Brouwer, I.A., Raitt, M.H., Dullemeijer, C., Kraemer, D.F., Zock, P.L., Morris, C., ...
Aims: To determine the effects of omega-3 polyunsaturated fatty acids (omega-3 PUFAs) from fish on the incidence of recurrent ventricular arrhythmia in implantable cardioverter defibrillator (ICD)...
Mulder, P.J.P., Kunne, C., Boekschoten, M.V., Katan, M.B., ...
Cafestol and kahweol are diterpene compounds present in unfiltered coffees. Cafestol is known as the most potent cholesterol-raising agent that may be present in the human diet. Remarkably, the...
Ricketts, M.L., Boekschoten, M.V., Kreeft, A.J., Moen, C.J.A., Müller, M.R., ...
Cafestol, a diterpene present in unfiltered coffee brews such as Scandinavian boiled, Turkish, and cafetière coffee, is the most potent cholesterol-elevating compound known in the human diet....
Salmonella induces prominent gene expression in the rat colon (2007)
Bovee-Oudenhoven, Ingeborg, Katan, M.B., Keijer, Jaap, Kramer, Evelien, Rodenburg, Wendy, Roosing, Susanne, ...
BACKGROUND:Salmonella enteritidis is suggested to translocate in the small intestine. In vivo it induces gene expression changes in the ileal mucosa and Peyer's patches. Stimulation of Salmonella...
Which are the greatest recent discoveries and the greatest future challenges in nutrition? (2007)
Katan, M.B., Boekschoten, M.V., Connor, W.E., Mensink, R.P., Seidell, J., Vessby, B., ...
Bioavailability of Food Folates is 80% of that of folic acid 1-3 (2007)
Winkels, R.M., Brouwer, I.A., Siebelink, E., Katan, M.B., Verhoef, P.
Background: The bioavailability of natural food folates is lower than that of synthetic folic acid, but no agreement exists as to the extent of the difference. Objective: In a 4-wk dietary...
Rodenburg, G.C.H., Keijer, J., Kramer, E.H.M., Roosing, S., Vink, C., Katan, M.B., ...
Background Salmonella enteritidis is suggested to translocate in the small intestine. In vivo it induces gene expression changes in the ileal mucosa and Peyer's patches. Stimulation of Salmonella...
What can we learn from the FACIT trial: A randomized, double blind, controlled trial (2007)
Durga, J., Schouten, E.G., Kok, F.J., Jolles, J., Katan, M.B., ...
Trans Fatty Acids and Cardiovascular Disease (2006)
Mozaffarian, D., Katan, M.B., Ascherio, A., Stampfer, M.J., Willett, W.C.
Trans fats, unsaturated fatty acids with at least one double bond in the trans configuration (Figure 1), are formed during the partial hydrogenation of vegetable oils, a process that converts...
Dietary fructo-oligosaccharides affect intestinal barrier function in healthy men (2006)
In contrast to most expectations, we showed previously that dietary fructooligosaccharides (FOS) stimulate intestinal colonization and translocation of invasive Salmonella enteritidis in rats. Even...
Goyens, P.L.L., Spilker, M.E., Zock, P.L., Katan, M.B., Mensink, R.P.
BACKGROUND: Human in vivo data on dietary determinants of alpha-linolenic acid (ALA; 18:3n-3) metabolism are scarce. OBJECTIVE: We examined whether intakes of ALA or linoleic acid (LA; 18:2n-6) or...
Regulation of trans fats: the gap, the Polder, and McDonald's French fries (2006)
Lowering the intake of trans fatty acids (TFA) probably reduces the incidence of coronary heart disease. Estimates of the reduction vary from 4% based on changes in plasma LDL and HDL concentrations...
The elimination of trans fats from spreads: how science helped to turn an industry around (2006)
Mensink and Katan showed in 1990 that trans fats reduce high- and increase low-density lipoprotein cholesterol. Unilever aided this study because the company considered knowledge on trans fats...
N-3 fatty acids, cardiac arrhythmia and fatal coronary heart disease (2006)
Brouwer, I.A., Geelen, A., Katan, M.B.
n-3 Polyunsaturated fatty acids (n-3 PUFA) are suggested to prevent cardiac death via inhibition of cardiac arrhythmia. In this review we discuss the results of human studies on intake of n-3 PUFAs...
Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials (2006)
Mozaffarian, D, Brouwer, I.A., Geelen, A., Geleijnse, J.M., Zock, P.L., Katan, M.B.
Olthof, M.R., Bots, M.L., Katan, M.B., Verhoef, P.
Objectives We investigated whether lowering of fasting homocysteine concentrations, either with folic acid or with betaine supplementation, differentially affects vascular function, a surrogate...
Onzekere effecten van foliumzuur op andere aandoeningen dan neuraalbuisdefecten (2006)
Suppletie met foliumzuur rondom de bevruchting reduceert de kans op het krijgen van een baby met een neuraalbuisdefect. 1 Observationele epidemiologische studies wekten hoop dat een hoge inname van...
Brouwer, I.A., Zock, P.L., Camm, A.J., Bocker, D., Hauer, R.N.W., Wever, E.F.D., ...
Background Very long-chain n-3 polyunsaturated fatty acids (n-3 PUFA, also named omega-3 fatty acids) from fish may reduce risk of sudden death through reducing the susceptibility for cardiac...
Dietary Flavonols and Flavonol-rich foods intake and the risk of breast cancer (2005)
Adebamowo, C.A., Sampson, L, Katan, M.B., Spiegelman, D., Willett, W.C., Holmes, M.D., ...
Laboratory and animal studies suggest that dietary flavonols may reduce breast cancer risk but there are limited epidemiological studies. We computed flavonol intakes from dietary data collected by...
Coffee Oil Consumption Increases Plasma Levels of 7alpha-Hydroxy-4-cholesten-3-one in Humans (2005)
Boekschoten, M.V., Hofman, M.K., Buytenhek, R., Schouten, E.G., Princen, H.M.G., Katan, M.B.
Unfiltered coffee brews such as French press and espresso contain a lipid from coffee beans named cafestol that raises serum cholesterol in humans. Cafestol decreases the expression and activity of...
Olthof, M.R., Verhoef, P., Zock, P.L., Katan, M.B.
Background Betaine (trimethylglycine) lowers plasma homocysteine, a possible risk factor for cardiovascular disease. However, studies in renal patients and in obese individuals who are on a...
Olthof, M.R., Brink, E.J., Katan, M.B., Verhoef, P.
Background: A high homocysteine concentration is a potential risk factor for cardiovascular disease that can be reduced through betaine supplementation. Choline is the precursor for betaine, but the...
Verhoef, P., Olthof, M.R., Katan, M.B.
Background: A high plasma concentration of total homocysteine (tHcy) is associated with increased risk of cardiovascular disease. A high protein intake and hence a high intake of methionine¿the sole...
Diets high in red meat and low in green vegetables are associated with an increased risk of colon cancer. In rats, dietary heme, mimicking red meat, increases colonic cytotoxicity and proliferation...
