiple Sclerosis (MS) is a central nervous system (CNS) chronic inflammatory demyelinating disease leading to various neurological disabilities. The disorder is more prevalent for women with a...

Allelic variation investigation of the estrogen receptor within an Australian multiple sclerosis population (2007)

Tajouri, Lotfi, Fernandez, Francesca, Tajouri, Sophie, Detriche, Geraldine, Szvetko, Attila Laszlo, Colson, Natalie Jane, ...

Multiple Sclerosis (MS) is a central nervous system (CNS) chronic inflammatory demyelinating disease leading to various neurological disabilities. The disorder is more prevalent for women with a...

Gene expression studies in Multiple Sclerosis. (2007)

Tajouri, Lotfi, Fernandez, Francesca, Griffiths, Lyn

Multiple sclerosis (MS) is a serious neurological disorder affecting young Caucasian individuals, usually with an age of onset at 18 to 40 years old. Females account for approximately 60% of MS cases...

Mutations in Cardiac T-Box Factor Gene TBX20 are associated with Diverse Cardiac Pathologies, Including Defects of Septation and Valvulogenesis and Cardiomyopathy (2007)

Kirk, Edwin P., Sunde, Margaret, Costa, Mauro W., Rankin, Scott A, Wolstein, Orit, Castro, M. Leticia, ...

The T-box family transcription factor gene TBX20 acts in a conserved regulatory network, guiding heart formation and patterning in diverse species. Mouse Tbx20 is expressed in cardiac progenitor...

No association between MTHFR A1298C and MTRR A66G polymorphisms, and MS in an Australian cohort (2007)

Szvetko, Attila Laszlo, Fowdar, Javed, Nelson, Jessica, Colson, Natalie Jane, Tajouri, Lotfi, Csurhes, P.A., ...

Multiple sclerosis (MS) is a complex neurological disease that affects the central nervous system (CNS) resulting in debilitating neuropathology. Pathogenesis is primarily defined by CNS inflammation...

Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma. (2007)

Smith, Robert Anthony, Lea, Rodney Arthur, Weinstein, Stephen Rudolph, Griffiths, Lyn

Our laboratory has previously found that anti-mitogenic nuclear receptor mRNA is elevated in late stage tumours and this study was performed to scrutinize the possibility of cancer-stroma crosstalk...

Association analysis of chromosome 1 migraine candidate genes (2007)

Fernandez, Francesca, Curtain, Rob, Colson, Natalie Jane, Ovcaric, Micky, MacMillan, John, Griffiths, Lyn

Background Migraine with aura (MA) is a subtype of typical migraine. Migraine with aura (MA) also encompasses a rare severe subtype Familial Hemiplegic Migraine (FHM) with several known genetic loci....

Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility (2007)

McCallum, L. K., Fernandez, Francesca, Quinlan, Sharon Anne, Macartney, D. P., Lea, Rodney Arthur, Griffiths, Lyn

Migraine is a common, genetically influenced neurovascular disorder. The dopamine transporter gene is a candidate for migraine association studies. This study tested a functionally linked variable...

Pharmacogenetics of Migraine: genetic variants and their potential role in migraine therapy (2007)

Fernandez, Francesca, Colson, Natalie Jane, Griffiths, Lyn

Migraine is a paroxysmal neurological disorder affecting up to 6% of males and 18% of females in the general population, and has been demonstrated to have a strong, but complex, genetic component....

A pharmacogenomic evaluation of migraine therapy (2007)

Johnson, Matthew Peter, Fernandez, Francesca, Colson, Natalie Jane, Griffiths, Lyn

Migraine is a common idiopathic primary headache disorder with significant mental, physical and social health implications. Accompanying an intense unilateral pulsating head pain other characteristic...

Allelic variation investigation of the estrogen receptor within an Australian multiple sclerosis population (2007)

Tajouri, Lotfi, Fernandez, Francesca, Tajouri, Sophie, Detriche, Geraldine, Szvetko, Attila Laszlo, Colson, Natalie Jane, ...

Multiple Sclerosis (MS) is a central nervous system (CNS) chronic inflammatory demyelinating disease leading to various neurological disabilities. The disorder is more prevalent for women with a...

Gene expression studies in Multiple Sclerosis. (2007)

Tajouri, Lotfi, Fernandez, Francesca, Griffiths, Lyn

Multiple sclerosis (MS) is a serious neurological disorder affecting young Caucasian individuals, usually with an age of onset at 18 to 40 years old. Females account for approximately 60% of MS cases...

Mutations in Cardiac T-Box Factor Gene TBX20 are associated with Diverse Cardiac Pathologies, Including Defects of Septation and Valvulogenesis and Cardiomyopathy (2007)

Kirk, Edwin P., Sunde, Margaret, Costa, Mauro W., Rankin, Scott A, Wolstein, Orit, Castro, M. Leticia, ...

The T-box family transcription factor gene TBX20 acts in a conserved regulatory network, guiding heart formation and patterning in diverse species. Mouse Tbx20 is expressed in cardiac progenitor...

No association between MTHFR A1298C and MTRR A66G polymorphisms, and MS in an Australian cohort (2007)

Szvetko, Attila Laszlo, Fowdar, Javed, Nelson, Jessica, Colson, Natalie Jane, Tajouri, Lotfi, Csurhes, P.A., ...

Multiple sclerosis (MS) is a complex neurological disease that affects the central nervous system (CNS) resulting in debilitating neuropathology. Pathogenesis is primarily defined by CNS inflammation...

Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma. (2007)

Smith, Robert Anthony, Lea, Rodney Arthur, Weinstein, Stephen Rudolph, Griffiths, Lyn

Our laboratory has previously found that anti-mitogenic nuclear receptor mRNA is elevated in late stage tumours and this study was performed to scrutinize the possibility of cancer-stroma crosstalk...

Association analysis of chromosome 1 migraine candidate genes (2007)

Fernandez, Francesca, Curtain, Rob, Colson, Natalie Jane, Ovcaric, Micky, MacMillan, John, Griffiths, Lyn

Background Migraine with aura (MA) is a subtype of typical migraine. Migraine with aura (MA) also encompasses a rare severe subtype Familial Hemiplegic Migraine (FHM) with several known genetic loci....

Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility (2007)

McCallum, L. K., Fernandez, Francesca, Quinlan, Sharon Anne, Macartney, D. P., Lea, Rodney Arthur, Griffiths, Lyn

Migraine is a common, genetically influenced neurovascular disorder. The dopamine transporter gene is a candidate for migraine association studies. This study tested a functionally linked variable...

Pharmacogenetics of Migraine: genetic variants and their potential role in migraine therapy (2007)

Fernandez, Francesca, Colson, Natalie Jane, Griffiths, Lyn

Migraine is a paroxysmal neurological disorder affecting up to 6% of males and 18% of females in the general population, and has been demonstrated to have a strong, but complex, genetic component....

A pharmacogenomic evaluation of migraine therapy (2007)

Johnson, Matthew Peter, Fernandez, Francesca, Colson, Natalie Jane, Griffiths, Lyn

Migraine is a common idiopathic primary headache disorder with significant mental, physical and social health implications. Accompanying an intense unilateral pulsating head pain other characteristic...

The search for migraine genes: an overview of current knowledge (2007)

Colson, Natalie Jane, Fernandez, Francesca, Lea, Rodney Arthur, Griffiths, Lyn

Migraine is a complex familial condition that imparts a significant burden on society. There is evidence for a role of genetic factors in migraine, and elucidating the genetic basis of this disabling...

