A study of the original acid reaction of milk to phenolphthalein / (1914)
Thesis (D.V.M.)--Michigan Agricultural College, 1914.
Discovery of Novel Antifungal (1,3)-β-d-Glucan Synthase Inhibitors
Onishi, J., Meinz, M., Thompson, J., Curotto, J., Dreikorn, S., Rosenbach, M., ...
The increasing incidence of life-threatening fungal infections has driven the search for new, broad-spectrum fungicidal agents that can be used for treatment and prophylaxis in immunocompromised...
Bowman, J. C., Hicks, P. Scott, Kurtz, M. B., Rosen, H., Schmatz, D. M., Liberator, P. A., ...
Caspofungin acetate is an antifungal antibiotic that inhibits synthesis of 1,3-β-d-glucan, an essential component of the fungal cell wall. While caspofungin causes cell death in yeasts and dimorphic...
Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis.
Kurtz, M B, Bernard, E M, Edwards, F F, Marrinan, J A, Dropinski, J, Douglas, C M, ...
The pneumocandins are semisynthetic analogs of echinocandin-like compounds that have shown efficacy in animal models of systemic candidiasis, disseminated aspergillosis, and pneumocystis pneumonia....
Douglas, C M, D'Ippolito, J A, Shei, G J, Meinz, M, Onishi, J, Marrinan, J A, ...
Pneumocandins and echinocandins are fungicidal antibiotics, currently in clinical development, that inhibit 1,3-beta-D-glucan synthase (GS) in several human fungal pathogens. We have identified a...
Kurtz, M B, Abruzzo, G, Flattery, A, Bartizal, K, Marrinan, J A, Li, W, ...
The pneumocandins are potent antifungal agents of the echinocandin class which are under development for use as broad-spectrum antimycotic therapy. One important consideration for any new therapeutic...
Kurtz, M B, Douglas, C, Marrinan, J, Nollstadt, K, Onishi, J, Dreikorn, S, ...
The pneumocandins are natural lipopeptide products of the echinocandin class which inhibit the synthesis of 1,3-beta-D-glucan in susceptible fungi. The lack of a corresponding pathway in mammalian...
A Saccharomyces cerevisiae mutant with echinocandin-resistant 1,3-beta-D-glucan synthase.
Douglas, C M, Marrinan, J A, Li, W, Kurtz, M B
A novel, potent, semisynthetic pneumocandin, L-733,560, was used to isolate a resistant mutant in Saccharomyces cerevisiae. This compound, like other pneumocandins and echinocandins, inhibits...
Cloning and characterization of the plasma membrane H(+)-ATPase from Candida albicans.
Monk, B C, Kurtz, M B, Marrinan, J A, Perlin, D S
The Candida albicans PMA1 gene was isolated from a genomic library by using a hybridization probe obtained from the PMA1 gene of Saccharomyces cerevisiae. The gene was localized to chromosome III of...
Butnick, N Z, Yager, L N, Hermann, T E, Kurtz, M B, Champe, S P
Mutants of Aspergillus nidulans defective in conidiation (asexual sporulation) can be classified according to whether they are blocked before or after induction of conidiation. Mutants blocked before...
Genetic analysis of mutants of Aspergillus nidulans blocked at an early stage of sporulation.
Butnick, N Z, Yager, L N, Kurtz, M B, Champe, S P
Three mutants of Aspergillus nidulans, selected to have a block at an early stage of conidiation (asexual sporulation), exhibit similar pleiotropic phenotypes. Each of these mutants, termed...
The ascomycete Aspergillus nidulans produces green conidia (asexual spores). Recessive mutants which produce yellow conidia have been previously isolated from haploid strains and have been shown to...
Laccase localized in hulle cells and cleistothecial primordia of Aspergillus nidulans.
Hermann, T E, Kurtz, M B, Champe, S P
Several species of the genus Aspergillus form sexual spores within minute (approximately 0.2 mm) spherical shells (cleisthothecia) which are woven from specialized hyphae. Aspergillus nidulans...
Purification and characterization of the conidial laccase of Aspergillus nidulans.
Conidial laccase of Aspergillus nidulans was purified by standard protein purification methods. Although the purified material showed a cluster of several protein bands on a nondenaturing gel, each...
Kurtz, M B, Heath, I B, Marrinan, J, Dreikorn, S, Onishi, J, Douglas, C
The lipopeptide antifungal agents, echinocandins, papulacandins, and pneumocandins, kill Candida albicans by inhibiting glucan synthesis. For this fungus, there is a good correlation of in vitro...
Directed mutagenesis in Candida albicans: one-step gene disruption to isolate ura3 mutants.
Kelly, R, Miller, S M, Kurtz, M B, Kirsch, D R
A method for introducing specific mutations into the diploid Candida albicans by one-step gene disruption and subsequent UV-induced recombination was developed. The cloned C. albicans URA3 gene was...
Development of autonomously replicating plasmids for Candida albicans.
Kurtz, M B, Cortelyou, M W, Miller, S M, Lai, M, Kirsch, D R
A pool of Candida albicans RsaI fragments cloned onto a vector containing pBR322 sequences and the Candida ADE2 gene was used to transform a Candida ade2 mutant to adenine protrophy. A potential...
Integrative transformation of Candida albicans, using a cloned Candida ADE2 gene.
Kurtz, M B, Cortelyou, M W, Kirsch, D R
Candida albicans is a diploid dimorphic yeast with no known sexual cycle. The development of a DNA transformation system would greatly improve the prospects for genetic analyses of this yeast....
Precursors of the T4 internal peptides.
The precursors of the two T4 internal peptides have been identified by in vitro cleavage of individual phage proteins eluted from sodium dodecyl sulfate-acrylamide gels. The precursor of internal...
