M. C. Michel

The influence of complexity in monologic versus dialogic tasks in Dutch L2 (2007)

Michel, M.C., Kuiken, F., Vedder, I.

Effects of alpha 1-adrenoceptor antagonists on male sexual function (2006)

Dijk, M.M. Van, Michel, M.C.

alpha(1)-Adrenoceptor antagonists such as alfuzosin, doxazosin, tamsulosin and terazosin are first-line agents for the treatment of lower urinary tract symptoms suggestive of benign prostatic...

Candidate genes for the hereditary component of cardiac hypertrophy (2006)

Postma, A.V., Michel, M.C.

Rho kinase: a target for treating urinary bladder dysfunction? (2006)

Peters, S.L.M., Schmidt, M., Michel, M.C.

Urinary incontinence and other urinary storage symptoms are frequent in the general population but available treatments have limited efficacy and tolerability. Rho kinase (ROCK) has a central role in...

Safety and tolerability of duloxetine in women with stress urinary incontinence (2006)

Oelke, M., Michel, M.C.

Background The serotonin/noradrenaline uptake inhibitor duloxetine has been shown to be effective in the medical treatment of stress urinary incontinence (SUI) in women. Aim To review the safety and...

Comparison of three radioligands for the labelling of human beta-adrenoceptor subtypes (2006)

Niclauss, N., Michel-Reher, M.B., Alewijnse, A.E., Michel, M.C.

We have compared the ability of three radioligands, [I-125]-cyanopindolol, [H-3]-CGP 12,177 and [H-3]-dihydroalprenolol, to label the three human beta-adrenoceptor subtypes. Saturation and...

Sphingosine kinase-dependent activation of endothelial nitric oxide synthase by angiotensin II (2006)

Mulders, A.C.M., Hendriks-Balk, M.C., Mathy, M.J., Michel, M.C., Alewijnse, A.E., Peters, S.L.M.

Objective - In addition to their role in programmed cell death, cell survival, and cell growth, sphingolipid metabolites such as ceramide, sphingosine, and sphingosine-1-phosphate have vasoactive...

alpha(1)-, alpha(2)- and beta-adrenoceptors in the urinary bladder, urethra and prostate (2006)

Michel, M.C., Vrydag, W.

1 We have systematically reviewed the presence, functional responses and regulation of alpha(1)-, alpha(2)- and beta-adrenoceptors in the bladder, urethra and prostate, with special emphasis on human...

What is the significance of intraoperative floppy iris syndrome for the urologist? (2006)

Michel, M.C., Pfeiffer, N., Hoefner, K.

In vivo studies on the effects of alpha(1)-adrenoceptor antagonists on pupil diameter and urethral tone in rabbits (2006)

Michel, M.C., Okutsu, H., Noguchi, Y., Suzuki, M., Ohtake, A., Yuyama, H., ...

alpha(1)-Adrenoceptors mediate contraction of iris dilator smooth muscle and hence pupil dilatation. We compared the ability of i.v. bolus injections of alfuzosin, doxazosin, naftopidil, prazosin,...

Treatment of the overactive bladder syndrome with muscarinic receptor antagonists - a matter of metabolites? (2006)

Michel, M.C., Hegde, S.S.

alpha-blocker treatment of urolithiasis (2006)

Michel, M.C.

Comparison of the cardiovascular effects of tamsulosin oral controlled absorption system (OCAS (R)) and alfuzosin prolonged release (XL) (2006)

Michel, M.C., Chapple, C.R.

Objective: The cardiovascular (CV) effects of tamsulosin oral controlled absorption system (OCAS (R))) 0.4 mg were compared with those of alfuzosin prolonged release (XL) 10 mg. Methods: Two...

Anticholinergics for overactive bladder. Does subtype selectivity play a role? (2006)

Michel, M.C., Barendrecht, M.M., Oelke, M.

Anticholinergics; act in the treatment of overactive bladder by blocking muscarinic receptors of which five subtypes exist. Their desired effects occur via M-3 receptors, but a role for M-2 receptors...

Transient receptor potential (TRP) channels as drug targets (2006)

Michel, M.C.

