SIV/HIV latency in the CNS: role of innate immune responses (2008)
Clements, Janice E, Zink, M Christine, Mankowski, Joseph L
No abstract available.
Chase, Amanda J, Sedaghat, Ahmad R, German, Jennifer R, Gama, Lucio, Zink, M Christine, Clements, Janice E, ...
No abstract available.
Carter, Mark G., Johns, Margaret A., Zeng, Xiaobei, Zhou, Li, Zink, M. Christine, Mankowski, Joseph L., ...
HIC1 is a candidate tumor suppressor gene which is frequently hypermethylated in human tumors, and its location within the Miller–Dieker syndrome’s critical deletion region at chromosome 17p13.3...
Edinger, Aimee L., Mankowski, Joseph L., Doranz, Benjamin J., Margulies, Barry J., Lee, Benhur, Rucker, Joseph, ...
Brain capillary endothelial cells (BCECs) are targets of CD4-independent infection by HIV-1 and simian immunodeficiency virus (SIV) strains in vitro and in vivo. Infection of BCECs may provide a...
Zink, M. Christine, Suryanarayana, Kalachar, Mankowski, Joseph L., Shen, Anding, Piatak, Michael, Spelman, Jeffrey P., ...
AIDS dementia and encephalitis are complications of AIDS occurring most frequently in patients who are immunosuppressed. The simian immunodeficiency virus (SIV) model used in this study was designed...
Barber, Sheila A., Bruett, Linda, Douglass, Brian R., Herbst, David S., Zink, M. Christine, Clements, Janice E.
It is well accepted that viruses require access to specific intracellular environments in order to proliferate or, minimally, to secure future proliferative potential as latent reservoirs. Hence,...
Babas, Tahar, Muñoz, Daniel, Mankowski, Joseph L., Tarwater, Patrick M., Clements, Janice E., Zink, M. Christine
An accelerated, consistent macaque simian immunodeficiency virus (SIV) model in which over 90% of pigtailed macaques (Macaca nemestrina) coinoculated with SIV/17E-Fr and SIV/DeltaB670 developed...
Shen, Anding, Zink, M. Christine, Mankowski, Joseph L., Chadwick, Karen, Margolick, Joseph B., Carruth, Lucy M., ...
Despite suppression of viremia in patients on highly active antiretroviral therapy (HAART), human immunodeficiency virus type 1 persists in a latent reservoir in the resting memory CD4+ T lymphocytes...
Overholser, Emily D., Coleman, Gary D., Bennett, Jennifer L., Casaday, Rebecca J., Zink, M. Christine, Barber, Sheila A., ...
As the most numerous cells in the brain, astrocytes play a critical role in maintaining central nervous system homeostasis, and therefore, infection of astrocytes by human immunodeficiency virus...
Overholser, Emily D., Babas, Tahar, Zink, M. Christine, Barber, Sheila A., Clements, Janice E.
Previous studies have demonstrated that the genetic determinants of simian immunodeficiency virus (SIV) neurovirulence map to the env and nef genes. Recent studies from our laboratory demonstrated...
Postanesthetic Poliomyelomalacia in a Horse
A clinically normal horse was anesthetized preparatory to surgery in dorsal recumbency for removal of a retained testicle. After recovery from the anesthetic, the horse was weak in the hind legs,...
Corynebacterium equi Infections in Horses, 1958-1984: A Review of 131 Cases
Zink, M. Christine, Yager, Julie A., Smart, Nonie L.
Of 131 cases of Corynebacterium equi infection in horses submitted for necropsy to the Ontario Veterinary College or Veterinary Laboratory Services, OMAF, Guelph, Ontario from 1958 to 1984, 115 were...
Edinger, Aimee L., Mankowski, Joseph L., Doranz, Benjamin J., Margulies, Barry J., Lee, Benhur, Rucker, Joseph, ...
Brain capillary endothelial cells (BCECs) are targets of CD4-independent infection by HIV-1 and simian immunodeficiency virus (SIV) strains in vitro and in vivo. Infection of BCECs may provide a...
Zink, M. Christine, Suryanarayana, Kalachar, Mankowski, Joseph L., Shen, Anding, Piatak, Michael, Spelman, Jeffrey P., ...
AIDS dementia and encephalitis are complications of AIDS occurring most frequently in patients who are immunosuppressed. The simian immunodeficiency virus (SIV) model used in this study was designed...
Barber, Sheila A., Bruett, Linda, Douglass, Brian R., Herbst, David S., Zink, M. Christine, Clements, Janice E.