Goyens, P.L.L., Spilker, M.E., Zock, P.L., Katan, M.B., Mensink, R.P.
To estimate in vivo -linolenic acid (ALA; C18:3n-3) conversion, 29 healthy subjects consumed for 28 days a diet providing 7% of energy from linoleic acid (C18:2n-6) and 0.4% from ALA. On day 19,...
Diets high in red meat and low in green vegetables are associated with increased colon cancer risk. This association might be partly due to the haem content of red meat. In rats, dietary haem is...
Geelen, A., Zock, P.L., Brouwer, I.A., Katan, M.B., Kors, J.A., Ritsema, H.J, ...
n-3 Fatty acids may protect against heart disease mortality by preventing fatal arrhythmias. Underlying effects on cardiac electrophysiology may be demonstrable in the standard electrocardiogram...
Effect of fish oil on heart rate in humans. A meta-analysis of randomized controlled trials (2005)
Mozaffarian, D, Geelen, A., Brouwer, I.A., Geleijnse, J.M., Katan, M.B., Zock, P.L.
Dietary fructo-oligosaccharides increase intestinal permeability in rats (2005)
We showed previously that fructooligosaccharides (FOS) decrease the resistance to salmonella infection in rats. However, the mechanism responsible for this effect is unclear. Therefore, we examined...
Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials (2005)
Geelen, A., Mozaffarian, D, Brouwer, I.A., Geleijnse, J.M., Zock, P.L., Katan, M.B.
Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials (2005)
Mozaffarian, D, Brouwer, I.A., Geelen, A., Geleijnse, J.M., Zock, P.L., Katan, M.B.
Differential gene expression in rat colon by dietary heme and calcium (2005)
Kramer, E., Jonker-Termont, D., Katan, M.B., Keijer, J.
Dietary heme and calcium are alleged modulators of colon cancer risk. Little is known about the molecular and cellular changes in the colon epithelium that are induced by consumption of these...
Diet, nutrition and the prevention of hypertension and cardiovascular diseases (2004)
Cardiovascular diseases (CVD) are growing contributors to global disease burdens, with epidemics of CVD advancing across many regions of the world which are experiencing a rapid health transition....
We have shown recently that rapid fermentable fructo-oligosaccharides (FOS) decreased resistance of rats towards salmonella. It is not known whether inulin (which is fermented more gradually) has...
Within-person variation in serum lipids: implications for clinical trials (2004)
Pereira, M.A., Weggemans, R.M., Jacobs, D.R., Hannan, P.J., Zock, P.L., Ordovas, J.M., ...
Geelen, A., Brouwer, I.A., Schouten, E.G., Katan, M.B., Zock, P.L., Kluft, C.
Objective: High-sensitivity C-reactive protein (CRP), a marker of systemic inflammation, is a powerful predictor of cardiovascular risk. We hypothesised that n-3 fatty acids reduce underlying...
Giltay, E.J., Duschek, E.J.J., Katan, M.B., Neele, S.J., Netelenbos, J.C., Zock, P.L.
Estrogens may affect the essential n-6 and n-3 fatty acids arachidonic acid (AA; C20:4n-6) and docosahexaenoic acid (DHA; C22:6n-3). Therefore, we investigated the long-term effects of hormone...
Hofman, M.K., Weggemans, R.M., Zock, P.L., Schouten, E.G., Katan, M.B., Princen, H.M.G.
The response of plasma lipids to dietary cholesterol and fat varies among individuals. Variations in genes involved in cholesterol metabolism can be important in these interindividual differences....
Promises and problems of functional foods (2004)
“Functional”foods are branded foods, which claim, explicitly or implicitly, to improve health or well being. We review typical functional foods and their ingredients, efficacy, and safety. We...
Bioavailability of heptaglutamyl relative to monoglutamyl folic acid in healthy adults. (2004)
Melse-Boonstra, A., West, C.E., Katan, M.B., Kok, F.J., Verhoef, P.
Bioavailability and antioxidant effects of olive oil phenols in humans: a review (2004)
Vissers, M.N., Katan, M.B., Zock, P.L.
Objective: We reviewed the bioavailability and antioxidant effects of phenols from extra virgin olive oil. Search strategy: We searched the MEDLINE database for the years 1966-2002. To review the...
Development of a new method to study bioavailability of folate from total diets in health (2004)
Winkels, R.M., Melse-Boonstra, A., West, C.E., Katan, M.B., Verhoef, P.
Antiarrhythmic effects of n-3 fatty acids: evidence from human studies (2004)
Geelen, A., Brouwer, I.A., Zock, P.L., Katan, M.B.
Purpose of review: N-3 fatty acids from fish reduce cardiovascular mortality including sudden cardiac death. In this paper, the authors discuss the results of human studies with regard to the...
Brouwer, I.A., Katan, M.B., Zock, P.L.
The objective of this meta-analysis was to estimate quantitatively the associations between intake of -linolenic acid [ALA, the (n-3) fatty acid in vegetable oils], mortality from heart disease, and...
Dietary fish oil and fatty acid composition of plasma and myocardium in pigs (2004)
Dullemeijer, C., Brouwer, I.A., Coronel, R, Katan, M.B., Zock, P.L.
Geelen, A., Brouwer, I.A., Schouten, E.G., Katan, M.B., Maan, A.C., Zock, P.L.
A large body of evidence suggests that n-3 fatty acids from fish prevent fatal heart disease. They may be an effective and safe alternative to drug treatment for reducing the risk of arrhythmia and...
Dietary fat and arrhythmias: Where from here? (2004)
Brouwer, I.A., Coronel, R, Geelen, A., Katan, M.B., Schouten, E.G., Zock, P.L.
Determinants of the conversion of dietary alpha-linolenic acid into EPA and DHA in humans. (2004)
Goyens, P.L.L., Spilker, M.E., Zock, P.L., Katan, M.B., Mensink, R.P.
N-3 fatty acids and electrocardiographic risk indicators of arrhythmia (2004)
Katan, M.B., Geelen, A., Brouwer, I.A., Zock, P.L., Schouten, E.G.
Determinants of the Conversion of Dietary a-Linolenic Acid into Epa and Dha in humans (2004)
Katan, M.B., Goyens, P.L.L., Mensink, R.P., Spilker, M.E., Zock, P.L.
The rise and fall of postprandial lipids (2004)
The remnants of absorbed fat particles which circulate after a meal might cause atherosclerosis, but such a causal role is still unproven. High levels of such lipoprotein remnants are often found in...
Differential gene expression in rat colon by dietary heme and calcium (2004)
Kramer, E., Jonker-Termont, D., Katan, M. B., Keijer, J.
Dietary heme and calcium are alleged modulators of colon cancer risk. Little is known about the molecular and cellular changes in the colon epithelium that are induced by consumption of these...
High Stability of Markers of Cardiovascular Risk in Blood Samples (2003)
Giltay, E.J., Geleijnse, J.M., Schouten, E.G., Katan, M.B., Kromhout, D.
