M. Carolyn Hardegree

Influence of Mouse Strain on the Assayed Potency (Unitage) of Tetanus Toxoid

Hardegree, M. Carolyn, Pittman, Margaret, Maloney, Clifford J.

The assayed potency of an adsorbed tetanus toxoid C2, relative to the international standard for tetanus toxoid (adsorbed), varied significantly with the use of different strains of mice. The unitage...

Effect of tetanus toxin on the accumulation of the permeant lipophilic cation tetraphenylphosphonium by guinea pig brain synaptosomes

Ramos, Sofia, Grollman, Evelyn F., Lazo, Pedro S., Dyer, Sherry A., Habig, William H., Hardegree, M. Carolyn, ...

Accumulation of the permeant lipophilic cation [3H]tetraphenylphosphonium (TPP+) by synaptosome preparations from guinea pig brain cerebral cortex is inhibited 1:10 by medium containing 193 mM K+ and...

Introductory remarks

Hardegree, M. Carolyn

Vaccines may be useful in pregnancy to reduce neonatal risk of infection. Childhood immunization decreases the risk of maternal exposure and infection which may result in time lost at work and...

Influence of Mouse Strain on the Assayed Potency (Unitage) of Tetanus Toxoid

Hardegree, M. Carolyn, Pittman, Margaret, Maloney, Clifford J.

The assayed potency of an adsorbed tetanus toxoid C2, relative to the international standard for tetanus toxoid (adsorbed), varied significantly with the use of different strains of mice. The unitage...

Effect of tetanus toxin on the accumulation of the permeant lipophilic cation tetraphenylphosphonium by guinea pig brain synaptosomes

Ramos, Sofia, Grollman, Evelyn F., Lazo, Pedro S., Dyer, Sherry A., Habig, William H., Hardegree, M. Carolyn, ...

Accumulation of the permeant lipophilic cation [3H]tetraphenylphosphonium (TPP+) by synaptosome preparations from guinea pig brain cerebral cortex is inhibited 1:10 by medium containing 193 mM K+ and...

Introductory remarks

Hardegree, M. Carolyn

Vaccines may be useful in pregnancy to reduce neonatal risk of infection. Childhood immunization decreases the risk of maternal exposure and infection which may result in time lost at work and...

Immunization against neonatal tetanus in New Guinea: 3. The toxin-neutralization test and the response of guinea-pigs to the toxoids as used in the immunization schedules in New Guinea

Barile, Michael F., Hardegree, M. Carolyn, Pittman, Margaret

The mouse toxin-neutralization test procedure described has been used for antitoxin titration of sera of New Guinea women following primary immunization with plain and adjuvant tetanus toxoids and...

Immunization against neonatal tetanus in New Guinea: 2. Duration of primary antitoxin responses to adjuvant tetanus toxoids and comparison of booster responses to adjuvant and plain toxoids*

Hardegree, M. Carolyn, Barile, Michael F., Pittman, Margaret, Schofield, F. D., MacLennan, R., Kelly, A.

This paper describes: (1) a continuation of the study reported in 1965 of tetanus antitoxin titres among women after primary immunization with plain, AlPO4-adsorbed or oil adjuvant toxoids; (2) the...

Immunization against neonatal tetanus in New Guinea: 5. Laboratory assayed potency of tetanus toxoids and relationship to human antitoxin response

Pittman, Margaret, Kolb, Robert W., Barile, Michael F., Hardegree, M. Carolyn, Seligmann, Edward B., MacLennan, R., ...

Previous papers in this series have shown that plain toxoids induced early primary antitoxin levels in women in New Guinea that were not significantly different from those induced by adsorbed toxoids...

Immunization against neonatal tetanus in New Guinea: 4. Comparison of tetanus antitoxin titres abtained by haemagglutination and toxin neutralization in mice

Hardegree, M. Carolyn, Barile, Michael F., Pittman, Margaret, Maloney, Clifford J., Schofield, Frank, MacLennan, Robert

Haemagglutination (HA) has been used frequently for the titration of tetanus antitoxin but published results have varied in relation to the ”unitage” determined by the mouse toxin-neutralization...

Immunization against neonatal tetanus in New Guinea: Antitoxin response of pregnant women to adjuvant and plain toxoids*

MacLennan, R., Schofield, F. D., Pittman, Margaret, Hardegree, M. Carolyn, Barile, Michael F.

Immunization of pregnant women in New Guinea with three injections of plain toxoid had previously been shown to prevent neonatal tetanus. In the present study antitoxin levels induced by two...