The search for migraine genes: an overview of current knowledge (2007)

Colson, Natalie Jane, Fernandez, Francesca, Lea, Rodney Arthur, Griffiths, Lyn

Migraine is a complex familial condition that imparts a significant burden on society. There is evidence for a role of genetic factors in migraine, and elucidating the genetic basis of this disabling...

Migraine genetics and prospects for pharmacotherapy (2007)

Colson, Natalie Jane, Fernandez, Francesca, Griffiths, Lyn

Migraine is a common complex neurological disorder with a well-known but poorly characterized genetic liability. The search for migraine susceptibility genes has been the focus of intense research....

Migraine genetics and prospects for pharmacotherapy (2007)

Colson, Natalie Jane, Fernandez, Francesca, Griffiths, Lyn

Migraine is a common complex neurological disorder with a well-known but poorly characterized genetic liability. The search for migraine susceptibility genes has been the focus of intense research....

Allelic variation investigation of the estrogen receptor within an Australian multiple sclerosis population (2007)

Tajouri, Lotfi, Fernandez, Francesca, Tajouri, Sophie, Detriche, Geraldine, Szvetko, Attila Laszlo, Colson, Natalie Jane, ...

Multiple Sclerosis (MS) is a central nervous system (CNS) chronic inflammatory demyelinating disease leading to various neurological disabilities. The disorder is more prevalent for women with a...

Gene expression studies in Multiple Sclerosis. (2007)

Tajouri, Lotfi, Fernandez, Francesca, Griffiths, Lyn

Multiple sclerosis (MS) is a serious neurological disorder affecting young Caucasian individuals, usually with an age of onset at 18 to 40 years old. Females account for approximately 60% of MS cases...

Mutations in Cardiac T-Box Factor Gene TBX20 are associated with Diverse Cardiac Pathologies, Including Defects of Septation and Valvulogenesis and Cardiomyopathy (2007)

Kirk, Edwin P., Sunde, Margaret, Costa, Mauro W., Rankin, Scott A, Wolstein, Orit, Castro, M. Leticia, ...

The T-box family transcription factor gene TBX20 acts in a conserved regulatory network, guiding heart formation and patterning in diverse species. Mouse Tbx20 is expressed in cardiac progenitor...

No association between MTHFR A1298C and MTRR A66G polymorphisms, and MS in an Australian cohort (2007)

Szvetko, Attila Laszlo, Fowdar, Javed, Nelson, Jessica, Colson, Natalie Jane, Tajouri, Lotfi, Csurhes, P.A., ...

Multiple sclerosis (MS) is a complex neurological disease that affects the central nervous system (CNS) resulting in debilitating neuropathology. Pathogenesis is primarily defined by CNS inflammation...

Progesterone, glucocorticoid, but not estrogen receptor mRNA is altered in breast cancer stroma (2007)

Smith, Robert Anthony, Lea, Rodney Arthur, Weinstein, Stephen Rudolph, Griffiths, Lyn

Our laboratory has previously found that anti-mitogenic nuclear receptor mRNA is elevated in late stage tumours and this study was performed to scrutinize the possibility of cancer-stroma crosstalk...

Association analysis of chromosome 1 migraine candidate genes (2007)

Fernandez, Francesca, Curtain, Rob, Colson, Natalie Jane, Ovcaric, Micky, MacMillan, John, Griffiths, Lyn

Background Migraine with aura (MA) is a subtype of typical migraine. Migraine with aura (MA) also encompasses a rare severe subtype Familial Hemiplegic Migraine (FHM) with several known genetic loci....

Association study of a functional variant in intron 8 of the dopamine transporter gene and migraine susceptibility (2007)

McCallum, L. K., Fernandez, Francesca, Quinlan, Sharon Anne, Macartney, D. P., Lea, Rodney Arthur, Griffiths, Lyn

Migraine is a common, genetically influenced neurovascular disorder. The dopamine transporter gene is a candidate for migraine association studies. This study tested a functionally linked variable...

Pharmacogenetics of Migraine: genetic variants and their potential role in migraine therapy (2007)

Fernandez, Francesca, Colson, Natalie Jane, Griffiths, Lyn

Migraine is a paroxysmal neurological disorder affecting up to 6% of males and 18% of females in the general population, and has been demonstrated to have a strong, but complex, genetic component....

A pharmacogenomic evaluation of migraine therapy (2007)

Johnson, Matthew Peter, Fernandez, Francesca, Colson, Natalie Jane, Griffiths, Lyn

Migraine is a common idiopathic primary headache disorder with significant mental, physical and social health implications. Accompanying an intense unilateral pulsating head pain other characteristic...

The search for migraine genes: an overview of current knowledge (2007)

Colson, Natalie Jane, Fernandez, Francesca, Lea, Rodney Arthur, Griffiths, Lyn

Migraine is a complex familial condition that imparts a significant burden on society. There is evidence for a role of genetic factors in migraine, and elucidating the genetic basis of this disabling...

Migraine genetics and prospects for pharmacotherapy (2007)

Colson, Natalie Jane, Fernandez, Francesca, Griffiths, Lyn

Migraine is a common complex neurological disorder with a well-known but poorly characterized genetic liability. The search for migraine susceptibility genes has been the focus of intense research....

No role for estrogen receptor I gene intron I Pvu II and exon 4 C325G polymorphisms in migraine susceptibility (2006)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, Griffiths, Lyn

Background We have previously reported an association between the estrogen receptor 1 (ESR1) gene exon 8 G594A polymorphism and migraine susceptibility in two independent Australian cohorts. In this...

The role of vascular and hormonal genes in migraine susceptibility. (2006)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, Griffiths, Lyn

Migraine is a primary headache disorder that involves both genetic and environmental components. Migraine is considered to be a polygenic disorder with a number of susceptibility genes having a minor...

Minor Head Trauma Induced Sporadic Hemiplegic Migraine (SHM) Coma (2006)

Curtain, Rob, Smith, Robert Anthony, Ovcaric, Micky, Griffiths, Lyn

Familial hemiplegic migraine is a severe, rare subtype of migraine. Gene mutations on chromosome 19 have been identified in the calcium channel, voltage-dependent, P/Q type, alpha-1A subunit gene...

Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis (2006)

Tajouri, Lotfi, Martin, Virginie, Gasparini, Claudia Francesca, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, ...

Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination. The C677T substitution variant in the methylenetetrahydrofolate...

Phenotypical Characterisation of the Isolated Norfolk Island Population Focusing on Epidemiological Indicators of Cardiovascular Disease (2006)

Bellis, Claire, Hughes, Roger Michael, Begley, Kimberly Nina, Quinlan, Sharon Anne, Lea, Rodney Arthur, Heath, Simon C., ...

Objectives: Only 193 people from Pitcairn Island, all descended from 9 'Bounty' mutineers and 12 Tahitian women, moved to the uninhabited Norfolk Island in 1856. Our objective was to assess the...

No mutations detected in the INSR gene in a chromosome 19p13 linked migraine pedigree (2006)

Curtain, Rob, Tajouri, Lotfi, Lea, Rodney Arthur, MacMillan, John, Griffiths, Lyn

The aim of this study was to investigate through direct sequencing the insulin receptor (INSR) gene in DNA samples from a migraine affected family previously showing linkage to chromosome 19p13 in an...

Phenotypical Characterisation of the Isolated Norfolk Island Population Focusing on Epidemiological Indicators of Cardiovascular Disease (2006)

Bellis, Claire, Hughes, Roger Michael, Begley, Kimberly Nina, Quinlan, Sharon Anne, Lea, Rodney Arthur, Heath, Simon C., ...