Low Relative Bioavailability of Heptaglutamul Folic Acid (2003)
Boonstra, A., West, C.E., Katan, M.B., Kok, F.J., Verhoef, P.
Reproducibility of the serum lipid response to coffee oil in healthy volunteers (2003)
Boekschoten, M.V., Engberink, M.F., Katan, M.B., Schouten, E.G.
Brouwer, I.A., Zock, P.L., Katan, M.B., Hauer, R.N.W., Camm, A., Bocker, D.I., ...
Background: Evidence from earlier studies indicates that intake of very long-chain n-3 polyunsaturated fatty acids (n-3 PUFA, also named omega-3 fatty acids) as present in fish oil reduces the risk...
Geelen, A., Zock, P.L., Swenne, C.A., Brouwer, I.A., Schouten, E.G., Katan, M.B.
Background N-3 fatty acids may reduce the risk of sudden death by preventing life-threatening cardiac arrhythmias. Heart rate variability (HRV) and baroreflex sensitivity (BRS) reflect cardiac...
De Roos, N.M., Bots, M.L., Schouten, E.G., Katan, M.B.
Flow-mediated vasodilation (FMD) of the brachial artery is used as a marker of cardiovascular disease risk. It is defined as the percentage dilation from the baseline diameter in response to a...
N-3 fatty acids in human fat tissue aspirates are stable for up to 6y (2003)
Objectives: The content of n-3 (omega-3) polyunsaturated fatty acids in fat tissue is a valid indicator of their long-term consumption. We studied the stability of n-3 fatty acids in human...
Efficacy and safety of plant stanols and sterols in the control of blood cholesterol levels (2003)
Katan, M.B., Grundy, S.M., Jones, P.J.H., Law, M.R., Miettinen, T., Paoletti, R.
Foods with plant stanol or sterol esters lower serum cholesterol levels. We summarize the deliberations of 32 experts on the efficacy and safety of sterols and stanols. A meta-analysis of 41 trials...
Mensink, R.P., Zock, P.L., Kester, A.D.M., Katan, M.B.
Background: The effects of dietary fats on the risk of coronary artery disease (CAD) have traditionally been estimated from their effects on LDL cholesterol. Fats, however, also affect HDL...
Betaine supplementation lowers plasma homocysteine levels in healthy men and women (2003)
Steenge, G.R.S., Verhoef, P., Katan, M.B.
Elevated levels of plasma total homocysteine are associated with a higher risk of cardiovascular disease. Betaine and 5-methyltetrahydrofolate can remethylate homocysteine into methionine via...
Boonstra, A., Brouwer, I.A., Clarke, R.J., West, C.E., Katan, M.B.
Background: Elevated homocysteine concentrations, a likely risk factor for cardiovascular disease, can be lowered effectively with folic acid. The minimum dose of folic acid required for maximal...
De Roos, N.M., Schouten, E.G., Katan, M.B.
A high consumption of trans fatty acids increases the risk of cardiovascular disease (CVD). We investigated whether this increase in risk was due to the decrease in serum HDL-cholesterol by trans...
N-3 fatty acids and markers of cardiac arrhythmia in healthy middle-aged subjects (2003)
Geelen, A., Zock, P.L., Brouwer, I.A., Schouten, E.G., Katan, M.B.
N-3 fatty acids and markers of cardiac arrhythmia inhealthy middle-aged subjects (2003)
Geelen, A., Zock, P.L., Brouwer, I.A., Schouten, E.G., Katan, M.B.
Variability in Flow Mediated Vasodilation of the brachial artery in young healthy subjects (2003)
Olthof, M.R., Verkooijen, I., Dammers, R., De Roos, N.M., Katan, M.B.
Dietary serine and cystine diminish the homocysteine raising effect of methionine in humans (2003)
Verhoef, P., Steenge, G.R.S., Boelsma, E., Olthof, M.R., Katan, M.B.
Voeding en gezondheid : zin en onzin van voedingssupplementen en functionele voedingsmiddelen (2003)
Voeding en gezondheid - zin en onzin van voedingssupplementen en functionele voedingsmiddelen (2003)
Swinburn, Boyd, Baba, N.H., Belhadj, M., Deurenberg-Yap, M., Djazayery, A., Forrester, T., ...
This report examines the science base of the relationship between diet and physical activity patterns, and the major nutrition-related chronic diseases. Recommendations are made to help prevent death...
Swinburn, Boyd, Baba, N.H., Belhadj, M., Deurenberg-Yap, M., Djazayery, A., Forrester, T., ...
This report examines the science base of the relationship between diet and physical activity patterns, and the major nutrition-related chronic diseases. Recommendations are made to help prevent death...
(N-3) fatty acids do not affect electrocardiographic characteristics of healthy men and women (2002)
Geelen, A., Brouwer, I.A., Zock, P.L., Kors, J.A., Swenne, C.A., Katan, M.B., ...
(n-3) Fatty acids may reduce the risk of sudden death by preventing life-threatening cardiac arrhythmia. A standard electrocardiogram (ECG) may be used to detect clues as to the mechanism by which...
Siebelink, E., Bots, M.L., Schouten, E.G., Katan, M.B.
Objective: Several studies suggest that a fatty meal impairs flow-mediated vasodilation (FMD), a measur9e of endothelial function. We tested whether the impairment was greater for trans fats than for...
Flavonol and flavone intakes in US health professionals (2002)
Sampson, L., Rimm, E., Hollman, P.C.H., Katan, M.B.
Objective To determine flavonoid content of US foods, mean individual intakes, major food sources, and associations with other nutrients. Subjects US men (n=37,886) and women (n=78,886) who completed...
Apolipoprotein E polymorphism and serum lipid response to plant sterols in humans (2002)
Geelen, A., Zock, P.L., Katan, M.B.
BackgroundThe apolipoprotein E polymorphism may influence the absorption of cholesterol from the intestine and thus the response of serum cholesterol to diet. We decided to use plant sterols to...
Olive oil phenols are absorbed in humans (2002)
Vissers, M.N., Zock, P.L., Roodenburg, A.J.C., Leenen, R., Katan, M.B.
Animal and in vitro studies suggest that olive oil phenols are effective antioxidants. The most abundant phenols in olive oil are the nonpolar oleuropein- and ligstroside-aglycones and the polar...
Terpstra, A.H.M., Beynen, A.C., Everts, H., Kocsis, S., Katan, M.B., Zock, P.L.
We carried out energy balance studies in four groups of young, growing, 5-wk-old Balb-C mice (n = 12/group) that were either food restricted or nonrestricted and fed high fat diets (38 energy%) with...
Rationale and design of a clinical trial on n-3 fatty acids and cardiac arrhythmia (2002)
Brouwer, I.A., Schouten, E.G., Zock, P.L., Katan, M.B., Camm, A.J., Bocker, D., ...
Weggemans, R.M., Zock, P.L., Tai, E.S., Ordovas, J.M., Molhuizen, H.O.F., Katan, M.B.
