Force Feedback Joystick Therapy for Children with Cerebral Palsy (2008)
B. Geerdink, M. C. Levesley, B. Bhakta, M. Clarke, S. Spinty, F. Cnossen, ...
Cerebral palsy (CP) is the commonest cause of severe physical disability in childhood, affecting 1 in 400 children. It is a heterogeneous group of motor disorders which affect posture and movement....
F. Argenty, L. Alparone, G. Benelli, S. Barnard, W. Thompson, ...
(with discussions), ” Journal of the Royal Statistical Society, Series B, vol. 36,
using localised spatial filters”, IEEE Transactions on Pattern Analysis (2008)
Angelopoulou Elli Angelopoulou, James P. Williams, Photometric Surface, R. Thomas, ...
Chantler94a M. J. Chantler, “The effect of illuminant direction on texture
Hopewell, S., Clarke, M., Moher, D., Wager, E., Middleton, P. F., Altman, Douglas G., ...
Copyright © 2008 Hopewell et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and...
Hopewell, S., Clarke, M., Moher, D., Wager, E., Middleton, P. F., Altman, Douglas G., ...
Copyright © 2008 Hopewell et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and...
Hopewell, S, Clarke, M, Moher, D, Wager, E, Middleton, P. F., Altman, D. G, ...
BACKGROUND: Clear, transparent, and sufficiently detailed abstracts of conferences and journal articles related to randomized controlled trials (RCTs) are important, because readers often base their...
Nineteenth-century English artists’ colourmen’s archives as a source of technical information (2008)
A cardiac rehabilitation program to improve psychosocial outcomes of women with heart disease (2008)
Davidson, Patricia, DiGiacomo, Michelle, Zecchin, R., Clarke, M., Paul, G., Lamb, K., ...
Background: Heart disease in women is characterised by greater disability and a higher rate of morbidity and early death after an acute coronary event as compared to men. Women also have lower...
A cardiac rehabilitation program to improve psychosocial outcomes of women with heart disease (2008)
Davidson, Patricia, DiGiacomo, Michelle, Zecchin, R., Clarke, M., Paul, G., Lamb, K., ...
Background: Heart disease in women is characterised by greater disability and a higher rate of morbidity and early death after an acute coronary event as compared to men. Women also have lower...
Evaluating land administration projects in developing countries (2008)
Baxter, J, Clarke, M, Mitchell, D
There have been various approaches to evaluating and comparing the performance of land administration and land titling projects in developing countries. Many of these consider the efficiency of land...
The Millennium Development Goals (MDGs) are a set of international development targets agreed to by members of the United Nations in 2000. The goals aim to improve many of the dimensions of extreme...
This paper reports the experiences of staff from one international NGO who undertook short-term deployments to tsunami-affected areas in 2005. This qualitative analysis finds three major issues that...
Genuine progress across the Asia-Pacific region : comparisons, trends and policy implications (2008)
What determines Australia's response to emergencies and natural disasters ? (2007)
This article examines the determinants of Australia's response to emergencies and natural disasters. It examines the response from the Australian public by examining contributions made to the appeals...
Health research - How to formulate research recommendations (2006)
Brown, P., Brunnhuber, K., Chalkidou, K., Chalmers, I., Clarke, M., Fenton, M., ...
[First paragraph] Long awaited reports of new research, systematic reviews, and clinical guidelines are too often a disappointing anticlimax for those wishing to use them to direct future research....
Storying Joanne, an undergraduate mathematician (2006)
Povey, H., Angier, C., Clarke, M.
In this article two different accounts are juxtaposed. In one, we use a variety of texts to narrate the story of Joanne, a woman undergraduate student of mathematics. Like many of our mature students...
Wright, J. A., Clarke, M., Donlan, C., Newton, C.
Papers 1 and 2 are two of 4 papers from a DfES funded independent evaluation of the Communication Aids Project led by Wright. The research report DfES 580 appeared on the DfES web site.
Wright, Jannet A., Clarke, M., Donlan, C., Newton, C.
Papers 1 and 2 are two of 4 papers from a DfES funded independent evaluation of the Communication Aids Project led by Wright. The research report DfES 580 appeared on the DfES web site.
Mechanically induced actin-mediated rocketing of phagosomes (2006)
Clarke, M., Müller-Taubenberger, A., Anderson, K. I., Engel, U., Gerisch, G.
Davis, M.F., Clarke, M., Levason, W., Reid, G., Webster, M.
The first phosphane complexes of the hard Lewis acid SnF4 have been synthesised including trans- [SnF4(PR3)(2)] (R = Me or Cy) and cis-[SnF4(diphosphane)][diphosphane = R2P(CH2)(2)-PR2, R = Me, Et,...
Adams, C.E., Rathbone, J., Thornley, B., Clarke, M., Borrill, J., Wahlbeck, K., ...
BACKGROUND: Chlorpromazine (CPZ) remains one of the most common drugs used for people with schizophrenia worldwide, and a benchmark against which other treatments can be evaluated. Quantitative...
Adams, C.E., Rathbone, J., Thornley, B., Clarke, M., Borrill, J., Wahlbeck, K., ...
BACKGROUND: Chlorpromazine (CPZ) remains one of the most common drugs used for people with schizophrenia worldwide, and a benchmark against which other treatments can be evaluated. Quantitative...
Adams, C.E., Rathbone, J., Thornley, B., Clarke, M., Borrill, J., Wahlbeck, K., ...
BACKGROUND: Chlorpromazine (CPZ) remains one of the most common drugs used for people with schizophrenia worldwide, and a benchmark against which other treatments can be evaluated. Quantitative...
Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis (2005)
Mills, E, Wilson, K, Clarke, M, Foster, B, Walker, S, Rachlis, B, ...
