Plasma Lipid and Lipoprotein Responses during Exercise. (2003)
Ferguson, M. A., Alderson, N. L., Durstine, L. J., Trost, S. G., Davis, P. G., Mosher, P. E.
The purpose of this study was to examine the effect of prolonged exercise on plasma lipid and lipoprotein concentrations and to identify caloric time-points where changes occurred. Eleven active male...
Ferguson, M. A., Smales, L. R., Cribb, T. H.
Pretestis laticaecum is described from the small intestine of the freshwater turtle Emydura krefftil. The new species can be distinguished from its congener P. australianus by the following...
Ferguson, M. A., Smales, L. R., Cribb, T. H.
Pretestis laticaecum is described from the small intestine of the freshwater turtle Emydura krefftil. The new species can be distinguished from its congener P. australianus by the following...
Transient-evoked otoacoustic emissions in a representative population sample aged 18-25 years (2000)
Proudfoot, L, Nikolaev, A V, Feng, G J, Wei, W Q, Ferguson, M A, Brimacombe, J S, ...
Lipophosphoglycan (LPG) glycoconjugates from promastigotes of Leishmania were not able to induce the expression of the cytokine-inducible nitric oxide synthase (iNOS) by the murine macrophage cell...
Antibody to cytotoxin in infection by Helicobacter pylori.
Leunk, R D, Ferguson, M A, Morgan, D R, Low, D E, Simor, A E
Gastrointestinal disease and colonization by Helicobacter pylori were determined in 36 asymptomatic volunteers and 30 symptomatic individuals undergoing endoscopy and biopsy. Serum antibody...
The role of inositol acylation and inositol deacylation in GPI biosynthesis in Trypanosoma brucei.
The compound diisopropylfluorophosphate (DFP) selectively inhibits an inositol deacylase activity in living trypanosomes that, together with the previously described phenylmethylsulfonyl fluoride...
Phenylmethanesulphonyl fluoride inhibits GPI anchor biosynthesis in the African trypanosome.
A wide variety of eukaryotic membrane proteins are anchored to the outside of cells by covalent linkage to glycosyl phosphatidylinositol (GPI). One of the best characterized examples is the variant...
McConville, M J, Turco, S J, Ferguson, M A, Sacks, D L
Protozoan parasites of the genus Leishmania produce the novel surface glycoconjugate, lipophosphoglycan (LPG), which is required for parasite infectivity. In this study we show that LPG structure is...
Ferguson, M A, Murray, P, Rutherford, H, McConville, M J
The procyclic acidic repetitive protein is the major cell-surface glycoprotein of the insect-dwelling procyclic forms of the Trypanosoma brucei species of African trypanosomes. The glycoprotein...
Site of palmitoylation of a phospholipase C-resistant glycosylphosphatidylinositol membrane anchor.
The site of palmitoylation of the phosphatidylinositol moiety of the glycosyl-phosphatidylinositol membrane anchor of Trypanosoma brucei procyclic acidic repetitive protein was studied by using...
Bailyes, E M, Ferguson, M A, Colaco, C A, Luzio, J P
myo-Inositol analysis of detergent-solubilized immunoaffinity-purified rat liver 5'-nucleotidase showed the presence of 1 mol of myo-inositol/mol of enzyme monomer. This provides unequivocal evidence...
Xia, M Q, Hale, G, Lifely, M R, Ferguson, M A, Campbell, D, Packman, L, ...
CAMPATH-1 antibodies recognize a unique molecule on human lymphocytes and are unusually efficient at causing cell lysis with homologous complement. They have been successfully used for lymphocyte...
Schneider, P, Rosat, J P, Ransijn, A, Ferguson, M A, McConville, M J
The major macromolecules on the surface of the parasitic protozoan Leishmania major appear to be down-regulated during transformation of the parasite from an insect-dwelling promastigote stage to an...
Pingel, S, Field, R A, Güther, M L, Duszenko, M, Ferguson, M A
The variant surface glycoproteins (VSGs) of Trypanosoma brucei are attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) membrane anchor. This anchor contains the core sequence...