Re: Tatemichi S, Tomiyama Y, Maruyama I, Kobayashi S, Kobayashi K, Maezawa A, Kobayashi M, Yamazaki Y, Shibata N. 2006. Uroselectivity in male dogs of silodosin (KMD-3213), a novel drug for the obstructive component of benign prostatic hyperplasia. Neurourol Urodynam 25 : 792-799. Editorial comment (2006)

Michel, M.C.

An anthology from Naunyn-Schmiedeberg's archives of pharmacology (2006)

Michel, M.C.

BML-241 fails to display selective antagonism at the sphingosine-1-phosphate receptor, S1P(3) (2006)

Jongsma, M., Hendriks-Balk, M.C., Michel, M.C., Peters, S.L.M., Alewijnse, A.E.

Background and purpose: The thiazolidine carboxylic acid, BML-241, has been proposed as a lead compound in development of selective antagonists at the sphingosine-1-phosphate receptor (S1P(3)), based...

The beta(2)-adrenoceptor gene and hypertension: is it the promoter or the coding region or neither? (2006)

Hahntow, I.N., Koopmans, R.P., Michel, M.C.

Effects of gender, age and hypertension on beta-adrenergic receptor function in rat urinary bladder (2006)

Puspitoayu, E., Schneider, T., Michel, M.C.

beta-Adrenoceptors mediate urinary bladder relaxation, and gender, age and hypertension have been linked to bladder dysfunction. Therefore, we have studied whether any of these factors affects the...

Cyclic AMP-dependent and Epac-mediated activation of R-ras by G protein-coupled receptors leads to phospholipase D stimulation (2006)

Jesus, M.L. De, Stope, M.B., Weernink, P.A.O., Mahlke, Y., Boergermann, C., Ananaba, V.N., ...

The activation of the Ras-related GTPase R-Ras, which has been implicated in the regulation of various cellular functions, by G protein-coupled receptors (GPCRs) was studied in HEK293 cells stably...

Indomethacin differentiates the renal effects of sphingosine-1-phosphate and sphingosylphosphorylcholine (2006)

Czyborra, C., Bischoff, A., Michel, M.C.

The sphingomyelin breakdown products sphingosine-1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) constrict intrarenal microvessels in vitro in a pertussis toxin (PTX) sensitive manner, and...

Sphingosine-1-phosphate and sphingosylphosphorylcholine: two of a kind? (2006)

Alewijnse, A.E., Michel, M.C.

Sphingosine-1-phosphate and sphingosylphosphorylcholine are structurally related signalling molecules. Although they share some biological effects, it is debated whether this involves the same...

Effects of alpha(1)-adrenoreceptor antagonists on pupil diameter and intraurethral pressure in rabbits (2006)

Watanabe, M., Ohtake, A., Yuyama, H., Yanai-Inamura, H., Ukai, M., Someya, A., ...

Tamsulosin - modified-release and oral-controlled absorption system formulations in the treatment of benign prostatic hyperplasia (2006)

Dijk, M.M. Van, Michel, M.C.

Adrenergic receptors in clinical medicine (2006)

Michel, M.C., Insel, P.A.

New medical developments in the management of LUTS in adult men (2006)

Chapple, C., Artibani, W., Berges, R., Kaplan, S., Michel, M.C., Perrin, P., ...

Tolerability of amine uptake inhibitors in urologic diseases (2006)

Michel, M.C., Ruhe, H.G., Groot, A.A. De, Castro, R., Oelke, M.

Sequence of echocardiographic changes during development of right ventricular failure in rat (2006)

Hardziyenka, M., Campian, M.E., Michel, M.C., Tan, H.L.

How valid are animal models to evaluate treatments for pulmonary hypertension? (2006)

Campian, M.E., Hardziyenka, M., Michel, M.C., Tan, H.L.

The neuro-urological connection (2005)

Michel, M.C., Oelke, M., Peters, S.L.M.

Comparison of symptom severity and treatment response in patients with incontinent and continent overactive bladder (2005)

Michel, M.C., Piro, M, Schneider, T.

Role of muscarinic receptor antagonists in urgency and nocturia (2005)

Michel, M.C.

