Wannemacher, R. W., Dupont, H. L., Pekarek, R. S., Powanda, M. C., Schwartz, A.
Concentrations of most amino acids and of zinc in serum were depressed during periods of incubation and illness in 11 volunteers who developed symptoms after an oral dose of 100,000 virulent...
Sobocinski,P. Z., Powanda,M. C., Canterbury,W. J., Machotka,S. V., Walker,R. I.
Intraperitoneal administration of zinc, as zinc chloride, prior to or simultaneously with a lethal quantity of Salmonella typhimurium endotoxin significantly protects rats against toxin-induced...
Subhuman Primate Model for the Study of Infection Induced by 'Klebsiella Pneumoniae'. (2002)
Berendt,R. F., Knutsen,G. L, Powanda,M. C.
Squirrel monkeys were instilled intratracheally with 700 Klebsiella pneumoniae organisms and developed lobar pneumonia in about 24 h. Characteristic clinical findings were fever, anorexia, and...
Berendt,R. F., Schneider,M. A., Frola,F. R., Young,H. W., Powanda,M. C.
The objective of this study was to compare the efficacy of i.m.- and aerosol-administered kanamycin for the treatment of pneumonia due to Klebsiella pneumoniae in the squirrel monkey. Both routes...
Metabolic Sequelae of Respiratory Q Fever in the Guinea Pig. (2002)
Powanda,M. C., Machotka,S. V., Kishmoto,R. A.
Guinea pigs infected with Coxiella burnetii administered in small-particle aerosols responded with a significant increase in plasma copper, seromucoid, and lysozyme on days 9 through 13. In contrast,...
Differential Effect of Parenteral Zinc on the Course of Various Bacterial Infections (39931), (2002)
Sobocinski,P. Z., Canterbury,W. J. , Jr., Powanda ,M. C.
Canonico, P G, Powanda, M C, Cockerell, G L, Moe, J B
A temporal study is reported of the febrile responses, tissue bacterial contents, and serum concentration of the lysosomal enzymes, beta-glucuronidase and lysozyme, in nonimmune rats inoculated with...
Tissue Amino Acid Flux After Exposure of Rats to Diplococcus pneumoniae
Wannemacher, R. W., Powanda, M. C., Pekarek, R. S., Beisel, W. R.
The concentration of 21 individual free amino acids in serum, liver, and skeletal muscle was determined in rats during the incubation, acute illness, and terminal stages of experimental infection...
Berendt, R F, Long, G G, Abeles, F B, Canonico, P G, Elwell, M R, Powanda, M C
Gram-negative bacterial pneumonias have been increasingly important as nosocomial infections. The following model was developed to study the pathogenesis and evaluate therapy of such infections....
Role of zinc in the abatement of hepatocellular damage and mortality incidence in endotoxemic rats.
Sobocinski, P Z, Powanda, M C, Canterbury, W J, Machotka, S V, Walker, R I, Snyder, S L
Intraperitoneal administration of zinc (ZnIP) as zinc chloride prior to or simultaneously with a lethal quantity of intraperitoneally administered Salmonella typhimurium endotoxin significantly...
Nonhuman primate model for the study of respiratory Klebsiella pneumoniae infection.
Berendt, R F, Knutsen, G L, Powanda, M C
Squirrel monkeys were inoculated by the intratracheal inoculation of 700 Klebsiella pneumoniae organisms and developed lobar pneumonia in about 24 h. Characteristic clinical findings were fever,...
Nitrogen Metabolism and Protein Synthesis During Pneumococcal Sepsis in Rats
Powanda, M. C., Wannemacher, R. W., Cockerell, G. L.
Markedly increased synthesis of α2 and β globulins and α1, α2, and β glycoglobulins occurs during pneumococcal sepsis in the rat simultaneously with decreased albumin formation, diminished...
Canonico, P G, Little, J S, Powanda, M C, Bostian, K A, Beisel, W R
Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha 2-fucosyltransferase, and alpha 3-fucosyltransferase activity of rat liver. Such...
Effect of injury and infection on visceral metabolism and circulation.
Wilmore, D W, Goodwin, C W, Aulick, L H, Powanda, M C, Mason, A D, Pruitt, B A
To characterize the role of the liver and kidney in the metabolic response to injury and infection, selective catheterization of the hepatic (42 veins) and renal veins (21 veins) was performed in 31...
Canonico, P G, Powanda, M C, Cockerell, G L, Moe, J B
A temporal study is reported of the febrile responses, tissue bacterial contents, and serum concentration of the lysosomal enzymes, beta-glucuronidase and lysozyme, in nonimmune rats inoculated with...
Tissue Amino Acid Flux After Exposure of Rats to Diplococcus pneumoniae
Wannemacher, R. W., Powanda, M. C., Pekarek, R. S., Beisel, W. R.
The concentration of 21 individual free amino acids in serum, liver, and skeletal muscle was determined in rats during the incubation, acute illness, and terminal stages of experimental infection...
Berendt, R F, Long, G G, Abeles, F B, Canonico, P G, Elwell, M R, Powanda, M C
Gram-negative bacterial pneumonias have been increasingly important as nosocomial infections. The following model was developed to study the pathogenesis and evaluate therapy of such infections....
Role of zinc in the abatement of hepatocellular damage and mortality incidence in endotoxemic rats.
Sobocinski, P Z, Powanda, M C, Canterbury, W J, Machotka, S V, Walker, R I, Snyder, S L
Intraperitoneal administration of zinc (ZnIP) as zinc chloride prior to or simultaneously with a lethal quantity of intraperitoneally administered Salmonella typhimurium endotoxin significantly...
Nonhuman primate model for the study of respiratory Klebsiella pneumoniae infection.
Berendt, R F, Knutsen, G L, Powanda, M C
Squirrel monkeys were inoculated by the intratracheal inoculation of 700 Klebsiella pneumoniae organisms and developed lobar pneumonia in about 24 h. Characteristic clinical findings were fever,...
Nitrogen Metabolism and Protein Synthesis During Pneumococcal Sepsis in Rats
Powanda, M. C., Wannemacher, R. W., Cockerell, G. L.
Markedly increased synthesis of α2 and β globulins and α1, α2, and β glycoglobulins occurs during pneumococcal sepsis in the rat simultaneously with decreased albumin formation, diminished...
Canonico, P G, Little, J S, Powanda, M C, Bostian, K A, Beisel, W R
Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha 2-fucosyltransferase, and alpha 3-fucosyltransferase activity of rat liver. Such...
Effect of injury and infection on visceral metabolism and circulation.
Wilmore, D W, Goodwin, C W, Aulick, L H, Powanda, M C, Mason, A D, Pruitt, B A
To characterize the role of the liver and kidney in the metabolic response to injury and infection, selective catheterization of the hepatic (42 veins) and renal veins (21 veins) was performed in 31...