Cullen, M.D., Cheung, Y.F., Houslay, M.D., Hartman, T.L., Watson, K.M., Buckheit, R.W., ...
The alkenyldiarylmethanes (ADAMs) are currently being investigated as non- nucleoside HIV- 1 reverse transcriptase inhibitors (NNRTIs) of potential value in the treatment of HIV infection and AIDS....
Danesh, J, Erqou, S, Walker, M, Thompson, S G, Tipping, R, Ford, C, ...
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Psychosocial Factors and Inflammation in the Multi-Ethnic Study of Atherosclerosis (2007)
Ranjit, N, Diez Roux, AV, Shea, S, Cushman, M, Seeman, T
Background Psychosocial factors are associated with the development and progress of cardiovascular disease, but the pathological mechanisms remain unclear. We examined the associations of...
Ranjit, N, Diez Roux, AV, Shea, S, Cushman, M, Ni, H, Seeman, T
Background— Low socioeconomic position is known to be associated with cardiovascular events and atherosclerosis. Reasons for these associations remain a topic of research. Inflammation could be an...
Diez Roux, AV, Auchincloss, A, Astor, B, Barr, RG, Cushman, M, Dvonch, T, ...
http://deepblue.lib.umich.edu/bitstream/2027.42/55422/1/Diez Roux et al Sep 2006 Recent exposure to particulate matter and C-reactive protein concentration in the multi-ethnic study of...
Diez Roux, A. V., Auchincloss, A. H., Astor, B., Barr, R. G., Cushman, M., Dvonch, T., ...
Ambient levels of particulate matter have been linked to cardiovascular disease. The mechanisms mediating these associations are poorly understood. One candidate mechanism is inflammation. Using data...
Koch,M., Breithaupt,C., Gerhardt,S., Weber,S., Cushman,M., Huber,R., ...
Sensitivity of a questionnaire for data collection on venous thrombosis (2004)
Vossen, C.Y., Korlaar, I.M. Van, Cushman, M., Rosendaal, F.R., Bovill, E.G.
Estrogen plus progestin and risk of venous thrombosis (2004)
Cushman, M., Kuller, L.H., Prentice, R., Rodabough, R.J., Psaty, B.M., Stafford, R.S., ...
The impact of venous thrombosis on quality of life (2004)
Korlaar, I.M. Van, Vossen, C.Y., Rosendaal, F.R., Bovill, E.G., Cushman, M., Naud, S., ...
Sensitivity of a questionnaire for data collection on venous thrombosis (2004)
Vossen, C.Y., Korlaar, I.M. Van, Cushman, M., Rosendaal, F.R., Bovill, E.G.
Estrogen plus progestin and risk of venous thrombosis (2004)
Cushman, M., Kuller, L.H., Prentice, R., Rodabough, R.J., Psaty, B.M., Stafford, R.S., ...
The impact of venous thrombosis on quality of life (2004)
Korlaar, I.M. Van, Vossen, C.Y., Rosendaal, F.R., Bovill, E.G., Cushman, M., Naud, S., ...
Kostis, J.B., Wilson, A.C., Folsom, A.R., Chambless, L., Wu, K., Benderly, M., ...
Background Many long-term studies have reported on associations of plasma fibrinogen concentration with cardiovascular disease, but few have been large enough to provide reliable estimates in...
Fischer,M., Haase,I., Kis,K., Meining,W., Ladenstein,R., Cushman,M., ...
Cushman,M., Yang,D. L., Mihalic,J. T., Chen,J. H., Gerhardt,S., Huber,R., ...
Several analogues of a hypothetical intermediate in the reaction catalyzed by lumazine synthase were synthesized and tested as inhibitors of both Bacillus subtilis lumazine synthase and Escherichia...
Gerhardt,S., Schott,A. K., Kairies,N., Cushman,M., Illarionov,B., Eisenreich,W., ...
Riboflavin synthase catalyzes the disproportionation of 6,7- dimethyl-8-ribityllumazine affording riboflavin and 5-amino-6- ribitylamino-2,4(1H,3H)-pyrimidinedione. We have determined the structure...
Cushman,M., Yang,D. L., Gerhardt,S., Huber,R., Fischer,M., Kis,K., ...
A series of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-D-ribityllumazine were synthesized as inhibitors of both Escherichia coli riboflavin synthase and Bacillus subtilis lumazine...
Cushman, M., Yang, D. L., Mihalic, J. T., Chen, J. H., Gerhardt, S., Huber, R., ...
Several analogues of a hypothetical intermediate in the reaction catalyzed by lumazine synthase were synthesized and tested as inhibitors of both Bacillus subtilis lumazine synthase and Escherichia...