Objectives: Only 193 people from Pitcairn Island, all descended from 9 'Bounty' mutineers and 12 Tahitian women, moved to the uninhabited Norfolk Island in 1856. Our objective was to assess the...

No role for estrogen receptor I gene intron I Pvu II and exon 4 C325G polymorphisms in migraine susceptibility (2006)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, Griffiths, Lyn

Background We have previously reported an association between the estrogen receptor 1 (ESR1) gene exon 8 G594A polymorphism and migraine susceptibility in two independent Australian cohorts. In this...

The role of vascular and hormonal genes in migraine susceptibility. (2006)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, Griffiths, Lyn

Migraine is a primary headache disorder that involves both genetic and environmental components. Migraine is considered to be a polygenic disorder with a number of susceptibility genes having a minor...

Minor Head Trauma Induced Sporadic Hemiplegic Migraine (SHM) Coma (2006)

Curtain, Rob, Smith, Robert Anthony, Ovcaric, Micky, Griffiths, Lyn

Familial hemiplegic migraine is a severe, rare subtype of migraine. Gene mutations on chromosome 19 have been identified in the calcium channel, voltage-dependent, P/Q type, alpha-1A subunit gene...

Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis (2006)

Tajouri, Lotfi, Martin, Virginie, Gasparini, Claudia Francesca, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, ...

Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination. The C677T substitution variant in the methylenetetrahydrofolate...

Phenotypical Characterisation of the Isolated Norfolk Island Population Focusing on Epidemiological Indicators of Cardiovascular Disease (2006)

Bellis, Claire, Hughes, Roger Michael, Begley, Kimberly Nina, Quinlan, Sharon Anne, Lea, Rodney Arthur, Heath, Simon C., ...

Objectives: Only 193 people from Pitcairn Island, all descended from 9 'Bounty' mutineers and 12 Tahitian women, moved to the uninhabited Norfolk Island in 1856. Our objective was to assess the...

No mutations detected in the INSR gene in a chromosome 19p13 linked migraine pedigree (2006)

Curtain, Rob, Tajouri, Lotfi, Lea, Rodney Arthur, MacMillan, John, Griffiths, Lyn

The aim of this study was to investigate through direct sequencing the insulin receptor (INSR) gene in DNA samples from a migraine affected family previously showing linkage to chromosome 19p13 in an...

Detection of mRNA levels for the estrogen alpha, estrogen beta and androgen nuclear receptor genes in archival breast cancer tissue (2006)

Smith, Robert Anthony, Lea, Rodney Arthur, Weinstein, Stephen Rudolph, Griffiths, Lyn

Previous studies in our laboratory have shown association of nuclear receptor expression and histological breast cancer grade. To further investigate these findings, it was the objective of this...

No role for estrogen receptor I gene intron I Pvu II and exon 4 C325G polymorphisms in migraine susceptibility (2006)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, Griffiths, Lyn

Background We have previously reported an association between the estrogen receptor 1 (ESR1) gene exon 8 G594A polymorphism and migraine susceptibility in two independent Australian cohorts. In this...

The role of vascular and hormonal genes in migraine susceptibility. (2006)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, Griffiths, Lyn

Migraine is a primary headache disorder that involves both genetic and environmental components. Migraine is considered to be a polygenic disorder with a number of susceptibility genes having a minor...

Minor Head Trauma Induced Sporadic Hemiplegic Migraine (SHM) Coma (2006)

Curtain, Rob, Smith, Robert Anthony, Ovcaric, Micky, Griffiths, Lyn

Familial hemiplegic migraine is a severe, rare subtype of migraine. Gene mutations on chromosome 19 have been identified in the calcium channel, voltage-dependent, P/Q type, alpha-1A subunit gene...

Genetic investigation of methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) in multiple sclerosis (2006)

Tajouri, Lotfi, Martin, Virginie, Gasparini, Claudia Francesca, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, ...

Multiple sclerosis (MS) is a chronic neurological disease characterized by central nervous system (CNS) inflammation and demyelination. The C677T substitution variant in the methylenetetrahydrofolate...

Phenotypical Characterisation of the Isolated Norfolk Island Population Focusing on Epidemiological Indicators of Cardiovascular Disease (2006)

Bellis, Claire, Hughes, Roger Michael, Begley, Kimberly Nina, Quinlan, Sharon Anne, Lea, Rodney Arthur, Heath, Simon C., ...

Objectives: Only 193 people from Pitcairn Island, all descended from 9 'Bounty' mutineers and 12 Tahitian women, moved to the uninhabited Norfolk Island in 1856. Our objective was to assess the...

No mutations detected in the INSR gene in a chromosome 19p13 linked migraine pedigree (2006)

Curtain, Rob, Tajouri, Lotfi, Lea, Rodney Arthur, MacMillan, John, Griffiths, Lyn

The aim of this study was to investigate through direct sequencing the insulin receptor (INSR) gene in DNA samples from a migraine affected family previously showing linkage to chromosome 19p13 in an...

Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3and migraine susceptibility (2005)

Curtain, Robert, Sundholm, James, Lea, Rod, Ovcaric, Mick, MacMillan, John, Griffiths, Lyn

Abstract Background Migraine is a polygenic multifactorial disease, possessing environmental and genetic causative factors with multiple involved genes. Mutations in various ion channel genes are...

Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population. (2005)

Tajouri, Lotfi, Ovcaric, Micky, Curtain, Rob, Johnson, Matthew Peter, Griffiths, Lyn, Csurhes, Peter, ...

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) resulting in accumulating neurological disability. The disorder is more prevalent at higher...

An examination of MS candidate genes identified as differentially regulated in multiple sclerosis plaque tissue, using absolute and comparative real-time Q-PCR analysis. (2005)

Tajouri, Lotfi, Mellick, Albert, Tourtellotte, A., Nagra, R. M., Griffiths, Lyn

We have developed methods in real time detection of quantitative-polymerase chain reaction (Q-PCR) to analyse the relative levels of gene expression in post mortem brain tissue. We have then examined...

Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility. (2005)

Curtain, Rob, Sundholm, James Rodney, Lea, Rodney Arthur, Ovcaric, Micky, MacMillan, John, Griffiths, Lyn

Background Migraine is a polygenic multifactorial disease, possessing environmental and genetic causative factors with multiple involved genes. Mutations in various ion channel genes are responsible...

Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility. (2005)

Lea, Rodney Arthur, Ovcaric, Micky, Sundholm, James Rodney, Solyom, Leah, MacMillian, John, Griffiths, Lyn

Migraine, with and without aura (MA and MO), is a prevalent and complex neurovascular disorder that is likely to be influenced by multiple genes some of which may be capable of causing vascular...

A genome-wide scan provides evidence for loci influencing a severe heritable form of common migraine. (2005)

Lea, Rodney Arthur, Nyholt, D. R., Curtain, Rob, Ovcaric, Micky, Sciascia, Rachel, Bellis, Claire, ...

Migraine is a prevalent neurovascular disease with a significant genetic component. Linkage studies have so far identified migraine susceptibility loci on chromosomes 1, 4, 6, 11, 14, 19 and X. We...

Investigation of hormone receptor genes in migraine. (2005)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, MacMillan, John, Griffiths, Lyn

Migraine is a common neurological condition with a complex mode of inheritance. Steroid hormones have long been implicated in migraine, although their role remains unclear. Our investigation...

Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population. (2005)

Tajouri, Lotfi, Ovcaric, Micky, Curtain, Rob, Johnson, Matthew Peter, Griffiths, Lyn, Csurhes, Peter, ...

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) resulting in accumulating neurological disability. The disorder is more prevalent at higher...

An examination of MS candidate genes identified as differentially regulated in multiple sclerosis plaque tissue, using absolute and comparative real-time Q-PCR analysis. (2005)

Tajouri, Lotfi, Mellick, Albert, Tourtellotte, A., Nagra, R. M., Griffiths, Lyn

We have developed methods in real time detection of quantitative-polymerase chain reaction (Q-PCR) to analyse the relative levels of gene expression in post mortem brain tissue. We have then examined...

Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility. (2005)

Curtain, Rob, Sundholm, James Rodney, Lea, Rodney Arthur, Ovcaric, Micky, MacMillan, John, Griffiths, Lyn

Background Migraine is a polygenic multifactorial disease, possessing environmental and genetic causative factors with multiple involved genes. Mutations in various ion channel genes are responsible...

Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility. (2005)

Lea, Rodney Arthur, Ovcaric, Micky, Sundholm, James Rodney, Solyom, Leah, MacMillian, John, Griffiths, Lyn

Migraine, with and without aura (MA and MO), is a prevalent and complex neurovascular disorder that is likely to be influenced by multiple genes some of which may be capable of causing vascular...

A genome-wide scan provides evidence for loci influencing a severe heritable form of common migraine. (2005)

Lea, Rodney Arthur, Nyholt, D. R., Curtain, Rob, Ovcaric, Micky, Sciascia, Rachel, Bellis, Claire, ...

Migraine is a prevalent neurovascular disease with a significant genetic component. Linkage studies have so far identified migraine susceptibility loci on chromosomes 1, 4, 6, 11, 14, 19 and X. We...

Investigation of hormone receptor genes in migraine. (2005)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, MacMillan, John, Griffiths, Lyn

Migraine is a common neurological condition with a complex mode of inheritance. Steroid hormones have long been implicated in migraine, although their role remains unclear. Our investigation...

Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population. (2005)

Tajouri, Lotfi, Ovcaric, Micky, Curtain, Rob, Johnson, Matthew Peter, Griffiths, Lyn, Csurhes, Peter, ...

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) resulting in accumulating neurological disability. The disorder is more prevalent at higher...

An examination of MS candidate genes identified as differentially regulated in multiple sclerosis plaque tissue, using absolute and comparative real-time Q-PCR analysis. (2005)

Tajouri, Lotfi, Mellick, Albert, Tourtellotte, A., Nagra, R. M., Griffiths, Lyn

We have developed methods in real time detection of quantitative-polymerase chain reaction (Q-PCR) to analyse the relative levels of gene expression in post mortem brain tissue. We have then examined...

Association analysis of a highly polymorphic CAG Repeat in the human potassium channel gene KCNN3 and migraine susceptibility. (2005)

Curtain, Rob, Sundholm, James Rodney, Lea, Rodney Arthur, Ovcaric, Micky, MacMillan, John, Griffiths, Lyn

Background Migraine is a polygenic multifactorial disease, possessing environmental and genetic causative factors with multiple involved genes. Mutations in various ion channel genes are responsible...

Genetic variants of angiotensin converting enzyme and methylenetetrahydrofolate reductase may act in combination to increase migraine susceptibility. (2005)

Lea, Rodney Arthur, Ovcaric, Micky, Sundholm, James Rodney, Solyom, Leah, MacMillian, John, Griffiths, Lyn

Migraine, with and without aura (MA and MO), is a prevalent and complex neurovascular disorder that is likely to be influenced by multiple genes some of which may be capable of causing vascular...

A genome-wide scan provides evidence for loci influencing a severe heritable form of common migraine. (2005)

Lea, Rodney Arthur, Nyholt, D. R., Curtain, Rob, Ovcaric, Micky, Sciascia, Rachel, Bellis, Claire, ...

Migraine is a prevalent neurovascular disease with a significant genetic component. Linkage studies have so far identified migraine susceptibility loci on chromosomes 1, 4, 6, 11, 14, 19 and X. We...

Investigation of hormone receptor genes in migraine. (2005)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, MacMillan, John, Griffiths, Lyn

Migraine is a common neurological condition with a complex mode of inheritance. Steroid hormones have long been implicated in migraine, although their role remains unclear. Our investigation...

Variation in the vitamin D receptor gene is associated with multiple sclerosis in an Australian population. (2005)

Tajouri, Lotfi, Ovcaric, Micky, Curtain, Rob, Johnson, Matthew Peter, Griffiths, Lyn, Csurhes, Peter, ...

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) resulting in accumulating neurological disability. The disorder is more prevalent at higher...

An examination of MS candidate genes identified as differentially regulated in multiple sclerosis plaque tissue, using absolute and comparative real-time Q-PCR analysis. (2005)

Tajouri, Lotfi, Mellick, Albert, Tourtellotte, A., Nagra, R. M., Griffiths, Lyn

We have developed methods in real time detection of quantitative-polymerase chain reaction (Q-PCR) to analyse the relative levels of gene expression in post mortem brain tissue. We have then examined...

Use of the Norfolk Island Genetic Isolate to Identify Genetic Risk Factors for CVD. (2005)

Griffiths, Lyn, Bellis, Claire, Lea, Rodney Arthur, Hughes, Roger Michael, Quinlan, Sharon Anne, Heath, S., ...

Geographical isolation and limited environmental variation make genetic isolates powerful tools for gene mapping. Our research is aimed at identifying the genes that play a role in cardiovascular...

Locked nucleic acid (LNA) single nucleotide polymorphism (SNP) genotype analysis and validation using real-time PCR (2004)

Johnson, Matthew Peter, Haupt, Larisa, Griffiths, Lyn

With an increased emphasis on genotyping of single nucleotide polymorphisms (SNPs) in disease association studies, the genotyping platform of choice is constantly evolving. In addition, the...

Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine (2004)

Curtain, Rob, Lea, Rodney Arthur, Quinlan, Sharon, Bellis, Claire, Tajouri, Lotfi, Hughes, Roger Michael, ...

The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene...

Investigation of an unducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population (2004)

Tajouri, Lotfi, Martin, Virginie, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, Csurhes, Peter, ...

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting most commonly the Caucasian population. Nitric oxide (NO) is a biological signaling and...

The estrogen receptor 1 G594A polymorphism is associated with migraine susceptibility in two independant case/control groups (2004)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, MacMillian, John, Griffiths, Lyn

Migraine is a painful and debilitating disorder with a significant genetic component. Steroid hormones, in particular estrogen, have long been considered to play a role in migraine, as variations in...

Investigation of a neuronal nitric oxide synthase gene (NOS1) polymorphism in a multiple sclerosis population (2004)

Tajouri, Lotfi, Ferreira, Linda Anne, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, Csurhes, Peter, ...

Multiple Sclerosis (MS) is a chronic neurological disease characterized by demyelination associated with infiltrating white blood cells in the central nervous system (CNS). Nitric oxide synthases...

Age-related changes in cardiac adenosine receptor expression (2004)

Jenner, Tamsin, Mellick, Albert, Harrison, Glenn, Griffiths, Lyn, Rose'Meyer, Roselyn

Adenosine is an important cardioprotective agent that works via several adenosine receptor (ADOR) subtypes to regulate cardiovascular activity. It is well established that functional responses to...