Objectives: To determine whether ingestion of milk thistle affects the pharmacokinetics of indinavir. Methods: We conducted a three-period, randomized controlled trial with 16 healthy participants....
ABE, O, ABE, R, ENOMOTO, K, KIKUCHI, K, KOYAMA, H, MASUDA, H, ...
ABE, O, ABE, R, ENOMOTO, K, KIKUCHI, K, KOYAMA, H, MASUDA, H, ...
Milk thistle and indinavir: a randomized controlled pharmacokinetics study and meta-analysis (2005)
Mills, E, Wilson, K, Clarke, M, Foster, B, Walker, S, Rachlis, B, ...
Objectives: To determine whether ingestion of milk thistle affects the pharmacokinetics of indinavir. Methods: We conducted a three-period, randomized controlled trial with 16 healthy participants....
Adaptive Eager Boolean Encoding for Arithmetic Reasoning in Verification (2005)
Abstract Decision procedures for first-order logics are widely applicable in design verification and static program analysis. However, existing procedures rarely scale to large systems, especially...
This paper presents a new measure of sustainability within a welfare economics framework. Gross domestic product (GDP) can be used as an indicator of sustainability if the GDP estimates are...
Thailand has achieved remarkable levels of economic growth over the last three decades. This sustained economic growth has played a major role in reducing absolute poverty levels from nearly one...
The relationship between national income and health: A new measure applied to Bangkok (2005)
The importance of good health of a population is crucial when determining social welfare. A new health-adjusted national income indicator that explores the relationships between economic growth,...
Dynamic actin patterns and Arp2/3 assembly at the substrate-attached surface of motile cells (2004)
Bretschneider,T., Diez,S., Anderson,K., Heuser,J., Clarke,M., Müller-Taubenberger,A., ...
Mudrooroo: Crafty Impostor or Rebel with a Cause? (2004)
HILLEL Schwartz defines imposture as 'the compulsive assumption of invented lives' and impersonation as 'the concerted assumption of another's public identity' (72). This is not to say that one...
Pressure stimulated currents in rocks and their correlation with mechanical properties (2004)
I. Stavrakas, D. Triantis, Z. Agioutantis, S. Maurigiannakis, V. Saltas, F. Vallianatos, ...
The spontaneous electrification of marble samples was studied while they were subjected to uniaxial stress. The Pressure Stimulated Current (PSC) technique was applied to measure the charge released...
Dynamic actin patterns and Arp2/3 assembly at the substrate-attached surface of motile cells (2004)
Bretschneider, T., Diez, S., Anderson, K., Heuser, J., Clarke, M., Müller-Taubenberger, A., ...
Storage symptoms of the bladder: prevalence, incidence and need for services in the UK. (2004)
McGrother, C.W., Donaldson, M.M.K., Shaw, Chris, Matthews, Ruth J., Hayward, T.A., Dallosso, H.M., ...
Pressure stimulated currents in rocks and their correlation with mechanical properties (2004)
Stavrakas, I., Triantis, D., Agioutantis, Z., Maurigiannakis, S., Saltas, V., Vallianatos, F., ...
The spontaneous electrification of marble samples was studied while they were subjected to uniaxial stress. The Pressure Stimulated Current (PSC) technique was applied to measure the charge released...
Pressure stimulated currents in rocks and their correlation with mechanical properties (2004)
Stavrakas, I., Triantis, D., Agioutantis, Z., Maurigiannakis, S., Saltas, V., Vallianatos, F., ...
The spontaneous electrification of marble samples was studied while they were subjected to uniaxial stress. The Pressure Stimulated Current (PSC) technique was applied to measure the charge released...
Biometrics and sexing criteria of the yellow-faced honeyeater lichenostomus chrysops (2004)
Clarke, Rohan H., Schipper, C., Boulton, R., Ewen, J., Clarke, M.
Morphometric data on 99 adult and 13 juvenile Yellow-faced Honeyeaters Lichenostomus chrysops that were independently sexed using molecular techniques were analysed to investigate size dimorphism...
Mudrooroo: Crafty Impostor or Rebel with a Cause? (2004)
HILLEL Schwartz defines imposture as 'the compulsive assumption of invented lives' and impersonation as 'the concerted assumption of another's public identity' (72). This is not to say that one...
Mudrooroo: Crafty Impostor or Rebel with a Cause? (2004)
HILLEL Schwartz defines imposture as 'the compulsive assumption of invented lives' and impersonation as 'the concerted assumption of another's public identity' (72). This is not to say that one...
Biometrics and sexing criteria of the yellow-faced honeyeater lichenostomus chrysops (2004)
Clarke, Rohan H., Schipper, C., Boulton, R., Ewen, J., Clarke, M.
Morphometric data on 99 adult and 13 juvenile Yellow-faced Honeyeaters Lichenostomus chrysops that were independently sexed using molecular techniques were analysed to investigate size dimorphism...
Optimum Delivery of Telemedicine Over Low Bandwidth Satellite Links (2003)
Clarke, M., Fragos, A., Jones, R. W., Lioupis, D.
Telemedicine is frequently used to support the delivery of medicine to remote regions, but it can often be the case that these areas are poorly served by communications, The AIDMAN project...
Clarke,M., Köhler,J., Heuser,J., Gerisch,G.
Dictyostelium amoebae, like mammalian macrophages, take up fluid by macropinocytosis. The present study used fluorescent fluid-phase markers and GFP-labeled microtubules to visualize the uptake,...
Clarke,M., Köhler,J., Arana,Q., Liu,T. Y., Heuser,J., Gerisch,G.
The vacuolar H+-ATPase (V-ATPase) is a multi-subunit enzyme that plays important roles in eukaryotic cells. In Dictyostelium, it is found primarily in membranes of the contractile vacuole complex,...
