M. C. Poirier

Publication List Details

Period

2006 - 2006

Number

36

Co-Authors

Reduced DNA adduct formation in replicating liver cells during continuous feeding of a chemical carcinogen.

Huitfeldt, H S, Brandtzaeg, P, Poirier, M C

To investigate early cellular alterations in liver DNA during hepatocarcinogenesis, we have visualized replicating cells and analyzed their DNA adduct content in livers of rats continuously fed a...

Benzo[alpha]pyrene diol epoxide I binds to DNA at replication forks.

Paules, R S, Cordeiro-Stone, M, Mass, M J, Poirier, M C, Yuspa, S H, Kaufman, D G

The distribution of lesions in DNA caused by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo [alpha]pyrene (B[alpha]P diol epoxide-I) was studied in synchronized...

Platinum-DNA adducts in leukocyte DNA correlate with disease response in ovarian cancer patients receiving platinum-based chemotherapy.

Reed, E, Ozols, R F, Tarone, R, Yuspa, S H, Poirier, M C

Fifty-five ovarian cancer patients receiving platinum drug-based chemotherapy have been studied prospectively to determine the extent of formation of the bidentate intrastrand adducts of...

Antibodies elicited against cis-diamminedichloroplatinum(II)-modified DNA are specific for cis-diamminedichloroplatinum(II)-DNA adducts formed in vivo and in vitro.

Poirier, M C, Lippard, S J, Zwelling, L A, Ushay, H M, Kerrigan, D, Thill, C C, ...

Rabbit antiserum elicited against calf thymus DNA modified to 4.4% (Pt drug/nucleotide ratio = 0.044) with the antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP) contains antibodies specific...

Quantitation of cis-diamminedichloroplatinum II (cisplatin)-DNA-intrastrand adducts in testicular and ovarian cancer patients receiving cisplatin chemotherapy.

Reed, E, Yuspa, S H, Zwelling, L A, Ozols, R F, Poirier, M C

The antitumor activity of cis-diamminedichloroplatinum II (cisplatin) is believed to be related to its covalent interaction with DNA where a major DNA binding product is an intrastrand N7-bidentate...

Specific quantification of mouse and human keratin proteins by radioimmunoassay.

Yuspa, S H, Poirier, M C, Harness, J R, Olsom, D R, Steinert, P M

Mouse epidermal keratin proteins were purified and labelled with 125I by chemical techniques. A radioimmunoassay method was established with a rabbit antibody elicited against the mouse keratin. This...

Human DNA adduct measurements: state of the art.

Poirier, M C, Weston, A

Human DNA adduct formation (covalent modification of DNA with chemical carcinogens) is a promising biomarker for elucidating the molecular epidemiology of cancer. Classes of compounds for which human...

DNA adducts as exposure biomarkers and indicators of cancer risk.

Poirier, M C

Quantitation of DNA adducts in human tissues has been achieved with highly sensitive techniques based on adduct radiolabeling, antisera specific for DNA adducts or modified DNA, and/or adduct...

DNA adduct measurements and tumor incidence during chronic carcinogen exposure in rodents.

Poirier, M C, Beland, F A

In an attempt to elucidate the relationship between DNA adduct formation and tumorigenesis, DNA adducts were measured in the livers and bladders of mice during chronic exposure to several different...

Platinum drug-DNA interactions in human tissues measured by cisplatin-DNA enzyme-linked immunosorbent assay and atomic absorbance spectroscopy.

Poirier, M C, Reed, E, Shamkhani, H, Tarone, R E, Gupta-Burt, S

Studies of platinum drug-DNA adduct formation in tissues of cancer patients have involved both atomic absorbance spectroscopy (AAS), which measures total DNA-bound platinum, and anti-cisplatin-DNA...

Detection of polycyclic aromatic hydrocarbon-DNA adducts in human lung.

Weston, A, Bowman, E D, Shields, P G, Trivers, G E, Poirier, M C, Santella, R M, ...

Synchronous fluorescence spectroscopy has been combined with immunoaffinity chromatography (IAC) and HPLC to detect polycyclic aromatic hydrocarbon (PAH)-DNA adducts and measure...

Biomarkers of carcinogen exposure and cancer risk in a coke plant.