Locked nucleic acid (LNA) single nucleotide polymorphism (SNP) genotype analysis and validation using real-time PCR (2004)

Johnson, Matthew Peter, Haupt, Larisa, Griffiths, Lyn

With an increased emphasis on genotyping of single nucleotide polymorphisms (SNPs) in disease association studies, the genotyping platform of choice is constantly evolving. In addition, the...

The Methylentetrahydrofolate Reductase Gene Variant (C677T) as a Risk Factor for Essential Hypertension in Caucasions (2004)

Heuy, Stephanie, Morin, Fabien, Lea, Rodney Arthur, Ovcaric, Micky, Tajouri, Lotfi, Griffiths, Lyn

Essential hypertension (EH) is a common, multifactorial disorder likely to be influenced by multiple genes of modest effect. The methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation is...

Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine (2004)

Curtain, Rob, Lea, Rodney Arthur, Quinlan, Sharon, Bellis, Claire, Tajouri, Lotfi, Hughes, Roger Michael, ...

The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene...

Investigation of an unducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population (2004)

Tajouri, Lotfi, Martin, Virginie, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, Csurhes, Peter, ...

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting most commonly the Caucasian population. Nitric oxide (NO) is a biological signaling and...

The estrogen receptor 1 G594A polymorphism is associated with migraine susceptibility in two independent case/control groups (2004)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, MacMillan, John, Griffiths, Lyn

Migraine is a painful and debilitating disorder with a significant genetic component. Steroid hormones, in particular estrogen, have long been considered to play a role in migraine, as variations in...

The methylenetetrahydofolate reductase gene variant C677T influences susceptibility to migraine with aura (2004)

Lea, Rodney Arthur, Ovcaric, Micky, Sundholm, James, MacMillan, John, Griffiths, Lyn

Background The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease....

Investigation of a neuronal nitric oxide synthase gene (NOS1) polymorphism in a multiple sclerosis population (2004)

Tajouri, Lotfi, Ferreira, Linda Anne, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, Csurhes, Peter, ...

Multiple Sclerosis (MS) is a chronic neurological disease characterized by demyelination associated with infiltrating white blood cells in the central nervous system (CNS). Nitric oxide synthases...

Age-related changes in cardiac adenosine receptor expression (2004)

Jenner, Tamsin, Mellick, Albert, Harrison, Glenn, Griffiths, Lyn, Rose'Meyer, Roselyn

Adenosine is an important cardioprotective agent that works via several adenosine receptor (ADOR) subtypes to regulate cardiovascular activity. It is well established that functional responses to...

Locked nucleic acid (LNA) single nucleotide polymorphism (SNP) genotype analysis and validation using real-time PCR (2004)

Johnson, Matthew Peter, Haupt, Larisa, Griffiths, Lyn

With an increased emphasis on genotyping of single nucleotide polymorphisms (SNPs) in disease association studies, the genotyping platform of choice is constantly evolving. In addition, the...

The Methylentetrahydrofolate Reductase Gene Variant (C677T) as a Risk Factor for Essential Hypertension in Caucasions (2004)

Heuy, Stephanie, Morin, Fabien, Lea, Rodney Arthur, Ovcaric, Micky, Tajouri, Lotfi, Griffiths, Lyn

Essential hypertension (EH) is a common, multifactorial disorder likely to be influenced by multiple genes of modest effect. The methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation is...

Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine (2004)

Curtain, Rob, Lea, Rodney Arthur, Quinlan, Sharon, Bellis, Claire, Tajouri, Lotfi, Hughes, Roger Michael, ...

The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene...

Investigation of an unducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population (2004)

Tajouri, Lotfi, Martin, Virginie, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, Csurhes, Peter, ...

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting most commonly the Caucasian population. Nitric oxide (NO) is a biological signaling and...

The estrogen receptor 1 G594A polymorphism is associated with migraine susceptibility in two independent case/control groups (2004)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, MacMillan, John, Griffiths, Lyn

Migraine is a painful and debilitating disorder with a significant genetic component. Steroid hormones, in particular estrogen, have long been considered to play a role in migraine, as variations in...

The methylenetetrahydofolate reductase gene variant C677T influences susceptibility to migraine with aura (2004)

Lea, Rodney Arthur, Ovcaric, Micky, Sundholm, James, MacMillan, John, Griffiths, Lyn

Background The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease....

Investigation of a neuronal nitric oxide synthase gene (NOS1) polymorphism in a multiple sclerosis population (2004)

Tajouri, Lotfi, Ferreira, Linda Anne, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, Csurhes, Peter, ...

Multiple Sclerosis (MS) is a chronic neurological disease characterized by demyelination associated with infiltrating white blood cells in the central nervous system (CNS). Nitric oxide synthases...

Age-related changes in cardiac adenosine receptor expression (2004)

Jenner, Tamsin, Mellick, Albert, Harrison, Glenn, Griffiths, Lyn, Rose'Meyer, Roselyn

Adenosine is an important cardioprotective agent that works via several adenosine receptor (ADOR) subtypes to regulate cardiovascular activity. It is well established that functional responses to...

Locked nucleic acid (LNA) single nucleotide polymorphism (SNP) genotype analysis and validation using real-time PCR (2004)

Johnson, Matthew Peter, Haupt, Larisa, Griffiths, Lyn

With an increased emphasis on genotyping of single nucleotide polymorphisms (SNPs) in disease association studies, the genotyping platform of choice is constantly evolving. In addition, the...

The Methylentetrahydrofolate Reductase Gene Variant (C677T) as a Risk Factor for Essential Hypertension in Caucasions (2004)

Heuy, Stephanie, Morin, Fabien, Lea, Rodney Arthur, Ovcaric, Micky, Tajouri, Lotfi, Griffiths, Lyn

Essential hypertension (EH) is a common, multifactorial disorder likely to be influenced by multiple genes of modest effect. The methylenetetrahydrofolate reductase (MTHFR) gene C677T mutation is...

Investigation of the low-density lipoprotein receptor gene and cholesterol as a risk factor for migraine (2004)

Curtain, Rob, Lea, Rodney Arthur, Quinlan, Sharon, Bellis, Claire, Tajouri, Lotfi, Hughes, Roger Michael, ...

The Low-Density Lipoprotein Receptor (LDLR) gene is a cell surface receptor that plays an important role in cholesterol homeostasis. We investigated the (TA)n polymorphism in exon 18 of the LDLR gene...

Investigation of an unducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population (2004)

Tajouri, Lotfi, Martin, Virginie, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, Csurhes, Peter, ...

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting most commonly the Caucasian population. Nitric oxide (NO) is a biological signaling and...

The estrogen receptor 1 G594A polymorphism is associated with migraine susceptibility in two independent case/control groups (2004)

Colson, Natalie Jane, Lea, Rodney Arthur, Quinlan, Sharon Anne, MacMillan, John, Griffiths, Lyn

Migraine is a painful and debilitating disorder with a significant genetic component. Steroid hormones, in particular estrogen, have long been considered to play a role in migraine, as variations in...

The methylenetetrahydofolate reductase gene variant C677T influences susceptibility to migraine with aura (2004)

Lea, Rodney Arthur, Ovcaric, Micky, Sundholm, James, MacMillan, John, Griffiths, Lyn

Background The C677T variant in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with increased levels of circulating homocysteine and is a mild risk factor for vascular disease....

Investigation of a neuronal nitric oxide synthase gene (NOS1) polymorphism in a multiple sclerosis population (2004)

Tajouri, Lotfi, Ferreira, Linda Anne, Ovcaric, Micky, Curtain, Rob, Lea, Rodney Arthur, Csurhes, Peter, ...