The glycoinositol-phospholipids of Phytomonas.
Redman, C A, Schneider, P, Mehlert, A, Ferguson, M A
The Phytomonas spp. are trypanosomatid parasites of plants. A polar glycolipid fraction of a Phytomonas sp., isolated from the plant Euphorbia characias and grown in culture, was fractionated into...
Schneider, P, Nikolaev, A, Ferguson, M A
GDP-D-arabinopyranose (GDP-D-Ara) is the precursor of the uncommon D-arabinopyranose residues present in the glycoconjugates of a few trypanosomatid parasites. Biosynthetic labelling experiments with...
Neville, D C, Field, R A, Ferguson, M A
Several hydrophobic glycosides of N-acetylglucosamine (GlcNAc) served as primers for polylactosamine synthesis when added to Chinese hamster ovary (CHO) cells. The modified glycosides, containing one...
Proudfoot, L, Schneider, P, Ferguson, M A, McConville, M J
The major macromolecule on the surface of the protozoan parasite Leishmania major is a lipophosphoglycan (LPG) which contains a glycosylphosphatidylinositol glycolipid anchor. This parasite also...
Redman, C A, Thomas-Oates, J E, Ogata, S, Ikehara, Y, Ferguson, M A
The glycosylphosphatidylinositol membrane anchor of human placental alkaline phosphatase was isolated by exhaustive proteolysis followed by hydrophobic interaction chromatography. The resulting...
Almeida, I C, Ferguson, M A, Schenkman, S, Travassos, L R
Sera of patients with chronic Chagas' disease (American trypanosomiasis) contain elevated levels of anti-alpha-galactosyl antibodies that are lytic to Trypanosoma cruzi. The T. cruzi trypomastigote...
Glycoinositol-phospholipid profiles of four serotypically distinct Old World Leishmania strains.
Schneider, P, Schnur, L F, Jaffe, C L, Ferguson, M A, McConville, M J
Glycoinositol-phospholipids (GIPLs) are the major glycolipid class and prominant surface antigens of leishmanial parasites. The GIPLs from four serologically distinct Old World strains of Leishmania...
Mehlert, A, Varon, L, Silman, I, Homans, S W, Ferguson, M A
The structure of the glycan moiety of the glycosyl-phosphatidylinositol (GPI) membrane anchor from Torpedo californica (electric fish) electric-organ acetylcholinesterase was solved using n.m.r.,...
Trypanosoma brucei brucei variant surface glycoprotein contains non-N-acetylated glucosamine.
Strang, A M, Williams, J M, Ferguson, M A, Holder, A A, Allen, A K
The C-terminal amino acid of the variant surface glycoprotein of the parasitic protozoan Trypanosoma brucei brucei is glycosylated and the oligosaccharide has been shown to contain glucosamine. By...
Zamze, S E, Ferguson, M A, Moxon, E R, Dwek, R A, Rademacher, T W
A phosphorylated 3-deoxy-manno-octulosonic acid (KDO) was released from the lipopolysaccharide (LPS) of the deep rough mutant (Rb+169) of Haemophilus influenzae by acid hydrolysis. Both...
Direct measurement of inositol in bovine myelin basic protein.
Smith, R, Braun, P E, Ferguson, M A, Low, M G, Sherman, W R
Myelin basic protein has been isolated from bovine central-nervous-system myelin by four methods, none of which exposes the protein to acid. After purification the inositol content of both hydrolysed...
Studies on the structure of a phosphoglycoprotein from the parasitic protozoan Trypanosoma cruzi.
Ferguson, M A, Allen, A K, Snary, D
A glycoprotein (GP72) has been isolated from Trypanosoma cruzi and found to contain 41% protein, 49% carbohydrate and 10% phosphate. All phosphate was covalently attached to the carbohydrate which...
Smith, T K, Sharma, D K, Crossman, A, Dix, A, Brimacombe, J S, Ferguson, M A
Glycosylphosphatidylinositol (GPI) structures are attached to many cell surface glycoproteins in lower and higher eukaryotes. GPI structures are particularly abundant in trypanosomatid parasites...