Cushman, M., Yang, D. L., Gerhardt, S., Huber, R., Fischer, M., Kis, K., ...
A series of 6-carboxyalkyl and 6-phosphonoxyalkyl derivatives of 7-oxo-8-D-ribityllumazine were synthesized as inhibitors of both Escherichia coli riboflavin synthase and Bacillus subtilis lumazine...
Gerhardt, S., Schott, A. K., Kairies, N., Cushman, M., Illarionov, B., Eisenreich, W., ...
Riboflavin synthase catalyzes the disproportionation of 6,7- dimethyl-8-ribityllumazine affording riboflavin and 5-amino-6- ribitylamino-2,4(1H,3H)-pyrimidinedione. We have determined the structure...
Loftus, T L, Turpin, J A, ...
A new series of cosalane analogues incorporating two fragments of the dichlorodisalicylmethane pharmacophore has been synthesized. In order to identify the position for the attachment of the...
Paul, G C, Loftus, T L, ...
Cosalane and its synthetic derivatives inhibit the binding of gp120 to CD4 as well as the fusion of the viral envelope with the cell membrane. The binding of the cosalanes to CD4 is proposed to...
Synthesis and anti-HIV activity of a bile acid analog of cosalane (2001)
Hartman, T, Turpin, J, ...
Cosalane is a novel anti-HIV agent that inhibits the attachment of gp120 to CD4. The therapeutic potential of cosalane is limited by poor oral absorption. In an attempt to target the ileal bile acid...
Loftus, T L, Turpin, J A, ...
The binding of the anti-HIV agent cosalane to CD4 is thought to involve ionic interactions of negatively charged carboxylates of the ligand with positively charged residues on the surface of the...
Stup, T L, Turpin, J A, ...
Introduction of an amido group or an amino moiety into the alkenyl linker chain of cosalane (1) provided a new series of analogues 3-8. The new compounds were evaluated as inhibitors of the...
Stup, TL, Turpin, JA, ...
The cosalane pharmacophore has been extended by the attachment of two additional substituted benzoic acid rings through amide and methylene linkers. The resulting compounds display significant...
Mechanism of the antiviral activity of new aurintricarboxylic acid analogues (1996)
Esté, JA, Cushman, M, ...
Various new aurintricarboxylic acid (ATA) polymer analogues have been evaluated for their antiviral activity against a wide array of DNA and RNA viruses, and their mechanism of action against human...
Wutzler, P, Cushman, M, Klöcking, R, Helbig, B, ...
Collaborative meta-analysis of prospective studies of plasma fibrinogen and cardiovascular disease
Kostis, J.B., Wilson, A.C., Folsom, A.R., Chambless, L., Wu, K., Benderly, M., ...
Background Many long-term studies have reported on associations of plasma fibrinogen concentration with cardiovascular disease, but few have been large enough to provide reliable estimates in...
Production and antibacterial activity of malforming C, a toxic metabolite of Aspergillus niger.
Kobbe, B, Cushman, M, Wogan, G N, Demain, A L
The production of the new mycotoxin malformin C by a solid substrate fermentation is described. Malformin C is highly toxic (mean lethal dose = 0.9 mg/kg) and exerts antibacterial activity against a...
Production and antibacterial activity of malforming C, a toxic metabolite of Aspergillus niger.
Kobbe, B, Cushman, M, Wogan, G N, Demain, A L
The production of the new mycotoxin malformin C by a solid substrate fermentation is described. Malformin C is highly toxic (mean lethal dose = 0.9 mg/kg) and exerts antibacterial activity against a...
Collaborative meta-analysis of prospective studies of plasma fibrinogen and cardiovascular disease
Kostis, J.B., Wilson, A.C., Folsom, A.R., Chambless, L., Wu, K., Benderly, M., ...
Background Many long-term studies have reported on associations of plasma fibrinogen concentration with cardiovascular disease, but few have been large enough to provide reliable estimates in...
Cullen, M.D., Cheung, Y.F., Houslay, M.D., Hartman, T.L., Watson, K.M., Buckheit, R.W., ...
The alkenyldiarylmethanes (ADAMs) are currently being investigated as non- nucleoside HIV- 1 reverse transcriptase inhibitors (NNRTIs) of potential value in the treatment of HIV infection and AIDS....
Jackson, S. A., Burke, G. L., Thach, C., Cushman, M., Ives, D., Powe, N., ...
Although coronary heart disease (CHD) is the leading cause of death and morbidity in older African Americans, relatively little is known about the incidence and predictors of CHD in this population....