Assennato, G, Ferri, G M, Tockman, M S, Poirier, M C, Schoket, B, Porro, A, ...

To evaluate the association between an indicator of carcinogen exposure (peripheral blood leukocyte DNA adducts of polycyclic aromatic hydrocarbons) and an early indicator of neoplastic...

DNA adducts in peripheral blood lymphocytes from aluminum production plant workers determined by 32P-postlabeling and enzyme-linked immunosorbent assay.

Schoket, B, Phillips, D H, Poirier, M C, Vincze, I

32P-Postlabeling analysis and enzyme-linked immunosorbent assay (ELISA) have been used to detect DNA adducts in peripheral blood lymphocytes from primary aluminum production plant workers who were...

Significance of DNA adduct studies in animal models for cancer molecular dosimetry and risk assessment.

Beland, F A, Poirier, M C

To elucidate the relationship between DNA adduct formation and tumorigenesis, a number of experiments have been conducted to measure DNA adducts in target tissues from experimental animals during...

Association of PAH-DNA adducts in peripheral white blood cells with dietary exposure to polyaromatic hydrocarbons.

Rothman, N, Poirier, M C, Haas, R A, Correa-Villasenor, A, Ford, P, Hansen, J A, ...

Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). In the current study, we...

Biphasic removal of DNA adducts in a repetitive DNA sequence after dietary administration of 2-acetylaminofluorene.

Culp, S J, Poirier, M C, Beland, F A

Dietary administration of the hepatocarcinogen 2-acetylaminofluorene (2-AAF) to rats results in the formation of a major hepatic DNA adduct, N-(deoxyguanosin-8-yl)-2-aminofluorene (dG-C8-AF). In...

Polyclonal antibodies to quantitate cis-diamminedichloroplatinum(II)--DNA adducts in cancer patients and animal models.

Poirier, M C, Reed, E, Zwelling, L A, Ozols, R F, Litterst, C L, Yuspa, S H

cis-Diamminedichloroplatinum (II) (cis-DDP), the antitumor drug, is cytotoxic in vitro primarily by binding to DNA and disrupting its normal functions. We have studied cis-DDP modification of DNA in...

Reduced DNA adduct formation in replicating liver cells during continuous feeding of a chemical carcinogen.

Huitfeldt, H S, Brandtzaeg, P, Poirier, M C

To investigate early cellular alterations in liver DNA during hepatocarcinogenesis, we have visualized replicating cells and analyzed their DNA adduct content in livers of rats continuously fed a...

Benzo[alpha]pyrene diol epoxide I binds to DNA at replication forks.

Paules, R S, Cordeiro-Stone, M, Mass, M J, Poirier, M C, Yuspa, S H, Kaufman, D G

The distribution of lesions in DNA caused by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo [alpha]pyrene (B[alpha]P diol epoxide-I) was studied in synchronized...

Platinum-DNA adducts in leukocyte DNA correlate with disease response in ovarian cancer patients receiving platinum-based chemotherapy.

Reed, E, Ozols, R F, Tarone, R, Yuspa, S H, Poirier, M C

Fifty-five ovarian cancer patients receiving platinum drug-based chemotherapy have been studied prospectively to determine the extent of formation of the bidentate intrastrand adducts of...

Antibodies elicited against cis-diamminedichloroplatinum(II)-modified DNA are specific for cis-diamminedichloroplatinum(II)-DNA adducts formed in vivo and in vitro.

Poirier, M C, Lippard, S J, Zwelling, L A, Ushay, H M, Kerrigan, D, Thill, C C, ...

Rabbit antiserum elicited against calf thymus DNA modified to 4.4% (Pt drug/nucleotide ratio = 0.044) with the antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP) contains antibodies specific...

Quantitation of cis-diamminedichloroplatinum II (cisplatin)-DNA-intrastrand adducts in testicular and ovarian cancer patients receiving cisplatin chemotherapy.

Reed, E, Yuspa, S H, Zwelling, L A, Ozols, R F, Poirier, M C

The antitumor activity of cis-diamminedichloroplatinum II (cisplatin) is believed to be related to its covalent interaction with DNA where a major DNA binding product is an intrastrand N7-bidentate...

Specific quantification of mouse and human keratin proteins by radioimmunoassay.