Selective inhibitors of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei.
Smith, T K, Sharma, D K, Crossman, A, Brimacombe, J S, Ferguson, M A
Synthetic analogues of D-GlcNalpha1-6D-myo-inositol-1-HPO(4)-3(sn-1, 2-diacylglycerol) (GlcN-PI), with the 2-position of the inositol residue substituted with an O-octyl ether...
Structural studies on a lipoarabinogalactan of Crithidia fasciculata.
Schneider, P, Treumann, A, Milne, K G, McConville, M J, Zitzmann, N, Ferguson, M A
The monosaccharide D-arabinopyranose has only been found in glycoconjugates of the trypanasomatid parasites Leishmania major, Endotrypanum schaudinni and Crithidia fasciculata. The donor molecule for...
Paturiaux-Hanocq, F, Zitzmann, N, Hanocq-Quertier, J, Vanhamme, L, Rolin, S, Geuskens, M, ...
Procyclic forms of Trypanosoma brucei have been genetically modified to express the major metacyclic variant surface glycoprotein (VSG variant AnTat 11.17) of Trypanosoma gambiense. The VSG is...
Early steps in glycosylphosphatidylinositol biosynthesis in Leishmania major.
Smith, T K, Milne, F C, Sharma, D K, Crossman, A, Brimacombe, J S, Ferguson, M A
A cell-free system based on washed Leishmania major membranes was labelled with GDP-[3H]Man in the presence of synthetic glucosaminyl-phosphatidylinositol (GlcN-PI) and...
Sharma, D K, Smith, T K, Crossman, A, Brimacombe, J S, Ferguson, M A
De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol (GlcNAc-PI) is the second step of glycosylphosphatidylinositol (GPI) membrane anchor biosynthesis in eukaryotes. This step is a...
Lischke, A, Klein, C, Stierhof, Y D, Hempel, M, Mehlert, A, Almeida, I C, ...
Wild and farmed freshwater fishes are widely and heavily parasitized by the haemoflagellate Trypanosoma carassii. In contrast, common carp, a natural host, can effectively control experimental...
Weinhart, U, Thomas, J R, Pak, Y B, Thompson, G A, Ferguson, M A
A glycolipid metabolically labelled with [14C]GlcN was isolated from the free-living protozoan Tetrahymena mimbres. The glycolipid was sensitive to a bacterial phosphatidylinositol-specific...
Proudfoot, L, Nikolaev, A V, Feng, G J, Wei, W Q, Ferguson, M A, Brimacombe, J S, ...
Lipophosphoglycan (LPG) glycoconjugates from promastigotes of Leishmania were not able to induce the expression of the cytokine-inducible nitric oxide synthase (iNOS) by the murine macrophage cell...
Antibody to cytotoxin in infection by Helicobacter pylori.
Leunk, R D, Ferguson, M A, Morgan, D R, Low, D E, Simor, A E
Gastrointestinal disease and colonization by Helicobacter pylori were determined in 36 asymptomatic volunteers and 30 symptomatic individuals undergoing endoscopy and biopsy. Serum antibody...
The role of inositol acylation and inositol deacylation in GPI biosynthesis in Trypanosoma brucei.
The compound diisopropylfluorophosphate (DFP) selectively inhibits an inositol deacylase activity in living trypanosomes that, together with the previously described phenylmethylsulfonyl fluoride...
Phenylmethanesulphonyl fluoride inhibits GPI anchor biosynthesis in the African trypanosome.
A wide variety of eukaryotic membrane proteins are anchored to the outside of cells by covalent linkage to glycosyl phosphatidylinositol (GPI). One of the best characterized examples is the variant...
McConville, M J, Turco, S J, Ferguson, M A, Sacks, D L
Protozoan parasites of the genus Leishmania produce the novel surface glycoconjugate, lipophosphoglycan (LPG), which is required for parasite infectivity. In this study we show that LPG structure is...
Ferguson, M A, Murray, P, Rutherford, H, McConville, M J
The procyclic acidic repetitive protein is the major cell-surface glycoprotein of the insect-dwelling procyclic forms of the Trypanosoma brucei species of African trypanosomes. The glycoprotein...
