Mårten Fernö

Tiling array-CGH for the assessment of genomic similarities among synchronous unilateral and bilateral invasive breast cancer tumor pairs (2008)

Brommesson, Sara, Jönsson, Göran, Strand, Carina, Grabau, Dorthe, Malmström, Per, Ringnér, Markus, ...

Abstract Background Today, no objective criteria exist to differentiate between individual primary tumors and intra- or intermammary dissemination respectively, in patients diagnosed with two or more...

The CD44+/CD24-phenotype is enriched in basal-like breast tumors (2008)

Honeth, Gabriella, Bendahl, Pär-Ola, Ringnér, Markus, Saal, Lao H, Gruvberger-Saal, Sofia K, Lövgren, Kristina, ...

Abstract Introduction Human breast tumors are heterogeneous and consist of phenotypically diverse cells. Breast cancer cells with a CD44 + /CD24 - phenotype have been suggested to have...

Gene expression profiling in primary breast cancer distinguishes patients developing local recurrence after breast-conservation surgery, with or without postoperative radiotherapy (2008)

Niméus-Malmström, Emma, Krogh, Morten, Malmström, Per, Strand, Carina, Fredriksson, Irma, Karlsson, Per, ...

Abstract Introduction Some patients with breast cancer develop local recurrence after breast-conservation surgery despite postoperative radiotherapy, whereas others remain free of local recurrence...

Exploring the two-gene ratio in breast cancer – independent roles for HOXB13 and IL17BR in prediction of clinical outcome (2008)

Jerevall, Piiha-Lotta, Brommesson, Sara, Strand, Carina, Gruvberger-Saal, Sofia, Malmström, Per, Nordenskjöld, Bo, ...

Background: The two-gene expression ratio HOXB13:IL17BR has been proposed to predict the outcome of tamoxifen-treated breast cancer patients. We intended to examine whether this ratio can predict the...

Commentary (2007)

Sofia K Gruvberger, Markus Ringnér, Patrik Edén, Åke Borg, Mårten Fernö, Carsten Peterson, ...

Breast Cancer Research Vol 5 No 1 Gruvberger et al.

RNA quality in frozen breast cancer samples and the influence on gene expression analysis – a comparison of three evaluation methods using microcapillary electrophoresis traces (2007)

Strand, Carina, Enell, Johan, Hedenfalk, Ingrid, Fernö, Mårten

Abstract Background Assessing RNA quality is essential for gene expression analysis, as the inclusion of degraded samples may influence the interpretation of expression levels in relation to...

Basal-like phenotype is not associated with patient survival in estrogen-receptor-negative breast cancers (2007)

Jumppanen, Mervi, Gruvberger-Saal, Sofia, Kauraniemi, Päivikki, Tanner, Minna, Bendahl, Pär-Ola, Lundin, Mikael, ...

Abstract Introduction Basal-phenotype or basal-like breast cancers are characterized by basal epithelium cytokeratin (CK5/14/17) expression, negative estrogen receptor (ER) status and distinct gene...

BMC Molecular Biology BioMed Central Methodology article (2007)

Carina Str, Johan Enell, Ingrid Hedenfalk, Mårten Fernö

RNA quality in frozen breast cancer samples and the influence on gene expression analysis – a comparison of three evaluation methods using microcapillary electrophoresis traces

Expression profiling to predict outcome in breast cancer: the influence of sample selection (2003)

Gruvberger, Sofia K, Ringnér, Markus, Edén, Patrik, Borg, Åke, Fernö, Mårten, Peterson, Carsten, ...

Gene expression profiling of tumors using DNA microarrays is a promising method for predicting prognosis and treatment response in cancer patients. It was recently reported that expression profiles...

Expression profiling to predict outcome in breast cancer: the influence of sample selection (2002)

Gruvberger, Sofia K, Ringnér, Markus, Edén, Patrik, Borg, Åke, Fernö, Mårten, Peterson, Carsten, ...

Abstract Gene expression profiling of tumors using DNA microarrays is a promising method for predicting prognosis and treatment response in cancer patients. It was recently reported that expression...

High tumor tissue concentration of plasminogen activator inhibitor 2 (PAI-2) is an independent marker for shorter progression-free survival in patients with early stage endometrial cancer. (2002)

Nordengren, Johanna, Fredstorp Lidebring, Margareta, Bendahl, Pär-Ola, Brünner, Nils, Fernö, Mårten, Högberg, Thomas, ...

Previous studies including various tumor types have shown different associations between tumor tissue levels of plasminogen activator inhibitor 2 (PAI-2) and patient survival. High tumor tissue...

Evaluation of the tissue microarray technique for immunohistochemical analysis in rectal cancer. (2002)

Fernebro, Eva, Dictor, Michael, Bendahl, Pär-Ola, Fernö, Mårten, Nilbert, Mef

BACKGROUND: Immunohistochemical staining for tumor-associated proteins is widely used for the identification of novel prognostic markers. Recently, a tissue-conserving, high-throughput technique,...

Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients (2002)

Look, Maxime P., Duffy, Michael J., Harbeck, Nadia, Christensen, Ib Jarle, Thomssen, Christoph, ...

Background: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are associated with poor...

Advances in Brief Estrogen Receptor Status in Breast Cancer Is Associated with Remarkably Distinct Gene Expression Patterns 1 (2001)

Sofia Gruvberger, Markus Ringnér, Yidong Chen, Sujatha Panavally, Lao H. Saal, Åke Borg, ...

To investigate the phenotype associated with estrogen receptor � (ER) expression in breast carcinoma, gene expression profiles of 58 nodenegative breast carcinomas discordant for ER status were...

Immunologic Proliferation Marker Ki-S2 as Prognostic Indicator for Lymph Node-Negative Breast Cancer (1999)

Rudolph, Pierre, Alm, Per, Heidebrecht, Hans-Jürgen, Bolte, Hendrik, Ratjen, Virgo, Baldetorp, Bo, ...

BACKGROUND: Proper treatment of lymph node-negative breast cancer depends on an accurate prognosis. To improve prognostic models for this disease, we evaluated whether an immunohistochemical marker...

Expression profiling to predict outcome in breast cancer: the influence of sample selection

Gruvberger, Sofia K, Ringnér, Markus, Edén, Patrik, Borg, Åke, Fernö, Mårten, Peterson, Carsten, ...

Gene expression profiling of tumors using DNA microarrays is a promising method for predicting prognosis and treatment response in cancer patients. It was recently reported that expression profiles...

Expression profiling to predict outcome in breast cancer: the influence of sample selection

Gruvberger, Sofia K, Ringnér, Markus, Edén, Patrik, Borg, Åke, Fernö, Mårten, Peterson, Carsten, ...

Gene expression profiling of tumors using DNA microarrays is a promising method for predicting prognosis and treatment response in cancer patients. It was recently reported that expression profiles...

Genetic Aberrations in Hypodiploid Breast Cancer : Frequent Loss of Chromosome 4 and Amplification of Cyclin D1 Oncogene

Tanner, Minna M., Karhu, Ritva A., Nupponen, Nina N., Borg, Åke, Baldetorp, Bo, Pejovic, Tanja, ...

The evolution of somatic genetic aberrations in breast cancer has remained poorly understood. The most common chromosomal abnormality is hyperdiploidy, which is thought to arise via a transient...