ATP binding cassette protein G5 (ABCG5) and G8 (ABCG8) may be involved in the regulation of intestinal cholesterol absorption. Therefore, genetic variation at these loci may affect blood cholesterol...
Schouten, E.G., Scheek, L.M., Katan, M.B.
A high intake of saturated fat and of trans isomers of unsaturated fat is associated with increased risk of cardiovascular disease. Recently, we found that replacement of saturated fat by trans fat...
Verhoef, P., Pasman, W.J., Urgert, R., Katan, M.B.
Background: A high plasma total homocysteine concentration is associated with increased risk of cardiovascular disease. Consumption of unfiltered or filtered coffee raises total homocysteine...
Chlorogenic acid and caffeic acid are absorbed in humans (2001)
Olthof, M.R., Hollman, P.C.H., Katan, M.B.
Chlorogenic acid, an ester of caffeic acid and quinic acid, is a major phenolic compound in coffee; daily intake in coffee drinkers is 0.5-1 g. Chlorogenic acid and caffeic acid are antioxidants in...
Solid fats are used in food manufacturing to provide texture and firmness to foods. Such fats are rich in either saturated or trans-fatty acids, both of which increase the risk of coronary heart...
Effect of phenol-rich extra virgin olive oil on markers of oxidation in healthy volunteers (2001)
Vissers, M.N., Zock, P.L., Wiseman, S.A., Meyboom, S., Katan, M.B.
Objective: We studied whether consumption of phenol-rich extra virgin olive oil affects the susceptibility of low density lipoproteins (LDL) to oxidation and other markers of oxidation in humans....
Red wine is a poor source of bioavailable flavonols in men (2001)
Hollman, P.C.H., Olthof, M.R., Katan, M.B.
Red wine is a source of polyphenolic antioxidants, of which flavonols such as quercetin are representatives. Red wine might therefore prevent LDL oxidation and atherosclerosis. However, data on the...
Weggemans, R.M., Zock, P.L., Katan, M.B.
Several epidemiologic studies found no effect of egg consumption on the risk of coronary heart disease. It is possible that the adverse effect of eggs on LDL-cholesterol is offset by their favorable...
Serum lithium as a compliance marker for food and supplement intake (2001)
Analyzing 24-h urine for lithium after consumption of lithium-tagged foods or supplements provides a validated compliance marker but is laborious. Objective: Most studies involve blood sampling;...
Weggemans, R.M., Zock, P.L., Ordovas, J.M., Pedro-Botet, J., Katan, M.B.
Previous studies on the effect of apoprotein E (APOE) polymorphism on the response of serum lipids to diet showed inconsistent results. We therefore studied the effect of apoprotein E polymorphism on...
Addition of milk does not affect the absorption of flavonols from tea in man (2001)
Hollman, P.C.H., Tijburg, L.B.M., Katan, M.B.
Tea is a major source of flavonols, a subclass of antioxidant flavonoids present in plant foods which potentially are beneficial to human health. Milk added to tea, a frequent habit in the United...
Olthof, M.R., Hollman, P.C., Zock, P.L., Katan, M.B.
In population studies, high intakes of coffee are associated with raised concentrations of plasma homocysteine, a predictor of risk of cardiovascular disease. Chlorogenic acid is a major polyphenol...
Essenberg, M., Olthof, M., Tangerman, A., Katan, M.B., ...
Resistant starch decreases the concentration of secondary bile acids in the feces and the proliferation rate of colonic mucosal cells in healthy volunteers. This may reduce the risk of colon cancer....
Rationale and design of a clinical trial on N-3 fatty acids and cardiac arrhythmia (SOFA) (2001)
Brouwer, I.A., Katan, M.B., Schouten, E.G., Camm, A.J., Böcker, D., Hauer, R.N.W., ...
Absorption of phenols from extra virgin olive oil in humans (abstract) (2001)
Vissers, M.N., Zock, P.L., Roodenburg, A.J.C., Leenen, R., Katan, M.B.
Vissers, M.N., Zock, P.L., Leenen, R., Roodenburg, A.J.C., Katan, M.B.
A high intake of olive oil has been proposed as an explanation for the low incidence of coronary heart disease in Mediterranean countries, but it is unclear whether olive oil offers specific benefits...
Genetic polymorphisms and lipid response to dietary changes in humans (2001)
Weggemans, R.M., Zock, P.L., Ordovas, J.M., Ramos-Galluzzi, J., Katan, M.B.
Previous studies on the effects of genetic polymorphisms on the serum cholesterol response to dietary treatments were often inconsistent and frequently involved small numbers of subjects. We studied...
Voortman, A., Melse-Boonstra, A., Schultz, M., Burema, J., Katan, M.B., Verhoef, P.
Many studies have shown that increased plasma concentrations of total homocysteine (tHcy) are associated with cardiovascular disease (1). Like most biological variables, plasma tHcy fluctuates within...
LC-MS/MS analysis of stable isotopically-labelled 5-methyl-tetrahydrofolate in human plasma (2001)
Melse-Boonstra, A., Lasaroms, J.J.P., Verhoef, P., Hollman, P.C.H., Katan, M.B., ...
Caslake, M.J., Stalenhoef, A.F.H., Bedford, D., Demacker, P.N., Katan, M.B., ...
Background: Cafestol is a diterpene in unfiltered coffee that raises plasma triacylglycerol in humans. Objective: We studied whether cafestol increases plasma triacylglycerol by increasing the...
We tested whether trans fatty acids and saturated fatty acids had different effects on flow-mediated vasodilation (FMD), a risk marker of coronary heart disease (CHD). Consumption of trans fatty...
The glutathione biotransformation system and colon carcinogenesis in human (2001)
Nagengast, F.M., Katan, M.B., Peters, W.H.M.
Evidence for a protective role of the glutathione biotransformation system in carcinogenesis is growing. However, most data on this system in relation to colorectal cancer originate from animal...
Olthof, M.R., Hollman, P.C.H., Zock, P.L., Katan, M.B.
In population studies, high intakes of coffee are associated with raised concentrations of plasma homocysteine, a predictor of risk of cardiovascular disease. Chlorogenic acid is a major polyphenol...
Chlorogenic acid and Caffeic acid absorbed in humans (2001)
Olthof, M.R., Hollman, P.C.H., Katan, M.B.
Chlorogenic acid, an ester of caffeic acid and quinic acid, is a major phenolic compound in coffee; daily intake in coffee drinkers is 0.5-1 g. Chlorogenic acid and caffeic acid are antioxidants in...
Effect of phenol-rich extra virgin olive oil on markers of oxidation in healthy volunteers (2001)
Vissers, M.N., Meyboom, S., Wiseman, M., Zock, P.L., Katan, M.B.
Urgert, R., Scheek, L.M., Buytenhek, R., ...
We reviewed the evidence from human intervention studies for the health effects of probiotic bacteria, ie, live bacteria that survive passage through the gastrointestinal tract and have beneficial...
Broekhuizen, R., ...