Tubular-vesicular transformation in the contractile vacuole system of Dictyostelium (2002)
Gerisch,G., Heuser,J., Clarke,M.
The contractile vacuole complex of Dictyostelium is the paradigm of a membrane system that undergoes tubular-vesicular transitions during its regular cycle of activities. This system acts as an...
Clarke, M., Köhler, J., Heuser, J., Gerisch, G.
Dictyostelium amoebae, like mammalian macrophages, take up fluid by macropinocytosis. The present study used fluorescent fluid-phase markers and GFP-labeled microtubules to visualize the uptake,...
Clarke, M., Köhler, J., Arana, Q., Liu, T. Y., Heuser, J., Gerisch, G.
The vacuolar H+-ATPase (V-ATPase) is a multi-subunit enzyme that plays important roles in eukaryotic cells. In Dictyostelium, it is found primarily in membranes of the contractile vacuole complex,...
Tubular-vesicular transformation in the contractile vacuole system of Dictyostelium (2002)
Gerisch, G., Heuser, J., Clarke, M.
The contractile vacuole complex of Dictyostelium is the paradigm of a membrane system that undergoes tubular-vesicular transitions during its regular cycle of activities. This system acts as an...
Clarke, M., Mitchell, K.W., Goodship, J., McDonnell, S., Barker, M.D., Griffiths, I.D., ...
AIMS: To describe the phenotype in three family members affected by a novel mutation in the gene coding for the enzyme tissue inhibitor of metalloproteinase-3 (TIMP-3). METHODS: Three members of the...
Clarke, M., Mitchell, K.W., Goodship, J., McDonnell, S., Barker, M.D., Griffiths, I.D., ...
AIMS: To describe the phenotype in three family members affected by a novel mutation in the gene coding for the enzyme tissue inhibitor of metalloproteinase-3 (TIMP-3). METHODS: Three members of the...
Clarke, M., Mitchell, K.W., Goodship, J., McDonnell, S., Barker, M.D., Griffiths, I.D., ...
AIMS: To describe the phenotype in three family members affected by a novel mutation in the gene coding for the enzyme tissue inhibitor of metalloproteinase-3 (TIMP-3). METHODS: Three members of the...
Discovery of Radio Emission from the Brown Dwarf LP944-20 (2001)
Berger, E., Ball, S., Becker, K. M., Clarke, M., Frail, D. A., Fukuda, T. A., ...
Brown dwarfs are classified as objects which are not massive enough to sustain nuclear fusion of hydrogen, and are distinguished from planets by their ability to burn deuterium. Old (>10 Myr) brown...
The Design and Implementation of Open ORB V2 (2001)
Blair, G., Blair, L., Coulson, G., Andersen, A., Clarke, M., Costas, F., ...
Changing perceptions in language learning and testing (2001)
Beverly, J., Beverly, E., Clarke, M., White, S.
This is a conference paper.
Patterns of Onset of Disability in Activities of Daily Living with Age. (2001)
Jagger, Carol, Arthur, Antony J., Spiers, Nicola A., Clarke, M.
Changing perceptions in language learning and testing (2001)
Beverly, J., Beverly, E., Clarke, M., White, Su
This is a conference paper.
Langton, K.P., McKie, N., Curtis, A., Goodship, J.A., Bond, P.M., Barker, M.D., ...
Sorsby’s fundus dystrophy (SFD) is a dominantly inherited degenerative disease of the retina that leads to loss of vision in middle age. It has been shown to be caused by mutations in the gene for...
Langton, K.P., McKie, N., Curtis, A., Goodship, J.A., Bond, P.M., Barker, M.D., ...
Sorsby’s fundus dystrophy (SFD) is a dominantly inherited degenerative disease of the retina that leads to loss of vision in middle age. It has been shown to be caused by mutations in the gene for...
Langton, K.P., McKie, N., Curtis, A., Goodship, J.A., Bond, P.M., Barker, M.D., ...
Sorsby’s fundus dystrophy (SFD) is a dominantly inherited degenerative disease of the retina that leads to loss of vision in middle age. It has been shown to be caused by mutations in the gene for...
A Principled Approach to Supporting Adaptation in Distributed Mobile Environments (2000)
Blair, G., Coulson, G., Blair, L., Duran-Limon, H., Parlavantzas, N., Saikoski, K., ...
Perry, S, Shaw, C, Assassa, P, Dallosso, H, Williams, K, Brittain, KR, ...
Background.The aim of the study was to establish the prevalence of urinary symptoms and felt the need in adults. This paper discusses problems with setting thresholds to distinguish cases from...
Optimizing Model Checking Based on BDD Characterization (1999)
Bwolen Yang, E. Bryant, M. Clarke, Thomas R. Gross, Kenneth L. Mcmillan, Cadence Berkeley Labs
study Symbolic model checking has been successfully applied in verification of various finite state systems, ranging from hardware circuits to software protocols. A core technology underlying this...
Optimizing Model Checking Based on BDD Characterization (1999)
Bwolen Yang, E. Bryant, M. Clarke, Thomas R. Gross, Kenneth L. Mcmillan, Cadence Berkeley Labs
study Symbolic model checking has been successfully applied in verification of various finite state systems, ranging from hardware circuits to software protocols. A core technology underlying this...
AIDMAN-A Versatile Telemedicine Platform (1998)
Telemedicine has long promised to be introduced on a wide scale, yet despite dramatic falls in the cost of hardware and increasing power and capability of equipment, there has been little impact on...
The trials of Dr. Bernard Fisher: a European perspective on an American episode (1997)
BUYSE, Marc, Peto, R., Collins, R., Sackett, D., Darbyshire, J., Babiker, A., ...