Multiple Sclerosis (MS) is a chronic neurological disease characterized by demyelination associated with infiltrating white blood cells in the central nervous system (CNS). Nitric oxide synthases...

Age-related changes in cardiac adenosine receptor expression (2004)

Jenner, Tamsin, Mellick, Albert, Harrison, Glenn, Griffiths, Lyn, Rose'Meyer, Roselyn

Adenosine is an important cardioprotective agent that works via several adenosine receptor (ADOR) subtypes to regulate cardiovascular activity. It is well established that functional responses to...

Migraine Susceptibility: Role for Vascular and Hormonal Gene Variants (2004)

Griffiths, Lyn, Colson, Natalie Jane, Johnson, Matthew Peter, Curtain, Rob, Quinlan, Sharon, MacMillan, J

Migraine is a multifactorial disorder characterised by headpain, nausea, vomiting, photophobia and often severe, neurological disturbances. Neurotransmitter-related pathways have been the main focus...

Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis (2003)

Tajouri, Lotfi, Mellick, Albert, Ashton, Kevin John, Tannenberg, Anthony E.G., Nagra, Rashed M., Tourtellotte, Wallace W., ...

Multiple sclerosis (MS) is a complex autoimmune disorder of the CNS with both genetic and environmental contributing factors. Clinical symptoms are broadly characterized by initial onset, and...

An analysis of clinical characteristics in genetically linked migraine-affected pedigrees (2003)

Lea, Rodney Arthur, Hilton, Deborah, MacMillian, JC, Griffiths, Lyn, Dr. P Goadsby

Migraine is a common complex disorder characterized by severe recurrent headache and usually accompanied by nausea and vomiting. Previous studies in our laboratory have utilized three large...

A molecular genetic approach for forensic animal species identification (2003)

Bellis, Claire, Ashton, Kevin John, Freney, L., Blair, B., Griffiths, Lyn, P. Saukko

This study investigated potential markers within chromosomal, mitochondrial DNA (mtDNA) and ribosomal RNA (rRNA) with the aim of developing a DNA based method to allow differentiation between animal...

The measurement of adenosine and estrogen receptor expression in rat brains following ovariectomy using quantitative PCR analysis (2003)

Rose'Meyer, Roselyn, Mellick, Albert, Garnham, Bronwyn Gaye, Harrison, Glenn, Massa, Helen Maureen, Griffiths, Lyn, ...

In our laboratory we have developed a quantitative-polymerase chain reaction (Q-PCR) strategy to examine the differential expression of adenosine receptor (ADOR), A1, A2A, A2B and A3, and estrogen...

Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis (2003)

Tajouri, Lotfi, Mellick, Albert, Ashton, Kevin John, Tannenberg, Anthony E.G., Nagra, Rashed M., Tourtellotte, Wallace W., ...

Multiple sclerosis (MS) is a complex autoimmune disorder of the CNS with both genetic and environmental contributing factors. Clinical symptoms are broadly characterized by initial onset, and...

An analysis of clinical characteristics in genetically linked migraine-affected pedigrees (2003)

Lea, Rodney Arthur, Hilton, Deborah, MacMillian, JC, Griffiths, Lyn

Migraine is a common complex disorder characterized by severe recurrent headache and usually accompanied by nausea and vomiting. Previous studies in our laboratory have utilized three large...

A molecular genetic approach for forensic animal species identification (2003)

Bellis, Claire, Ashton, Kevin John, Freney, L., Blair, B., Griffiths, Lyn

This study investigated potential markers within chromosomal, mitochondrial DNA (mtDNA) and ribosomal RNA (rRNA) with the aim of developing a DNA based method to allow differentiation between animal...

An Investigation of the 5-HT2C Receptor Gene as a Migraine Candidate Gene (2003)

Johnson, Matthew Peter, Lea, Rodney Arthur, Curtain, Rob, MacMillan, John Crichton, Griffiths, Lyn

Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an...

An Assessment of MMP and TIMP Gene Expression in Cell Lines and Stroma - Tumour Differences in Microdissected Breast Cancer Biopsies (2003)

Mellick, Albert, Blackmore, Daneia, Weinstein, Stephen R., Griffiths, Lyn

To examine matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinases (TIMP) mRNA levels in archival breast cancer biopsies, we employed microdissection to separate tumour tissue from...

The measurement of adenosine and estrogen receptor expression in rat brains following ovariectomy using quantitative PCR analysis (2003)

Rose'Meyer, Roselyn, Mellick, Albert, Garnham, Bronwyn Gaye, Harrison, Glenn, Massa, Helen Maureen, Griffiths, Lyn

In our laboratory we have developed a quantitative-polymerase chain reaction (Q-PCR) strategy to examine the differential expression of adenosine receptor (ADOR), A1, A2A, A2B and A3, and estrogen...

Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis (2003)

Tajouri, Lotfi, Mellick, Albert, Ashton, Kevin John, Tannenberg, Anthony E.G., Nagra, Rashed M., Tourtellotte, Wallace W., ...

Multiple sclerosis (MS) is a complex autoimmune disorder of the CNS with both genetic and environmental contributing factors. Clinical symptoms are broadly characterized by initial onset, and...

An analysis of clinical characteristics in genetically linked migraine-affected pedigrees (2003)

Lea, Rodney Arthur, Hilton, Deborah, MacMillian, JC, Griffiths, Lyn

Migraine is a common complex disorder characterized by severe recurrent headache and usually accompanied by nausea and vomiting. Previous studies in our laboratory have utilized three large...

A molecular genetic approach for forensic animal species identification (2003)

Bellis, Claire, Ashton, Kevin John, Freney, L., Blair, B., Griffiths, Lyn

This study investigated potential markers within chromosomal, mitochondrial DNA (mtDNA) and ribosomal RNA (rRNA) with the aim of developing a DNA based method to allow differentiation between animal...

An Investigation of the 5-HT2C Receptor Gene as a Migraine Candidate Gene (2003)

Johnson, Matthew Peter, Lea, Rodney Arthur, Curtain, Rob, MacMillan, John Crichton, Griffiths, Lyn

Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an...

An Assessment of MMP and TIMP Gene Expression in Cell Lines and Stroma - Tumour Differences in Microdissected Breast Cancer Biopsies (2003)

Mellick, Albert, Blackmore, Daneia, Weinstein, Stephen R., Griffiths, Lyn

To examine matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinases (TIMP) mRNA levels in archival breast cancer biopsies, we employed microdissection to separate tumour tissue from...

The measurement of adenosine and estrogen receptor expression in rat brains following ovariectomy using quantitative PCR analysis (2003)

Rose'Meyer, Roselyn, Mellick, Albert, Garnham, Bronwyn Gaye, Harrison, Glenn, Massa, Helen Maureen, Griffiths, Lyn

In our laboratory we have developed a quantitative-polymerase chain reaction (Q-PCR) strategy to examine the differential expression of adenosine receptor (ADOR), A1, A2A, A2B and A3, and estrogen...

Quantitative and qualitative changes in gene expression patterns characterize the activity of plaques in multiple sclerosis (2003)

Tajouri, Lotfi, Mellick, Albert, Ashton, Kevin John, Tannenberg, Anthony E.G., Nagra, Rashed M., Tourtellotte, Wallace W., ...

Multiple sclerosis (MS) is a complex autoimmune disorder of the CNS with both genetic and environmental contributing factors. Clinical symptoms are broadly characterized by initial onset, and...