Pharmakotherapie der Belastungsinkontinenz (Stressinkontinenz) [Pharmacotherapy in stress urinary therapy ] (2005)

Jost, W.H., Marsalek, P., Michel, M.C.

Duloxetine in the treatment of stress urinary incontinence (2005)

Michel, M.C., Oelke, M.

A rapid and validated HPLC method to quantify sphingosine 1-phosphate in human plasma using solid-phase extraction followed by derivatization with fluorescence detection (2005)

Butter, J.J., Koopmans, R-P., Michel, M.C.

Treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: the cardiovascular system (2005)

Barendrecht, M.M., Koopmans, R-P., Michel, M.C.

Diabetes mellitus (2005)

Ufkes, J.G.R., Knuistingh Neven, A., Koopmans, R-P., Michel, M.C., Mulder, W.M.C.

Astma en COPD (2005)

Ufkes, J.G.R., Knuistingh Neven, A., Koopmans, R-P., Michel, M.C., Mulder, W.M.C.

Coronaire hartziekten (2005)

Ufkes, J.G.R., Knuistingh Neven, A., Koopmans, R-P., Michel, M.C., Mulder, W.M.C.

Rhinitis (2005)

Ufkes, J.G.R., Knuistingh Neven, A., Koopmans, R-P., Michel, M.C., Mulder, W.M.C.

Mictiestoornissen en erectiele disfunctie (2005)

Ufkes, J.G.R., Knuistingh Neven, A., Koopmans, R-P., Michel, M.C., Mulder, W.M.C.

Fluor vaginalis, dysmenorroe en vaginaal bloedverlies (2005)

Ufkes, J.G.R., Knuistingh Neven, A., Koopmans, R-P., Michel, M.C., Mulder, W.M.C.

Zakkompas bij Farmacotherapie op recept. Een leidraad bij het voorschrijven van geneesmiddelen [derde geheel herziene druk] (2005)

Ufkes, J.G.R., Knuistingh Neven, A., Koopmans, R-P., Michel, M.C., Mulder, W.M.C.

Can a GDP-liganded G-protein be active? (2005)

Wieland, T., Michel, M.C.

Effects of ageing on muscarinic receptor subtypes and function in rat urinary bladder (2005)

Schneider, T., Hein, P., Michel-Reher, M.B., Michel, M.C.

A role for muscarinic receptors or rho-kinase in hypertension associated rat bladder dysfunction? (2005)

Schneider, T., Hein, P., Bai, J., Michel, M.C.

Medikamentöse Therapie der Harninkontinenz (2005)

Oelke, M., Michel, M.C., Jonas, U.

Role of muscarinic receptor antagonists in urgency and nocturia (2005)

Michel, M.C.

Multiple gene approaches to delineate the role of the renin-angiotensin-aldosterone system in nephropathy (2005)

Michel, M.C., Hahntow, I., Koopmans, R-P.

Editorial guidelines for manuscripts on the pharmacology of plant extracts (2005)

Michel, M.C., König, G., Mohr, K., Simmet, T.

The neuro-urological connection (2005)

Michel, M.C., Oelke, M., Peters, S.L.M.

The pharmacokinetic profile of tamsulosin oral controlled absorption system (OCAS (R)) (2005)

Michel, M.C., Korstanje, C., Krauwinkel, W., Kuipers, M.

Comparison of vascular alpha(1)-adrenoceptor antagonism of tamsulosin in oral controlled absorption system (OCAS) and modified release (MR) formulations (2005)

Michel, M.C., Korstanje, C., Krauwinkel, W., Shear, M., Davies, J., Quartel, A.

Cardiovascular safety of tamsulosin modified release in the fasted and fed state in elderly healthy subjects (2005)

Michel, M.C., Korstanje, C., Krauwinkel, W.

Cardiovascular safety of the oral controlled absorption system (OCAS) formulation of tamsulosin compared to the modified release (MR) formulation (2005)

Michel, M.C., Korstanje, C., Krauwinkel, W., Shear, M., Davies, J., Quartel, A.

Comparison of symptom severity and treatment response in patients with incontinent and continent overactive bladder (2005)

Michel, M.C., Piro, M, Schneider, T.

Is cyclic AMP formation desensitized in patients with end-stage renal failure? (2005)

Leineweber, K., Schwiebert, C., Büscher, R., Michel, M.C.