The trials of Dr. Bernard Fisher: a European perspective on an American episode (1997)
BUYSE, Marc, Peto, R., Collins, R., Sackett, D., Darbyshire, J., Babiker, A., ...
Ovarian ablation in early breast cancer: Overview of the randomised trials. (1996)
CLARKE, M, COLLINS, R, DAVIES, C, GODWIN, J, GRAY, R, PETO, R, ...
H-alpha Photometry of an X-ray Binary (1995)
Greenhill, JG, Watson, RD, Clarke, M, Pritchard, JD, Tobin, W
JAGGER, C., SPIERS, N. A., CLARKE, M.
Movements between dependency states, institutionalization and death are investigated in a general practice cohort of people aged 75 years and over with follow-up at 5 and 7 years from initial...
JAGGER, C., CLARKE, M., ANDERSON, J., BATTCOCK, T.
The 1988 Melton Mowbray Study of the Elderly comprised an initial screen with the Mini-Mental State Examination (MMSE) followed by a detailed clinical assessment using the Cambridge Mental Disorders...
Dementia in Melton Mowbray--A Validation of Earlier Findings (1992)
JAGGER, C., CLARKE, M., ANDERSON, J., BATTCOCK, T.
In 1981 a survey of elderly persons aged 75 years and over who belonged to a general practice in Melton Mowbray, Leicestershire found a prevalence of moderate cognitive impairment of 4.7%. The...
Housing careers, asset accumulation and subsidies to owner occupiers - a microsimulation (1991)
Owner occupiers in the UK housing market receive considerable central government subsidies, namely through provision of tax relief upon mortgage interest, through exemption of private house sales...
The Prevalence of Dementia in Europe: A Collaborative Study of 1980-1990 Findings (1991)
HOFMAN, A, ROCCA, W A, BRAYNE, C, BRETELER, M M B, CLARKE, M, COOPER, B, ...
To obtain age- and gender-specific estimates of the prevalence of dementia in Europe and to study differences in prevalence across countries, we pooled and re-analysed original data of prevalence...
Clarke , M., Longley, P., Williams, H.
Issues surrounding the financial benefits of owner occupation and how these are related to a variety of socioeconomic and geographical factors are examined through the development of a...
Teaching Epidemiology and Statistics to Medical Students the Leicester Experience (1980)
CLARKE, M, CLAYTON, D G, DONALDSON, L J
Clarke M [Department of Community Health, Medical School, University of Leicester, Clinical Sciences Building, Leicester Royal Infirmary, Leicester], Clayton D G, Donaldson L J. Teaching epidemiology...
OCCULT GASTROINTESTINAL BLEEDING DUE TO ASPIRIN: COMPARISON OF TWO COMPOUNDS (1976)
ROSSOUW, J. E., DAVIS, M., CLARKE, M., WILLIAMS, ROGER
Occult gastrointestinal bleeding as measured by the faecal 51Cr-labelled red-cell loss was compared in eight healthy volunteers while on therapeutic doses of soluble aspirin and a new slow-release...
Rapid Identification of Candida dubliniensis with Commercial Yeast Identification Systems
Pincus, D. H., Coleman, D. C., Pruitt, W. R., Padhye, A. A., Salkin, I. F., Geimer, M., ...
Candida dubliniensis is a newly described species that is closely related phylogenetically to Candida albicans and that is commonly associated with oral candidiasis in human immunodeficiency...
Beauparlant, P, Kwon, H, Clarke, M, Lin, R, Sonenberg, N, Wainberg, M, ...
The human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) contains two binding sites for the NF-kappa B/Rel family of transcription factors which are required for the transcriptional...
Liu, T, Williams, J G, Clarke, M
The single gene encoding calmodulin in the eukaryotic microorganism Dictyostelium discoideum was cloned and sequenced. The gene was found to contain three introns, one lying immediately after the...
Isolation and properties of calmodulin from Dictyostelium discoideum.
Clarke, M, Bazari, W L, Kayman, S C
A calcium-dependent regulatory protein (calmodulin) was purified from vegetative amoebae of Dictyostelium discoideum. The properties of Dictyostelium calmodulin are similar but not identical to those...
Genetic and physiologic modulation of the prestarvation response in Dictyostelium discoideum.
Throughout vegetative growth, Dictyostelium amoebae secrete an autocrine factor, prestarvation factor, PSF, which accumulates in proportion to cell density. During late exponential growth, PSF...
Schatzle, J, Rathi, A, Clarke, M, Cardelli, J A
In Dictyostelium discoideum, there is a group of genes that are expressed following starvation and when exponentially growing cells reach high densities. We have examined the expression of one of...
Identification of the single gene for calmodulin in Dictyostelium discoideum.
We report the isolation and sequence determination of a cDNA containing most of the coding sequence for Dictyostelium discoideum calmodulin. The cloned cDNA was used as a probe to examine the...
Biswas, S, Kayman, S C, Clarke, M
Dictyostelium discoideum MC2 is a temperature-sensitive motility mutant of AX3. Mutant cells are incapable of growth, phagocytosis, and migration under restrictive conditions (Kayman et al., J. Cell...
Mann, D L, Clark, J, Clarke, M, Reitz, M, Popovic, M, Franchini, G, ...
Cell lines were established from the peripheral blood of two patients with adult T cell leukemia. In contrast to our previous experience, where all such lines expressed T cell markers, these two cell...
Clarke, M, Schatten, G, Mazia, D, Spudich, J A
Amoebae of Dictyostelium discoideum were attached to a surface coated with polylysine, and the upper portion of the cells was sheared off with a stream of buffer. Scanning and transmission electron...