An analysis of clinical characteristics in genetically linked migraine-affected pedigrees (2003)

Lea, Rodney Arthur, Hilton, Deborah, MacMillian, JC, Griffiths, Lyn

Migraine is a common complex disorder characterized by severe recurrent headache and usually accompanied by nausea and vomiting. Previous studies in our laboratory have utilized three large...

A molecular genetic approach for forensic animal species identification (2003)

Bellis, Claire, Ashton, Kevin John, Freney, L., Blair, B., Griffiths, Lyn

This study investigated potential markers within chromosomal, mitochondrial DNA (mtDNA) and ribosomal RNA (rRNA) with the aim of developing a DNA based method to allow differentiation between animal...

An Investigation of the 5-HT2C Receptor Gene as a Migraine Candidate Gene (2003)

Johnson, Matthew Peter, Lea, Rodney Arthur, Curtain, Rob, MacMillan, John Crichton, Griffiths, Lyn

Migraine is a common complex disorder, currently classified into two main subtypes, migraine with aura (MA) and migraine without aura (MO). The strong preponderance of females to males suggests an...

An Assessment of MMP and TIMP Gene Expression in Cell Lines and Stroma - Tumour Differences in Microdissected Breast Cancer Biopsies (2003)

Mellick, Albert, Blackmore, Daneia, Weinstein, Stephen R., Griffiths, Lyn

To examine matrix metalloproteinase (MMP) and tissue inhibitor of metalloproteinases (TIMP) mRNA levels in archival breast cancer biopsies, we employed microdissection to separate tumour tissue from...

The measurement of adenosine and estrogen receptor expression in rat brains following ovariectomy using quantitative PCR analysis (2003)

Rose'Meyer, Roselyn, Mellick, Albert, Garnham, Bronwyn Gaye, Harrison, Glenn, Massa, Helen Maureen, Griffiths, Lyn

In our laboratory we have developed a quantitative-polymerase chain reaction (Q-PCR) strategy to examine the differential expression of adenosine receptor (ADOR), A1, A2A, A2B and A3, and estrogen...

The GSTM1 Null Genotype Confers an Increased Risk for Solar Keratosis Development in an Australian Caucasian Population (2002)

Carless, Melanie, Lea, Rodney Arthur, Curran, Joanne Elizabeth, Appleyard, Bridget, Gaffney, Philip Thomas, Green, A., ...

Solar keratoses affect approximately 50% of Australian Caucasians aged over 40 y. Solar keratoses can undergo malignant transformation into squamous cell carcinoma followed by possible metastasis and...

Dopamine Receptor Genes and Migraine With and Without Aura: An Association Study. (2002)

Shepherd, A.G., Lea, Rodney Arthur, Hutchins, Colin, Jordan, K., Brimage, P.J., Griffiths, Lyn

Objective. To investigate the role of the dopamine receptor genes, DRD1, DRD3, and DRD5 in the pathogenesis of migraine.Background. Migraine is a chronic debilitating disorder affecting approximately...

Fluorescence Detection of Plant Extracts That Affect Neuronal Voltage-gated Ca2+ Channels (2002)

Rogers, Kelly, Fong, W.F., Redburn, J., Griffiths, Lyn

Structurally novel compounds able to block voltage-gated Ca2+ channels (VGCCs) are currently being sought for the development of new drugs directed at neurological disorders. Fluorescence techniques...

The GSTM1 Null Genotype Confers an Increased Risk for Solar Keratosis Development in an Australian Caucasian Population (2002)

Carless, Melanie, Lea, Rodney Arthur, Curran, Joanne Elizabeth, Appleyard, Bridget, Gaffney, Philip Thomas, Green, A., ...

Solar keratoses affect approximately 50% of Australian Caucasians aged over 40 y. Solar keratoses can undergo malignant transformation into squamous cell carcinoma followed by possible metastasis and...

Dopamine Receptor Genes and Migraine With and Without Aura: An Association Study. (2002)

Shepherd, A.G., Lea, Rodney Arthur, Hutchins, Colin, Jordan, K., Brimage, P.J., Griffiths, Lyn

Objective. To investigate the role of the dopamine receptor genes, DRD1, DRD3, and DRD5 in the pathogenesis of migraine. Background. Migraine is a chronic debilitating disorder affecting...

Fluorescence Detection of Plant Extracts That Affect Neuronal Voltage-gated Ca2+ Channels (2002)

Rogers, Kelly, Fong, W.F., Redburn, J., Griffiths, Lyn

Structurally novel compounds able to block voltage-gated Ca2+ channels (VGCCs) are currently being sought for the development of new drugs directed at neurological disorders. Fluorescence techniques...

Differential Gene Expression in Breast Cancer Cell Lines and Stroma-Tumour Differences in Microdissected Breast Cancer Biopsies Revealed by Display Array Analysis (2002)

Mellick, Albert, Day, Chris, Weinstein, S.R., Griffiths, Lyn, Morrison, Nigel Alexander

To examine gene-expression patterning in late-stage breast cancer biopsies, we used a microdissection technique to separate tumor from the surrounding breast tissue or stroma. A DD-PCR protocol was...

The GSTM1 Null Genotype Confers an Increased Risk for Solar Keratosis Development in an Australian Caucasian Population (2002)

Carless, Melanie, Lea, Rodney Arthur, Curran, Joanne Elizabeth, Appleyard, Bridget, Gaffney, Philip Thomas, Green, A., ...

Solar keratoses affect approximately 50% of Australian Caucasians aged over 40 y. Solar keratoses can undergo malignant transformation into squamous cell carcinoma followed by possible metastasis and...

Dopamine Receptor Genes and Migraine With and Without Aura: An Association Study. (2002)

Shepherd, A.G., Lea, Rodney Arthur, Hutchins, Colin, Jordan, K., Brimage, P.J., Griffiths, Lyn

Objective. To investigate the role of the dopamine receptor genes, DRD1, DRD3, and DRD5 in the pathogenesis of migraine. Background. Migraine is a chronic debilitating disorder affecting...

Fluorescence Detection of Plant Extracts That Affect Neuronal Voltage-gated Ca2+ Channels (2002)

Rogers, Kelly, Fong, W.F., Redburn, J., Griffiths, Lyn

Structurally novel compounds able to block voltage-gated Ca2+ channels (VGCCs) are currently being sought for the development of new drugs directed at neurological disorders. Fluorescence techniques...

Differential Gene Expression in Breast Cancer Cell Lines and Stroma-Tumour Differences in Microdissected Breast Cancer Biopsies Revealed by Display Array Analysis (2002)

Mellick, Albert, Day, Chris, Weinstein, S.R., Griffiths, Lyn, Morrison, Nigel Alexander

To examine gene-expression patterning in late-stage breast cancer biopsies, we used a microdissection technique to separate tumor from the surrounding breast tissue or stroma. A DD-PCR protocol was...

The GSTM1 Null Genotype Confers an Increased Risk for Solar Keratosis Development in an Australian Caucasian Population (2002)

Carless, Melanie, Lea, Rodney Arthur, Curran, Joanne Elizabeth, Appleyard, Bridget, Gaffney, Philip Thomas, Green, A., ...

Solar keratoses affect approximately 50% of Australian Caucasians aged over 40 y. Solar keratoses can undergo malignant transformation into squamous cell carcinoma followed by possible metastasis and...