Does cyclic AMP mediate rat urinary bladder relaxation by isoproterenol? (2005)

Puspitoayu, E., Mathy, M.J., Peters, S.L.M., Michel, M.C.

A rapid and validated HPLC method to quantify sphingosine 1-phosphate in human plasma using solid-phase extraction followed by derivatization with fluorescence detection (2005)

Butter, J.J., Koopmans, R-P., Michel, M.C.

Medikamentöse Therapie der Harzinkontinenz (2005)

Oelke, M., Michel, M.C., Jonas, U.

Novel muscarinic antagonists to treat incontinence and/or overactive bladder (2005)

Michel, M.C., Oelke, M., Zinner, N.

Treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia: the cardiovascular system (2005)

Barendrecht, M.M., Koopmans, R-P., Michel, M.C.

Medical therapy of urinary incontinence (2004)

Oelke, M., Michel, M.C., Jonas, U.

Does concomitant stress incontinence alter the efficacy of tolterodine in patients with overactive bladder (2004)

Michel, M.C., Piro, M, Goepel, M.

Het autonome zenuwstelsel (2004)

Wilde, D. De, Michel, M.C., Versteeg, D.H.G.

Duloxetin (2004)

Michel, M.C., Marsalek, P.

Neuropeptide Y and the kidney (2004)

Michel, M.C.

Neuropeptide Y (2004)

Michel, M.C.

Neuropeptide Y (2004)

Michel, M.C.

NPY receptor subtypes and their signal transduction (2004)

Holliday, N.D., Michel, M.C., Cox, H.M.

Longinfecties (2004)

Ufkes, J.G.R., Knuistingh Neven, A., Koopmans, R-P., Michel, M.C., Mulder, W.M.C.

Hoofdpijn (2004)

Ufkes, J.G.R., Knuistingh Neven, A., Koopmans, R-P., Michel, M.C., Mulder, W.M.C.

Hartfalen (2004)

Ufkes, J.G.R., Knuistingh Neven, A., Koopmans, R-P., Michel, M.C., Mulder, W.M.C.

Peptische aandoeningen (2004)

Ufkes, J.G.R., Knuistingh Neven, A., Koopmans, R-P., Michel, M.C., Mulder, W.M.C.

Psychische aandoeningen: psychotische stoornissen (2004)

Ufkes, J.G.R., Knuistingh Neven, A., Koopmans, R-P., Michel, M.C., Mulder, W.M.C.

Psychische aandoeningen: depressieve stoornissen (2004)

Ufkes, J.G.R., Knuistingh Neven, A., Koopmans, R-P., Michel, M.C., Mulder, W.M.C.

Psychische aandoeningen: angststoornissen (2004)

Ufkes, J.G.R., Knuistingh Neven, A., Koopmans, R-P., Michel, M.C., Mulder, W.M.C.

Efficacy and safety of tamsulosin in the treatment of urological diseases (2004)

Michel, M.C.

Comparison of noradrenaline and lysosphingolipid-induced vasoconstriction in mouse and rat small mesenteric arteries (2004)

Hedemann, J., Fetscher, C., Michel, M.C.

Signal transduction underlying carbachol-induced contraction of rat urinary bladder. I. Phospholipases and Ca2+ sources (2004)

Schneider, T., Hein, P., Michel, M.C.

Signal transduction underlying carbachol-induced contraction of human urinary bladder (2004)

Schneider, T., Fetscher, C., Krege, S., Michel, M.C.

Role of serotonin and noradrenaline in stress urinary incontinence: editorial (2004)

Michel, M.C., Peters, S.L.M.

Association of hypertension with symptoms of benign prostatic hyperplasia (2004)

Michel, M.C., Heemann, U., Schumacher, H., Mehlburger, L., Goepel, M.

Does concomitant stress incontinence alter the efficacy of tolterodine in patients with overactive bladder? (2004)

Michel, M.C., Piro, L., Goepel, M.

Safety of telmisartan in patients with arterial hypertension - An open-label observational study (2004)

Michel, M.C., Bohner, H., Köster, J., Schäfers, R., Heemann, U.