Parathyroid hormone related protein in hypercalcaemia of Hodgkin's disease.
Bolo-Deoku, J, Basu, S, Lakhani, S, Dunne, F, Ratcliffe, W A, Clarke, M, ...
The role of parathyroid hormone related protein (PTHRP) as a humoral mediator of hypercalcaemia was investigated in a patient with lymphocyte depleted Hodgkin's disease during an episode of...
Winder, A F, Jagger, C, Garrick, D P, Vallance, D T, Butowski, P F, Anderson, J, ...
AIMS: To determine lipid profiles and associations with other metabolic disease in a representative British elderly population. METHODS: Part of a prevalence survey of dementia in all 75+ year olds...
Shorter, J, Watson, R, Giannakou, M E, Clarke, M, Warren, G, Barr, F A
We have identified a 55 kDa protein, named GRASP55 (Golgi reassembly stacking protein of 55 kDa), as a component of the Golgi stacking machinery. GRASP55 is homologous to GRASP65, an...
During 1976 to 1985 perinatal mortality in Leicestershire decreased from 21 to 9.5 per 1000 births. Throughout this period the incidence of lethal malformations, excluding neural tube defects,...
Antibody response and clinical reactions in children given measles vaccine with immunoglobulin.
Lingam, S, Miller, C L, Clarke, M, Pateman, J
Antibody responses and clinical reactions to three measles vaccines (Attenuvax, Mevilin, and Rimevax) injected into the opposite arm to immunoglobulin were assessed in 45 children with brain...
Leatherwork: a possible hazard to reproduction.
A retrospective study was carried out aimed at eliciting the causes of perinatal death in Leicestershire between 1976 and 1982. Case notes were reviewed and the mothers interviewed in over 1000...
Prevalence of known diabetes in Asians and Europeans
Samanta, A, Burden, A C, Jones, G R, Woollands, I G, Clarke, M, Swift, P G F, ...
Quality of obstetric care provided for Asian immigrants in Leicestershire.
Between 1976 and 1981 some 939 perinatal deaths occurred to women living in Leicestershire, of which 128 (14%) were to Asian women. The qualifications of the general practitioners, the gestation at...
Kayman, S. C., Birchman, R., Clarke, M.
The Dictyostelium discoideum mutant MC2 exhibits temperature-sensitive growth, temperature-sensitive motility, and temperature induction of discoidin I synthesis. These three phenotypes of MC2 were...
Help for parents after stillbirth.
Heward, J, Woodcock, P B, Phillips, L F, Williams, A J, Clarke, M, MacVicar, J, ...
Communications to an antenatal clinic.
When referring pregnant women to an antenatal clinic many general practitioners and midwives presented details of their care in an incomplete and inconsistent manner. As a result, hospital staff...
Course of patients discharged early after myocardial infarction.
Gelson, A D, Carson, P H, Tucker, H H, Phillips, R, Clarke, M, Oakley, G D
Two hundred and seventy-one (76%) out of 358 survivors of infarction were discharged by the eighth hospital day, and 251 (93%) of them survived to six weeks after discharge. Six of the 20 patients...
Attitudes to viability of preterm infants and their effect on figures for perinatal mortality.
Fenton, A C, Field, D J, Mason, E, Clarke, M
OBJECTIVE--To examine how local attitudes to management of extreme preterm labour can influence data on perinatal mortality. DESIGN--One year prospective study in a geographically defined population....
Residential care for elderly people: a decade of change.
Stern, M C, Jagger, C, Clarke, M, Anderson, J, McGrother, C, Battock, T, ...
OBJECTIVE--To determine the changes between 1979 and 1990 in demography and dependency levels in elderly people in residential care. DESIGN--Censuses of those aged 65 years and over in any type of...
Evaluating perinatal mortality rates: effects of referral and case mix.
Clarke, M, Mason, E S, MacVicar, J, Clayton, D G
OBJECTIVE--To evaluate perinatal mortality rates as a method of auditing obstetric and neonatal care after account had been taken of transfer between hospitals during pregnancy and case mix....
Rapid Identification of Candida dubliniensis with Commercial Yeast Identification Systems
Pincus, D. H., Coleman, D. C., Pruitt, W. R., Padhye, A. A., Salkin, I. F., Geimer, M., ...
Candida dubliniensis is a newly described species that is closely related phylogenetically to Candida albicans and that is commonly associated with oral candidiasis in human immunodeficiency...
Beauparlant, P, Kwon, H, Clarke, M, Lin, R, Sonenberg, N, Wainberg, M, ...
The human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) contains two binding sites for the NF-kappa B/Rel family of transcription factors which are required for the transcriptional...
Liu, T, Williams, J G, Clarke, M
The single gene encoding calmodulin in the eukaryotic microorganism Dictyostelium discoideum was cloned and sequenced. The gene was found to contain three introns, one lying immediately after the...
Isolation and properties of calmodulin from Dictyostelium discoideum.
Clarke, M, Bazari, W L, Kayman, S C
A calcium-dependent regulatory protein (calmodulin) was purified from vegetative amoebae of Dictyostelium discoideum. The properties of Dictyostelium calmodulin are similar but not identical to those...
Genetic and physiologic modulation of the prestarvation response in Dictyostelium discoideum.
Throughout vegetative growth, Dictyostelium amoebae secrete an autocrine factor, prestarvation factor, PSF, which accumulates in proportion to cell density. During late exponential growth, PSF...
Schatzle, J, Rathi, A, Clarke, M, Cardelli, J A
In Dictyostelium discoideum, there is a group of genes that are expressed following starvation and when exponentially growing cells reach high densities. We have examined the expression of one of...
Identification of the single gene for calmodulin in Dictyostelium discoideum.