Dopamine Receptor Genes and Migraine With and Without Aura: An Association Study. (2002)

Shepherd, A.G., Lea, Rodney Arthur, Hutchins, Colin, Jordan, K., Brimage, P.J., Griffiths, Lyn

Objective. To investigate the role of the dopamine receptor genes, DRD1, DRD3, and DRD5 in the pathogenesis of migraine. Background. Migraine is a chronic debilitating disorder affecting...

Fluorescence Detection of Plant Extracts That Affect Neuronal Voltage-gated Ca2+ Channels (2002)

Rogers, Kelly, Fong, W.F., Redburn, J., Griffiths, Lyn

Structurally novel compounds able to block voltage-gated Ca2+ channels (VGCCs) are currently being sought for the development of new drugs directed at neurological disorders. Fluorescence techniques...

Differential Gene Expression in Breast Cancer Cell Lines and Stroma-Tumour Differences in Microdissected Breast Cancer Biopsies Revealed by Display Array Analysis (2002)

Mellick, Albert, Day, Chris, Weinstein, S.R., Griffiths, Lyn, Morrison, Nigel Alexander

To examine gene-expression patterning in late-stage breast cancer biopsies, we used a microdissection technique to separate tumor from the surrounding breast tissue or stroma. A DD-PCR protocol was...

Modulation of in vitro platelet 5-HT release by species of Erythrina and Cambopogon (2001)

Rogers, Kelly, Grice, Darren, Griffiths, Lyn, Not Stated

Extracts of Australian plants were screened to detect constituents affecting adenosine di-phosphate (ADP) induced platelet aggregation and [14C]5-hydroxytryptamine (5-HT) release. Extracts of four...

Modulation of in vitro platelet 5-HT release by species of Erythrina and Cambopogon (2001)

Rogers, Kelly, Grice, Darren, Griffiths, Lyn

Extracts of Australian plants were screened to detect constituents affecting adenosine di-phosphate (ADP) induced platelet aggregation and [14C]5-hydroxytryptamine (5-HT) release. Extracts of four...

Modulation of in vitro platelet 5-HT release by species of Erythrina and Cambopogon (2001)

Rogers, Kelly, Grice, Darren, Griffiths, Lyn

Extracts of Australian plants were screened to detect constituents affecting adenosine di-phosphate (ADP) induced platelet aggregation and [14C]5-hydroxytryptamine (5-HT) release. Extracts of four...

Modulation of in vitro platelet 5-HT release by species of Erythrina and Cambopogon (2001)

Rogers, Kelly, Grice, Darren, Griffiths, Lyn

Extracts of Australian plants were screened to detect constituents affecting adenosine di-phosphate (ADP) induced platelet aggregation and [14C]5-hydroxytryptamine (5-HT) release. Extracts of four...

Inhibition of platelet aggregation and 5-HT release by extracts of Australian plants used traditionally as headache treatments (2000)

Rogers, Kelly, Grice, Darren, Griffiths, Lyn

To identify potential migraine therapeutics, extracts of eighteen plants were screened to detect plant constituents affecting ADP induced platelet aggregation and [14C]5-hydroxytryptamine (5-HT)...

Patellar tendinopathy in junior basketball players:a controlled clinical & ultrasonographic study of 268 patellar tendons in players aged 14-18 (2000)

Griffiths, Lyn, Cook, JL, Khan, KM, Kiss, ZS

Anterior knee pain is a common presenting complaint amongst adolescent athletes. We hypothesised that patellar tendinopathy may occur at a younger age than is generally recognised. Thus, we studied...

Inhibition of platelet aggregation and 5-HT release by extracts of Australian plants used traditionally as headache treatments (2000)

Rogers, Kelly, Grice, Darren, Griffiths, Lyn

To identify potential migraine therapeutics, extracts of eighteen plants were screened to detect plant constituents affecting ADP induced platelet aggregation and [14C]5-hydroxytryptamine (5-HT)...

Patellar tendinopathy in junior basketball players:a controlled clinical & ultrasonographic study of 268 patellar tendons in players aged 14-18 (2000)

Griffiths, Lyn, Cook, JL, Khan, KM, Kiss, ZS

Anterior knee pain is a common presenting complaint amongst adolescent athletes. We hypothesised that patellar tendinopathy may occur at a younger age than is generally recognised. Thus, we studied...

Evidence for allelic association of the dopamine ß-hydroxylase gene (DBH) with susceptibility to typical migraine (2000)

Lea, Rodney Arthur, Dohy, Adam, Jordan, Kathryn Lee, Quinlan, Sharon Anne, Brimage, PJ, Griffiths, Lyn

Migraine is a debilitating neurological disorder characterized by recurrent attacks of severe headache. The disorder is highly prevalent, affecting approximately 12% of Caucasian populations. It is...

Inhibition of platelet aggregation and 5-HT release by extracts of Australian plants used traditionally as headache treatments (2000)

Rogers, Kelly, Grice, Darren, Griffiths, Lyn

To identify potential migraine therapeutics, extracts of eighteen plants were screened to detect plant constituents affecting ADP induced platelet aggregation and [14C]5-hydroxytryptamine (5-HT)...

Patellar tendinopathy in junior basketball players:a controlled clinical & ultrasonographic study of 268 patellar tendons in players aged 14-18 (2000)

Griffiths, Lyn, Cook, JL, Khan, KM, Kiss, ZS

Anterior knee pain is a common presenting complaint amongst adolescent athletes. We hypothesised that patellar tendinopathy may occur at a younger age than is generally recognised. Thus, we studied...

Evidence for allelic association of the dopamine ß-hydroxylase gene (DBH) with susceptibility to typical migraine (2000)

Lea, Rodney Arthur, Dohy, Adam, Jordan, Kathryn Lee, Quinlan, Sharon Anne, Brimage, PJ, Griffiths, Lyn

Migraine is a debilitating neurological disorder characterized by recurrent attacks of severe headache. The disorder is highly prevalent, affecting approximately 12% of Caucasian populations. It is...

Inhibition of platelet aggregation and 5-HT release by extracts of Australian plants used traditionally as headache treatments (2000)

Rogers, Kelly, Grice, Darren, Griffiths, Lyn

To identify potential migraine therapeutics, extracts of eighteen plants were screened to detect plant constituents affecting ADP induced platelet aggregation and [14C]5-hydroxytryptamine (5-HT)...

Patellar tendinopathy in junior basketball players:a controlled clinical & ultrasonographic study of 268 patellar tendons in players aged 14-18 (2000)

Griffiths, Lyn, Cook, JL, Khan, KM, Kiss, ZS

Anterior knee pain is a common presenting complaint amongst adolescent athletes. We hypothesised that patellar tendinopathy may occur at a younger age than is generally recognised. Thus, we studied...

Evidence for allelic association of the dopamine ß-hydroxylase gene (DBH) with susceptibility to typical migraine (2000)

Lea, Rodney Arthur, Dohy, Adam, Jordan, Kathryn Lee, Quinlan, Sharon Anne, Brimage, PJ, Griffiths, Lyn

Migraine is a debilitating neurological disorder characterized by recurrent attacks of severe headache. The disorder is highly prevalent, affecting approximately 12% of Caucasian populations. It is...

Investigation of the NOTCH3 and TNFSF7 Genes on C19p13 as Candidates for Migraine

Smith, Robert A, Curtain, Robert, Ovcaric, Mick, Tajouri, Lotti, MacMillan, John, Griffiths, Lyn

To investigate the migraine locus around the C19p13 region through analysis of the NOTCH3 gene (C19p13.2-p13.1), previously shown to be a gene involved in CADASIL and the TNFSF7 gene (C19p13),...