Ejaculatory dysfunction and ALPHA(1)-adrenoceptor antagonists: letter (2004)

Michel, M.C.

Absorption of intravesically applied drugs: Comparison of normal and ileal augmented rabbit bladder (2004)

Krege, S., Kinzing-Schippers, M., Sörgel, F., Baschek, R., Michel, M.C., Rübben, H.

Signal transduction underlying carbachol-induced contraction of rat urinary bladder. II. Protein kinases (2004)

Fleichman, M., Schneider, T., Fetscher, C., Michel, M.C.

Small and intermediate conductance Ca2+-activated K+ channels confer distinctive patterns of distribution in human tissues and differential cellular localisation in the colon and corpus cavernosum (2004)

Chen, M.X., Gorman, S.A., Benson, B., Singh, B., Hieble, J.P., Michel, M.C., ...

Extracts from Rhois aromatica and Solidaginis virgaurea inhibit rat and human bladder contraction (2004)

Borchert, M., Czyborra, C., Fetscher, C., Goepel, M., Michel, M.C.

Cardiovascular effects of sphingosine-1-phosphate and other sphingomyelin metabolites (2004)

Alewijnse, A.E., Peters, S.L.M., Michel, M.C.

Van molecuul tot geneesmiddel (2004)

Michel, M.C.

Pharmacogenetics of hypertension treatment: a structured review (2003)

Koopmans, R-P., Insel, P.A., Michel, M.C.

Protecting bladder function and reducing disease progression (2003)

Michel, M.C.

Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine (2003)

Altmann, C., Steenpass, V., Czyborra, C., Hein, P., Michel, M.C.

Receptor gene polymorphisms: lessons on functional relevance from the beta(1)-adrenoceptor (2003)

Michel, M.C., Insel, P.A.

Sphingosylphosphorylcholine, a naturally occurring lipid mediator, inhibits human platelet function (2003)

Altmann, C., Boyukbas, D., Haude, M., Jakobs, K.H., Michel, M.C.

Gender comparison of muscarinic receptor expression and function in rat and human urinary bladder: differential regulation of M-2 and M-3 receptors? (2003)

Kories, C., Czyborra, C., Fetscher, C., Schneider, T., Krege, S., Michel, M.C.

Guidelines of German urologists on diagnosis of benign prostate syndrome (2003)

Palmtag, H., Goepel, M., Berges, R., Dreikorn, K., Hofner, K., Jonas, U., ...

Guidelines of German urologists on therapy of benign prostate syndrome (2003)

Berges, R., Dreikorn, K., Hofner, K., Jonas, U., Laval, K.U., Madersbacher, St., ...

Effect of the C825T polymorphism of the G protein beta 3 subunit on the systolic blood pressure-lowering effect of clonidine in young, healthy male subjects (2003)

Nurnberger, J., Dammer, S., Mitchell, A., Siffert, W., Wenzel, R.R., Gossl, M., ...

New pharmacological treatment concepts for overactive bladder (2003)

Michel, M.C.

Differential agonist-induced regulation of human M-2 and M-3 muscarinic receptors (2003)

Stope, M.B., Kunkel, C., Kories, C., Schmidt, M., Michel, M.C.

Pharmacogenetics of hypertension treatment: a structured review (2003)

Koopmans, R-P., Insel, P.A., Michel, M.C.

cAMP-independent relaxation of smooth muscle cells via G(s)-coupled receptors (2003)

Peters, S.L.M., Michel, M.C.

Die medikamenten-induzierte Dysfunktion der Harnblase (2003)

Schneider, T., Rubben, H., Michel, M.C.

Pharmacogenetics of hypertension treatment: a structured review (2003)

Koopmans, R-P., Insel, P.A., Michel, M.C.

Enhanced adenosine A2B mediated coronary response in reserpinised rat heart. (2003)

Rose'Meyer, Roselyn, Harrison, Glenn, Headrick, John Patrick, M C Michel

Yes

A mitogen-activated protein kinase is involved in the inotropic but not chronotropic actions of adrenoceptor agonists and endothelin-1 (2002)

Peters, S.L.M., Sand, C., Michel, M.C., Pfaffendorf, M., Zwieten, P.A. Van

Comprehensive pig manure treatment using the BIOSOR TM biofiltration process (1999)

Buelna, G., Dube, R., Michel, M.C., Turgeon, N., Bernard, Y., Lessard, P.