We report the isolation and sequence determination of a cDNA containing most of the coding sequence for Dictyostelium discoideum calmodulin. The cloned cDNA was used as a probe to examine the...
Biswas, S, Kayman, S C, Clarke, M
Dictyostelium discoideum MC2 is a temperature-sensitive motility mutant of AX3. Mutant cells are incapable of growth, phagocytosis, and migration under restrictive conditions (Kayman et al., J. Cell...
Mann, D L, Clark, J, Clarke, M, Reitz, M, Popovic, M, Franchini, G, ...
Cell lines were established from the peripheral blood of two patients with adult T cell leukemia. In contrast to our previous experience, where all such lines expressed T cell markers, these two cell...
Clarke, M, Schatten, G, Mazia, D, Spudich, J A
Amoebae of Dictyostelium discoideum were attached to a surface coated with polylysine, and the upper portion of the cells was sheared off with a stream of buffer. Scanning and transmission electron...
Parathyroid hormone related protein in hypercalcaemia of Hodgkin's disease.
Bolo-Deoku, J., Basu, S., Lakhani, S., Dunne, F., Ratcliffe, W. A., Clarke, M., ...
The role of parathyroid hormone related protein (PTHRP) as a humoral mediator of hypercalcaemia was investigated in a patient with lymphocyte depleted Hodgkin's disease during an episode of...
Winder, A F, Jagger, C, Garrick, D P, Vallance, D T, Butowski, P F, Anderson, J, ...
AIMS: To determine lipid profiles and associations with other metabolic disease in a representative British elderly population. METHODS: Part of a prevalence survey of dementia in all 75+ year olds...
Shorter, J, Watson, R, Giannakou, M E, Clarke, M, Warren, G, Barr, F A
We have identified a 55 kDa protein, named GRASP55 (Golgi reassembly stacking protein of 55 kDa), as a component of the Golgi stacking machinery. GRASP55 is homologous to GRASP65, an...
Kayman, S. C., Birchman, R., Clarke, M.
The Dictyostelium discoideum mutant MC2 exhibits temperature-sensitive growth, temperature-sensitive motility, and temperature induction of discoidin I synthesis. These three phenotypes of MC2 were...
During 1976 to 1985 perinatal mortality in Leicestershire decreased from 21 to 9.5 per 1000 births. Throughout this period the incidence of lethal malformations, excluding neural tube defects,...
Antibody response and clinical reactions in children given measles vaccine with immunoglobulin.
Lingam, S, Miller, C L, Clarke, M, Pateman, J
Antibody responses and clinical reactions to three measles vaccines (Attenuvax, Mevilin, and Rimevax) injected into the opposite arm to immunoglobulin were assessed in 45 children with brain...
Leatherwork: a possible hazard to reproduction.
A retrospective study was carried out aimed at eliciting the causes of perinatal death in Leicestershire between 1976 and 1982. Case notes were reviewed and the mothers interviewed in over 1000...
Prevalence of known diabetes in Asians and Europeans
Samanta, A, Burden, A C, Jones, G R, Woollands, I G, Clarke, M, Swift, P G F, ...
Quality of obstetric care provided for Asian immigrants in Leicestershire.
Between 1976 and 1981 some 939 perinatal deaths occurred to women living in Leicestershire, of which 128 (14%) were to Asian women. The qualifications of the general practitioners, the gestation at...
Help for parents after stillbirth.
Heward, J, Woodcock, P B, Phillips, L F, Williams, A J, Clarke, M, MacVicar, J, ...
Communications to an antenatal clinic.
When referring pregnant women to an antenatal clinic many general practitioners and midwives presented details of their care in an incomplete and inconsistent manner. As a result, hospital staff...
Course of patients discharged early after myocardial infarction.
Gelson, A D, Carson, P H, Tucker, H H, Phillips, R, Clarke, M, Oakley, G D
Two hundred and seventy-one (76%) out of 358 survivors of infarction were discharged by the eighth hospital day, and 251 (93%) of them survived to six weeks after discharge. Six of the 20 patients...
Attitudes to viability of preterm infants and their effect on figures for perinatal mortality.
Fenton, A C, Field, D J, Mason, E, Clarke, M
OBJECTIVE--To examine how local attitudes to management of extreme preterm labour can influence data on perinatal mortality. DESIGN--One year prospective study in a geographically defined population....
Residential care for elderly people: a decade of change.
Stern, M C, Jagger, C, Clarke, M, Anderson, J, McGrother, C, Battock, T, ...
OBJECTIVE--To determine the changes between 1979 and 1990 in demography and dependency levels in elderly people in residential care. DESIGN--Censuses of those aged 65 years and over in any type of...
Evaluating perinatal mortality rates: effects of referral and case mix.
Clarke, M, Mason, E S, MacVicar, J, Clayton, D G
OBJECTIVE--To evaluate perinatal mortality rates as a method of auditing obstetric and neonatal care after account had been taken of transfer between hospitals during pregnancy and case mix....
Epidemiology of the Hong Kong/68 Variant of Influenza A2 in Britain
Miller, D. L., Pereira, Marguerite S., Clarke, M.
Two influenza epidemics in Britain in 1968-9 and 1969-70, were due to the Hong Kong/68 variant of influenza A2 virus. The first epidemic was prolonged with low morbidity and mortality rates; the...
Metabolic activity of erosions in rheumatoid arthritis.
Pitt, P, Berry, H, Clarke, M, Foley, H, Barratt, J, Parsons, V
The hands of 10 patients with rheumatoid arthritis were investigated with diphosphonate scanning and radiology. Increased uptake of isotope can be associated with some erosions but not all and also...
Clarke, M., Clayton, D. G., Mason, E. S., MacVicar, J.