Yuspa, S H, Poirier, M C, Harness, J R, Olsom, D R, Steinert, P M

Mouse epidermal keratin proteins were purified and labelled with 125I by chemical techniques. A radioimmunoassay method was established with a rabbit antibody elicited against the mouse keratin. This...

Human DNA adduct measurements: state of the art.

Poirier, M C, Weston, A

Human DNA adduct formation (covalent modification of DNA with chemical carcinogens) is a promising biomarker for elucidating the molecular epidemiology of cancer. Classes of compounds for which human...

DNA adducts as exposure biomarkers and indicators of cancer risk.

Poirier, M C

Quantitation of DNA adducts in human tissues has been achieved with highly sensitive techniques based on adduct radiolabeling, antisera specific for DNA adducts or modified DNA, and/or adduct...

DNA adduct measurements and tumor incidence during chronic carcinogen exposure in rodents.

Poirier, M C, Beland, F A

In an attempt to elucidate the relationship between DNA adduct formation and tumorigenesis, DNA adducts were measured in the livers and bladders of mice during chronic exposure to several different...

Platinum drug-DNA interactions in human tissues measured by cisplatin-DNA enzyme-linked immunosorbent assay and atomic absorbance spectroscopy.

Poirier, M C, Reed, E, Shamkhani, H, Tarone, R E, Gupta-Burt, S

Studies of platinum drug-DNA adduct formation in tissues of cancer patients have involved both atomic absorbance spectroscopy (AAS), which measures total DNA-bound platinum, and anti-cisplatin-DNA...

Detection of polycyclic aromatic hydrocarbon-DNA adducts in human lung.

Weston, A, Bowman, E D, Shields, P G, Trivers, G E, Poirier, M C, Santella, R M, ...

Synchronous fluorescence spectroscopy has been combined with immunoaffinity chromatography (IAC) and HPLC to detect polycyclic aromatic hydrocarbon (PAH)-DNA adducts and measure...

Biomarkers of carcinogen exposure and cancer risk in a coke plant.

Assennato, G, Ferri, G M, Tockman, M S, Poirier, M C, Schoket, B, Porro, A, ...

To evaluate the association between an indicator of carcinogen exposure (peripheral blood leukocyte DNA adducts of polycyclic aromatic hydrocarbons) and an early indicator of neoplastic...

DNA adducts in peripheral blood lymphocytes from aluminum production plant workers determined by 32P-postlabeling and enzyme-linked immunosorbent assay.

Schoket, B, Phillips, D H, Poirier, M C, Vincze, I

32P-Postlabeling analysis and enzyme-linked immunosorbent assay (ELISA) have been used to detect DNA adducts in peripheral blood lymphocytes from primary aluminum production plant workers who were...

Significance of DNA adduct studies in animal models for cancer molecular dosimetry and risk assessment.

Beland, F A, Poirier, M C

To elucidate the relationship between DNA adduct formation and tumorigenesis, a number of experiments have been conducted to measure DNA adducts in target tissues from experimental animals during...

Association of PAH-DNA adducts in peripheral white blood cells with dietary exposure to polyaromatic hydrocarbons.

Rothman, N, Poirier, M C, Haas, R A, Correa-Villasenor, A, Ford, P, Hansen, J A, ...

Previous investigations suggest that dietary sources of polycyclic aromatic hydrocarbons (PAHs) contribute to the PAH-DNA adduct load in peripheral white blood cells (WBCs). In the current study, we...

Biphasic removal of DNA adducts in a repetitive DNA sequence after dietary administration of 2-acetylaminofluorene.

Culp, S J, Poirier, M C, Beland, F A

Dietary administration of the hepatocarcinogen 2-acetylaminofluorene (2-AAF) to rats results in the formation of a major hepatic DNA adduct, N-(deoxyguanosin-8-yl)-2-aminofluorene (dG-C8-AF). In...

Polyclonal antibodies to quantitate cis-diamminedichloroplatinum(II)--DNA adducts in cancer patients and animal models.

Poirier, M C, Reed, E, Zwelling, L A, Ozols, R F, Litterst, C L, Yuspa, S H

cis-Diamminedichloroplatinum (II) (cis-DDP), the antitumor drug, is cytotoxic in vitro primarily by binding to DNA and disrupting its normal functions. We have studied cis-DDP modification of DNA in...