Lewis, Peter A., Mullany, D.V., Townsend, S, Johnson, J, Wood, L, Courtney, M, ...
The aim of this study was to review and describe indications for intraaortic balloon counterpulsation (IABP) use and identify the impact these have on outcomes at an Australian cardiothoracic...
Aim. The purpose of the research study was to evaluate a diet intervention in relation to the perceived weight loss and ways of coping of people living with HIV and lipodystrophy. The objectives were...
Education based on the theory of planned behavior promotes evidence-based fever management (2006)
Walsh, A., Edwards, H., Courtney, M., Wilson, J., Monaghan, S., Young, J.
Rickard, CM, Lipman, J, Courtney, M, Siversen, R, Daley, P
OBJECTIVE: To determine the effect of routine intravenous (IV) administration set changes on central venous catheter (CVC) colonization and catheter-related bacteremia. DESIGN: Prospective,...
Browne, G., Courtney, M., Meehan, T.
Accommodation is considered to be important by institutions interested in mental health care both in Australia and internationally. Some authorities assert that no component of a community mental...
A fever management education program for paediatric nurses (2003)
Edwards, H., Walsh, A., Courtney, M., Wilson, J., Monaghan, S., Young, J.
Barnes, M, Courtney, M, Pratt, J, Walsh, A
This paper describes the findings of a qualitative study that sought to identify the changing role of the child health nurse within the contemporary health service environment. Using a case study...
Research to promote rational, consistent fever management by paediatric nurses (2002)
Edwards, H., Courtney, M., Walsh, A., Monaghan, S., Wilson, J., Young, J.
Degryse, E., Acker, M., Defreyn, G., Bernat, A., Maffrand, J.P., Roitsch, C., ...
The hirudin variant HV2 was modified by in vitro site-specific mutagenesis of HV2 cDNA to generate HV2(Asn-47 – Lys), HV2(Asn-47 – Arg) and HV2(Lys-35 – Thr, Asn-47 – Lys). Residues 35 and 47...
Altered specificities of genetically engineered {alpha}1 antitrypsin variants (1986)
Jallat, S., Carvallo, D., Tessier, L.H., Roecklin, D., Roitsch, C., Ogushi, F., ...
Seven active site variants of human α1-antitrypsin (α1AT) were produced in Escherichia coli following site-specific mutagenesis of the α1AT complementary DNA. α1AT (Ala 358), α1AT (Ile358 and...
A nuclear precursor to human {gamma}-globin messenger RNA (1979)
RNA isolated from human foetal liver at an erythroid stage of development was transferred from methyl mercury hydroxide agarose gels to diazobenzyloxymethyl paper. A l6S RNA species containing...
Garver, R I, Chytil, A, Karlsson, S, Fells, G A, Brantly, M L, Courtney, M, ...
Alpha 1-Antitrypsin (alpha 1AT) deficiency is a hereditary disorder characterized by reduced serum levels of alpha 1AT, resulting in destruction of the lower respiratory tract by neutrophil elastase....
The influence of mRNA primary and secondary structure on human IFN-gamma gene expression in E. coli.
Tessier, L H, Sondermeyer, P, Faure, T, Dreyer, D, Benavente, A, Villeval, D, ...
Parameters influencing the efficiency of expression of the human immune interferon (IFN-gamma) gene in E. coli were studied by comparing a series of eight in vitro-derived gene variants. These...
Harvey, R P, Degryse, E, Stefani, L, Schamber, F, Cazenave, J P, Courtney, M, ...
Cloned cDNAs have been isolated that encode a variant of hirudin, a potent thrombin inhibitor that is secreted by the salivary glands of the medicinal leech, Hirudo medicinalis. This variant probably...
A nuclear precursor to human gamma-globin messenger RNA.
RNA isolated from human foetal liver at an erythroid stage of development was transferred from methyl mercury hydroxide agarose gels to diazobenzyloxymethyl paper. A 16S RNA species containing...
High-level production of biologically active human alpha 1-antitrypsin in Escherichia coli.
Courtney, M, Buchwalder, A, Tessier, L H, Jaye, M, Benavente, A, Balland, A, ...
A cDNA clone containing the complete human alpha 1-antitrypsin sequence was isolated from a human liver cDNA bank by screening with a chemically synthesized oligonucleotide probe. DNA sequences...
Mornex, J F, Chytil-Weir, A, Martinet, Y, Courtney, M, LeCocq, J P, Crystal, R G
To evaluate the contribution of mononuclear phagocytes, and particularly alveolar macrophages, to alpha-1-antitrypsin (alpha 1AT) production in normal and alpha 1AT-deficient individuals, Northern...
Evaluation of "at risk" alpha 1-antitrypsin genotype SZ with synthetic oligonucleotide gene probes.
Nukiwa, T, Brantly, M, Garver, R, Paul, L, Courtney, M, LeCocq, J P, ...
Alpha 1-antitrypsin (alpha 1AT), a 52,000-mol-wt serum glycoprotein produced by hepatocytes and mononuclear phagocytes, functions as the major inhibitor of neutrophil elastase. The alpha 1AT...
Schapira, M, Ramus, M A, Jallat, S, Carvallo, D, Courtney, M
In normal plasma, the serine protease inhibitor alpha 1-antitrypsin (alpha 1-AT) plays little or no role in the control of plasma kallikrein or activated Factor XII fragment (Factor XIIf), this...
Schapira, M, Ramus, M A, Waeber, B, Brunner, H R, Jallat, S, Carvallo, D, ...
The specificity of serpin superfamily protease inhibitors such as alpha 1-antitrypsin or C1 inhibitor is determined by the amino acid residues of the inhibitor reactive center. To obtain an inhibitor...
Hubbard, R C, Ogushi, F, Fells, G A, Cantin, A M, Jallat, S, Courtney, M, ...
Current concepts relating to the pathogenesis of emphysema associated with cigarette smoking is that an imbalance exists within the lower respiratory tract between neutrophil elastase and the local...
Revak, S D, Merritt, T A, Degryse, E, Stefani, L, Courtney, M, Hallman, M, ...
Two low molecular weight (LMW) apoproteins were isolated from human pulmonary surfactant. SDS polyacrylamide gel analysis showed one protein (SP 18) to have an apparent molecular weight of 18,000...
Wainwright, B J, Scambler, P J, Stanier, P, Watson, E K, Bell, G, Wicking, C, ...
An expressed gene sequence which was identified by the isolation of a methylation free CpG island from human chromosome 7 has been cloned from a human lung cDNA library. The deduced protein sequence...
Gahéry-Ségard, H, Molinier-Frenkel, V, Le Boulaire, C, Saulnier, P, Opolon, P, Lengagne, R, ...
Animal studies indicate that the use of replication-deficient adenovirus for human gene therapy is limited by host antivector immune responses that result in transient recombinant protein expression...
Satoh, K, Nukiwa, T, Brantly, M, Garver, R I, Hofker, M, Courtney, M, ...
Homozygous inheritance of the null bellingham alpha 1-antitrypsin (alpha 1AT) gene is associated with early-onset emphysema, resulting from the lack of alpha 1AT to protect the lung from neutrophil...
Tartour, E, Mehtali, M, Sastre-Garau, X, Joyeux, I, Mathiot, C, Pleau, J M, ...
Various studies have emphasized an immunodepression state observed at the tumour site. To reverse this defect and based upon animal studies, we initiated a phase I clinical trial of gene therapy in...