Site of palmitoylation of a phospholipase C-resistant glycosylphosphatidylinositol membrane anchor.
The site of palmitoylation of the phosphatidylinositol moiety of the glycosyl-phosphatidylinositol membrane anchor of Trypanosoma brucei procyclic acidic repetitive protein was studied by using...
Bailyes, E M, Ferguson, M A, Colaco, C A, Luzio, J P
myo-Inositol analysis of detergent-solubilized immunoaffinity-purified rat liver 5'-nucleotidase showed the presence of 1 mol of myo-inositol/mol of enzyme monomer. This provides unequivocal evidence...
Xia, M Q, Hale, G, Lifely, M R, Ferguson, M A, Campbell, D, Packman, L, ...
CAMPATH-1 antibodies recognize a unique molecule on human lymphocytes and are unusually efficient at causing cell lysis with homologous complement. They have been successfully used for lymphocyte...
Schneider, P, Rosat, J P, Ransijn, A, Ferguson, M A, McConville, M J
The major macromolecules on the surface of the parasitic protozoan Leishmania major appear to be down-regulated during transformation of the parasite from an insect-dwelling promastigote stage to an...
Pingel, S, Field, R A, Güther, M L, Duszenko, M, Ferguson, M A
The variant surface glycoproteins (VSGs) of Trypanosoma brucei are attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) membrane anchor. This anchor contains the core sequence...
The glycoinositol-phospholipids of Phytomonas.
Redman, C A, Schneider, P, Mehlert, A, Ferguson, M A
The Phytomonas spp. are trypanosomatid parasites of plants. A polar glycolipid fraction of a Phytomonas sp., isolated from the plant Euphorbia characias and grown in culture, was fractionated into...
Schneider, P, Nikolaev, A, Ferguson, M A
GDP-D-arabinopyranose (GDP-D-Ara) is the precursor of the uncommon D-arabinopyranose residues present in the glycoconjugates of a few trypanosomatid parasites. Biosynthetic labelling experiments with...
Neville, D C, Field, R A, Ferguson, M A
Several hydrophobic glycosides of N-acetylglucosamine (GlcNAc) served as primers for polylactosamine synthesis when added to Chinese hamster ovary (CHO) cells. The modified glycosides, containing one...
Proudfoot, L, Schneider, P, Ferguson, M A, McConville, M J
The major macromolecule on the surface of the protozoan parasite Leishmania major is a lipophosphoglycan (LPG) which contains a glycosylphosphatidylinositol glycolipid anchor. This parasite also...
Redman, C A, Thomas-Oates, J E, Ogata, S, Ikehara, Y, Ferguson, M A
The glycosylphosphatidylinositol membrane anchor of human placental alkaline phosphatase was isolated by exhaustive proteolysis followed by hydrophobic interaction chromatography. The resulting...
Almeida, I C, Ferguson, M A, Schenkman, S, Travassos, L R
Sera of patients with chronic Chagas' disease (American trypanosomiasis) contain elevated levels of anti-alpha-galactosyl antibodies that are lytic to Trypanosoma cruzi. The T. cruzi trypomastigote...
Glycoinositol-phospholipid profiles of four serotypically distinct Old World Leishmania strains.
Schneider, P, Schnur, L F, Jaffe, C L, Ferguson, M A, McConville, M J
Glycoinositol-phospholipids (GIPLs) are the major glycolipid class and prominant surface antigens of leishmanial parasites. The GIPLs from four serologically distinct Old World strains of Leishmania...
Mehlert, A, Varon, L, Silman, I, Homans, S W, Ferguson, M A
The structure of the glycan moiety of the glycosyl-phosphatidylinositol (GPI) membrane anchor from Torpedo californica (electric fish) electric-organ acetylcholinesterase was solved using n.m.r.,...
Trypanosoma brucei brucei variant surface glycoprotein contains non-N-acetylated glucosamine.