Background: Epidemiologic studies suggest that coffee use might protect against colorectal cancer. Inconsistencies as to the effect of coffee use and colorectal cancer between epidemiologic studies...
Grubben, M.J., Boers, G.H., Blom, H.J., Broekhuizen, R., ...
Background: An elevated plasma homocysteine concentration is a putative risk factor for cardiovascular disease. Observational studies have reported an association between coffee consumption and...
Lipoproteins in health and disease (2000)
Death from cardiovascular disease in middle age is much less common now than it was 40 years ago. This change did not come about spontaneously. Concerted efforts to understand, treat, and prevent...
Bioavailabilities of quercetin-3-glucoside and quercetin-4'-glucoside do not differ in humans (2000)
Olthof, M., Hollman, P.C.H., Vree, T.B., Katan, M.B.
The flavonoid quercetin is an antioxidant which occurs in foods mainly as glycosides. The sugar moiety in quercetin glycosides affects their bioavailability in humans. Quercetin-3-rutinoside is an...
Post, S.M., Vermeulen, M., Afman, L., Jong, M.C., Dahlmans, V.E.H., ...
Cafestol, a diterpene present in unfiltered coffee, potently increases serum cholesterol levels in humans. So far, no suitable animal model has been found to study the biochemical background of this...
The hypercholesterolemic effect of cafestol in coffee oil in gerbils and rats (2000)
Terpstra, A.H.M., Katan, M.B., Beynen, A.C.
Coffee beans contain the diterpene cafestol, which raises plasma cholesterol concentrations in humans. Daily consumption of 2 g coffee oil, which provides approximately 60 mg cafestol (equivalent to...
Effect of phenols from extra virgin olive oil on markers of oxidation in healthy humans (2000)
Vissers, M.N., Zock, P.L., Leenen, R., Roodenburg, A.J.C., Wiseman, S.A., Katan, M.B.
Weggemans, R.M., Zock, P.L., Meyboom, S., Funke, H., Katan, M.B.
The response of serum lipids to dietary changes is to some extent an innate characteristic. One candidate genetic factor that may affect the response of serum lipids to a change in cholesterol intake...
Trans fatty acids and coronary heart disease (1999)
Ascherio, A., Katan, M.B., Zock, P.L., Stampfer, M.J., Willett, W.C.
Trans unsaturated fatty acids are produced commercially in large quantities by heating vegetable oils in the presence of metal catalysts and hydrogen to form shortening and margarine.1 They are so...
Sawyer, J.K., Katan, M.B., Rudel, L.L.
Cafestol and kahweol, coffee lipids present in unfiltered coffee brews, potently increase LDL-cholesterol concentration in human subjects. We searched for an animal species in which cafestol...
Dietary flavonoids: intake, health effects and bioavailability (1999)
Flavonoids are polyphenolic compounds that occur ubiquitously in foods of plant origin. Over 4000 different flavonoids have been described. They may have beneficial health effects because of their...
Hollman, P.C.H., Cnossen, E.P.J., Katan, M.B.
Flavonoids are antioxidants present in plant foods. They occur mainly as glycosides, i.e. linked with various sugars. It is uncertain to what extent dietary flavonoid glycosides are absorbed from the...
Effect of phenol-rich extra virgin olive oil on LDL oxidation in healthy volunteers (1999)
Vissers, M.N., Meyboom, S., Wiseman, S.A., Zock, P.L., Katan, M.B.
Health aspects of fish and N-3 pufa from plant and marine origin: summary of a workshop. (1998)
Korver, O., Verschuren, P.M., Katan, M.B.
An expert workshop reviewed the health effects of n-3 polyunsaturated fatty acids (PUFA), and came to the following conclusions. Consumption of fish may reduce the risk of coronary heart disease...
Hollman, P.C.H., Meyboom, S., Zock, P.L., ...
Flavonols are antioxidants that may reduce the risk of heart disease. Two major flavonols in the diet are quercetin and kaempferol, and their main sources in The Netherlands are tea and onions. We...
Bioavailability and health effects of dietary flavonols in man. (1998)
Flavonoids are polyphenolic compounds that occur ubiquitously in foods of plant origin. Over 4000 different flavonoids have been described, and they are categorized into flavonols, flavones,...
Effect of low-fat diets on plasma high-density lipoprotein concentrations (1998)
Low concentrations of HDLs in plasma are a strong predictor of risk for coronary as well as other cardiovascular diseases. There is increasing evidence that this relation is causal and that...
Alles, M.S., Katan, M.B., Gerichhausen, M.J.W., Rozendaal, M.J., ...
Patients with large bowel disease may undergo ileal pouch-anal anastomosis, in which the colon is removed and part of the distal ileum is used to construct a pelvic reservoir. Competence of the ileal...
Blok, W.K.L., Deslypere, J.P., Demacker, P.N.M., Hectors, M.P.C., ...
Dietary supplementation with n-3 fatty acids from fish oil alleviates inflammation in various chronic inflammatory disease states. Reductions in the production of pro-inflammatory cytokines...
Urgert, R., Charrier, A., Katan, M.B.
Abstract Specific fatty acids and sterols in food composites from seven countries were analyzed. In the 1960s, groups of 8 to 49 men from 16 cohorts, ages 40–59 years and living in the United...
The fatty acid and sterol content of food composites of middle-aged men in seven countries. (1997)
Jansen, A.M., Kromhout, D., Mensink, R.P., ...
Specific fatty acids and sterols in food composites from seven countries were analyzed. In the 1960s, groups of 8 to 49 men from 16 cohorts, ages 40–59 years and living in the United States,...
Consumption of quercetin and kaempferol in free-living subjects eating a variety of diets. (1997)
Quercetin and related flavonoids are anticarcinogenic in rats, but little is known about human intakes. The intake of five major flavonols and flavones was calculated using 1-day dietary records of...
Bioavailability of the dietary antioxidant flavonol quercetin in man. (1997)
Hollman, P.C.H., Mengelers, M.J.B., Katan, M.B.
Quercetin, a dietary antioxidant flavonoid, has anticarcinogenic properties. We quantified the absorption of quercetin in ileostomists. Absorption was 52 ± 5␏or quercetin glucosides from onions,...
Relative bioavailability of the antioxidant quercetin from various foods in man. (1997)
Hollman, P.C.H., Mengeler, M.J.B., ...
Quercetin is a strong antioxidant and a major dietary flavonoid. Epidemiological studies suggest that consumption of quercetin protects against cardiovascular disease, but its absorption in man is...
Absorption, metabolism and health effects of dietary flavonoids in man. (1997)
Flavonoids are polyphenolic compounds that occur ubiquitously in foods of plant origin. Over 4,000 different flavonoids have been described, and they are categorized into flavonols, flavones,...
Acetylsalicylate and salicylates in foods. (1997)
Katan, M.B., Hollman, P.C.H., Venema, D.P.
Acetylsalicylic acid is effective in the prevention of cardiovascular disease. It was suggested that fruits and vegetables provide unknown amounts of acetylsalicylic acid. We could not find any...