Increasingly stringent standards and heightened public awareness regarding environmental issues has led to an increase in research on various treatment methods used in different countries. Among...

Thyroid status affects the rat cardiac beta-adrenoceptor system transiently and timedependently (1998)

Zwaveling, J., Batink, H.D., Taguchi, K., Jong, J. De, Michel, M.C., Pfaffendorf, M., ...

Possible mechanism of the negative inotropic effect of alfa1-adrenoceptor agonists in rat isolated left atria after exposure to free radicals (1998)

Peters, S.L.M., Batink, H.D., Michel, M.C., Pfaffendorf, M., Zwieten, P.A. Van

Decreased blood pressure response in mice deficient of the alpha1b-adrenergic receptor (1997)

Cavalli, A., Lattion, A. L., Hummler, E., Nenniger, M., Pedrazzini, T., Aubert, J. F., ...

To investigate the functional role of different alpha1-adrenergic receptor (alpha1-AR) subtypes in vivo, we have applied a gene targeting approach to create a mouse model lacking the alpha1b-AR...

Stability of cyclosporin in blood upon shipping-related extended storage (1995)

Michel, M. C., Thesing, A., Wagner, K., Philipp, T.

{beta}-adrenoceptor regulation in the human heart: can it be monitored in circulating lymphocytes? (1989)

Michel, M. C., Gordon, E. P., Sandoval, A., Gilbert, E. M., Bristow, M. R.

In heart failure a decrease in cardiac β-adrenoceptors presumably due to endogenous down-regulation by the elevated catecholamines is a general phenomenon. Thus, attempts have been made to assess...

Drug- and disease-induced changes of human cardiac {beta}1- and {beta}2-adrenoceptors (1989)

Borst, H. G., Maier, W., Michel, M. C.

Cardiac β-adrenoceptor density and subtype distribution has been determined in different kinds of heart failure. A decrease in cardiac β-adrenoceptor function appears to be a general phenomenon in...

Does the time of administration (morning or evening) affect the tolerability or efficacy of tamsulosin? (0000)

Michel, M C

Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment.

Maisel, A S, Knowlton, K U, Fowler, P, Rearden, A, Ziegler, M G, Motulsky, H J, ...

The current studies were undertaken to explore the relationship between enhanced sympathetic nervous activity and lymphocyte subset distribution in three settings: congestive heart failure, dynamic...

Making sense out of antisense for the study of drug receptors.

Michel, M C, Insel, P A

Dissociation between phytohaemagglutinin-stimulated generation of inositol phosphates and Ca2+ increase in human mononuclear leucocytes.

Michel, M C, Van Tits, L J, Trenn, G, Sykora, J, Brodde, O E

We have tested whether phytohaemagglutinin (PHA)-stimulated generation of inositol phosphates (IP) and increases in intracellular Ca2+ can be dissociated in human mononuclear leucocytes. Lowering the...

Neuropeptide Y-enhanced diuresis and natriuresis in anaesthetized rats is independent of renal blood flow reduction.

Bischoff, A, Erdbrügger, W, Smits, J, Michel, M C

1. Neuropeptide Y (NPY) has been reported to enhance diuresis and natriuresis in anaesthetized rats although it is a potent renal vasoconstrictor in vitro in vivo in several species. Therefore, we...

Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive heart failure, dynamic exercise, and terbutaline treatment.

Maisel, A S, Knowlton, K U, Fowler, P, Rearden, A, Ziegler, M G, Motulsky, H J, ...

The current studies were undertaken to explore the relationship between enhanced sympathetic nervous activity and lymphocyte subset distribution in three settings: congestive heart failure, dynamic...

Making sense out of antisense for the study of drug receptors.

Michel, M C, Insel, P A

Dissociation between phytohaemagglutinin-stimulated generation of inositol phosphates and Ca2+ increase in human mononuclear leucocytes.

