Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.
Brannan, C I, Lyman, S D, Williams, D E, Eisenman, J, Anderson, D M, Cosman, D, ...
Mice homozygous for the viable Sl allele steel-Dickie (Sld) are sterile, severely anemic, and black-eyed white. The nature of the Sld mutation was investigated at the molecular level and was found to...
Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation.
Bedell, M A, Hudson, J B, Golub, T R, Turyk, M E, Hosken, M, Wilbanks, G D, ...
Human papillomaviruses (HPVs) infect squamous epithelium and establish their genomes as episomes in proliferating basal cells. As infected cells differentiate, the viral DNA is amplified to high copy...
Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells.
Bedell, M A, Jones, K H, Grossman, S R, Laimins, L A
The selective retention and expression of the E6-E7 region of human papillomavirus (HPV) types 16 and 18 in cervical carcinomas suggests that these viral sequences play a role in the development of...
Hudson, J B, Bedell, M A, McCance, D J, Laiminis, L A
The E6-E7 region of human papillomavirus types 16 and 18 is selectively retained and expressed in cervical carcinoma cells. In cultured human keratinocytes, expression of the E6 and E7 open reading...
Inducible and constitutive enhancer domains in the noncoding region of human papillomavirus type 18.
Gius, D, Grossman, S, Bedell, M A, Laimins, L A
The noncoding region of human papillomavirus type 18 (HPV-18) is shown to contain at least three enhancer elements. Two of these elements are responsive to papillomavirus-encoded trans-acting...
Bedell, M A, Jones, K H, Laimins, L A
Plasmids containing the E6 and E7 open reading frames of human papillomavirus type 18 expressed from an autologous transcriptional control region were sufficient for transformation of NIH 3T3 and...
Swenberg, J A, Dyroff, M C, Bedell, M A, Popp, J A, Huh, N, Kirstein, U, ...
In previous investigations into the mechanisms responsible for cell specificity in hepatocarcinogenesis, we have demonstrated that O6-methylguanine accumulates in the DNA of nonparenchymal cells...
Swenberg, J A, Bedell, M A, Billings, K C, Umbenhauer, D R, Pegg, A E
The activity of the alkyl acceptor protein (AAP) responsible for repair of DNA containing the promutagenic lesion O6-alkylguanine was determined in hepatocytes and nonparenchymal cells (NPC) obtained...
Bedell, M. A., Copeland, N. G., Jenkins, N. A.
The Steel (Sl) locus encodes mast cell growth factor (Mgf) that is required for the development of germ cells, hematopoietic cells and melanocytes. Although the expression patterns of the Mgf gene...
Deletion and Interallelic Complementation Analysis of Steel Mutant Mice
Bedell, M. A., Cleveland, L. S., O'Sullivan, T. N., Copeland, N. G., Jenkins, N. A.
Mutations at the Steel (St) locus produce pleiotropic effects on viability as well as hematopoiesis, pigmentation and fertility. Several homozygous viable Sl alleles have previously been shown to...
Rajaraman, S, Davis, W S, Mahakali-Zama, A, Evans, H K, Russell, L B, Bedell, M A
An allelic series of mutations is an extremely valuable genetic resource for understanding gene function. Here we describe eight mutant alleles at the Steel (Sl) locus of mice that were induced with...
Rajaraman, S, Davis, W S, Mahakali-Zama, A, Evans, H K, Russell, L B, Bedell, M A
The ligand for the Kit receptor tyrosine kinase is Kit ligand (Kitl; also known as mast cell growth factor, stem cell factor, and Steel factor), which is encoded at the Steel (Sl) locus of mice....
Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.
Brannan, C I, Lyman, S D, Williams, D E, Eisenman, J, Anderson, D M, Cosman, D, ...
Mice homozygous for the viable Sl allele steel-Dickie (Sld) are sterile, severely anemic, and black-eyed white. The nature of the Sld mutation was investigated at the molecular level and was found to...
Amplification of human papillomavirus genomes in vitro is dependent on epithelial differentiation.
Bedell, M A, Hudson, J B, Golub, T R, Turyk, M E, Hosken, M, Wilbanks, G D, ...
Human papillomaviruses (HPVs) infect squamous epithelium and establish their genomes as episomes in proliferating basal cells. As infected cells differentiate, the viral DNA is amplified to high copy...
Identification of human papillomavirus type 18 transforming genes in immortalized and primary cells.
Bedell, M A, Jones, K H, Grossman, S R, Laimins, L A
The selective retention and expression of the E6-E7 region of human papillomavirus (HPV) types 16 and 18 in cervical carcinomas suggests that these viral sequences play a role in the development of...
Hudson, J B, Bedell, M A, McCance, D J, Laiminis, L A
The E6-E7 region of human papillomavirus types 16 and 18 is selectively retained and expressed in cervical carcinoma cells. In cultured human keratinocytes, expression of the E6 and E7 open reading...
Inducible and constitutive enhancer domains in the noncoding region of human papillomavirus type 18.
Gius, D, Grossman, S, Bedell, M A, Laimins, L A
The noncoding region of human papillomavirus type 18 (HPV-18) is shown to contain at least three enhancer elements. Two of these elements are responsive to papillomavirus-encoded trans-acting...
Bedell, M A, Jones, K H, Laimins, L A
Plasmids containing the E6 and E7 open reading frames of human papillomavirus type 18 expressed from an autologous transcriptional control region were sufficient for transformation of NIH 3T3 and...
Swenberg, J A, Dyroff, M C, Bedell, M A, Popp, J A, Huh, N, Kirstein, U, ...
In previous investigations into the mechanisms responsible for cell specificity in hepatocarcinogenesis, we have demonstrated that O6-methylguanine accumulates in the DNA of nonparenchymal cells...
Swenberg, J A, Bedell, M A, Billings, K C, Umbenhauer, D R, Pegg, A E
The activity of the alkyl acceptor protein (AAP) responsible for repair of DNA containing the promutagenic lesion O6-alkylguanine was determined in hepatocytes and nonparenchymal cells (NPC) obtained...
Bedell, M. A., Copeland, N. G., Jenkins, N. A.
The Steel (Sl) locus encodes mast cell growth factor (Mgf) that is required for the development of germ cells, hematopoietic cells and melanocytes. Although the expression patterns of the Mgf gene...
Deletion and Interallelic Complementation Analysis of Steel Mutant Mice
Bedell, M. A., Cleveland, L. S., O'Sullivan, T. N., Copeland, N. G., Jenkins, N. A.
Mutations at the Steel (St) locus produce pleiotropic effects on viability as well as hematopoiesis, pigmentation and fertility. Several homozygous viable Sl alleles have previously been shown to...
Rajaraman, S, Davis, W S, Mahakali-Zama, A, Evans, H K, Russell, L B, Bedell, M A
An allelic series of mutations is an extremely valuable genetic resource for understanding gene function. Here we describe eight mutant alleles at the Steel (Sl) locus of mice that were induced with...
Rajaraman, S, Davis, W S, Mahakali-Zama, A, Evans, H K, Russell, L B, Bedell, M A
The ligand for the Kit receptor tyrosine kinase is Kit ligand (Kitl; also known as mast cell growth factor, stem cell factor, and Steel factor), which is encoded at the Steel (Sl) locus of mice....