Katan, M.B., Deslypere, J.P., Zegwaard, M.J.
Tissue levels of n-3 fatty acids reflect dietary intake, but quantitative data about rate of incorporation and levels as a function of intake are scarce. We fed 58 men 0, 3, 6, or 9 g/d of fish oil...
Katan, M.B., Willett, W.C., Grundy, S.M.
Low-fat diets are often advocated for weight reduction and to lower the risk of coronary heart disease and certain forms of cancer. However, there is no universal agreement about the value of low-fat...
Phytosterol concentrations in parenteral lipid emulsions. (1997)
Naber, A.H.J., Elzerman, H., Tangerman, A., Hectors, M.P.C., Demacker, P.N.M., Bakker, H., ...
Tea flavonoids and cardiovascular diseases: A review. (1997)
Tijburg, L.B.M., Mattern, T., Folts, J.D., Weisgerber, U.M., Katan, M.B.
Urgert, R., Hovenier, R., Meyboom, S., Beynen, A.C., Katan, M.B.
Objective: Unfiltered coffee raises serum LDL cholesterol in humans, owing to the presence of the diterpenes cafestol and kahweol. Norwegians with a chronic high intake of unfiltered coffee also had...
Urgert, R., Essed, N., Kosmeijer-Schuil, T.G., Katan, M.B.
The coffee diterpene cafestol occurs in both robusta and arabica beans. It is present in unfiltered coffee brews and raises serum concentrations of cholesterol, triacylglycerols, and alanine...
Urgert, R., Scheek, L.M., ...
Cafestol and kahweol–diterpenes present in unfiltered coffee— strongly raise serum VLDL and LDL cholesterol and slightly reduce HDL cholesterol in humans. The mechanism of action is unknown. We...
Butter, margarine and serum lipoproteins. (1997)
Intake of trans fatty acids unfavorably affects blood lipoproteins. As margarines are a major source of trans, claims for the advantages of margarines over butter need to be scrutinized. Here we...
Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man (1997)
Hollman, P.C.H., Mengelers, M.J.B., ...
Quercetin is a strong antioxidant and a major dietary flavonoid. Epidemiological studies suggest that consumption of quercetin protects against cardiovascular disease, but its absorption in man is...
Acetylsalicylate and salicylates in foods (1997)
Katan, M.B., Staveren, W.A. Van, Hollman, P.C.H., Venema, D.P.
The fatty acid and sterol content of food composites of middle- aged men in seven countries (1997)
Jansen, A.M., Kromhout, D., Bovenkamp, P. Van De, Staveren, W.A. Van, Mensink, R.P., ...
Zock, P.L., Gerritsen, J., Katan, M.B.
The authors investigated the effect of the position of fatty acids within dietary triglycerides on the composition of plasma lipids. Sixty volunteers consumed two diets of equal fatty acid...
Analysis and health effects of flavonoids. (1996)
Hollman, P.C.H., Hertog, M.G.L., Katan, M.B.
Flavonoids are polyphenolic compounds that occur ubiquitously in foods of plant origin. Over 4000 different flavonoids have been described. Flavonoids have a variety of biological effects in numerous...
Chronic consumers of boiled coffee have elevated serum levels of lipoprotein(a). (1996)
Urgert, R., Hovenier, R., Lund-Larsen, P.G., Katan, M.B.
OBJECTIVES: Lipoprotein(a) consists of an LDL-particle attached to apolipoprotein(a), which is made by the liver. Diterpenes present in boiled coffee raise serum levels of LDL cholesterol and of the...
Absorption and disposition kinetics of the dietary antioxidant quercetin in man. (1996)
Hollman, P.C.H., Mengelers, M.J.B., Katan, M.B.
Quercetin is a dietary antioxidant that prevents oxidation of low-density lipoproteins in vitro by scavenging of free oxygen radicals. Its intake was inversely associated with coronary heart disease...
Venema, D.P., Hollman, P.C.H., Katan, M.B.
We developed a specific and sensitive HPLC method with fluorescence detection for the determination of free acetylsalicylic acid, free salicylic acid, and free salicylic acid plus salicylic acid...
Urgert, R., Meyboom, S., Kuilman, M., Rexwinkel, H., Vissers, M.N., Klerk, M., ...
Objectives: To examine the association of plasma caffeine concentrations during pregnancy with fetal growth and to compare this with relations with reported caffeine intake. Design: Prospective...
Red wine consumption does not affect oxidizability of low-density lipoproteins in volunteers. (1996)
Demacker, P.N.M., Assen, N.A., Sloots, L.M., Katan, M.B., Stalenhoef, A.F.H.
Hollman, P.C.H., Reichman, E., Venema, D.P., Katan, M.B.
Intake of acetylsalicylic acid reduces the risk of cardiovascular disease and is associated with a decreased risk for colorectal cancer. Amounts of salicylates in foods are thus of interest, but data...
The cholesterol-raising factor from coffee beans. (1996)
Coffee beans and some types of coffee brew - not the regular types of coffee prepared with a paper filter or with soluble coffee granules - contain the diterpenes cafestol and kahweol. Cafestol and...
Maas, M.I.M., Hopman, W.P.M., Katan, M.B.
Long-chain triglycerides inhibit gastric acid secretion, but the effect of medium-chain triglycerides in humans is unknown. We compared the effects of intraduodenally perfused saline, medium-chain...
Essenberg, M., Olthof, M., Tangerman, A., ...
Individual fatty acid effects on plasma lipids. (1996)
Jonnalagadda, S.S., Yu, S., Katan, M.B., Zock, P.L., Kris-Etherton, P.M.
Anti-oxidant vitamin status of Russian children and elderly. (1996)
Poortvliet, E.J., Kok, F.J., Alexandrov, A.A., Mazaev, V., ...
Essenberg, M., Olthof, M., Tangerman, A., ...
Red wine consumption does not affect the oxidation of low-density lipoproteins in humans. (1995)
Demacker, P.N.M., Assen, N.A., Sloots, L.M., Katan, M.B., Stalenhoef, A.F.H.
Levels of the cholesterol-elevating diterpenes cafestol and kawheol in various coffee brews. (1995)
Urgert, R., Kosmeijer-Schuil, T.G., Hovenier, R., Katan, M.B.
Cafestol and kahweol in coffee brews: effects on serum cholesterol in humans. (1995)
Urgert, R., Schulz, A.G.M., Katan, M.B.
Scandinavian boiled coffee and coffee oil raise serum cholesterol and alanine aminotransferase (ALT) in humans. The diterpenes cafestol, and possibly kahweol, are responsible; every 10 mg of cafestol...
Hertog, M.G.L., Kromhout, D., Aravanis, C., Blackburn, H., Buzina, R., Fidanza, F., ...
To determine whether flavonoid intake explains differences in mortality rates from chronic diseases between populations. DESIGN: Cross-cultural correlation study. SETTING/PARTICIPANTS: Sixteen...