Michel, M C, Van Tits, L J, Trenn, G, Sykora, J, Brodde, O E

We have tested whether phytohaemagglutinin (PHA)-stimulated generation of inositol phosphates (IP) and increases in intracellular Ca2+ can be dissociated in human mononuclear leucocytes. Lowering the...

Neuropeptide Y-enhanced diuresis and natriuresis in anaesthetized rats is independent of renal blood flow reduction.

Bischoff, A, Erdbrügger, W, Smits, J, Michel, M C

1. Neuropeptide Y (NPY) has been reported to enhance diuresis and natriuresis in anaesthetized rats although it is a potent renal vasoconstrictor in vitro in vivo in several species. Therefore, we...

Mitigation of β1- and/or β2-adrenoceptor function in human heart failure

Michel, M. C., Maisel, A. S.

1 Patients with congestive heart failure (CHF) have an elevated activity of the sympatho-adrenal system. We have investigated several aspects of β-adrenoceptor desensitization in such patients.

β-adrenoceptor control of immune function in congestive heart failure

Maisel, A. S., Michel, M. C.

1 We have determined the number of β-adrenoceptors and the isoprenaline-stimulated cAMP generation in lymphocyte subsets. The in vitro β-adrenergic sensitivity was greatest in...

The β-adrenoceptor antagonist carteolol and its metabolite 8-hydroxycarteolol have different intrinsic sympathomimetic activities

Jasper, J. R., Michel, M. C., Insel, P. A.

We have tested the effects of carteolol and 8-hydroxycarteolol on cAMP generation in S49 lymphoma and BC3H1 smooth muscle-like cells. Carteolol was a high affinity β-adrenoceptor antagonist in both...

Does treatment with beta-adrenoceptor antagonists in vivo alter human adenylate cyclase responsiveness in vitro?

Michel, M C, Klüppel, M, Philipp, T, Brodde, O E

1. Treatment with beta-adrenoceptor antagonists in vivo can alter adenylate cyclase responsiveness in the human heart. We have determined the effects of treatment with four different...

Lack of effect of chronic calcium antagonist treatment on beta 1- and beta 2-adrenoceptors in right atria from patients with or without heart failure.

Brodde, O E, Hundhausen, H J, Zerkowski, H R, Michel, M C

1. We studied the effects of chronic calcium antagonist (calcium entry blocker, CEB; nifedipine, verapamil, diltiazem) treatment on beta-adrenoceptor density (assessed by (-)-[125I]-iodocyanopindolol...

Sensitization by dexamethasone of lymphocyte cyclic AMP formation: evidence for increased function of the adenylyl cyclase catalyst.

Michel, M C, Knapp, J, Ratjen, H

1. Glucocorticoids and elevations of intracellular adenosine 3':5'-cyclic monophosphate (cyclic AMP) may affect lymphocyte activation, proliferation and effector functions in similar ways. Therefore,...

Protein kinase C isoenzymes in rat and human cardiovascular tissues

Erdbrügger, W, Keffel, J, Knocks, M, Otto, T, Philipp, T, Michel, M C

We have compared the expression of protein kinase C (PKC) activity and immuno-detectable isoenzymes in cytosolic and membrane extracts of rat and human cardiovascular tissues (heart, kidney, aorta,...

Selective regulation of beta 1- and beta 2-adrenoceptors in the human heart by chronic beta-adrenoceptor antagonist treatment.

Michel, M. C., Pingsmann, A., Beckeringh, J. J., Zerkowski, H. R., Doetsch, N., Brodde, O. E.

1. In 44 patients undergoing coronary artery bypass grafting, the effect of chronic administration of the beta-adrenoceptor antagonists sotalol, propranolol, pindolol, metoprolol and atenolol on...

Cyclic AMP counteracts mitogen-induced inositol phosphate generation and increases in intracellular Ca2+ concentrations in human lymphocytes.

Van Tits, L. J., Michel, M. C., Motulsky, H. J., Maisel, A. S., Brodde, O. E.

1. The effects of increases in intracellular adenosine 3':5'-cyclic monophosphate (cyclic AMP) on mitogen-induced generation of inositol phosphates and increases in intracellular Ca2+ concentration...

Neuropeptide Y (NPY) receptors in HEL cells: comparison of binding and functional parameters for full and partial agonists and a non-peptide antagonist.

