M. Angela Cenci

Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease. (2002)

Lundblad, M, Andersson, M, Winkler, C, Kirik, D, Wierup, N, Cenci, M Angela

In an attempt to define clinically relevant models of akinesia and dyskinesia in 6-hydroxydopamine (6-OHDA)-lesioned rats, we have examined the effects of drugs with high (L-DOPA) vs. low...

Animal models of neurological deficits: how relevant is the rat? (2002)

Cenci, M Angela, Whishaw, Ian Q, Schallert, Timothy

Animal models of neurological deficits are essential for the assessment of new therapeutic options. It has been suggested that rats are not as appropriate as primates for the symptomatic modelling of...

L-DOPA-Induced Dyskinesia in the Intrastriatal 6-Hydroxydopamine Model of Parkinson's Disease: Relation to Motor and Cellular Parameters of Nigrostriatal Function. (2002)

Winkler, Christian, Kirik, Deniz, Björklund, Anders, Cenci, M Angela

In order to assess the role of striatal dopamine (DA) afferents in L-DOPA-induced dyskinesia, we have studied a large series of rats sustaining 2, 3, or 4 unilateral injections of 6-hydroxydopamine...

Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's disease (2000)

Lee, Chong S., Cenci, M. Angela, Schulzer, Michael, Björklund, Anders

We investigated the role of dopamine neurons in the manifestation of levodopa-induced dyskinesia in a rat model of Parkinson's disease. Daily treatment with a subthreshold dose of levodopa gradually...