Dietary trans fatty acids increase serum cholesterylester transfer protein activity in man. (1995)
Zock, P.L., Scheek, L.M., Katan, M.B.
The average diet may provide some 8–10 g/day of unsaturated fatty acids with a trans double bond. Previous studies showed that dietary trans fatty acids may simultaneously raise low-density...
Kromhout, D., Menotti, A., Bloemberg, B., Aravanis, C., Blackburn, H., Buzina, R., ...
Background. In the Seven Countries Study associations between intake of individual fatty acids and dietary cholesterol were studied in relation to serum cholesterol and 25-year mortality from...
Red wine consumption and oxidation of low-density lipoproteins (1995)
Rijke, Y.B. De, Demacker, P.N.M., Assen, N.A., Sloots, L.M., Katan, M.B., Stalenhoef, A.F.H.
Levels of the cholesterol-elevating diterpenes cafestol and kahweol in various coffee brews (1995)
Urgert, R., Weg, G. Van Der, Kosmeijer-Schuil, J.G., Bovenkamp, P. Van De, Hovenier, R., Katan, M.B.
Kromhout, D., Nedeljkovic, S.I., Grujic, M.Z., Ostojic, M.C., Keys, A., Menotti, A., ...
The Serbian cohorts of the Seven Countries Study were examined four times during a 25-year period. Large changes were observed in average serum cholesterol, blood pressure and the prevalence of...
Effect of resistant starch on breath-hydrogen and methane excretion in healthy volunteers. (1994)
Jansen, M.C., Katan, M.B., ...
Fats for diabetics. (Letter). (1994)
Opinion. Comments on the treatment of type 2 diabetes from the interaction between nature and nurture. Effective form of treatment for type 2 diabetes; Composition of the diet for diabetics;...
Dietary flavonoids and cancer risk in the Zutphen Elderly Study. (1994)
Hertog, M.G.L., Feskens, E.J.M., Hollman, P.C.H., Katan, M.B., Kromhout, D.
Flavonoïden: non-nutriënten of nutriënten? (1994)
Hertog, M.G.L., Hollman, P.C.H., Katan, M.B., Feskens, E.J.M., Kromhout, D.
Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. (1993)
Hertog, M.G.L., Feskens, E.J.M., Hollman, P.C.H., Katan, M.B., Kromhout, D.
Goff, D.C., Shekelle, R.B., Moyé, L.A., Katan, M.B., Gotto, A.M., Stamler, J.
The hypothesis that lean persons are more responsive than fat persons to the effects of dietary cholesterol was investigated in 1,903 middle-aged employed men who were examined in 1958 and 1959 as...
Effects of rapeseed oil and sunflower oil on serum lipoproteins in healthy subjects. (1993)
Aro, A., Valsta, L.M., Jauhiainen, M., Katan, M.B., Mutanen, M.
In vivo oxidized cholesterol in atherosclerosis. Letter to the editors. (1993)
Stalenhoef, A.F.H., Kleinveld, H.A., Kosmeijer-Schuil, T.G., Demacker, P.N.M., Katan, M.B.
Mogelijke beschermende rol van flavonoiden tegen coronaire hartziekten. (1993)
Hertog, M.G.L., Feskens, E.J.M., Hollman, P.C.H., Katan, M.B., Kromhout, D.
Colonic Fermentation of Resistant Starch (Hylon Vii) Measured by Breath H2 and Ch4 Excretion (1993)
Nagengast, F.M., Jansen, M., Deboer, H., Vanmunster, I.P., Dehaan, T., Katan, M.B.
In vivo oxidised cholesterol in atherosclerosis (1993)
Stalenhoef, A.F.H., Kleinveld, H.A., Kosmeijer-Schuil, J.G., Demacker, P.N.M., Katan, M.B.
Letter: Serum cholesterol and long-term death rates from suicide, accidents, or violence. (1992)
Kromhout, D., Katan, M.B., Menotti, A., Keys, A., Bloemberg, B.P.
Effect of dietary fatty acids on serum lipids and lipoproteins: a meta-analysis of 27 trials. (1992)
Boiled coffee does not increase serum cholesterol in gerbils and hamsters. (1992)
Mensink, R.P., Zock, P.L., Katan, M.B., Beynen, A.C.
In contrast to drip filter coffee, boiled coffee increases the serum cholesterol level in man. To identify the substance(s) responsible for this effect, it is necessary to find an animal model...
Effects of coffee on cardiovascular responses to stress: a 14-week controlled trial. (1992)
Smits, P., Lenders, J.W.M., Temme, L., Thien, T., Katan, M.B.
We studied the cardiovascular responses to orthostatic and mental stress of 43 healthy subjects who daily received six cups of boiled or filtered coffee and of 21 healthy subjects who abstained from...
Effect of dietary cis and trans fatty acids on serum lipoprotein(a) levels in humans. (1992)
Mensink, R.P., Zock, P.L., Katan, M.B., Hornstra, G.
Serum lipoprotein[a] (Lp[a]) is a strong risk factor for coronary heart disease. We therefore examined the effect of dietary fatty acid composition on serum Lp[a] levels in three strictly controlled...
The objective of this study was to compare the effects of linoleic acid (cis,cis-C18:2(n-6)) and its hydrogenation products elaidic (trans-C18:1(n-9)) and stearic acid (C18:0) on serum lipoprotein...
14th Marabou Symposium - the Nutritional Role of Fat - Discussion (1992)
James, P., Gurr, M., Bjerve, K., Dreven, C.A., Gustafson, J.A., Andersson, Andersson, ...
Serum cholesterol and long-term death rates from suicide, accidents, or violence (1992)
Bloemberg, B.P.M., Katan, M.B., Keys, A., Kromhout, D., Menotti, A.
The cholesterol-raising factor from boiled coffee does not pass a paper filter. (1991)
Katan, M.B., Demacker, P.N.M., Stalenhoef, A.F.H.
Previous studies have indicated that consumption of boiled coffee raises total and low density lipoprotein (LDL) cholesterol, whereas drip-filtered coffee does not. We have tested the effect on serum...
Effect of dietary C18 fatty acids on PAI-1 plasma levels in healthy subjects. (1991)
Huisveld, I.A., Zock, P.L., Katan, M.B., Hospers, J.E.H., Mosterd, W.L., Bouma, B.N.
BACKGROUND. Fatty acids that contain a trans double bond are consumed in large amounts as hydrogenated oils, but their effects on serum lipoprotein levels are unknown. METHODS. We placed 34 women...
Effect of a lipid-rich fraction from boiled coffee on serum cholesterol. (1990)
Zock, P.L., Katan, M.B., Merkus, M.P., Dusseldorp, M., Harryvan, J.L.
Scandinavian-style boiled coffee, which raises serum cholesterol, was found to contain more lipid material than drip filter coffee, which does not. Ten volunteers consumed a lipid-enriched fraction...
Lucker, T.P.C., Cremers, S.B.L., Katan, M.B.
The relation of the level of education attained by the father and mother with caries prevalence and food intake in the child was investigated in 284 fourteen-year-old Dutch schoolchildren.Foods were...