Strang, A M, Williams, J M, Ferguson, M A, Holder, A A, Allen, A K
The C-terminal amino acid of the variant surface glycoprotein of the parasitic protozoan Trypanosoma brucei brucei is glycosylated and the oligosaccharide has been shown to contain glucosamine. By...
Zamze, S E, Ferguson, M A, Moxon, E R, Dwek, R A, Rademacher, T W
A phosphorylated 3-deoxy-manno-octulosonic acid (KDO) was released from the lipopolysaccharide (LPS) of the deep rough mutant (Rb+169) of Haemophilus influenzae by acid hydrolysis. Both...
Direct measurement of inositol in bovine myelin basic protein.
Smith, R, Braun, P E, Ferguson, M A, Low, M G, Sherman, W R
Myelin basic protein has been isolated from bovine central-nervous-system myelin by four methods, none of which exposes the protein to acid. After purification the inositol content of both hydrolysed...
Weinhart, U, Thomas, J R, Pak, Y B, Thompson, G A, Ferguson, M A
A glycolipid metabolically labelled with [14C]GlcN was isolated from the free-living protozoan Tetrahymena mimbres. The glycolipid was sensitive to a bacterial phosphatidylinositol-specific...
Studies on the structure of a phosphoglycoprotein from the parasitic protozoan Trypanosoma cruzi.
Ferguson, M A, Allen, A K, Snary, D
A glycoprotein (GP72) has been isolated from Trypanosoma cruzi and found to contain 41% protein, 49% carbohydrate and 10% phosphate. All phosphate was covalently attached to the carbohydrate which...
Smith, T K, Sharma, D K, Crossman, A, Dix, A, Brimacombe, J S, Ferguson, M A
Glycosylphosphatidylinositol (GPI) structures are attached to many cell surface glycoproteins in lower and higher eukaryotes. GPI structures are particularly abundant in trypanosomatid parasites...
Selective inhibitors of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei.
Smith, T K, Sharma, D K, Crossman, A, Brimacombe, J S, Ferguson, M A
Synthetic analogues of D-GlcNalpha1-6D-myo-inositol-1-HPO(4)-3(sn-1, 2-diacylglycerol) (GlcN-PI), with the 2-position of the inositol residue substituted with an O-octyl ether...
Structural studies on a lipoarabinogalactan of Crithidia fasciculata.
Schneider, P, Treumann, A, Milne, K G, McConville, M J, Zitzmann, N, Ferguson, M A
The monosaccharide D-arabinopyranose has only been found in glycoconjugates of the trypanasomatid parasites Leishmania major, Endotrypanum schaudinni and Crithidia fasciculata. The donor molecule for...
Paturiaux-Hanocq, F, Zitzmann, N, Hanocq-Quertier, J, Vanhamme, L, Rolin, S, Geuskens, M, ...
Procyclic forms of Trypanosoma brucei have been genetically modified to express the major metacyclic variant surface glycoprotein (VSG variant AnTat 11.17) of Trypanosoma gambiense. The VSG is...
Early steps in glycosylphosphatidylinositol biosynthesis in Leishmania major.
Smith, T K, Milne, F C, Sharma, D K, Crossman, A, Brimacombe, J S, Ferguson, M A
A cell-free system based on washed Leishmania major membranes was labelled with GDP-[3H]Man in the presence of synthetic glucosaminyl-phosphatidylinositol (GlcN-PI) and...
Sharma, D K, Smith, T K, Crossman, A, Brimacombe, J S, Ferguson, M A
De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol (GlcNAc-PI) is the second step of glycosylphosphatidylinositol (GPI) membrane anchor biosynthesis in eukaryotes. This step is a...
Lischke, A, Klein, C, Stierhof, Y D, Hempel, M, Mehlert, A, Almeida, I C, ...
Wild and farmed freshwater fishes are widely and heavily parasitized by the haemoflagellate Trypanosoma carassii. In contrast, common carp, a natural host, can effectively control experimental...
The surface glycoconjugates of trypanosomatid parasites.
Insect-transmitted protozoan parasites of the order Kinetoplastida, suborder Trypanosomatina, include Trypanosoma brucei (aetiological agent of African sleeping sickness), Trypanosoma cruzi...