A case-control study of all perinatal deaths in Leicestershire was established in 1976. By 1985 some 1342 singleton perinatal deaths had occurred. Perinatal mortality among patients of Asian origin...
The relation between fertility rates and legal abortion rates was investigated in a sample of health authorities in England and Wales to see how these varied. Total period fertility rates and total...
Cardiac catheterisation by the Judkins technique as an outpatient procedure.
Oldroyd, K. G., Phadke, K. V., Phillips, R., Carson, P. H., Clarke, M., Davis, J. A.
OBJECTIVE--To assess the safety and cost benefit of left heart catheterisation by a modified Judkins technique performed as a day patient procedure. DESIGN--Review study of case notes of consecutive...
Determinants of delayed gastric emptying in anorexia nervosa and bulimia nervosa.
Robinson, P H, Clarke, M, Barrett, J
Gastric emptying was measured using a gamma camera in 22 patients with anorexia nervosa, in 10 patients of normal or high weight with bulimia nervosa and in 10 controls. Patients with anorexia...
Prevalence of faecal incontinence in adults aged 40 years or more living in the community
Perry, S, Shaw, C, McGrother, C, Matthews, R J, Assassa, R P, Dallosso, H, ...
Background: Prevalence studies of faecal incontinence in the general population are rare and the impact of faecal incontinence on quality of life has not been previously addressed.
Is acute glaucoma a symptom of diabetes?
Forty-three patients who had suffered an episode of angle closure glaucoma had an assessment of glucose tolerance. Two patients were known diabetics and one new diabetic was found as a result of the...
Loss of vision in one eye following scoliosis surgery.
West, J, Askin, G, Clarke, M, Vernon, S A
A 50-year-old woman developed left sided total external ophthalmoplegia and complete visual loss, with evidence of choroidal non-perfusion, immediately following scoliosis surgery. The ocular...
Risk factors for strabismus in children born before 32 weeks' gestation
Pennefather, P., Clarke, M., Strong, N., Cottrell, D., Dutton, J., Tin, W.
AIM—To investigate risk factors associated with strabismus in children born prematurely. METHODS—Prospective study of all children born before 32 weeks' gestation between 1 January 1990 and...
Bias due to incomplete follow up in a cohort study
Pennefather, P, Tin, W, Clarke, M, Dutton, J, Fritz, S, Hey, E
AIM—To investigate the bias introduced by incomplete follow up in a cohort study of ocular outcome after premature birth. METHODS—A geographically defined cohort of children born before...
Clarke, M., Mitchell, K., Goodship, J., McDonnell, S., Barker, M., Griffiths, I., ...
AIMS—To describe the phenotype in three family members affected by a novel mutation in the gene coding for the enzyme tissue inhibitor of metalloproteinase-3 (TIMP-3). METHODS—Three members of...
Ziakas, N, Cottrell, D, Milligan, D, Pennefather, P, Bamashmus, M, Clarke, M
AIMS—This project was designed to determine whether a coordinated regional strategy can improve the implementation of national guidelines for screening for retinopathy of prematurity (ROP), and to...
Davies, R J, Vardi-Visy, K, Clarke, M, Stradling, J R
BACKGROUND--Respiratory sleep studies are frequently performed to identify sleep disruption resulting from upper airway obstruction. Traditional polysomnographic studies may not detect brief...
Davies, R J, Crosby, J, Vardi-Visy, K, Clarke, M, Stradling, J R
BACKGROUND--Obstructive sleep apnoea, and possibly snoring, are associated with a poorly understood increase in cardiovascular mortality which may be explained by their effects on systemic blood...
Pregnant women at work: a study of ethnic minority risk in Leicestershire.
Possible reasons for the excess risk of perinatal mortality experienced by Asian women living in Leicestershire who work during pregnancy were investigated. This entailed a detailed examination of...
Ambulatory electrocardiographic monitoring in patients with transient focal cerebral ischaemia.
Francis, D A, Heron, J R, Clarke, M
Sixty-four patients with transient ischaemic attacks were investigated for the presence of an associated cardiac arrhythmia. 24-hour ambulatory monitoring showed arrhythmia in 41% of patients where...
High incidence of Meckel's syndrome in Gujarati Indians.
Young, I D, Rickett, A B, Clarke, M
Five probable cases of Meckel's syndrome have been ascertained retrospectively through the Leicestershire Perinatal Mortality Survey for the years 1976 to 1982. All of these babies were born to Hindu...
Genetic analysis of malformations causing perinatal mortality.
Young, I D, Rickett, A B, Clarke, M
An analysis of congenital malformations, other than neural tube defects, which have contributed to perinatal mortality in Leicestershire is presented for the years 1976 to 1982 inclusive....
Goodship, J, O'Sullivan, J, Chinnery, P, Ryan, A, Ziakas, N, Hall, C, ...
Case-control study of leatherwork and male infertility
OBJECTIVES—To test the hypothesis that leatherwork is associated with male infertility mediated through the development of oligozoospermia. The basis of any association was postulated, at the...
Peptic ulceration in men. Epidemiology and medical care.
Clarke, M, Halil, T, Salmon, N
Estimates of the population prevalence of peptic and duodenal ulceration in men aged between 25 and 64 years were made in the London borough of Lambeth. The sampling frame for these estimates was a...
The elderly in residential care: mortality in relation to functional capacity.
Donaldson, L J, Clayton, D G, Clarke, M
A census in which 4514 people aged 65 and over had been enumerated in all types of institutional care both within and outside the National Health Service in Leicestershire was taken as a starting...
Provision of services for incontinent elderly people at home.
McGrother, C W, Castleden, C M, Duffin, H, Clarke, M
Results of a survey of elderly people living at home suggest that 8% suffer from important degrees of urinary dysfunction and are accessible to community based services. Supply of NHS incontinence...