Discovery of Novel Antifungal (1,3)-β-d-Glucan Synthase Inhibitors
Onishi, J., Meinz, M., Thompson, J., Curotto, J., Dreikorn, S., Rosenbach, M., ...
The increasing incidence of life-threatening fungal infections has driven the search for new, broad-spectrum fungicidal agents that can be used for treatment and prophylaxis in immunocompromised...
Bowman, J. C., Hicks, P. Scott, Kurtz, M. B., Rosen, H., Schmatz, D. M., Liberator, P. A., ...
Caspofungin acetate is an antifungal antibiotic that inhibits synthesis of 1,3-β-d-glucan, an essential component of the fungal cell wall. While caspofungin causes cell death in yeasts and dimorphic...
Aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis.
Kurtz, M B, Bernard, E M, Edwards, F F, Marrinan, J A, Dropinski, J, Douglas, C M, ...
The pneumocandins are semisynthetic analogs of echinocandin-like compounds that have shown efficacy in animal models of systemic candidiasis, disseminated aspergillosis, and pneumocystis pneumonia....
Douglas, C M, D'Ippolito, J A, Shei, G J, Meinz, M, Onishi, J, Marrinan, J A, ...
Pneumocandins and echinocandins are fungicidal antibiotics, currently in clinical development, that inhibit 1,3-beta-D-glucan synthase (GS) in several human fungal pathogens. We have identified a...
Kurtz, M B, Abruzzo, G, Flattery, A, Bartizal, K, Marrinan, J A, Li, W, ...
The pneumocandins are potent antifungal agents of the echinocandin class which are under development for use as broad-spectrum antimycotic therapy. One important consideration for any new therapeutic...
Kurtz, M B, Douglas, C, Marrinan, J, Nollstadt, K, Onishi, J, Dreikorn, S, ...
The pneumocandins are natural lipopeptide products of the echinocandin class which inhibit the synthesis of 1,3-beta-D-glucan in susceptible fungi. The lack of a corresponding pathway in mammalian...
A Saccharomyces cerevisiae mutant with echinocandin-resistant 1,3-beta-D-glucan synthase.
Douglas, C M, Marrinan, J A, Li, W, Kurtz, M B
A novel, potent, semisynthetic pneumocandin, L-733,560, was used to isolate a resistant mutant in Saccharomyces cerevisiae. This compound, like other pneumocandins and echinocandins, inhibits...
Cloning and characterization of the plasma membrane H(+)-ATPase from Candida albicans.
Monk, B C, Kurtz, M B, Marrinan, J A, Perlin, D S
The Candida albicans PMA1 gene was isolated from a genomic library by using a hybridization probe obtained from the PMA1 gene of Saccharomyces cerevisiae. The gene was localized to chromosome III of...
Butnick, N Z, Yager, L N, Hermann, T E, Kurtz, M B, Champe, S P
Mutants of Aspergillus nidulans defective in conidiation (asexual sporulation) can be classified according to whether they are blocked before or after induction of conidiation. Mutants blocked before...
Genetic analysis of mutants of Aspergillus nidulans blocked at an early stage of sporulation.
Butnick, N Z, Yager, L N, Kurtz, M B, Champe, S P
Three mutants of Aspergillus nidulans, selected to have a block at an early stage of conidiation (asexual sporulation), exhibit similar pleiotropic phenotypes. Each of these mutants, termed...
The ascomycete Aspergillus nidulans produces green conidia (asexual spores). Recessive mutants which produce yellow conidia have been previously isolated from haploid strains and have been shown to...
Laccase localized in hulle cells and cleistothecial primordia of Aspergillus nidulans.
Hermann, T E, Kurtz, M B, Champe, S P
Several species of the genus Aspergillus form sexual spores within minute (approximately 0.2 mm) spherical shells (cleisthothecia) which are woven from specialized hyphae. Aspergillus nidulans...
Purification and characterization of the conidial laccase of Aspergillus nidulans.
Conidial laccase of Aspergillus nidulans was purified by standard protein purification methods. Although the purified material showed a cluster of several protein bands on a nondenaturing gel, each...
Kurtz, M B, Heath, I B, Marrinan, J, Dreikorn, S, Onishi, J, Douglas, C
The lipopeptide antifungal agents, echinocandins, papulacandins, and pneumocandins, kill Candida albicans by inhibiting glucan synthesis. For this fungus, there is a good correlation of in vitro...
Directed mutagenesis in Candida albicans: one-step gene disruption to isolate ura3 mutants.
Kelly, R, Miller, S M, Kurtz, M B, Kirsch, D R
A method for introducing specific mutations into the diploid Candida albicans by one-step gene disruption and subsequent UV-induced recombination was developed. The cloned C. albicans URA3 gene was...
Development of autonomously replicating plasmids for Candida albicans.
Kurtz, M B, Cortelyou, M W, Miller, S M, Lai, M, Kirsch, D R
A pool of Candida albicans RsaI fragments cloned onto a vector containing pBR322 sequences and the Candida ADE2 gene was used to transform a Candida ade2 mutant to adenine protrophy. A potential...
Integrative transformation of Candida albicans, using a cloned Candida ADE2 gene.
Kurtz, M B, Cortelyou, M W, Kirsch, D R
Candida albicans is a diploid dimorphic yeast with no known sexual cycle. The development of a DNA transformation system would greatly improve the prospects for genetic analyses of this yeast....
Precursors of the T4 internal peptides.
The precursors of the two T4 internal peptides have been identified by in vitro cleavage of individual phage proteins eluted from sodium dodecyl sulfate-acrylamide gels. The precursor of internal...