It is well accepted that viruses require access to specific intracellular environments in order to proliferate or, minimally, to secure future proliferative potential as latent reservoirs. Hence,...
Babas, Tahar, Muñoz, Daniel, Mankowski, Joseph L., Tarwater, Patrick M., Clements, Janice E., Zink, M. Christine
An accelerated, consistent macaque simian immunodeficiency virus (SIV) model in which over 90% of pigtailed macaques (Macaca nemestrina) coinoculated with SIV/17E-Fr and SIV/DeltaB670 developed...
Shen, Anding, Zink, M. Christine, Mankowski, Joseph L., Chadwick, Karen, Margolick, Joseph B., Carruth, Lucy M., ...
Despite suppression of viremia in patients on highly active antiretroviral therapy (HAART), human immunodeficiency virus type 1 persists in a latent reservoir in the resting memory CD4+ T lymphocytes...
Overholser, Emily D., Coleman, Gary D., Bennett, Jennifer L., Casaday, Rebecca J., Zink, M. Christine, Barber, Sheila A., ...
As the most numerous cells in the brain, astrocytes play a critical role in maintaining central nervous system homeostasis, and therefore, infection of astrocytes by human immunodeficiency virus...
Overholser, Emily D., Babas, Tahar, Zink, M. Christine, Barber, Sheila A., Clements, Janice E.
Previous studies have demonstrated that the genetic determinants of simian immunodeficiency virus (SIV) neurovirulence map to the env and nef genes. Recent studies from our laboratory demonstrated...
Postanesthetic Poliomyelomalacia in a Horse
A clinically normal horse was anesthetized preparatory to surgery in dorsal recumbency for removal of a retained testicle. After recovery from the anesthetic, the horse was weak in the hind legs,...
Corynebacterium equi Infections in Horses, 1958-1984: A Review of 131 Cases
Zink, M. Christine, Yager, Julie A., Smart, Nonie L.
Of 131 cases of Corynebacterium equi infection in horses submitted for necropsy to the Ontario Veterinary College or Veterinary Laboratory Services, OMAF, Guelph, Ontario from 1958 to 1984, 115 were...
Perturbations in the CD4+CD25+ regulatory T cell population of the GALT during acute SIV infection
Chase, Amanda J, Sedaghat, Ahmad R, German, Jennifer R, Gama, Lucio, Zink, M Christine, Clements, Janice E, ...
Barber, Sheila A., Uhrlaub, Jennifer L., DeWitt, Jesse B., Tarwater, Patrick M., Zink, M. Christine
Central nervous system (CNS) disease is a frequent complication of human immunodeficiency virus (HIV)-1 infection. Identification of cellular mechanisms that control virus replication and that...
Shen, Anding, Yang, Hung-Chih, Zhou, Yan, Chase, Amanda J., Boyer, Jean D., Zhang, Hao, ...
Although combination therapy allows the suppression of human immunodeficiency virus type 1 (HIV-1) viremia to undetectable levels, eradication has not been achieved because the virus persists in...
Pathogenesis of Simian Immunodeficiency Virus Pneumonia : An Immunopathological Response to Virus
Mankowski, Joseph L., Carter, Darryl L., Spelman, Jeffrey P., Nealen, Michele L., Maughan, Kevin R., Kirstein, Lynn M., ...
Although many human immunodeficiency virus-infected individuals develop lymphocytic interstitial pneumonia, the roles of host and viral factors in the pathogenesis of pneumonia are not well defined....
Regulatory T cells enhance persistence of the zoonotic pathogen Seoul virus in its reservoir host
Easterbrook, Judith D., Zink, M. Christine, Klein, Sabra L.
Hantaviruses are zoonotic pathogens that maintain a persistent infection in their reservoir hosts, yet the mechanisms mediating persistence remain unknown. Regulatory T cell responses cause...
Chase, Amanda J., Sedaghat, Ahmad R., German, Jennifer R., Gama, Lucio, Zink, M. Christine, Clements, Janice E., ...
CD4+ CD25+ regulatory T cells (Tregs) suppress the activation and proliferation of effector lymphocytes. In human immunodeficiency virus type 1 (HIV-1) infection, Tregs play a significant role in...
Pan, Chien-Hsiung, Nair, Nitya, Adams, Robert J., Zink, M. Christine, Lee, Eun-Young, Polack, Fernando P., ...
Measles remains an important cause of vaccine-preventable child mortality. Development of a low-cost, heat-stable vaccine for infants under the age of 6 months could improve measles control by...