Feth, F., Rascher, W., Michel, M. C.

1. We have compared the binding and Ca2+ mobilizing properties of various full agonists, partial agonists and a non-peptide antagonist at the neuropeptide Y (NPY) receptor of human erythroleukemia...

Comparison of guinea-pig, bovine and rat alpha 1-adrenoceptor subtypes.

Büscher, R., Heeks, C., Taguchi, K., Michel, M. C.

1. To elucidate a possible role of species differences in the classification of alpha 1-adrenoceptor subtypes, we have characterized the alpha 1-adrenoceptors in guinea-pig spleen, kidney and...

Radioligand binding studies of alpha 1-adrenoceptor subtypes in rat heart.

Michel, M. C., Hanft, G., Gross, G.

1. In order to characterize the alpha 1-adrenoceptor subtypes mediating positive inotropic effects of adrenaline (in the presence of propranolol) in rat right ventricular strips and the Ca2+ sources...

Functional studies on alpha 1-adrenoceptor subtypes mediating inotropic effects in rat right ventricle.

Michel, M. C., Hanft, G., Gross, G.

1. We have studied the alpha 1-adrenoceptor subtypes mediating inotropic effects of adrenaline in rat right ventricle and the Ca2+ sources used to elicit these effects. alpha 1A-Adrenoceptor-mediated...

Rapid desensitization of adrenaline- and neuropeptide Y-stimulated Ca2+ mobilization in HEL-cells.

Michel, M. C.

1. Desensitization of Gs-coupled receptors, the beta 2-adrenoceptor for example, involves rapid and slower components but little is known regarding the existence of rapid desensitization of...

The effects of SB 216469, an antagonist which discriminates between the alpha 1A-adrenoceptor and the human prostatic alpha 1-adrenoceptor.

Chess-Williams, R., Chapple, C. R., Verfurth, F., Noble, A. J., Couldwell, C. J., Michel, M. C.

1. The affinity of the alpha 1-adrenoceptor antagonist SB 216469 (also known as REC 15/2739) has been determined at native and cloned alpha 1-adrenoceptor subtypes by radioligand binding and at...

Chronic beta 1-adrenoceptor antagonist treatment sensitizes beta 2-adrenoceptors, but desensitizes M2-muscarinic receptors in the human right atrium.

Motomura, S., Deighton, N. M., Zerkowski, H. R., Doetsch, N., Michel, M. C., Brodde, O. E.

1. In 64 patients undergoing coronary artery bypass grafting the effects of chronic beta 1-adrenoceptor antagonist (metoprolol, atenolol, bisoprolol) treatment on right atrial beta-adrenoceptor and...

Letters to the Editors

Kremens, B, Brendel, E, Bald, M, Czyborra, P, Michel, M C

BML-241 fails to display selective antagonism at the sphingosine-1-phosphate receptor, S1P3

Jongsma, M, Hendriks-Balk, M C, Michel, M C, Peters, S L M, Alewijnse, A E

A 6-month large-scale study into the safety of tamsulosin

Michel, M C, Bressel, H-U, Goepel, M, Rübben, H

Endothelin-A receptor antagonist inhibits angiotensin II and noradrenaline in man

Wenzel, R R, Rüthemann, J, Bruck, H, Schäfers, R F, Michel, M C, Philipp, Th

Does the time of administration (morning or evening) affect the tolerability or efficacy of tamsulosin?

Michel, M C

Objective To determine whether the time of dosing (morning or evening) affects the tolerability or efficacy of tamsulosin in the treatment of lower urinary tract symptoms. Patients and methods Data...

α1-Adrenoceptors and ejaculatory function

Michel, M C

The abnormal ejaculation of semen is a typical but infrequent side effect of some α1-adrenoceptor antagonists, particularly those with selectivity for α1A-adrenoceptors such as silodosin or...

Pitfalls in the normalization of real-time polymerase chain reaction data

Hendriks-Balk, M. C., Michel, M. C., Alewijnse, A. E.

Real-time polymerase chain reaction (PCR) is commonly used for a sensitive and specific quantification of messenger RNA (mRNA). The levels of mRNA are frequently compared between two or more...