The elderly at home: indices of disability.
Jagger, C, Clarke, M, Davies, R A
The physical status of all people aged 75 and over living in and around Melton Mowbray was assessed by the responses to a series of questions on the activities of daily living that the respondents...
Handicaps associated with incontinence: implications for management.
McGrother, C W, Jagger, C, Clarke, M, Castleden, C M
STUDY OBJECTIVE--The aim was to explore the relationship between dementia, impairment of mobility, and incontinence and the implications for management. DESIGN--The study was a survey of a sample...
Extreme prematurity in the UK and Denmark: population differences in viability
Field, D, Petersen, S, Clarke, M, Draper, E
Background: Previous studies comparing different models of neonatal intensive care have generally not been population based. The objective of this study was to compare the perinatal services of two...
A confidential enquiry into cases of neonatal encephalopathy
Draper, E, Kurinczuk, J, Lamming, C, Clarke, M, James, D, Field, D
Objectives: To assess the quality of care and timing of possible asphyxial events for infants with neonatal encephalopathy; to compare the quality of care findings with those relating to the deaths...
Abnormal cognitive function in treated congenital hypopituitarism
Brown, K, Rodgers, J, Johnstone, H, Adams, W, Clarke, M, Gibson, M, ...
Aims: To assess cognitive function in school age children with congenital pituitary hormone deficiency (PHD).
H. Armstrong, D. Spooner, M. Kirby, G. Yannopoulos, G. Yannopoulos, P. Gripaios, ...
Regional Development in Western Europe, 3rd edition, H. D. CLOUT (Ed.), David Fulton, London (1987). xi + 453 pp. £11.95 (pbk). ISBN 1 85346 090 7. Government Factories and the Origins of British...
H. Armstrong, R. Leigh, C. Law, P. Johnson, T. O'Riordan, R. Bennett, ...
Regional Economic Development: Essays in Honour of Francois Perroux, B. J. HIGGINS and D. J. SAVOIE (Eds.), Unwin Hyman, London (1988). xiii + 415 pp. £25.00 (hbk). ISBN 0 04 388155 3. The Regional...
H. Armstrong, A. Williams, P. Bull, H. F. Campbell, M. Jackson, B. Naisbitt, ...
The European Challenge 1992: The Benefits of a Single Market, P. CECCHINI, Gower, Hants (1988). xxi + 127 pp. £6.95 (pbk). ISBN 0 7045 0613 0. Channel Tunnel: Vicious Circle, Pilot Study: The Impact...
Temporary sequential atrioventricular pacing in myocardial infarction.
The loss of atrial contraction can seriously impair cardiac output when complete heart block follows myocardial infarction. We describe two cases in which temporary sequential atrioventricular pacing...
Delaney, C., Reed, D., Clarke, M.
Dramatic changes in health care have intensified practitioners' efforts to access and use information to determine more efficacious approaches to patient outcomes. The overall goal of the study is to...
J R Beaumont, M Clarke, A G Wilson
It is demonstrated that a simple difference equation model, which exhibits complex bifurcation behaviour, can be used to represent change in urban retailing and residential systems. These submodels...
The allocation of scarce resources in public policy planning is seen to operate at a number of different levels: the strategic allocation of resources between and within different types of broad...
Much current interest in spatial interaction modeling centres around solving the Harris - Wilson equilibrium model. In this paper the role of different attractiveness functions is explored and some...
Vacancy chain models for housing and employment systems
In this paper a new approach is developed to the analysis of stratified housing and employment systems which exhibit interdependencies between movers in the allocation process. Vacancy chain models,...
The AGW spatial interaction workstation
Despite the advances made in the development of computer models of urban and regional systems the lack of an appropriate software package incorporating much of this work prevents the popularisation...
Towards an applicable human geography: some developments and observations
In this paper we outline the development of an applicable human geography founded upon model-based methods. First, we outline some of the recent trends that suggest cautious optimism within the...
There is a growing interest from a wide variety of sources in information pertaining to the characteristics of residents of small geographical areas together with their associated activity patterns....
In this paper it is argued that continuing advances in computing power present both a challenge and an opportunity to researchers in the social sciences. There are opportunities in at least two areas...
Reexamining old problems with new methods: Portbury revisited
G P Clarke, M Clarke, A G Wilson
It is now twenty years since the Ministry of Transport examined the feasibility of constructing new harbour facilities at Portbury, Bristol. Part of that analysis was based on the use of a gravity...
A model-based approach to planning in the National Health Service
In this paper a new framework for planning in the National Health Service is described. The approach is centred around the idea of providing adequate information for planning and decisionmaking....
Farmers' perceptions of the lay health worker on farms in the Western Cape, South Africa
Clarke, M., Dick, J., Van Zyl, H., Johansson, E.
This study is focussed on farms situated in the Boland health district of the Cape Winelands, South Africa. The aim was to explore, understand, and describe the perceptions of farmers of having a...
Epidemiological studies of rubella virus in a tropical African community
Clarke, M., Schild, G. C., Boustred, J., McGregor, I. A., Williams, K.
The single-radial-haemolysis test for antibody to rubella virus provides a simple rapid method for carrying out large serological surveys. The availability of a collection of sequential serum samples...
Reporting the findings of clinical trials: a discussion paper
Ghersi, D, Clarke, M, Berlin, J, Gülmezoglu, AM, Kush, R, Lumbiganon, P, ...
Individual patient data meta-analysis in cancer.
Clarke, M., Stewart, L., Pignon, J. P., Bijnens, L.
As in many areas of health care, treatments for cancer may differ only moderately in their effects on major end points, such as death. But, such differences are worth knowing about, particularly in...