Cras-Méneur, Corentin, Li, Lin, Kopan, Raphael, Permutt, M. Alan
Canonical Notch signaling is thought to control the endocrine/exocrine decision in early pancreatic progenitors. Later, RBP-Jκ interacts with Ptf1a and E12 to promote acinar differentiation. To...
Yiyong Zhou, Corentin Cras-méneur, Mitsuru Ohsugi, Gary D. Stormo, M. Alan Permutt
A global approach to identify differentially expressed
Katsuya Tanabe, Zhonghao Liu, Satish Patel, Bradley W. Doble, Lin Li, Corentin Cras-Méneur, ...
Despite treatment with agents that enhance β-cell function and insulin action, reduction in β-cell mass is relentless in patients with insulin resistance and type 2 diabetes mellitus. Insulin...
Love-Gregory, Latisha, Sherva, Richard, Sun, Lingwei, Wasson, Jon, Schappe, Timothy, Doria, Alessandro, ...
A region along chromosome 7q was recently linked to components of the metabolic syndrome (MetS) in several genome-wide linkage studies. Within this region, the CD36 gene, which encodes a membrane...
Zhou, Yiyong, Cras-Méneur, Corentin, Ohsugi, Mitsuru, Stormo, Gary D., Permutt, M. Alan.
Motivation: Currently most of the methods for identifying differentially expressed genes fall into the category of so called single-gene-analysis, performing hypothesis testing on a gene-by-gene...
Jonathon Wasson, Jiyan Ma, Carol H. Jin, Benjamin Glaser, Brian K. Suarez, ...
Variants in hepatocyte nuclear factor-4 � (HNF4�), a transcription factor that influences the expression of glucose metabolic genes, have been correlated with maturityonset diabetes of the young,...
Glaser, Benjamin, Chiu, Ken C., Liu, Li, Anker, Roberto, Nestorowicz, Ann, Cox, Nancy J., ...
A gene for autosomal recessive familial hyperinsulinism (HI) (OMIM: 256450), a neonatal metabolic disease characterized by inappropriate insulin secretion In the presence of severe hypoglycemia, was...
Bernal-Mizrachi, Ernesto, Wen, Wu, Stahlhut, Sarah, Welling, Cris M., Permutt, M. Alan
The phosphoinositide 3-kinase–Akt/PKB pathway mediates the mitogenic effects various nutrients and growth factors in cultured cells. To study its effects in vivo in pancreatic islet β cells, we...
The Effects of Fasting and Feeding on Preproinsulin Messenger RNA in Rats
Giddings, Stephen J., Chirgwin, John, Permutt, M. Alan
The purpose of these experiments was to determine whether alterations in preproinsulin messenger (m)RNA activity could account for changes in insulin biosynthesis during fasting and refeeding. Rats...
Bernal-Mizrachi, Ernesto, Fatrai, Szabolcs, Johnson, James D., Ohsugi, Mitsuru, Otani, Kenichi, Han, Zhiqiang, ...
The insulin and IGF signaling pathways are critical for development and maintenance of pancreatic β cell mass and function. The serine-threonine kinase Akt is one of several mediators regulated by...
Genetic epidemiology of diabetes
Permutt, M. Alan, Wasson, Jonathon, Cox, Nancy
Conventional genetic analysis focuses on the genes that account for specific phenotypes, while traditional epidemiology is more concerned with the environmental causes and risk factors related to...
Bernal-Mizrachi, Ernesto, Wen, Wu, Stahlhut, Sarah, Welling, Cris M., Permutt, M. Alan
The phosphoinositide 3-kinase–Akt/PKB pathway mediates the mitogenic effects various nutrients and growth factors in cultured cells. To study its effects in vivo in pancreatic islet β cells, we...
The Effects of Fasting and Feeding on Preproinsulin Messenger RNA in Rats
Giddings, Stephen J., Chirgwin, John, Permutt, M. Alan
The purpose of these experiments was to determine whether alterations in preproinsulin messenger (m)RNA activity could account for changes in insulin biosynthesis during fasting and refeeding. Rats...
Bernal-Mizrachi, Ernesto, Fatrai, Szabolcs, Johnson, James D., Ohsugi, Mitsuru, Otani, Kenichi, Han, Zhiqiang, ...
The insulin and IGF signaling pathways are critical for development and maintenance of pancreatic β cell mass and function. The serine-threonine kinase Akt is one of several mediators regulated by...
Genetic epidemiology of diabetes
Permutt, M. Alan, Wasson, Jonathon, Cox, Nancy
Conventional genetic analysis focuses on the genes that account for specific phenotypes, while traditional epidemiology is more concerned with the environmental causes and risk factors related to...
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome
Johnson, James D., Bernal-Mizrachi, Ernesto, Alejandro, Emilyn U., Han, Zhiqiang, Kalynyak, Tatyana B., Li, Hong, ...
Insulin is both a hormone regulating energy metabolism and a growth factor. We and others have shown that physiological doses of insulin initiate complex signals in primary human and mouse β-cells,...
Tanabe, Katsuya, Liu, Zhonghao, Patel, Satish, Doble, Bradley W, Li, Lin, Cras-Méneur, Corentin, ...
Despite treatment with agents that enhance β-cell function and insulin action, reduction in β-cell mass is relentless in patients with insulin resistance and type 2 diabetes mellitus. Insulin...
Barroso, Inês, Luan, Jian’an, Wheeler, Eleanor, Whittaker, Pamela, Wasson, Jon, Zeggini, Eleftheria, ...
OBJECTIVE—Single nucleotide polymorphisms (SNPs) in the P2 promoter region of HNF4A were originally shown to be associated with predisposition for type 2 diabetes in Finnish, Ashkenazi, and, more...