The Cholesterol-Raising Factor from Boiled Coffee Does Not Pass a Paper Filter (1990)
Vandusseldorp, M., Katan, M.B., Demacker, P.N.M., Stalenhoef, A.F.H.
Dietary Saturated Fatty-Acids and Low-Density or High-Density Lipoprotein Cholesterol - Reply (1990)
Evidence from controlled clinical trials shows convincingly that reducing serum cholesterol levels by diet or drug treatment reduces the incidence of coronary heart disease. On a population basis,...
Effect of a lipid-rich fraction from boiled coffee on serum cholesterol (1990)
Zock, P.L., Katan, M.B., Merkus, M.P., Dusseldorp, M. Van, Harryvan, J.L.
Mensink, R.P., Severijnen-Nobels, A.P., Demacker, P.N.M., Katan, M.B.
The effects of a high-carbohydrate, high-fiber diet and an olive-oil-rich diet on the distribution of cholesterol over the various lipoproteins, on serum apolipoproteins, and on the composition of...
Variability in lipoprotein concentrations in serum after prolonged storage at -20°C. (1989)
The effects of freezing and storage at − 20° C of serum on the measurement of cholesterol and triglycerides concentrations in lipoprotein fractions separated by density gradient...
Fecal steroid excretion by rabbits hypo- or hyperresponsive to dietary cholesterol. (1989)
Beynen, A.C., Meijer, G.W., Lemmens, A.G., Glatz, J.F.C., Versluis, A., Katan, M.B., ...
Fingerprick cholesterol testing with the 'Reflotron'. (1988)
Katan, M.B., Kruyswijk, Z., Demacker, P.M.J., Stalenhoef, A.F.H.
Changes in the triglyceride-rich lipoproteins and the response to dietary cholesterol in man. (1988)
Demacker, P.N.M., Glatz, J.F.C., Katan, M.B.
The effect of a cholesterol-enriched diet was studied in nine healthy volunteers with special emphasis to the changes which occurred in the triglyceride-rich lipoproteins (d
Congruence of individual responsiveness to dietary cholesterol and to saturated fat in man. (1988)
Katan, M.B., Berns, M.A.M., Glatz, J.F.C., Knuiman, J.T., Nobels, A.
Previous experiments have shown that differences between humans in the response of serum cholesterol to dietary cholesterol are at least partly reproducible and stable over a prolonged period. In...
Kempen, H.J.M., Glatz, J.F.C., Gevers Leuven, J.A., Katan, M.B.
The power of serum lathosterol concentration as an indicator of whole- body cholesterol synthesis was investigated in 47 human volunteers consuming two diets differing in fatty acid composition. The...
Bias and error in the determination of common macronutrients in foods: interlaboratory trial. (1988)
Burema, J., Deurenberg, P., Katan, M.B.
Day-to-day variation within an individual's dietary intake may obscure associations between diet and disease. We calculated the extent of misclassification of subjects by dietary polyunsaturated to...
Risk factors for coronary heart disease in middle-aged men in Crete in 1982. (1988)
Aravanis, C., Mensink, R.P., Corcondilas, A., Ioanidis, P., Feskens, E.J.M., Katan, M.B.
Risk factors for coronary heart disease were studied in healthy middle- aged Cretan men in order to compare them with the middle-aged men of a previous generation studied in 1960 as the Cretan cohort...
Aravanis, C., Mensink, R.P., Karalias, N., Christodoulou, B., Kafatos, A., Katan, M.B.
A high intake of olive oil has produced high levels of high-density and low levels of low-density lipoprotein cholesterol in short-term dietary trials. To investigate long-term effects of olive oil...
Determinants of the serum cholesterol increase with age, a longitudinal study. (1988)
In Western populations, the level of serum cholesterol increases with age, whereas in certain developing countries this increase is absent. In order to determine which factors are related to this...
Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans (1988)
Kempen, H.J.M., Glatz, J.F.C., Gevers Leuven, J.A., Katan, M.B.
Congruence of individual responsiveness to dietary cholesterol and to saturated fat in man (1988)
Katan, M.B., Berns, M.A.M., Glatz, J.F.C., Knuiman, J.T., Nobels, A.P.
Beynen, A.C., Lemmens, A.G., Katan, M.B.
1. 1. The increase in serum cholesterol after feeding a diet containing 2% (w/w) of cholesterol and 0.5% of cholate for 13 days was 200 and 800% in two hypo- and two hyper-responsive inbred strains...
In order to determine the influence of laboratory procedures on nutrient values in different food tables and data banks, an interlaboratory study was set up. Nineteen laboratories participated, and...
The effects of two strictly controlled diets, one rich in complex carbohydrates, the other rich in olive oil, on serum lipids were studied in healthy men and women. Serum cholesterol levels fell on...
Voedingsmiddelenanalyses van de Vakgroep Humane Voeding. Deel VII Maaltijden en produkten. (1987)
Bos, J., Germing-Nouwen, C., Kosmeijer-Schuil, T., Willems, M., Zijlmans, A., ...
Rotterdam, E.P., Katan, M.B., Knuiman, J.T.
We studied intra-individual variation in total and high-density lipoprotein (HDL) cholesterol in healthy volunteers (22 men and 19 women, ages 19 to 62 years) on controlled natural diets. The within-...
Serumlipoproteins in Cretan boys and men consuming a high olive oil diet. (1987)
Katan, M.B., Aravanis, C., Mensink, R.P., Sandker, G.W., Kromhout, D.
Dietary Fiber and Colon Cancer - Discussion (1987)
Nasengast, F.M., Rafter, J., Krag, E., Katan, M.B., Kritchevsky, D., Sorbris, R., ...
Dietary Fiber Chemistry and Definition - Discussion (1987)
Jenkins, D., Aman, P., Katan, M.B., Selvendran, R., Lister, R., Nyman, M., ...
Dietary Fiber and Colon Physiology and Constipation Diseases - Discussion (1987)
Eastwood, M., Edwards, C., Jenkins, D., Burkitt, D., Tomlin, J., Trowell, H., ...
In this study we addressed the question whether hypo- and hyper-responders to dietary cholesterol differ with regard to the flexibility of endogenous cholesterol synthesis after changes in...
The fatty acid composition of fat tissue is a valid indicator of the fatty acid composition of the diet over the preceding 1 to 3 yr. Here we describe a rapid method for sampling of buttock fat...
Why do polyunsaturated fatty acids lower serum cholesterol? (1985)
Replacement of saturated by polyunsaturated fatty acids in the diet may lower serum very low-density and low-density lipoprotein concentrations because the liver preferentially converts...
Characteristics of human hypo- and hyper-responders to dietary cholesterol (1985)
Katan, M.B., Beynen, A.C., Nobels, A., Berns, M.A.M., Glatz, J.F.C.
Combined determination of free, esterified and glycosilated plant sterols in foods (1985)
Jonker, D., Glatz, J.F.C., Homan, C., Posthumus, M.A., Katan, M.B.